Gene

KWMTBOMO07783  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001238

Annotation

PREDICTED:_cysteine--tRNA_ligase?_cytoplasmic_[Bombyx_mori]

Location

Bomo_Chr13(-):6795034-6799765      View in EpiBrowser

Full name

Cysteine--tRNA ligase, cytoplasmic      

Alternative Name

Cysteinyl-tRNA synthetase

Location in the cell

Cytoplasmic   Reliability : 1.12 Mitochondrial   Reliability : 1.499 Nuclear   Reliability : 1.147

CDS

ATGCCGTACCTGGAGGCGCTGAGTGCGTTCCGCGAGCGGGTGCGCGAGGCGGCGCGCGCGGGGCAGGGCGGCGCCGTGCTGGCGCTGTGCGACGCGCTGCGGGACCGCGTGCTGCCCGACCTCGGCGTGCGCCTCGAGGACAAGCCAGATCGGACAGTCGTAAAATTGGTCAGCAAAGAGGAACTGTTAAAGGAGAGAGAAGAGAAGAAGCGTTTGGAAGCAGAGAAGCAAAGAAAGAAACAGGAGTTACTCGAGGCGCAACGTTTGAAGGAGGAACAAAAGAAAATATCACCCGCCGAAATGTTCAGGAAGGAAACTGACAAGTATTCGAAGTTCGATGAAAAGGGTCTACCCACGCACGACCACGAGGGTAAGGAGTTGAGTAAGGGTCTCCTAAAAAAGCTGCAGAAACTACAACAAGCACAAGAGAAGAAATATAACGAGAAACGTTAA

Protein

MPYLEALSAFRERVREAARAGQGGAVLALCDALRDRVLPDLGVRLEDKPDRTVVKLVSKEELLKEREEKKRLEAEKQRKKQELLEAQRLKEEQKKISPAEMFRKETDKYSKFDEKGLPTHDHEGKELSKGLLKKLQKLQQAQEKKYNEKR

Catalytic Activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Cofactor

Zn(2+)

Subunit

Monomer.

Similarity

Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords

Acetylation   Alternative splicing   Aminoacyl-tRNA synthetase   ATP-binding   Chromosomal rearrangement   Complete proteome   Cytoplasm   Ligase   Metal-binding   Nucleotide-binding   Phosphoprotein   Protein biosynthesis   Proto-oncogene   Reference proteome   Zinc  

Feature

chain  Cysteine--tRNA ligase, cytoplasmic
splice variant  In isoform 3.

Uniprot

H9IVF8   A0A194RLJ5   A0A194PD26   S4NJ25   A0A2A4K2Y2   A0A2H1V0X0   + More
A0A212FI10   A0A183IRH3   K1RR58   A0A0K0EQL2   H2ZQZ9   A0A2C9JYF7   A0A1J1HW80   A0A2C9JYG3   F6VIR6   A0A0N5AW37   A0A3B4CES9   A0A3B4CCY9   A0A090KV00   E0W042   A0A3B3R6H7   V9KJ46   A0A3B3R8U4   A0A1L8DFF5   G3SWK2   A0A1A9Z1X1   A0A0N5DT98   A0A3Q3W390   A0A3Q2NQY4   A0A1B0G7D3   A0A1W5B582   A0A1W5B7A6   A0A1W5B6B8   A0A2K6TL87   A0A0N5CDI8   A0A2K6TKX6   A0A1A7XI20   A0A2K6TL39   A0A2K6TL57   A0A2D0QAQ4   W5UEW9   A0A2K6TL29   A0A1A7WZQ2   A0A2K6TL08   A0A0N4TDM4   A0A315VK40   A0A3L7HX10   A0A3Q0JV29   A0A1A9V1M4   A0A024RCG3   P49589   A8MVQ3   P49589-3   A0A1A8MGY8   G3IIT6   A0A1A8CBE9   A0A1A8IVE7   G3V9K0   A0A1A7ZYB4   A0A0K0FLR8   A0A1S3AJJ1   A0A3B4AJA0   A0A1A8BQB8   A0A1A8KY77   A0A1A8UVM3   A0A1A8B3A9   A0A1A8HWV0   A0A1A8L839   A0A1A8PLJ0   A0A2K5Y745   A0A2K6CDH4   A0A2K5UB12   F6YB56   A0A2R9AND1   A0A2R9AMQ6   A0A0D9RB19   I0FIG3   A0A2K5Y740   A0A2K5MIG2   A0A1D5QYM3   A0A2K5Y735   A0A2K6CDJ4   A0A2K5UAV9   A0A1D5Q3X0   A0A2I3N173   Q5M7N8   A0A2I3LMK1   A0A2R9AMR0   A0A2R9ASA0   A0A2K5MIH2   L5KNB0   A0A2K6CDG6   H9F7B3   A0A2R9AMS0   F6YJQ2   A0A2K5MII2   A0A1A8RPB7   A0A2K5RMX6   G7PNX8  

EC Number

6.1.1.16

Pubmed

19121390    26354079    23622113    22118469    22992520    15562597    + More
12481130    15114417    20566863    29240929    24402279    23127152    29703783    29704459    11181995    7987009    11347887    14702039    17974005    16554811    15489334    12112524    15592455    18669648    19608861    20068231    21269460    22814378    23186163    24275569    21804562    15057822    15632090    25463417    17431167    22722832    25319552    23258410    22002653   

EMBL

BABH01001027    BABH01001028    BABH01001029    BABH01001030    KQ460205    KPJ16856.1    + More
KQ459606    KPI91226.1    GAIX01013849    JAA78711.1    NWSH01000189    PCG78607.1    ODYU01000170    SOQ34495.1    AGBW02008449    OWR53371.1    UZAM01009578    VDP09540.1    JH818091    EKC36911.1    CVRI01000026    CRK92351.1    EAAA01000120    LN609406    CEF61211.1    DS235855    EEB18998.1    JW865425    AFO97942.1    GFDF01008892    JAV05192.1    CCAG010016608    HADW01016312    HADX01005624    SBP17712.1    JT414273    AHH40561.1    HADW01009997    SBP11397.1    UZAD01005500    VDN87461.1    NHOQ01001616    PWA23313.1    RAZU01000139    RLQ70230.1    CH471158    EAX02540.1    L06845    AF288206    AF288207    BT009913    AK302644    BX647906    AC108448    AC131971    BC002880    AK096313    BAG53256.1    EAX02537.1    HAEF01015031    SBR56190.1    JH003109    EGW13104.1    HADZ01012134    HAEA01006357    SBP76075.1    HAED01014871    SBR01316.1    AABR07072005    AC112093    CH473953    EDM12207.1    HADY01008898    HAEJ01004401    SBP47383.1    HADZ01005102    SBP69043.1    HAEE01017302    SBR37352.1    HAEJ01010646    SBS51103.1    HADY01023269    SBP61754.1    HAED01002148    SBQ87993.1    HAEF01002662    SBR40044.1    HAEG01008598    SBR82280.1    AQIA01019552    AQIA01019553    JSUE03011874    AJFE02054265    AJFE02054266    AJFE02054267    AQIB01077542    AQIB01077543    AQIB01077544    AQIB01077545    AQIB01077546    AQIB01077547    AQIB01077548    AQIB01077549    AQIB01077550    AQIB01077551    JV044168    AFI34239.1    AHZZ02006187    BC088531    KB030625    ELK13219.1    JU326766    AFE70522.1    HAEH01007742    HAEI01009496    SBS07940.1    CM001289    EHH55988.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000050793    + More
UP000005408    UP000035681    UP000007875    UP000076420    UP000183832    UP000008144    UP000046393    UP000261440    UP000009046    UP000261540    UP000007646    UP000092445    UP000046395    UP000261620    UP000265000    UP000092444    UP000192224    UP000233220    UP000046392    UP000221080    UP000038020    UP000278627    UP000273346    UP000078200    UP000005640    UP000001075    UP000002494    UP000035680    UP000079721    UP000261520    UP000233140    UP000233120    UP000233100    UP000006718    UP000240080    UP000029965    UP000233060    UP000028761    UP000008143    UP000010552    UP000008225    UP000233040    UP000009130   

PRIDE

H9IVF8    P49589    A8MVQ3    G3IIT6   

Pfam

PF01406   tRNA-synt_1e

Interpro

IPR009080   tRNAsynth_Ia_anticodon-bd        + More
IPR024909   Cys-tRNA/MSH_ligase       
IPR015803   Cys-tRNA-ligase       
IPR032678   tRNA-synt_1_cat_dom       
IPR014729   Rossmann-like_a/b/a_fold       
IPR036282   Glutathione-S-Trfase_C_sf       

SUPFAM

SSF47323   SSF47323        + More
SSF47616   SSF47616       

Gene 3D

3.40.50.620    

CDD

cd00672  CysRS_core

ProteinModelPortal

H9IVF8   A0A194RLJ5   A0A194PD26   S4NJ25   A0A2A4K2Y2   A0A2H1V0X0   + More
A0A212FI10   A0A183IRH3   K1RR58   A0A0K0EQL2   H2ZQZ9   A0A2C9JYF7   A0A1J1HW80   A0A2C9JYG3   F6VIR6   A0A0N5AW37   A0A3B4CES9   A0A3B4CCY9   A0A090KV00   E0W042   A0A3B3R6H7   V9KJ46   A0A3B3R8U4   A0A1L8DFF5   G3SWK2   A0A1A9Z1X1   A0A0N5DT98   A0A3Q3W390   A0A3Q2NQY4   A0A1B0G7D3   A0A1W5B582   A0A1W5B7A6   A0A1W5B6B8   A0A2K6TL87   A0A0N5CDI8   A0A2K6TKX6   A0A1A7XI20   A0A2K6TL39   A0A2K6TL57   A0A2D0QAQ4   W5UEW9   A0A2K6TL29   A0A1A7WZQ2   A0A2K6TL08   A0A0N4TDM4   A0A315VK40   A0A3L7HX10   A0A3Q0JV29   A0A1A9V1M4   A0A024RCG3   P49589   A8MVQ3   P49589-3   A0A1A8MGY8   G3IIT6   A0A1A8CBE9   A0A1A8IVE7   G3V9K0   A0A1A7ZYB4   A0A0K0FLR8   A0A1S3AJJ1   A0A3B4AJA0   A0A1A8BQB8   A0A1A8KY77   A0A1A8UVM3   A0A1A8B3A9   A0A1A8HWV0   A0A1A8L839   A0A1A8PLJ0   A0A2K5Y745   A0A2K6CDH4   A0A2K5UB12   F6YB56   A0A2R9AND1   A0A2R9AMQ6   A0A0D9RB19   I0FIG3   A0A2K5Y740   A0A2K5MIG2   A0A1D5QYM3   A0A2K5Y735   A0A2K6CDJ4   A0A2K5UAV9   A0A1D5Q3X0   A0A2I3N173   Q5M7N8   A0A2I3LMK1   A0A2R9AMR0   A0A2R9ASA0   A0A2K5MIH2   L5KNB0   A0A2K6CDG6   H9F7B3   A0A2R9AMS0   F6YJQ2   A0A2K5MII2   A0A1A8RPB7   A0A2K5RMX6   G7PNX8  

KEGG

101737111    K01883 cysteinyl-tRNA synthetase [EC:6.1.1.16] | (RefSeq) cysteine--tRNA ligase, cytoplasmic

GO

GO:0005524   GO:0004817   GO:0006423   GO:0004812   GO:0006418   GO:0005737   GO:0042803   GO:0000049   GO:0005829   GO:0016874   GO:0046872   GO:0016021  

PANTHER

PTHR10890  

Subcellular location

Cytoplasm  

Length:

150

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00019

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.04064

outside

1  -  150

 

 

Pi

160.582505

Theta

155.085099

Tajima's D

-1.216369

CLR

6.343916

CSRT

0.0998950052497375

Interpretation

Uncertain