Gene

KWMTBOMO07784  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001238

Annotation

PREDICTED:_cysteine--tRNA_ligase?_cytoplasmic_[Bombyx_mori]

Location

Bomo_Chr13(-):6800387-6814095      View in EpiBrowser

Full name

Cysteine--tRNA ligase, cytoplasmic      

Alternative Name

Cysteinyl-tRNA synthetase

Location in the cell

Cytoplasmic   Reliability : 2.198

CDS

ATGTCTAAAAGAAGTCAACCTGCTTGGTCACCTCCGGTTCGAAACAAGGAGCGACCAGTTTTAAAACTTTACAATAGTTTGAGCCGACAAAAAGAAGAATTCATACCCGCTAATGGTAATCGTGTCAACTGGTACAGCTGCGGCCCTACAGTCTACGATGCATCTCACATGGGACATGCGAGATCTTATATGTCATTTGACATACTCAGGAGGGTAATGGCTAATTATTTTGGATATGATATTTTATATGTCATGAATATAACTGATATAGATGATAAAATAATTAAAAGAGCCAGACAAAAATATTTATATGAAAAATATTTAAAAGAACCACGAAACCTTAACGACACCGTTGATGATGCAGTCAACGTTATAAATTACTATGAGGAAGCTGTAAAAAATGCAGAAGATCCAGATAAAAAAAAATTGATGCAGAAAACATTGGATGAGATTGCGGCCTCAGTAAAAGCCCTTAAAGTTGCTATTGAATCAAAAGACAATGAAAGGATTAAGAATTCAAGATGTGATTTATTAACATCAGCAAAGAGTCCAATCTCTGACTGGTTAGATTACAAATATGGAGAAACTGTTACAGACAATGCAATATTCACAACTCTACCTAGGTATTGGGAAAATGAATTTCATAAAGATATGAAAGCACTTAATGTATTACCACCGGATGTACTGACAAGAGTAAGTGAATATGTCCCTAAAATAATTGCATACATACAAAAGATTATTAGCAATGGTTTTGCATATGAATCAAATGGCTCTGTATATTTTAATGTGAGTGAGTTCGATGGAAATGAAAGGCATCATTATGCAAGATTAGTGCCTGAGGCATACGGTGATACTAAATCGTTGCAAGAAGGAGAAGGTGATCTAACTGATGATGCAGCAGAAAAGCGATCACCCAACGACTTTGCTCTATGGAAGCGTAGTAAAGCTGGCGAGCCATCATGGGATTCCCCATGGGGGGCAGGTCGACCCGGGTGGCATATAGAGTGTTCCGCAATGGCTTCGGATGTTTGCCAAAATAAACTTGATATACACACAGGGGGCGTCGATTTAAAATTCCCTCATCATGACAACGAATTGGCCCAGAGCGAGGCACATTTCGACGAGCCCGGTTGGGTTAATTATTTCCTTCACACGGGACATTTGATGATAGCTGGCTGCAAAATGTCGAAATCTTTGAAAAATTTCATCACGATCTCAGACGCACTGAAACGCCACACCGCAAGACAACTGCGGTTCGGTTTCCTGCTACACGGATGGAAGGAAACTTTAGATTACTCGGAGAATACAATGGAAATGGCCATTCAGACAGAAAAACAATTTAACGAATTCTTTTTGACAGTGAAAGATGCTCTTCGTAGCGGCTACGACGAGGGTTGCGGCGGTGGATGGGAACCGGAGGAACAGCGGCTGTTTGCTAAACTGTCAATGGCCAAGGAACAAGTTCACGCGGCACTCTGTGACAACATCGACACCCGCGGCGCCATCGACGCCTTGCGGGAGCTGGTGTGCGCGTGCCACGTGTACCTGCGCGGCGCGCGGGCGCGGCCCAGCCCCGCGCTGGCGGCGGCGGCGCGCTACGTCACGGACGTGCTGCACGTTTTCGGCGTCGTCGAGGGACCCAGGGGCGGCATCGGCTTCCCGGTCGGAGACGCTGATGGTGTTTCGCCCACCTGGTGTTAA

Protein

MSKRSQPAWSPPVRNKERPVLKLYNSLSRQKEEFIPANGNRVNWYSCGPTVYDASHMGHARSYMSFDILRRVMANYFGYDILYVMNITDIDDKIIKRARQKYLYEKYLKEPRNLNDTVDDAVNVINYYEEAVKNAEDPDKKKLMQKTLDEIAASVKALKVAIESKDNERIKNSRCDLLTSAKSPISDWLDYKYGETVTDNAIFTTLPRYWENEFHKDMKALNVLPPDVLTRVSEYVPKIIAYIQKIISNGFAYESNGSVYFNVSEFDGNERHHYARLVPEAYGDTKSLQEGEGDLTDDAAEKRSPNDFALWKRSKAGEPSWDSPWGAGRPGWHIECSAMASDVCQNKLDIHTGGVDLKFPHHDNELAQSEAHFDEPGWVNYFLHTGHLMIAGCKMSKSLKNFITISDALKRHTARQLRFGFLLHGWKETLDYSENTMEMAIQTEKQFNEFFLTVKDALRSGYDEGCGGGWEPEEQRLFAKLSMAKEQVHAALCDNIDTRGAIDALRELVCACHVYLRGARARPSPALAAAARYVTDVLHVFGVVEGPRGGIGFPVGDADGVSPTWC

Catalytic Activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Cofactor

Zn(2+)

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Cytoplasm   Ligase   Metal-binding   Nucleotide-binding   Phosphoprotein   Protein biosynthesis   Reference proteome   Zinc  

Feature

chain  Cysteine--tRNA ligase, cytoplasmic

Uniprot

H9IVF8   A0A2H1V0X0   A0A194PD26   A0A2A4K2Y2   A0A194RLJ5   A0A3G1T1M8   + More
A0A0L7LVC7   A0A212FI10   A0A336KAQ1   B0WTN4   Q17D29   A0A1Q3F0D5   A0A1S4F7D3   A0A182G6Q5   U5EX84   A0A067QG85   A0A3B0JHV4   W8B8T6   B4GAJ9   B3MEZ4   A0A1W4VD64   B4LNV7   Q291L4   A0A034WPC8   A0A182Y1T6   A0A182W968   A0A084WHX0   A0A182XD73   A0A182MYJ3   A0A0K8W2R7   A0A2M4AI81   A0A2M4AHD2   A0A182R5E9   A0A182LZQ6   V5G3B3   A0A182HQ23   A0A182JUY2   A0A0T6B9Z5   A0A182Q542   A0A182V8S6   A0A182TZT3   D6X4W8   W5JF22   A0A2M4BFA8   B4MRE1   A0A182FU34   A0A182SNQ8   A0A2M4BF35   A0A182PBQ9   Q7Q069   A0A2J7PX89   B4J615   B3NPW7   Q7KN90   A0A182IQE0   B4P6Q6   B4KMF6   B4QHF9   B4HSK5   A0A154PEB8   A0A0A1X8K6   A0A0L0BU99   A0A1B0D7F8   A0A0J7L1M4   A0A026WZQ9   A0A232EQ73   A0A0C9Q4F6   A0A1I8MA14   A0A0M4ELG6   K7IW79   A0A0L7R5R5   A0A1Y1KGG5   S6D9N4   A0A151IP49   A0A1I8PRH7   A0A1A9W3Q7   A0A195FVN4   A0A1A9Z1X1   A0A1B6DJE6   A0A195EDB8   A0A195B8J6   A0A158NW36   E2AI64   A0A1A9V1M4   E2BB49   A0A1J1HW80   A0A087ZRN6   A0A1L8DFF5   A0A151X7D2   F4WNS7   A0A2D4H751   U4U666   N6U905   A0A2H6N3Z8   A0A2H6N471   A0A2H6N428   A0A1B0G7D3   V5IHN7   A0A131XX93  

EC Number

6.1.1.16

Pubmed

19121390    26354079    26227816    22118469    17510324    26483478    + More
24845553    24495485    17994087    15632085    25348373    25244985    24438588    18362917    19820115    20920257    23761445    12364791    14747013    17210077    10731132    12537572    10731138    17372656    17550304    22936249    25830018    26108605    24508170    30249741    28648823    25315136    20075255    28004739    23938757    21347285    20798317    21719571    23537049    25765539   

EMBL

BABH01001027    BABH01001028    BABH01001029    BABH01001030    ODYU01000170    SOQ34495.1    + More
KQ459606    KPI91226.1    NWSH01000189    PCG78607.1    KQ460205    KPJ16856.1    MG992434    AXY94872.1    JTDY01000008    KOB79473.1    AGBW02008449    OWR53371.1    UFQS01000147    UFQT01000147    SSX00505.1    SSX20885.1    DS232090    EDS34492.1    CH477300    EAT44292.1    GFDL01014097    JAV20948.1    JXUM01149353    KQ570757    KXJ68306.1    GANO01001060    JAB58811.1    KK853502    KDR07133.1    OUUW01000001    SPP72806.1    GAMC01008875    JAB97680.1    CH479181    EDW31951.1    CH902619    EDV36615.1    CH940648    EDW61126.1    CM000071    GAKP01003349    JAC55603.1    ATLV01023892    KE525347    KFB49814.1    GDHF01006821    JAI45493.1    GGFK01007172    MBW40493.1    GGFK01006878    MBW40199.1    AXCM01007656    GALX01003961    JAB64505.1    APCN01003288    LJIG01002846    KRT84094.1    AXCN02001041    KQ971381    EEZ97225.1    ADMH02001693    ETN61399.1    GGFJ01002500    MBW51641.1    CH963850    EDW74680.1    GGFJ01002501    MBW51642.1    AAAB01008986    EAA00242.2    NEVH01020859    PNF20953.1    CH916367    EDW01873.1    CH954179    EDV55814.1    AE013599    AF132160    AXCP01006766    CM000158    EDW91983.1    CH933808    EDW09844.1    CM000362    CM002911    EDX07304.1    KMY94184.1    CH480816    EDW48083.1    KQ434886    KZC10167.1    GBXI01007071    JAD07221.1    JRES01001317    KNC23655.1    AJVK01003924    AJVK01003925    AJVK01003926    LBMM01001228    KMQ96682.1    KK107063    QOIP01000005    EZA61226.1    RLU22804.1    NNAY01002849    OXU20446.1    GBYB01008943    JAG78710.1    CP012524    ALC42417.1    KQ414648    KOC66183.1    GEZM01086190    JAV59688.1    HF586480    CCQ71393.1    KQ976892    KYN07250.1    KQ981215    KYN44486.1    GEDC01030934    GEDC01011489    JAS06364.1    JAS25809.1    KQ979074    KYN22812.1    KQ976565    KYM80565.1    ADTU01002914    ADTU01002915    GL439655    EFN66863.1    GL446901    EFN87140.1    CVRI01000026    CRK92351.1    GFDF01008892    JAV05192.1    KQ982449    KYQ56281.1    GL888237    EGI64270.1    IACK01004312    LAA67716.1    KB632081    ERL88572.1    APGK01038087    KB740952    ENN77131.1    IACI01043182    LAA24057.1    IACI01043183    LAA24060.1    IACI01043184    LAA24062.1    CCAG010016608    GANP01004617    JAB79851.1    GEFM01004157    JAP71639.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000037510    UP000007151    + More
UP000002320    UP000008820    UP000069940    UP000249989    UP000027135    UP000268350    UP000008744    UP000007801    UP000192221    UP000008792    UP000001819    UP000076408    UP000075920    UP000030765    UP000076407    UP000075884    UP000075900    UP000075883    UP000075840    UP000075881    UP000075886    UP000075903    UP000075902    UP000007266    UP000000673    UP000007798    UP000069272    UP000075901    UP000075885    UP000007062    UP000235965    UP000001070    UP000008711    UP000000803    UP000075880    UP000002282    UP000009192    UP000000304    UP000001292    UP000076502    UP000037069    UP000092462    UP000036403    UP000053097    UP000279307    UP000215335    UP000095301    UP000092553    UP000002358    UP000053825    UP000078542    UP000095300    UP000091820    UP000078541    UP000092445    UP000078492    UP000078540    UP000005205    UP000000311    UP000078200    UP000008237    UP000183832    UP000005203    UP000075809    UP000007755    UP000030742    UP000019118    UP000092444   

PRIDE

H9IVF8    Q7KN90    V5IHN7   

Pfam

PF01406   tRNA-synt_1e

Interpro

IPR009080   tRNAsynth_Ia_anticodon-bd        + More
IPR024909   Cys-tRNA/MSH_ligase       
IPR015803   Cys-tRNA-ligase       
IPR032678   tRNA-synt_1_cat_dom       
IPR014729   Rossmann-like_a/b/a_fold       
IPR036282   Glutathione-S-Trfase_C_sf       

SUPFAM

SSF47323   SSF47323        + More
SSF47616   SSF47616       

Gene 3D

3.40.50.620    

CDD

cd00672  CysRS_core

ProteinModelPortal

H9IVF8   A0A2H1V0X0   A0A194PD26   A0A2A4K2Y2   A0A194RLJ5   A0A3G1T1M8   + More
A0A0L7LVC7   A0A212FI10   A0A336KAQ1   B0WTN4   Q17D29   A0A1Q3F0D5   A0A1S4F7D3   A0A182G6Q5   U5EX84   A0A067QG85   A0A3B0JHV4   W8B8T6   B4GAJ9   B3MEZ4   A0A1W4VD64   B4LNV7   Q291L4   A0A034WPC8   A0A182Y1T6   A0A182W968   A0A084WHX0   A0A182XD73   A0A182MYJ3   A0A0K8W2R7   A0A2M4AI81   A0A2M4AHD2   A0A182R5E9   A0A182LZQ6   V5G3B3   A0A182HQ23   A0A182JUY2   A0A0T6B9Z5   A0A182Q542   A0A182V8S6   A0A182TZT3   D6X4W8   W5JF22   A0A2M4BFA8   B4MRE1   A0A182FU34   A0A182SNQ8   A0A2M4BF35   A0A182PBQ9   Q7Q069   A0A2J7PX89   B4J615   B3NPW7   Q7KN90   A0A182IQE0   B4P6Q6   B4KMF6   B4QHF9   B4HSK5   A0A154PEB8   A0A0A1X8K6   A0A0L0BU99   A0A1B0D7F8   A0A0J7L1M4   A0A026WZQ9   A0A232EQ73   A0A0C9Q4F6   A0A1I8MA14   A0A0M4ELG6   K7IW79   A0A0L7R5R5   A0A1Y1KGG5   S6D9N4   A0A151IP49   A0A1I8PRH7   A0A1A9W3Q7   A0A195FVN4   A0A1A9Z1X1   A0A1B6DJE6   A0A195EDB8   A0A195B8J6   A0A158NW36   E2AI64   A0A1A9V1M4   E2BB49   A0A1J1HW80   A0A087ZRN6   A0A1L8DFF5   A0A151X7D2   F4WNS7   A0A2D4H751   U4U666   N6U905   A0A2H6N3Z8   A0A2H6N471   A0A2H6N428   A0A1B0G7D3   V5IHN7   A0A131XX93  

PDB

3TQO     E-value=1.41268e-51,     Score=514

KEGG

101737111    K01883 cysteinyl-tRNA synthetase [EC:6.1.1.16] | (RefSeq) cysteine--tRNA ligase, cytoplasmic

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004817   GO:0006423   GO:0005737   GO:0046872   GO:0000049   GO:0016021   GO:0000166   GO:0004812   GO:0006418   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR10890  

Subcellular location

Cytoplasm  

Length:

566

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.3679

Exp number, first 60 AAs:

0.00149

Total prob of N-in:

0.02024

outside

1  -  566

 

 

Pi

235.130081

Theta

153.647884

Tajima's D

1.668441

CLR

0.679196

CSRT

0.826858657067147

Interpretation

Uncertain