Gene

KWMTBOMO07790

Pre Gene Modal

BGIBMGA000912

Annotation

PREDICTED:_cytoplasmic_dynein_2_heavy_chain_1-like?_partial_[Bombyx_mori]

Location

Bomo_Chr13(+):6922566-6938238      View in EpiBrowser

Full name

Cytoplasmic dynein 2 heavy chain 1      

Alternative Name

Dynein heavy chain isotype 1B

Location in the cell

Cytoplasmic   Reliability : 1.439 Mitochondrial   Reliability : 1.259

CDS

ATGACTAAAATTAATGTTGGTTTCAATTCATTAAAATACCGTCGCATACGTTGCAGTGCGCTGCTGAGTGGACAGCGGCACTACGACTGGGGTCTGCGCGCGCTGAAGGCGGTGGCGGGGGGCGTGCGCGCGGGGGAGGGCGCGGGCGGAGAGCGCGTGCACGCCGCCCGCCTGCTCGCCGTCAACAACGTCTCCAAACTAACTGCGCCGGATGCACGAATATTCCATAAAATACTGTCTCTCGTATTCGCCGATGTAAAAGATCTACATGCCACAGCTGATCCTATAGTGAACGCGCTGGAAGGATCCGTCCAGAATTTAAAACTTGTGGAAAATAAAGCACAGTTACAAAAATGCATCGAGTTATACGAACAGCTACAACAACGGATGGGGGTCGTGGTGGTGGGCCCGCCCGCCTCTGGGAAGTCTACGATTAGGCGTCTACTTAAAACAGCCCTCTTACAACAAGGAAAAACTATAATGGAGTACGTAATAAGTCCAAAAGCAATGAGCCGCGACTGGCTCCTTGGGCACATCGACCCTGACACCAGGCAGTGGACGGACGGGGTGATCTCCGCCACCGCCTTGGAGATATCCAATCAGCCGCCTGATGTATGGTCTTGGGTTGTGTGCGACGGAGACATAGACCCCGAGTGGATTGAGTCTCTGAACTCCGTGTTGGATGACAACCGGCTGCTGACGTTGCCGTCCGGCTGGCGGGTGCAGTTCGGGAACAACGTCAACTTCATATTCGAGACGCACAGCCTGGAGCACGCCTCGCCCGCCACCATCTCCAGAATGGGAATTATATTGATGAGCGATGACGTCAGTTGCGAGCTGGACGTGCTGCGGGGCTGGGTGCGCCGCGCCGACCACGAGGCCGCCAGCCCGGCGCTCCCGCTGCTGCAGCGGGCCGTCGCCGGCACCGTTCAGTGGCTCCACCGACACCAGGGCGCCGCCCTCACCAAGCTGTACAACGTCGCCGTAGTCCGACAGATACTTACACAGTTCGAATACCTAGTTCAAACCGCGAACGCGATCTCGACTCAACCCGGTCCCGAGGAAATGGTTATATGTGCGATACAAAGAAGCGTCGTCGACTTATTGAAAGAGGCCGCCGTTCCCAGTTTTTATGACGAGATATCTTCAGTGTTGGGTCCTCCCCCGCCCGAGCCCCCGTCCCCCAATGAATGGGTTTCGGAGTCTCTGTACATGTCGGCCAGACTCCTCGCCGTGGAGTCCGTCGTCAGGGCGTGTCTGGCGTCCGACTCGTCTCATCTGCTAATTGTAGGCCCCGATGCGTGTGCTAAAAGTGCGTTAGTGGAACACATTCTGAAGGAGAGCAACAGTCCTGTAATAACGATTGACTGCACGCCTATATTGGAGCCGGCTGACATAATACGCGAACTAAAGAGGTCTTTGGCTAACTAA

Protein

MTKINVGFNSLKYRRIRCSALLSGQRHYDWGLRALKAVAGGVRAGEGAGGERVHAARLLAVNNVSKLTAPDARIFHKILSLVFADVKDLHATADPIVNALEGSVQNLKLVENKAQLQKCIELYEQLQQRMGVVVVGPPASGKSTIRRLLKTALLQQGKTIMEYVISPKAMSRDWLLGHIDPDTRQWTDGVISATALEISNQPPDVWSWVVCDGDIDPEWIESLNSVLDDNRLLTLPSGWRVQFGNNVNFIFETHSLEHASPATISRMGIILMSDDVSCELDVLRGWVRRADHEAASPALPLLQRAVAGTVQWLHRHQGAALTKLYNVAVVRQILTQFEYLVQTANAISTQPGPEEMVICAIQRSVVDLLKEAAVPSFYDEISSVLGPPPPEPPSPNEWVSESLYMSARLLAVESVVRACLASDSSHLLIVGPDACAKSALVEHILKESNSPVITIDCTPILEPADIIRELKRSLAN

Description

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity).

Subunit

The cytoplasmic dynein complex 2 is probably composed by a heavy chain DYH1B homodimer and a number of light intermediate chains.

Similarity

Belongs to the dynein heavy chain family.

Keywords

ATP-binding   Cell membrane   Cell projection   Cilium   Coiled coil   Cytoplasm   Cytoskeleton   Developmental protein   Dynein   Membrane   Microtubule   Motor protein   Nucleotide-binding  

Feature

chain  Cytoplasmic dynein 2 heavy chain 1

Uniprot

A0A2H1VCZ8   A0A2A4JRE1   A0A194PJH1   A0A194RHE9   A0A212EMB2   A0A067RPD3   + More
A0A139WJC7   A0A139WIZ7   A0A1B0DN78   A0A1B6DJC9   A0A1B6DE21   A0A182JE49   A0A336M3L6   A0A182T1T8   A0A182GZV1   A0A182YIX2   A0A1J1HNC4   A0A182FVW0   B5DJ37   A0A0L8GPV2   A0A182MTE0   B4MYU6   A0A182P1X5   W4Z5Q0   A0A3M7QHH1   W4ZLI3   Q27802   A0A182NV76   A0A182REI9   A0A182KV98   A0A182X0I0   U4TSK0   A0A182W9J8   R7UM87   A0A182JQU2   A0A182V5H6   A0A182I5R9   C3XXR4   A0A0K2T8T7   A0A1S3I1P2   A0A2I2USA9   M3WYQ6   A0A1I8MV06   A0A210PLE7   A0A2T7PP94   F7BI91   A0A2I3N6K1   A0A3P7I7A9   A0A2I3NF61   A0A183USX4   A0A1S3JIZ4   A0A096N6I2  

Pubmed

26354079    22118469    24845553    18362917    19820115    26483478    + More
25244985    15632085    17994087    30375419    8186465    20966253    23537049    23254933    18563158    17975172    25315136    28812685    17495919   

EMBL

ODYU01001877    SOQ38695.1    NWSH01000724    PCG74605.1    KQ459606    KPI91235.1    + More
KQ460205    KPJ16864.1    AGBW02013857    OWR42617.1    KK852506    KDR22495.1    KQ971338    KYB27961.1    KYB27960.1    AJVK01017345    GEDC01011492    JAS25806.1    GEDC01031726    GEDC01013347    JAS05572.1    JAS23951.1    UFQT01000509    SSX24856.1    JXUM01100205    KQ564550    KXJ72098.1    CVRI01000010    CRK88884.1    CH379060    EDY70329.2    KQ420844    KOF79091.1    AXCM01001817    CH963913    EDW77285.2    AAGJ04048192    AAGJ04048193    AAGJ04048194    AAGJ04048195    AAGJ04048196    REGN01006095    RNA10897.1    AAGJ04048197    AAGJ04048198    AAGJ04048199    AAGJ04048200    U03969    KB631581    ERL84489.1    AMQN01008176    KB302363    ELU04382.1    APCN01003489    GG666471    EEN67524.1    HACA01004631    CDW21992.1    AANG04000690    NEDP02005592    OWF37256.1    PZQS01000003    PVD35241.1    AHZZ02007506    AHZZ02007507    AHZZ02007508    AHZZ02007509    AHZZ02007510    AHZZ02007511    AHZZ02007512    AHZZ02007513    UYWY01020917    VDM42915.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000027135    UP000007266    + More
UP000092462    UP000075880    UP000075901    UP000069940    UP000249989    UP000076408    UP000183832    UP000069272    UP000001819    UP000053454    UP000075883    UP000007798    UP000075885    UP000007110    UP000276133    UP000075884    UP000075900    UP000075882    UP000076407    UP000030742    UP000075920    UP000014760    UP000075881    UP000075903    UP000075840    UP000001554    UP000085678    UP000011712    UP000095301    UP000242188    UP000245119    UP000002280    UP000028761    UP000267007    UP000050794   

PRIDE

Q27802   

Pfam

PF12774   AAA_6        + More
PF12781   AAA_9
PF03028   Dynein_heavy
PF12780   AAA_8
PF18199   Dynein_C
PF12777   MT
PF08393   DHC_N2
PF18198   AAA_lid_11
PF00053   Laminin_EGF
PF00055   Laminin_N
PF07728   AAA_5
PF08385   DHC_N1
PF01683   EB
PF08395   7tm_7

Interpro

IPR035706   AAA_9        + More
IPR026815   DYNC2H1       
IPR027417   P-loop_NTPase       
IPR024743   Dynein_HC_stalk       
IPR024317   Dynein_heavy_chain_D4_dom       
IPR026983   DHC_fam       
IPR042219   AAA_lid_11_sf       
IPR004273   Dynein_heavy_D6_P-loop       
IPR041228   Dynein_C       
IPR035699   AAA_6       
IPR042228   Dynein_2_C       
IPR013602   Dynein_heavy_dom-2       
IPR003593   AAA+_ATPase       
IPR042222   Dynein_2_N       
IPR041658   AAA_lid_11       
IPR000742   EGF-like_dom       
IPR008211   Laminin_N       
IPR013032   EGF-like_CS       
IPR013015   Laminin_IV_B       
IPR038684   Laminin_N_sf       
IPR002049   Laminin_EGF       
IPR013594   Dynein_heavy_dom-1       
IPR011704   ATPase_dyneun-rel_AAA       
IPR006149   EB_dom       
IPR013604   7TM_chemorcpt       

SUPFAM

SSF52540   SSF52540       

Gene 3D

1.10.8.720     1.20.140.100     3.20.180.20     2.60.120.1490    

ProteinModelPortal

A0A2H1VCZ8   A0A2A4JRE1   A0A194PJH1   A0A194RHE9   A0A212EMB2   A0A067RPD3   + More
A0A139WJC7   A0A139WIZ7   A0A1B0DN78   A0A1B6DJC9   A0A1B6DE21   A0A182JE49   A0A336M3L6   A0A182T1T8   A0A182GZV1   A0A182YIX2   A0A1J1HNC4   A0A182FVW0   B5DJ37   A0A0L8GPV2   A0A182MTE0   B4MYU6   A0A182P1X5   W4Z5Q0   A0A3M7QHH1   W4ZLI3   Q27802   A0A182NV76   A0A182REI9   A0A182KV98   A0A182X0I0   U4TSK0   A0A182W9J8   R7UM87   A0A182JQU2   A0A182V5H6   A0A182I5R9   C3XXR4   A0A0K2T8T7   A0A1S3I1P2   A0A2I2USA9   M3WYQ6   A0A1I8MV06   A0A210PLE7   A0A2T7PP94   F7BI91   A0A2I3N6K1   A0A3P7I7A9   A0A2I3NF61   A0A183USX4   A0A1S3JIZ4   A0A096N6I2  

PDB

4RH7     E-value=1.4008e-70,     Score=677

KEGG

101738046    K10414 dynein heavy chain 2, cytosolic | (RefSeq) cytoplasmic dynein 2 heavy chain 1-like

PATHWAY

04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0030286   GO:0007018   GO:0005524   GO:0003777   GO:0016887   GO:0016021   GO:0050909   GO:0007628   GO:0031223   GO:0007605   GO:0045433   GO:0035721   GO:0005930   GO:0005868   GO:0060271   GO:0045503   GO:0051959   GO:0045505   GO:0008569   GO:0031514   GO:0007275   GO:0005886   GO:0030030   GO:0005737   GO:0005929   GO:0005874   GO:1905515   GO:0007368   GO:0060976   GO:0030326   GO:0061512   GO:0009953   GO:0005794   GO:0045880   GO:0016485   GO:0021522   GO:0007030   GO:0045177   GO:0030900   GO:0004084   GO:0009081   GO:0004817   GO:0006423   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR10676   PTHR10676:SF352  

Subcellular location

Cytoplasm  
Cytoskeleton  
Cilium axoneme  
Cell membrane  

Length:

476

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00111

Exp number, first 60 AAs:

0.00038

Total prob of N-in:

0.00457

outside

1  -  476

 

 

Pi

287.222472

Theta

189.609759

Tajima's D

2.24474

CLR

1.180823

CSRT

0.920253987300635

Interpretation

Uncertain