SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07791
Pre Gene Modal
BGIBMGA000913
Annotation
PREDICTED:_cytoplasmic_dynein_2_heavy_chain_1-like_[Bombyx_mori]
Full name
Cytoplasmic dynein 2 heavy chain 1      
Alternative Name
Dynein heavy chain isotype 1B
Cytoplasmic dynein 2 heavy chain
Dynein cytoplasmic heavy chain 2
Dynein heavy chain 11
Location in the cell
Cytoplasmic   Reliability : 1.385
 

Sequence

CDS
ATGCTATCCCTATTCCAAGAGGTAACCGAGATATTTAATACGCGACCTCATTACAAATGGAACGCGTCTCATTTGAAAAAGTGGTGCGAAAATGTGAAATGGTACAACCCGAAGAACACCGAAGATCTACTCACGGCAATCGTTTCGGAGGCGAATTTCATATTTCGCGATCGATTCGTAACTGACGAAGAAAAGTTGAGGTTCAGCACTATGTGTCGAGGTCACTTGAAGAACGATGCCACTCCGGTTCACTATACGTACAAACTGAGAGGCGATGGTGTGTATTTAGAGACGATTGATCGAACCGGCTGGCGACAATACATCAATAAACTCATTAATCAATGCTTGGCAGAACATGAATATAATATATTTGGGGACAGCGGAGTCGAGGTGTGTGACGAACTCAACGTATTGTGTCCTGCCATGGCTCGAGCTGCTAATGGCGGTATAGTAGTGTGCGTGGGCACGGCGGGCGTGGGCCGCGCCGCCGCGAGTCGCTTGGTGTGCGCCGCGCTGCAGGCCGCGCTCTACCCCATCGACAATCCCTCGCAGTTTAATGGACAGTTCAAAAATGCATTGTCATCGTCCGGAGACGCCACGCATACGCTAGTGGTGCTGTCGGAATCTGCTGCGAACAGTGCAACCATAGCGTGTATAGAAGCTCTGATCAGAGCGCGATCTTTGAATGCCATTCCCGAGCACATGCTACCCGGTGCGAACAACCCACACATGTTGGACAATATAAAACAATGCCTAGGTATTGTGATATGCCTTGACAAGAACCAAAGTAACCTAGCAGAGCTAATAGAGAAATATCCCATACTTTACAATCAAGCCGATTTAATATGGTTAGAGAAATGGTCGGAAGAGACACTGCGGGATGTTCCGTCATTGATCATAGATAGACTTCTAAAGGAGAACGTAACTGATATTACAAAGGATCAACTCGAAAAAATTCCTATCGATGGATTCGTTAAAATTCACAAAAGCCTCGAGACTGATTGCATGCGAGCTCCGTGCCGATATGTCAACTTCGTCAAAACCTACTTCTATATCATGAGCCGAAAGAAGACGGCCCTCGTTCAAAGACAAAATACACTTTCGGCCGGCCTCGATGCCTTGAAGCGCGCGCGTACTGAGGTGGCAACACTGCAGACCAACGCGTCCAAACAGGAAGCCGAACTCTCAGATAAACAAGCGAAAGCTAATCAGGCGCTGGACCAGATCAGCGCCACGGTGCGCGCCACCACCGACAGGAAGGAGGAAATGCATGCCTTGAAGAAGAACATCGAAATTGAAAACGAGAAATTGCAGAAACAGAAAGAAGAAATCGAGGCGGAGCTTGCATCAGTAGAGCCAGTGATTGCGGCCGCTCGGGCTGCCGTAGGAGACATACGGCCCGAATCACTCAGCGAAGTGCGGTCGTTGCGCGCCCCGCCGGACGTGGTGCGGGACGTGCTCGAAGGGGTGTTGCGGCTCATGGGCATCGCCGACACCTCGTGGCACTCCATGAAAAACTTCCTCGCGAAACGCGGAGTCAAGGAGGACATAAGGTGCCTGGACGCGAGCCAGATAAGCCCGGCCGCTATCGAAGGTGTGAAGAAGCTGCTGGAGCGTCGCGGCGCGTCGTTCGAGGCGGCGGCGGCGCGGCGCGCCAGTGCGGCGTGCGCCCCGCTCGCGGCCTGGGTGCGCGCCAACCTGCGCCACGCCGACGCGCTCGTCCGCGTGCGCCCGCTGCAGGACAAGCAGGCCACCTTACACAAGAACCTCCAAGAAGCCGAGGATCAGCTGTCGACATTGTCGAGCGGGCTGGCGACGGTGGACGAGCGCGTGGCGGCGCTGAAGGAGCAGCTGGGCCGGCACTCGCGGGACGCGGCCGCGCTCGAGCTCAGCGTCGCCAGCGCCGCGCAGACCATCGCCGCCGCCACGCAGCTACTCGACCAGCTCGCACACGAATACACGGCCTGGGAACGTGACCTGGCAAACATTTCGACGGAAATATCGCAGCTGAGCGTACGTTCGTTGTTAGCTGCGGCCTACGTCGTGTACCTCCCCGACCTGACAGAGCCACAAGCTCTGGTTTACATACATAAATGGAGTAAGTTTGTTGGATTTGACGACTCCTCATTTTCTGTCATCAATTTCCTATCTACGACGGAGAAGCAGTTGAAATGGGACGCGGACGGTCTTCCCGCGGATAGTTCAGCTGTCAAGAATGCCGTTTTAATCGATCAGGTGCTAGAAGCCCAGAAATGCGGCCTCACTCCGTTCCTGATAGACCCGGACGGCGAGGGCATGACGTGGCTAAAGAACACGCTCGCCGATCAACAATGCGATTTTGTTTCACAGAACAGTGAGAAGCTGTCTACCGCCGTTCAGTATGCAATTAGACTGGGCCGTATCTTGGTGATCACGGAGGCGGAGCACGTGGCGGAGGCGTACGGCGCGCTGGCGTGTGGGCGGCGCGGCGCGGCGGCGCGCGTGCTGTTGCACTGCCGTGACGTCACGGCGCCCGCGCGTCTGCCGCCACATCAGCGCGCCGCGCTCTCCCTGCTGCACTTCACCGCCAGACTCGATGGACTCACCGACCAGCTCGTCCACTACGCTTTACAACAACAGAATCCGGATATGAATGAAAAATTGAAGGAAATCAAAATTCAAAAAGCCACCTACCAGAAACAACAACACGAATTGCAGGAAAATCTGCTTAGGGACCTTTCCGGGAACGTGGACATATTGCACGACGCGAACCTGTTGGCGTCGTTGAACCGGACGCGCGCAGCGAACGCCGCGATAAGGGAAGCGCTCGACGGGGCGCGCGCGCTCGAGGCGCAGAGCCGCGGCGCGGGGGGGGCGCACGCGGCCGCCGCCCGCCGCACCGCGCGCCTGGCGCTGGCCGTGCGGCGCGTGGCGGAGCGACGCCCGCTCGTGGCGCTGCCCGTGGACGCCGTGCTCGAGATGTTCGCCGATGCCCTGCGTACTCTTGGCCAAAAATCTCAACCAAAAACGGACGACGTCATCAAGTATGTGACGAGGAGAATCATTGAAAGAGTTCTCTTGGGACTTTATAAAAAAGATAATTACATCATTGTTCTTCATCTACTGAAAGAAGTCTACGATGAGCTCATGCCGGATAAGTTGTGGAATTTACTTGTAAGTAGCAACGATGTTTTAGAAGATACAGATAATGTGAATGAAATTAGGAGATCATATCCGTGGATCCCAGATGGATGCGTAAGAAAAGTTGCGAAATTGAAGATAACGGATGAGAATCTATTTAACAAGTTGTGTTTGAACAAAGAAGATATGTGGAGAGAGTTTCTTGAATCTGGCGACAGCAAGGTCATCAGTAAATTGGGCATTACTCCTTTTGAATATGTCGTCTCCGTGGCATCGGTTCGTCCCGACGGCTTATATAGGGCCCTCGTGGAATTTGTTGATCAAGCTTTGGGTGCGGGCGTGATGTCATGCGGCTCGGCGCTGGGTGTGGCGGGGCGCAGCGCGGGGCGGGGCGGGGCGCGACGCCCGGTGCTGCTGCGGCACGCGCATGCGCGGGACCTGCTCCTCGCGCACGCACAGGCCAACGCTCTACCGCTCACGCTGGTAGGAATAGAAGAGGGCAAGAATTCATGGAATGTGGCACTGGAAGCCACCAGAAGCGGCGGCTGGCTCGCAATAGACGTTGGCGCTTCTCCATTTACGACTGAAATACAAACCTTTATTTCGGAATTCGTCGCCACGCCTCCTGAAAACTTGAGCGACGACTTCCGTATGTGGATTCTTTCTGAAGATCGTGACATACCGGCTCTGTTGTGTAATGCCTGTATCAATGTTATACTCGAGACGCCGGAAGGCGTTAAGAATAATATAATGAGCACGTTGGCCGCGTGGGGGAACTATGAAGCTGAACCGAATATCGTGCGCTTACATGCTTCACTCGCCGTATTCCACGCTCTCGTGCAAGAACGACAAGCCTATATACCACAAGGTTAA
Protein
MLSLFQEVTEIFNTRPHYKWNASHLKKWCENVKWYNPKNTEDLLTAIVSEANFIFRDRFVTDEEKLRFSTMCRGHLKNDATPVHYTYKLRGDGVYLETIDRTGWRQYINKLINQCLAEHEYNIFGDSGVEVCDELNVLCPAMARAANGGIVVCVGTAGVGRAAASRLVCAALQAALYPIDNPSQFNGQFKNALSSSGDATHTLVVLSESAANSATIACIEALIRARSLNAIPEHMLPGANNPHMLDNIKQCLGIVICLDKNQSNLAELIEKYPILYNQADLIWLEKWSEETLRDVPSLIIDRLLKENVTDITKDQLEKIPIDGFVKIHKSLETDCMRAPCRYVNFVKTYFYIMSRKKTALVQRQNTLSAGLDALKRARTEVATLQTNASKQEAELSDKQAKANQALDQISATVRATTDRKEEMHALKKNIEIENEKLQKQKEEIEAELASVEPVIAAARAAVGDIRPESLSEVRSLRAPPDVVRDVLEGVLRLMGIADTSWHSMKNFLAKRGVKEDIRCLDASQISPAAIEGVKKLLERRGASFEAAAARRASAACAPLAAWVRANLRHADALVRVRPLQDKQATLHKNLQEAEDQLSTLSSGLATVDERVAALKEQLGRHSRDAAALELSVASAAQTIAAATQLLDQLAHEYTAWERDLANISTEISQLSVRSLLAAAYVVYLPDLTEPQALVYIHKWSKFVGFDDSSFSVINFLSTTEKQLKWDADGLPADSSAVKNAVLIDQVLEAQKCGLTPFLIDPDGEGMTWLKNTLADQQCDFVSQNSEKLSTAVQYAIRLGRILVITEAEHVAEAYGALACGRRGAAARVLLHCRDVTAPARLPPHQRAALSLLHFTARLDGLTDQLVHYALQQQNPDMNEKLKEIKIQKATYQKQQHELQENLLRDLSGNVDILHDANLLASLNRTRAANAAIREALDGARALEAQSRGAGGAHAAAARRTARLALAVRRVAERRPLVALPVDAVLEMFADALRTLGQKSQPKTDDVIKYVTRRIIERVLLGLYKKDNYIIVLHLLKEVYDELMPDKLWNLLVSSNDVLEDTDNVNEIRRSYPWIPDGCVRKVAKLKITDENLFNKLCLNKEDMWREFLESGDSKVISKLGITPFEYVVSVASVRPDGLYRALVEFVDQALGAGVMSCGSALGVAGRSAGRGGARRPVLLRHAHARDLLLAHAQANALPLTLVGIEEGKNSWNVALEATRSGGWLAIDVGASPFTTEIQTFISEFVATPPENLSDDFRMWILSEDRDIPALLCNACINVILETPEGVKNNIMSTLAAWGNYEAEPNIVRLHASLAVFHALVQERQAYIPQG

Summary

Description
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity).
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to PubMed:8666668, it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
Subunit
The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYH1B homodimer and a number of light intermediate chains.
The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYNC2H1 homodimer and a number of DYNC2LI1 light intermediate chains.
Miscellaneous
Mice homozygous for Dync2h1 null alleles die at approximately 12.5 dpc with abnormal brain morphology, frequent heart-looping and occasionally with polysyndactily. Cilia have abnormal morphology.
Similarity
Belongs to the dynein heavy chain family.
Keywords
ATP-binding   Cell membrane   Cell projection   Cilium   Coiled coil   Cytoplasm   Cytoskeleton   Developmental protein   Dynein   Membrane   Microtubule   Motor protein   Nucleotide-binding   Alternative splicing   Complete proteome   Reference proteome  
Feature
chain  Cytoplasmic dynein 2 heavy chain 1
splice variant  In isoform 3.
EMBL
BABH01001010    BABH01001011    BABH01001012    ODYU01001877    SOQ38695.1    KQ460205    + More
KPJ16864.1    KQ459606    KPI91235.1    AGBW02013857    OWR42617.1    KQ971338    KYB27962.1    KYB27960.1    KK852506    KDR22495.1    GEDC01031726    GEDC01013347    JAS05572.1    JAS23951.1    LSMT01000499    PFX17074.1    DS235255    EEB14047.1    U03969    PZQS01000003    PVD35241.1    EAAA01001179    AAGJ04048192    AAGJ04048193    AAGJ04048194    AAGJ04048195    AAGJ04048196    AAGJ04048197    AAGJ04048198    AAGJ04048199    AAGJ04048200    AHAT01003056    AHAT01003057    RCHS01000683    RMX57290.1    CM012449    RVE64633.1    JH816566    EKC21500.1    AFYH01094485    AFYH01094486    AFYH01094487    AFYH01094488    AFYH01094489    AFYH01094490    AFYH01094491    AFYH01094492    AFYH01094493    AFYH01094494    GL192883    EFB17322.1    RQTK01000782    RUS74962.1    AKHW03000640    KYO44952.1    DS985243    EDV26458.1    AMQN01008176    KB302363    ELU04382.1    NOWV01000094    RDD40688.1    HAEB01016059    SBQ62586.1    KK656706    KFQ05379.1    ACTA01091390    ACTA01099390    ACTA01107390    ACTA01115390    ACTA01123390    ACTA01131390    ACTA01139390    ACTA01147389    ACTA01155388    ACTA01163387    GEBF01006149    JAN97483.1    JH171904    EHB12893.1    KL206940    KFV87413.1    CP026245    AWO99124.1    AAEX03003535    AAEX03003536    AQIA01022057    AQIA01022058    AQIA01022059    AQIA01022060    AQIA01022061    AQIA01022062    AQIA01022063    AQIA01022064    AQIA01022065    AHZZ02007506    AHZZ02007507    AHZZ02007508    AHZZ02007509    AHZZ02007510    AHZZ02007511    AHZZ02007512    AHZZ02007513    JSUE03013309    JSUE03013310    JSUE03013311    JSUE03013312    JH880376    ELR62148.1    AQIB01094309    AQIB01094310    AQIB01094311    AQIB01094312    AQIB01094313    AQIB01094314    AQIB01094315    AQIB01094316    AQIB01094317    AQIB01094318    NIVC01001409    PAA68244.1    AMGL01030340    AMGL01030341    AMGL01030342    AMGL01030343    AMGL01030344    AMGL01030345    AMGL01030346    AMGL01030347    AMGL01030348    AMGL01030349    KB201890    ESO93665.1    CABD030081295    CABD030081296    CABD030081297    CABD030081298    CABD030081299    CABD030081300    CABD030081301    CABD030081302    CABD030081303    CABD030081304    ADFV01056142    ADFV01056143    ADFV01056144    ADFV01056145    ADFV01056146    ADFV01056147    ADFV01056148    ADFV01056149    ADFV01056150    ADFV01056151    DQ104402    AK014500    AK032860    AK045978    AK046538    AK083433    AK084796    AC155908    CT010499    AY452064    AY452065    AY452066    AY452067    Z83809    AK173324    KK501879    KFP18444.1    AAGW02009058    AAGW02009059    AAGW02009060    AAGW02009061    AAGW02009062    AAGW02009063    AAGW02009064    AAGW02009065    AAGW02009066    AAGW02009067    LSYS01008465    OPJ68652.1    AERX01006980    AERX01006981    AERX01006982    AERX01006983    OPJ68653.1   
Pfam
PF12780   AAA_8        + More
PF12781   AAA_9
PF12774   AAA_6
PF03028   Dynein_heavy
PF18199   Dynein_C
PF12777   MT
PF00053   Laminin_EGF
PF18198   AAA_lid_11
PF08393   DHC_N2
PF00055   Laminin_N
PF08385   DHC_N1
PF07728   AAA_5
PF17857   AAA_lid_1
Interpro
IPR024317   Dynein_heavy_chain_D4_dom        + More
IPR035706   AAA_9       
IPR026815   DYNC2H1       
IPR027417   P-loop_NTPase       
IPR024743   Dynein_HC_stalk       
IPR026983   DHC_fam       
IPR042219   AAA_lid_11_sf       
IPR004273   Dynein_heavy_D6_P-loop       
IPR041228   Dynein_C       
IPR035699   AAA_6       
IPR041658   AAA_lid_11       
IPR000742   EGF-like_dom       
IPR042228   Dynein_2_C       
IPR008211   Laminin_N       
IPR013032   EGF-like_CS       
IPR013602   Dynein_heavy_dom-2       
IPR013015   Laminin_IV_B       
IPR038684   Laminin_N_sf       
IPR002049   Laminin_EGF       
IPR042222   Dynein_2_N       
IPR003593   AAA+_ATPase       
IPR013594   Dynein_heavy_dom-1       
IPR011704   ATPase_dyneun-rel_AAA       
IPR041589   DNAH3_AAA_lid_1       
SUPFAM
SSF52540   SSF52540       
PDB
4RH7     E-value=1.04632e-123,     Score=1140

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytoskeleton  
Cilium axoneme  
Cell membrane  
Length:
1330
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0729900000000001
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00116
outside
1  -  1330
 
 

Population Genetic Test Statistics

Pi
230.598468
Theta
177.363092
Tajima's D
1.16229
CLR
0.299818
CSRT
0.694815259237038
Interpretation
Uncertain
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