Gene

KWMTBOMO07781

Pre Gene Modal

BGIBMGA000904

Annotation

PREDICTED:_SUN_domain-containing_protein_2-like_[Bombyx_mori]

Location

Bomo_Chr13(+):6673353-6677078      View in EpiBrowser

Full name

SUN domain-containing protein 2      

Alternative Name

Protein unc-84 homolog B
Rab5-interacting protein
Sad1/unc-84 protein-like 2

Location in the cell

Cytoplasmic   Reliability : 1.169 Mitochondrial   Reliability : 1.087

CDS

ATGGAACGGATGTCGGCGGTGATTCCTGCCGTGGCTGCGGCTGCAGGACGCGCTAAAGACGCCTTGGAACCATCTCTGAGGAAGAACAGCCGACAGGCATTGGATAATTATGATTATGATAGACAGGTGGCTGATTACGCGCTCGAGTCTGCTGGTGGTCGCATATTAGATACTGGAGATACAATAGAGCATCTAGTTTATGAGTCGCCCATAAGTTGGGGCTTACATCTAATTACGTCGTGGATGTGTAGGGAATGTCAAGGGGCCAGTGCTATGATCCGCCCAGGTACTTTACCTGGTGAATGCTGGGCGTTCAAAGGATCGAAAGGTCAAGCTATGATACGTCTACTCGGTACTGTGAAGGTGATGGGTGTTAGTGTGGAGCATATTCCGGCGCATATCTCGCCAACCAGGGAAATATCTTCGGCGCCACGACTATTCCAAGTGGAAGGCTTAGAATATCGCAGCGATCCGTACCCCCACGACTTTGGTACCTTTGAGTACGATAAGGAGGGCAAACCGATCCAGTACTTTGAAGTGTTGTACCCTTCAACGAAGGGGTACAGCTTGATAAGGATACGCGTGCTTACTAATTGGGGACATCCTGTGTATACTTGCGTGTACCGAGTGAGGGTTCACGGTGAATTGTCGGGACGTAATCAAAACTTCGGTGCCGACGACACTGAGATGCGAATCGAAAATGAATGA

Protein

MERMSAVIPAVAAAAGRAKDALEPSLRKNSRQALDNYDYDRQVADYALESAGGRILDTGDTIEHLVYESPISWGLHLITSWMCRECQGASAMIRPGTLPGECWAFKGSKGQAMIRLLGTVKVMGVSVEHIPAHISPTREISSAPRLFQVEGLEYRSDPYPHDFGTFEYDKEGKPIQYFEVLYPSTKGYSLIRIRVLTNWGHPVYTCVYRVRVHGELSGRNQNFGADDTEMRIENE

Description

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Subunit

Core component of the LINC complex which is composed of inner nuclear membrane SUN domain-containing proteins coupled to outer nuclear membrane KASH domain-containing nesprins. SUN and KASH domain-containing proteins seem to bind each other promiscuously; however, differentially expression of LINC complex constituents is giving rise to specific assemblies. At least SUN1/2-containing core LINC complexes are proposed to be hexameric composed of three protomers of each KASH and SUN domain-containing protein. Interacts with SYNE2; the SUN2:SYNE2/KASH2 LINC complex is a heterohexamer; the homotrimeric cloverleave-like conformation of the SUN domain is a prerequisite for LINC complex formation in which three separate SYNE2/KASH2 peptides bind at the interface of adjacent SUN domains. Component of a probable SUN2:KASH5 LINC complex. Interacts with SYNE1 and SYNE3; probably forming respective LINC complexes. Interacts with A-type lamin. Interaction with lamins B1 and C is hardly detectable (By similarity). Interacts with EMD and RAB5A. Interacts with TMEM43 and TMEM201.

Keywords

3D-structure   Alternative splicing   Coiled coil   Complete proteome   Disulfide bond   Endosome   Glycoprotein   Meiosis   Membrane   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Signal-anchor   Transmembrane   Transmembrane helix  

Feature

chain  SUN domain-containing protein 2
splice variant  In isoform 2.
sequence variant  In dbSNP:rs2072799.

Uniprot

H9IUH4   A0A2H1VD83   A0A2A4K3H9   A0A212FI43   A0A194RHD8   A0A194PEV0   + More
A0A0L7LVD4   A0A151WZS1   A0A195D511   A0A195F5Z7   A0A2A3E2Q6   A0A195BU98   A0A026W149   A0A195EK48   A0A3L8DPI7   A0A0L7RA72   A0A1Y1LL45   A0A154P7G3   A0A088ATM6   F4WXT4   A0A3R7PZ44   K7IWR4   A0A0N5DHZ0   A0A0K2TYC1   A0A1D2MFR8   W5LYM1   Q6NT72   A0A2K5JCU8   H9FSI8   I0FQL1   A0A2Y9SW70   A0A2K6AWC8   A0A2K6QK73   A0A2K6JUX1   A0A2K6JUY5   F7FC46   A0A2K5YQ49   A0A2K5UID6   A0A0D9R2D4   H9Z7D3   A0A2K5UIF2   A0A2K5YQ22   I2CYJ6   L5KFV6   A0A2R9BY76   A0A2I3TT81   A0A2I2ZZ03   A0A024R1P7   Q9UH99   G1RYX5   A0A2I2YDX4   A0A2J8UWP8   A0A2J8LNL1   A0A2I3G549   H2R4A1   A0A096NK39   A0A2R9BP74   Q9UH99-2   A0A2J8UWN1   A0A2K6TID2   A0A2K6TIF2   B4E2A6   A0A232EG81   U3DHD4   U3FQT8   A0A2J7RGG7   A0A2K5R8B3   H0V6Q8   A0A091E028   B4DIU6   A0A2K5R883   A0A2K6TIA0   A0A1D2N6Q4   A0A093BDN0   A0A1S3FWD8   A0A0S7ET58   A0A1S3FUU3   A0A2K5NL97   A0A2U4C0T8   A0A2K5CW18   A0A2Y9QB58   F7B1Y2   A0A2Y9QBA5   A0A346QRB9   A8K129   A0A1U7UNM7   A0A067QSG5   A0A2F0B730   W5KNM3   A6QLV1   A0A250YKY5   K9ITX2   A0A2K6F7S0   A0A0A9YR80   H0WGK7   K9IU18   A0A2I0USJ5   A0A2Y9T081   A0A286ZN31  

Pubmed

19121390    22118469    26354079    26227816    24508170    30249741    + More
28004739    21719571    20075255    27289101    15489334    25319552    25362486    17431167    23258410    22722832    15164055    16136131    22398555    11181995    10818110    17132086    9734811    15461802    17974005    10591208    10375507    12393179    12239280    12958361    15082709    17081983    17724119    18845190    18396275    19159218    19690332    21391237    21269460    23186163    24275569    26244732    22632968    22945352    22170055    28648823    25243066    21993624    24845553    25329095    19393038    28087693    25401762   

EMBL

BABH01001039    ODYU01001917    SOQ38788.1    NWSH01000189    PCG78609.1    AGBW02008449    + More
OWR53369.1    KQ460205    KPJ16854.1    KQ459606    KPI91224.1    JTDY01000008    KOB79483.1    KQ982649    KYQ53201.1    KQ976842    KYN07936.1    KQ981805    KYN35494.1    KZ288452    PBC25546.1    KQ976403    KYM92189.1    KK107570    EZA48789.1    KQ978801    KYN28239.1    QOIP01000005    RLU22317.1    KQ414619    KOC67782.1    GEZM01056552    JAV72655.1    KQ434823    KZC07274.1    GL888427    EGI61012.1    QCYY01003330    ROT64082.1    AAZX01000616    HACA01013663    CDW31024.1    LJIJ01001441    ODM91732.1    AHAT01030100    BC069253    AAH69253.1    JU333841    JU333842    AFE77597.1    JV046666    JV046667    AFI36737.1    JSUE03005524    AQIA01006974    AQIB01136553    JU475045    JU475046    AFH31849.1    JV667368    AFJ72031.1    KB030755    ELK10222.1    AJFE02074311    AJFE02074312    AACZ04068045    CH471095    EAW60270.1    AB014568    AY682988    CR456474    BX537962    AL008583    AL021806    AL021707    BC030684    BC094797    BC111549    BC111717    AF202723    ADFV01024598    ADFV01024599    ABGA01111555    ABGA01111556    ABGA01111557    NDHI03003442    PNJ49677.1    PNJ49678.1    PNJ49680.1    NBAG03000283    PNI48857.1    GABC01000046    GABC01000045    GABF01001739    GABF01001738    GABD01000027    GABD01000026    GABE01000160    GABE01000159    GABE01000158    JAA11292.1    JAA11293.1    JAA20406.1    JAA33073.1    JAA44579.1    PNI48855.1    PNI48858.1    PNI48859.1    AHZZ02001248    PNJ49679.1    AK304188    BAG65068.1    NNAY01004848    OXU17344.1    GAMS01010345    GAMQ01006343    JAB12791.1    JAB35508.1    GAMT01000771    GAMR01009247    GAMP01003994    JAB11090.1    JAB24685.1    JAB48761.1    NEVH01003784    PNF39922.1    AAKN02031258    KN121328    KFO36672.1    AK295787    BAG58608.1    LJIJ01000180    ODN00948.1    KN125643    KFU83601.1    GBYX01474144    GBYX01474141    JAO07516.1    MH156453    AXR98509.1    AK289744    BAF82433.1    KK853076    KDR11726.1    NTJE010088800    MBV98801.1    BC148095    AAI48096.1    GFFW01000602    JAV44186.1    GABZ01000822    JAA52703.1    GBHO01008042    JAG35562.1    AAQR03016211    GABZ01000762    JAA52763.1    KZ505643    PKU49025.1    AEMK02000027   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000075809    UP000078542    UP000078541    UP000242457    UP000078540    UP000053097    UP000078492    UP000279307    UP000053825    UP000076502    UP000005203    UP000007755    UP000283509    UP000002358    UP000046395    UP000094527    UP000018468    UP000233080    UP000233120    UP000233200    UP000233180    UP000006718    UP000233140    UP000233100    UP000029965    UP000010552    UP000240080    UP000002277    UP000001519    UP000005640    UP000001073    UP000001595    UP000028761    UP000233220    UP000215335    UP000235965    UP000233040    UP000005447    UP000028990    UP000081671    UP000233060    UP000245320    UP000233020    UP000248483    UP000008225    UP000189704    UP000027135    UP000018467    UP000009136    UP000233160    UP000005225    UP000008227   

PRIDE

H9IUH4    Q6NT72    Q9UH99    B4E2A6    B4DIU6    A8K129    + More

Pfam

PF07738   Sad1_UNC        + More
PF10300   DUF3808
PF18580   Sun2_CC2
PF09387   MRP

Interpro

IPR012919   SUN_dom        + More
IPR008979   Galactose-bd-like_sf       
IPR030272   SUN2       
IPR018539   SUN1       
IPR019412   Iml2/TPR_39       
IPR011990   TPR-like_helical_dom_sf       
IPR040994   Sun_CC2       
IPR032680   SUN1_N       

SUPFAM

SSF48452   SSF48452        + More
SSF49785   SSF49785       

Gene 3D

2.60.120.260     1.25.40.10    

ProteinModelPortal

H9IUH4   A0A2H1VD83   A0A2A4K3H9   A0A212FI43   A0A194RHD8   A0A194PEV0   + More
A0A0L7LVD4   A0A151WZS1   A0A195D511   A0A195F5Z7   A0A2A3E2Q6   A0A195BU98   A0A026W149   A0A195EK48   A0A3L8DPI7   A0A0L7RA72   A0A1Y1LL45   A0A154P7G3   A0A088ATM6   F4WXT4   A0A3R7PZ44   K7IWR4   A0A0N5DHZ0   A0A0K2TYC1   A0A1D2MFR8   W5LYM1   Q6NT72   A0A2K5JCU8   H9FSI8   I0FQL1   A0A2Y9SW70   A0A2K6AWC8   A0A2K6QK73   A0A2K6JUX1   A0A2K6JUY5   F7FC46   A0A2K5YQ49   A0A2K5UID6   A0A0D9R2D4   H9Z7D3   A0A2K5UIF2   A0A2K5YQ22   I2CYJ6   L5KFV6   A0A2R9BY76   A0A2I3TT81   A0A2I2ZZ03   A0A024R1P7   Q9UH99   G1RYX5   A0A2I2YDX4   A0A2J8UWP8   A0A2J8LNL1   A0A2I3G549   H2R4A1   A0A096NK39   A0A2R9BP74   Q9UH99-2   A0A2J8UWN1   A0A2K6TID2   A0A2K6TIF2   B4E2A6   A0A232EG81   U3DHD4   U3FQT8   A0A2J7RGG7   A0A2K5R8B3   H0V6Q8   A0A091E028   B4DIU6   A0A2K5R883   A0A2K6TIA0   A0A1D2N6Q4   A0A093BDN0   A0A1S3FWD8   A0A0S7ET58   A0A1S3FUU3   A0A2K5NL97   A0A2U4C0T8   A0A2K5CW18   A0A2Y9QB58   F7B1Y2   A0A2Y9QBA5   A0A346QRB9   A8K129   A0A1U7UNM7   A0A067QSG5   A0A2F0B730   W5KNM3   A6QLV1   A0A250YKY5   K9ITX2   A0A2K6F7S0   A0A0A9YR80   H0WGK7   K9IU18   A0A2I0USJ5   A0A2Y9T081   A0A286ZN31  

PDB

3UNP     E-value=1.59727e-34,     Score=363

KEGG

101738307    K19347 SUN domain-containing protein 1/2 | (RefSeq) SUN domain-containing protein 2-like

GO

GO:0016021   GO:0005639   GO:0034993   GO:0090286   GO:0043495   GO:0005635   GO:0006998   GO:0021817   GO:0031022   GO:0000784   GO:0000794   GO:0090292   GO:0030335   GO:0005521   GO:0051642   GO:0042802   GO:0031965   GO:0010008   GO:0008017   GO:0007052   GO:0051321   GO:0007097  

PANTHER

PTHR12911:SF22   PTHR12911:SF23   PTHR31859  

Subcellular location

Nucleus inner membrane  
Nucleus envelope  
Endosome membrane  

Length:

235

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01067

Exp number, first 60 AAs:

0.00031

Total prob of N-in:

0.05231

outside

1  -  235

 

 

Pi

240.076015

Theta

152.77694

Tajima's D

1.351752

CLR

1.694449

CSRT

0.753512324383781

Interpretation

Uncertain