Silkworm Genome Informatics Database

Gene

KWMTBOMO07802

Pre Gene Modal

BGIBMGA001232

Annotation

ring_box_protein_[Bombyx_mori]

Location

Bomo_Chr13(-):7045348-7046285 View in EpiBrowser

Full name

RING-box protein 1A

Alternative Name

Regulator of cullins 1a
dRbx1

Location in the cell

Cytoplasmic Reliability : 1.029 Nuclear Reliability : 1.599

CDS

ATGGCTTCTGTGATGGATGTTGATGAAGAAGAAGTTGAAATGGCTTCGTCTAGTAGTGGCAAAGGAGATAAAAAAAGATTCGAAGTAAAAAAGTGGAATGCAGTAGCACTCTGGGCTTGGGATATTGTTGTCGACAACTGTGCTATTTGCCGAAATCACATAATGGATCTGTGTATCGAATGCCAAGCAAATCAAGCCTCAGCCACTAGTGAAGAATGCACAGTTGCTTGGGGTGTTTGTAATCATGCATTCCATTTCCACTGTATTTCCCGTTGGTTGAAGACTCGACAAGTTTGTCCACTAGACAATAGAGAATGGGAGTTCCAAAAGTATGGTCATTAA

Protein

MASVMDVDEEEVEMASSSSGKGDKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH

Description

Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Required for the specific SCF-dependent proteolysis of CI, but not that of ARM, suggesting that it also participates in the selection of substrates inside the SCF complex (PubMed:12062088). During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890). The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555). Also part of an SCF complex required for caspase activation during sperm differentiation (Probable).

Subunit

Component of SCF E3 ubiquitin-protein ligase complexes consisting of Skpa, Cul1, Roc1a and an F-box protein. In larvae neuroblast self renewal and asymmetric division, as well as ddaC dendrite and mushroom body axon pruning, the complex contains the F-box protein slmb (SCF-slmb) (PubMed:24068890, PubMed:24413555). Interacts directly with Cul1 and Slmb (PubMed:11500045). In caspase activation during sperm differentiation, the complex contains the F-box protein ntc (Probable).

Similarity

Belongs to the RING-box family.

Keywords

Complete proteome Cytoplasm Developmental protein Metal-binding Nucleus Reference proteome Ubl conjugation pathway Zinc Zinc-finger

Feature

chain RING-box protein 1A

Uniprot

S4NI94 A0A2A4JT75 Q2F5L9 A0A2R7WVP6 R4WDN4 A0A0P5U8B8 + More
A0A194RH10 A0A194PDC1 A0A1B6C3Y1 A0A0P5J9D5 T1IQB4 A0A0P6E2R3 A0A067R3E4 A0A0K8RNL9 A0A026W1Q9 A0A0J7NLT7 A0A158NZP4 A0A195D1W6 A0A0N8DX25 A0A0P5SLA0 W5JQ39 A6YPF3 A0A131Y652 B7PN13 T1HGK2 A0A224XTW8 A0A0V0G4C9 A0A023GDP4 G3MN29 A0A0C9QZ75 A0A023FW86 A0A023FDV0 A0A224YYP2 A0A131YU42 L7M651 A0A131XKA0 A0A2S2PZH7 A0A1J1J035 V5H427 A0A1Z5L4H9 A0A0P6B382 A0A1Y1NBP3 A0A0P5TNG5 A0A2A3ET71 A0A088AEC6 J3JVZ1 A0A336MQF9 D2A2S1 A0A1W4WIU3 A0A1B6KYB0 A0A1B6FIW4 A0A1B6K6I1 A0A1B6GL73 A0A164LRT1 V9IKT7 A0A0P5HPK9 E9FSM2 A0A0P4VUZ3 B4R7G5 B4I946 X2JA05 Q9W5E1 A0A0K8TPB9 A0A1L8EB16 A0A1L8DT49 A0A1B0FUX4 A0A1L8EAN7 A0A2H8U0L4 A0A2S2NN11 A0A2S2PV83 C4WUL2 A0A1W7R9S9 A0A1D2M7Y8 A0A1L8EAM6 A0A1L8EB02 A0A0L0BMU9 A0A1L8EB20 A0A1L8EB03 A0A1L8EAQ6 B4PX22 A0A1L8EAL2 A0A1I8M614 A0A1A9YQR0 A0A1A9UZS1 A0A1B0B142 A0A1I8P0D4 A0A1L8EH96 A0A1B0AHT3 A0A1A9WCG5 A0A2M4AIG8 A0A0A9XE03 B5DKH1 B2VU47 A0A2W1DVD3 V9LBY4 H9IVF2 W7F250 W6Y7S7 M2RM03 N4WQ84

Pubmed

23622113 23691247 26354079 24845553 24508170 30249741 + More
21347285 20920257 23761445 18207082 22216098 26131772 28797301 26830274 25576852 28049606 28528879 28004739 22516182 23537049 18362917 19820115 21292972 27129103 17994087 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 10731137 12537569 12062088 11500045 12850443 24068890 24413555 27331610 26369729 27289101 26108605 17550304 25315136 25401762 26823975 15632085 23316438 29685100 24402279 19121390 23357949 23236275

EMBL

GAIX01014169 JAA78391.1 NWSH01000724 PCG74600.1 DQ311404 ABD36348.1 + More
KK855671 PTY23481.1 AK417689 BAN20904.1 GDIP01133705 JAL70009.1 KQ460205 KPJ16872.1 KQ459606 KPI91242.1 GEDC01029194 JAS08104.1 GDIQ01205122 JAK46603.1 JH431303 GDIQ01083469 JAN11268.1 KK852782 KDR16613.1 GADI01001295 JAA72513.1 KK107488 QOIP01000012 EZA50005.1 RLU15682.1 LBMM01003509 KMQ93445.1 ADTU01004868 KQ976948 KYN06898.1 GDIQ01083468 JAN11269.1 GDIP01138361 JAL65353.1 ADMH02000800 ETN65005.1 EF638964 ABR27849.1 GEFM01001824 JAP73972.1 ABJB010899990 DS749722 EEC07985.1 ACPB03011656 GFTR01001832 JAW14594.1 GECL01003241 JAP02883.1 GBBM01003117 JAC32301.1 JO843280 AEO34897.1 GBZX01002720 JAG90020.1 GBBL01002342 JAC24978.1 GBBK01004347 GBBK01004346 JAC20136.1 GFPF01011602 MAA22748.1 GEDV01006891 JAP81666.1 GACK01006416 JAA58618.1 GEFH01002021 JAP66560.1 GGMS01001610 MBY70813.1 CVRI01000062 CRL04209.1 GALX01000908 JAB67558.1 GFJQ02004657 JAW02313.1 GDIP01020628 JAM83087.1 GEZM01007208 JAV95293.1 GDIP01125161 JAL78553.1 KZ288192 PBC34406.1 APGK01035108 BT127409 KB740923 KB632326 AEE62371.1 ENN78177.1 ERL92460.1 UFQT01000987 UFQT01001770 SSX28298.1 SSX31741.1 KQ971339 EFA01469.1 GEBQ01023733 JAT16244.1 GECZ01019634 JAS50135.1 GECU01017758 GECU01000646 JAS89948.1 JAT07061.1 GECZ01006565 JAS63204.1 LRGB01003123 KZS04368.1 JR052234 AEY61650.1 GDIQ01225016 JAK26709.1 GL732524 EFX89801.1 GDKW01000738 JAI55857.1 CM000366 EDX16776.1 CH480825 EDW43727.1 AE014298 KX531597 AHN59225.1 ANY27407.1 AL031581 AY119265 GDAI01001371 JAI16232.1 GFDG01003004 JAV15795.1 GFDF01004544 JAV09540.1 AJWK01006356 GFDG01003001 JAV15798.1 GFXV01007537 MBW19342.1 GGMR01005954 MBY18573.1 GGMS01000232 MBY69435.1 ABLF02025362 AK341114 BAH71582.1 GFAH01000492 JAV47897.1 LJIJ01002924 ODM89088.1 GFDG01003002 JAV15797.1 GFDG01002997 JAV15802.1 JRES01001642 KNC21263.1 GFDG01003003 JAV15796.1 GFDG01003000 JAV15799.1 GFDG01002998 JAV15801.1 CM000162 EDX00808.1 GFDG01002999 JAV15800.1 JXJN01006969 GFDG01000738 JAV18061.1 GGFK01007255 MBW40576.1 GBHO01025724 GBHO01025723 GBRD01001435 GDHC01002274 JAG17880.1 JAG17881.1 JAG64386.1 JAQ16355.1 CH379063 EDY72020.2 DS231615 EDU40409.1 NQIK01000002 NQWZ01000169 NRDI01000152 MVBI01000023 MUXC01000109 PWO16271.1 PWO25162.1 PZD07402.1 PZD45168.1 PZD51353.1 JW877595 AFP10112.1 BABH01000993 KI968706 EUN30307.1 KI964608 EUC33555.1 KB445639 EMD67644.1 KB733463 ENI02629.1

Proteomes

UP000218220 UP000053240 UP000053268 UP000027135 UP000053097 UP000279307 + More
UP000036403 UP000005205 UP000078542 UP000000673 UP000001555 UP000015103 UP000183832 UP000242457 UP000005203 UP000019118 UP000030742 UP000007266 UP000192223 UP000076858 UP000000305 UP000000304 UP000001292 UP000000803 UP000092461 UP000007819 UP000094527 UP000037069 UP000002282 UP000095301 UP000092443 UP000078200 UP000092460 UP000095300 UP000092445 UP000091820 UP000001819 UP000001471 UP000245403 UP000245464 UP000248883 UP000249551 UP000249757 UP000005204 UP000054337 UP000053841 UP000016934 UP000012338

PRIDE

Q2F5L9 Q9W5E1 H9IVF2

Pfam

PF12678 zf-rbx1

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR024766   Znf_RING_H2
IPR001841   Znf_RING

Gene 3D

3.30.40.10

ProteinModelPortal

S4NI94 A0A2A4JT75 Q2F5L9 A0A2R7WVP6 R4WDN4 A0A0P5U8B8 + More
A0A194RH10 A0A194PDC1 A0A1B6C3Y1 A0A0P5J9D5 T1IQB4 A0A0P6E2R3 A0A067R3E4 A0A0K8RNL9 A0A026W1Q9 A0A0J7NLT7 A0A158NZP4 A0A195D1W6 A0A0N8DX25 A0A0P5SLA0 W5JQ39 A6YPF3 A0A131Y652 B7PN13 T1HGK2 A0A224XTW8 A0A0V0G4C9 A0A023GDP4 G3MN29 A0A0C9QZ75 A0A023FW86 A0A023FDV0 A0A224YYP2 A0A131YU42 L7M651 A0A131XKA0 A0A2S2PZH7 A0A1J1J035 V5H427 A0A1Z5L4H9 A0A0P6B382 A0A1Y1NBP3 A0A0P5TNG5 A0A2A3ET71 A0A088AEC6 J3JVZ1 A0A336MQF9 D2A2S1 A0A1W4WIU3 A0A1B6KYB0 A0A1B6FIW4 A0A1B6K6I1 A0A1B6GL73 A0A164LRT1 V9IKT7 A0A0P5HPK9 E9FSM2 A0A0P4VUZ3 B4R7G5 B4I946 X2JA05 Q9W5E1 A0A0K8TPB9 A0A1L8EB16 A0A1L8DT49 A0A1B0FUX4 A0A1L8EAN7 A0A2H8U0L4 A0A2S2NN11 A0A2S2PV83 C4WUL2 A0A1W7R9S9 A0A1D2M7Y8 A0A1L8EAM6 A0A1L8EB02 A0A0L0BMU9 A0A1L8EB20 A0A1L8EB03 A0A1L8EAQ6 B4PX22 A0A1L8EAL2 A0A1I8M614 A0A1A9YQR0 A0A1A9UZS1 A0A1B0B142 A0A1I8P0D4 A0A1L8EH96 A0A1B0AHT3 A0A1A9WCG5 A0A2M4AIG8 A0A0A9XE03 B5DKH1 B2VU47 A0A2W1DVD3 V9LBY4 H9IVF2 W7F250 W6Y7S7 M2RM03 N4WQ84

PDB

4P5O E-value=1.0247e-43, Score=438

KEGG

692971 K03868 RING-box protein 1 [EC:2.3.2.32] | (RefSeq) ring box protein

PATHWAY

03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)
04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)
04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0008270 GO:0016874 GO:0061630 GO:0031467 GO:0097602 GO:0031146 GO:0031461 GO:0006511 GO:0019788 GO:0045116 GO:0031463 GO:0005634 GO:0043224 GO:0031462 GO:0080008 GO:0016021 GO:0045879 GO:0006508 GO:0016567 GO:0005829 GO:0032436 GO:0019005 GO:0008283 GO:1904801 GO:0046627 GO:0090090 GO:0019915 GO:0007224 GO:0005515 GO:0030286 GO:0009081 GO:0004817 GO:0006423 GO:0022891 GO:0003707 GO:0051537

Subcellular location

Cytoplasm
Nucleus

Length:

113

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0369300000000001

Exp number, first 60 AAs:

0.03366

Total prob of N-in:

0.19953

outside

1 - 113

Pi

182.637745

Theta

176.105014

Tajima's D

0.116702

CLR

81.324348

CSRT

0.4034798260087

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics