Gene

KWMTBOMO07770  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001244

Annotation

PREDICTED:_synembryn_[Bombyx_mori]

Location

Bomo_Chr13(-):6576371-6580892      View in EpiBrowser

Full name

Synembryn      

Alternative Name

Protein Ric-8

Location in the cell

Nuclear   Reliability : 2.797

CDS

ATGGATGAAATGGAAATTGATGACCTGAGAAATAGTAAGAGCTCAACAGAGATAACGAATATTTTACGAAAATTTGTTAAAGACAACGAAAAAACTTTCAAATTTCCTGAACTTACGAAGAGGTTTAACAGAGTTTTACTGTGGACAACACTTTTTCAACACCTGCAAAATGATGCTTTGGTTTCAACACATGCACTATGTTTAAAAGCTTTAAGGATTCTTAGCCGTGACCAAGATGACATTGAAAATGTTCTATGTGAACGTTGGGTCATAACATTAATCGACAAATCAGGCTTGTTAGAGCCTATGGAGTCTGCTGAAAAGGACCCAACTCTATTAGTCGTGCCCTGTAAAGAAGTAGCGATTGAAGCTATGAAGTGTTTGTGTAATATTACATTCAATAGTGAACTGGCTCGTAATGTTTGTGTAAACACAAGAATAGCACATGGGCTTATCACACGAATGAAAATATGCAAACACATTCCTTACAAAAAAGAGTTAATGCAGTATGATATGAAATTGATCTTCATACTGACAGCATTAATAGAAAACATAAGATTAAAATTTAGGCACGAGGATGGTGCAATGCATATGATTAATTATCTCAATGAAATATATTCTGAAAGTTTACAACCTAGTTCTGATGAGGCGAGTGTTAGTGCAAATTCAGAAGATGCTCCAAAATATTACTTCACTGATGAAGATCGAGTAATTGTGTGCGAGTTATCGAAGGCTTTATTTAACCTCATAATATTGCCTAATGAAGATACTCCCACAACAGAGAAAGAGAAACAACAATTTACAAACTTGGTGTCTGTGCTTGGGAAGATAATGACTGTACAAACCTCCTCCAAATCAAATGATTTAGATTTAATGAATAATATTGTTAATCTACTAACAAGCATCCACACACTGTTTTATATGTCCCTGACAGAAGAAATTGGAGACAAACAAAAGCCTGACCATATTTATGAAGGTAGAGATATGACTTCACTGGTCATACTACTTCAATTTTTGAAACATCAGCTAACTGCTAGCGATGAGCGACAGAACCTTTACGAAAAACTATCTCCGATATTGACGGTCCTCAATAAATGTGCCCGTGTACGCGTCCAACGTAAGTTCTTACGTAAAGCCGTGCTGCCGCATCTCCGCGACGTGTCGAAGCCCCCCGAGCAGGGCGACGAGCTGCGGAACCACCTGTGCCGGCTGCTGACGACGCCCGTCACCAGCGTGAGGGACTTGGTAGCGGAGTTCTTGTTCGTACTCTGCAAGGAAAAAGTGGCCGAGTTTTAG

Protein

MDEMEIDDLRNSKSSTEITNILRKFVKDNEKTFKFPELTKRFNRVLLWTTLFQHLQNDALVSTHALCLKALRILSRDQDDIENVLCERWVITLIDKSGLLEPMESAEKDPTLLVVPCKEVAIEAMKCLCNITFNSELARNVCVNTRIAHGLITRMKICKHIPYKKELMQYDMKLIFILTALIENIRLKFRHEDGAMHMINYLNEIYSESLQPSSDEASVSANSEDAPKYYFTDEDRVIVCELSKALFNLIILPNEDTPTTEKEKQQFTNLVSVLGKIMTVQTSSKSNDLDLMNNIVNLLTSIHTLFYMSLTEEIGDKQKPDHIYEGRDMTSLVILLQFLKHQLTASDERQNLYEKLSPILTVLNKCARVRVQRKFLRKAVLPHLRDVSKPPEQGDELRNHLCRLLTTPVTSVRDLVAEFLFVLCKEKVAEF

Description

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors. In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha function through control of its membrane targeting and/or assembling of associated components rather than a GEF. Also required during gastrulation and sensory organ precursors (SOP) formation.

Subunit

Interacts with GDP-bound G(i)-alpha protein G-i-alpha-65A. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.

Similarity

Belongs to the synembryn family.

Keywords

Complete proteome   Cytoplasm   Developmental protein   Gastrulation   Guanine-nucleotide releasing factor   Phosphoprotein   Reference proteome  

Feature

chain  Synembryn

Uniprot

H9IVG4   A0A2A4JI83   A0A2H1V6T5   A0A194PD95   A0A194RLI2   A0A212FI06   + More
A0A3S2M0Q3   A0A0L7KIR2   A0A1B6CFL8   A0A1B6GQF9   E0VBF7   A0A1W4WRA0   A0A182W9J5   D7ELV7   A0A182JMD9   A0A182ML23   A0A1L8DLU3   A0A1L8DM69   A0A1L8DLZ5   A0A1L8DLS4   A0A182P1X2   A0A182REI6   A0A182QH85   A0A2M4BJ08   A0A182NV79   A0A2M4BJ88   A0A336MUZ0   A0A084VB41   A0A336LV11   A0A182X0H7   A0A182I5R6   A0A182V4Q4   A0A182KVA1   A0A1Y1K411   A0A182TWI1   A0A182JQU5   T1JDW5   A0A2M4AES9   A0A182YIX5   A0A2M4AEX0   A0A182FVV7   W5JCX9   A0A210PSY0   A0A2C9LRV0   A0A1B0CID5   A0A2J7Q6S5   A0A2P8ZAT8   A0A182G2N3   A0A182G1A4   R7TAU9   Q7Q230   A0A1S3J7A8   A0A1S3J8T3   A0A0M4EJ54   A0A2T7PJJ5   A0A2C9LRS3   A0A1S4FML0   Q16VZ5   A0A067RVB2   E9FT91   A0A0P5IVU2   A0A0P5IXP1   A0A164LLS2   A0A0P4ZZI3   A0A1Q3FCR2   A0A1Q3FCU3   A0A0P5Q9Q1   A0A0P5QR10   A0A0P5A7S5   A0A151XGG3   A0A0P6IR75   A0A151IKH6   A0A151JWU8   A0A2S2NSR9   A0A087ZQU8   J9K2I4   B4L1T7   B4JL66   A0A2A3E1V6   A0A2H8TY62   E9IW71   V4AEY6   B0X751   B4M1J0   A0A0P5VL70   T1KGC9   B3MZS3   A0A0P6CZ49   A0A1W4VUN2   A0A0L7R0R1   A0A0K8URG8   K1PZH7   B3NT86   X2JEL4   Q9W358   A0A232EKM1   A0A3S3SEU1   A0A2S2QUL4  

Pubmed

19121390    26354079    22118469    26227816    20566863    18362917    + More
19820115    24438588    20966253    28004739    25244985    20920257    23761445    28812685    15562597    29403074    26483478    23254933    12364791    17510324    24845553    21292972    17994087    21282665    22992520    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    16228010    16228012    16228011    18327897    28648823   

EMBL

BABH01001044    BABH01001045    BABH01001046    NWSH01001481    PCG71122.1    ODYU01000982    + More
SOQ36560.1    KQ459606    KPI91212.1    KQ460205    KPJ16841.1    AGBW02008449    OWR53358.1    RSAL01000084    RVE48407.1    JTDY01009699    KOB62985.1    GEDC01025163    JAS12135.1    GECZ01005093    JAS64676.1    DS235030    EEB10713.1    KQ971431    EFA12419.2    AXCM01001817    GFDF01006655    JAV07429.1    GFDF01006654    JAV07430.1    GFDF01006653    JAV07431.1    GFDF01006675    JAV07409.1    AXCN02001805    GGFJ01003899    MBW53040.1    GGFJ01003902    MBW53043.1    UFQT01001264    SSX29758.1    ATLV01005273    KE524276    KFB35185.1    UFQT01000218    SSX21876.1    APCN01003489    GEZM01093661    JAV56204.1    JH432114    GGFK01005964    MBW39285.1    GGFK01005976    MBW39297.1    ADMH02001521    ETN62207.1    NEDP02005520    OWF39591.1    AJWK01013196    NEVH01017454    PNF24283.1    PYGN01000121    PSN53608.1    JXUM01139739    KQ568947    KXJ68826.1    JXUM01038146    KQ561155    KXJ79526.1    AMQN01003072    KB310836    ELT90642.1    AAAB01008979    EAA13709.3    CP012528    ALC49091.1    PZQS01000003    PVD33593.1    CH477579    EAT38718.1    KK852444    KDR23819.1    GL732524    EFX89689.1    GDIQ01208351    JAK43374.1    GDIQ01208352    JAK43373.1    LRGB01003123    KZS04236.1    GDIP01206383    JAJ17019.1    GFDL01009680    JAV25365.1    GFDL01009650    JAV25395.1    GDIQ01117636    JAL34090.1    GDIQ01117637    JAL34089.1    GDIP01206428    JAJ16974.1    KQ982169    KYQ59489.1    GDIQ01006970    JAN87767.1    KQ977203    KYN04970.1    KQ981629    KYN38963.1    GGMR01007558    MBY20177.1    ABLF02023906    ABLF02023907    CH933810    EDW06740.1    CH916370    EDW00319.1    KZ288439    PBC25723.1    GFXV01007054    MBW18859.1    GL766449    EFZ15232.1    KB201656    ESO95427.1    DS232438    EDS41745.1    CH940651    EDW65544.1    GDIP01098493    JAM05222.1    CAEY01000065    CH902635    EDV33874.1    GDIP01007689    JAM96026.1    KQ414670    KOC64428.1    GDHF01023045    JAI29269.1    JH816690    EKC27043.1    CH954180    EDV46266.1    AE014298    AHN59519.1    BT004873    NNAY01003783    OXU18872.1    NCKU01001085    NCKU01001026    NCKU01000756    NCKU01000755    RWS13130.1    RWS13317.1    RWS14306.1    RWS14319.1    GGMS01012007    MBY81210.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000283053    + More
UP000037510    UP000009046    UP000192223    UP000075920    UP000007266    UP000075880    UP000075883    UP000075885    UP000075900    UP000075886    UP000075884    UP000030765    UP000076407    UP000075840    UP000075903    UP000075882    UP000075902    UP000075881    UP000076408    UP000069272    UP000000673    UP000242188    UP000076420    UP000092461    UP000235965    UP000245037    UP000069940    UP000249989    UP000014760    UP000007062    UP000085678    UP000092553    UP000245119    UP000008820    UP000027135    UP000000305    UP000076858    UP000075809    UP000078542    UP000078541    UP000005203    UP000007819    UP000009192    UP000001070    UP000242457    UP000030746    UP000002320    UP000008792    UP000015104    UP000007801    UP000192221    UP000053825    UP000005408    UP000008711    UP000000803    UP000215335    UP000285301   

PRIDE

H9IVG4    X2JEL4    Q9W358   

Pfam

PF10165   Ric8        + More
PF01476   LysM

Interpro

IPR016024   ARM-type_fold        + More
IPR019318   Gua_nucleotide_exch_fac_Ric8       
IPR008376   Synembryn       
IPR011989   ARM-like       
IPR036779   LysM_dom_sf       
IPR018392   LysM_dom       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10     3.10.350.10    

CDD

cd00118  LysM

ProteinModelPortal

H9IVG4   A0A2A4JI83   A0A2H1V6T5   A0A194PD95   A0A194RLI2   A0A212FI06   + More
A0A3S2M0Q3   A0A0L7KIR2   A0A1B6CFL8   A0A1B6GQF9   E0VBF7   A0A1W4WRA0   A0A182W9J5   D7ELV7   A0A182JMD9   A0A182ML23   A0A1L8DLU3   A0A1L8DM69   A0A1L8DLZ5   A0A1L8DLS4   A0A182P1X2   A0A182REI6   A0A182QH85   A0A2M4BJ08   A0A182NV79   A0A2M4BJ88   A0A336MUZ0   A0A084VB41   A0A336LV11   A0A182X0H7   A0A182I5R6   A0A182V4Q4   A0A182KVA1   A0A1Y1K411   A0A182TWI1   A0A182JQU5   T1JDW5   A0A2M4AES9   A0A182YIX5   A0A2M4AEX0   A0A182FVV7   W5JCX9   A0A210PSY0   A0A2C9LRV0   A0A1B0CID5   A0A2J7Q6S5   A0A2P8ZAT8   A0A182G2N3   A0A182G1A4   R7TAU9   Q7Q230   A0A1S3J7A8   A0A1S3J8T3   A0A0M4EJ54   A0A2T7PJJ5   A0A2C9LRS3   A0A1S4FML0   Q16VZ5   A0A067RVB2   E9FT91   A0A0P5IVU2   A0A0P5IXP1   A0A164LLS2   A0A0P4ZZI3   A0A1Q3FCR2   A0A1Q3FCU3   A0A0P5Q9Q1   A0A0P5QR10   A0A0P5A7S5   A0A151XGG3   A0A0P6IR75   A0A151IKH6   A0A151JWU8   A0A2S2NSR9   A0A087ZQU8   J9K2I4   B4L1T7   B4JL66   A0A2A3E1V6   A0A2H8TY62   E9IW71   V4AEY6   B0X751   B4M1J0   A0A0P5VL70   T1KGC9   B3MZS3   A0A0P6CZ49   A0A1W4VUN2   A0A0L7R0R1   A0A0K8URG8   K1PZH7   B3NT86   X2JEL4   Q9W358   A0A232EKM1   A0A3S3SEU1   A0A2S2QUL4  

KEGG

101738713    no KO assigned | (RefSeq) synembryn

GO

GO:0007186   GO:0005085   GO:0005096   GO:0005737   GO:0001965   GO:0016021   GO:0005829   GO:0040001   GO:0008356   GO:0007163   GO:0008104   GO:0055057   GO:0050821   GO:0010004   GO:0005938   GO:0005488   GO:0008324   GO:0004890   GO:0005216   GO:0006811   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR12425  

Subcellular location

  

Length:

431

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02483

Exp number, first 60 AAs:

0.00286

Total prob of N-in:

0.00565

outside

1  -  431

 

 

Pi

216.306013

Theta

160.060291

Tajima's D

1.09579

CLR

0

CSRT

0.685865706714664

Interpretation

Uncertain