Gene

KWMTBOMO07762

Pre Gene Modal

BGIBMGA001250

Annotation

cyclin_D_[Danaus_plexippus]

Location

Bomo_Chr13(-):6402105-6417625      View in EpiBrowser

Full name

G1/S-specific cyclin-D3      

Location in the cell

PlasmaMembrane   Reliability : 1.451

CDS

ATGTTATGTATTATTATTTGGACGCCGTCGAATGGGAGAAACCTGCGTGCGGGCCTCACTGGCACCGCCCTGCCCCCGCGCCGCGCCGCTCCGATCATATTATTATGTTCGGTCGGCGGGCGAGTCTCGCACCGGCCGCTCACTGCGACTCGGGCGCTCGTCGTTGTCGCAACACTACGTGCAACACTCCGGCGCTCGCTCCCGACCGATCAGCTGTCGAGCACTCCGCGCAGAACAAATCATATCCTTCGCGACGCGTACGTGACCGTTCGGATAAACATGGAGCTGTTGTGCGCGGAACGCGTCAGCCCCGGCAGTGGCGAGGGCGCACCGCGGCTGCCGCAAGCTGCTGCACCCGACCCGGTGCTGCTGCGCCGCCGCGTGCTCGACAACCTGCTGCGGACCGAGGAGCGCTATGCCGTCACCGCTAACTACTTCGGCACTGTGCAGACCGAGATCACACCTCACATGCGCCGTCTCGTCGCCGAGTGGATGCTAGAGGTATGCGAAGATCGCGGCTGCCAAGAAGAAGTCTTTCCACTGGCGATATCGTTCCTGGATCGGTTCTTGAGCATCTGCGCGGTGGGAAAAAGTCAAGTGCAACTTTTGGGCACAGCCTGTCTACTGTTGGCTTCCAAACTCCGTGAGCCAGGATCGTGTGCCCTCCCCGCCGACCTACTTGTCTTCTACACCGCAAACAGCATCACCCTTACCGATCTTTGCAGCTGGGAGTTGCTAGTGCTGTCGAAGCTGAAATGGGATGTAGCAGGGGTGACAGCTCACGACTTCTTGCCTCTTCTGCTATCGCGGTTGCCAATCCGAGGCCTTGTCAACGTGGAAATGGTGCAAAGGCATGCAAAGACGTTTATTTCACTAGCGGCAAGAGATTATGAATTCACGCTGTACTCTTCAAGCACTCTTGCCGCTTGCAGCATCGCTGCTGCACTACGAGGTCTCGAACACGATGGCTACTTATCGAGACTCCAAGAGCTCACGCGCATTGACTTAGATTGCCTGCAGACCTGTCTCGAACAGATCGAGGATATGGTGCAAAGTTTGATAGTGGAGCGTGACTCGTGTCCCCCAAACGGCCAGGCGCGAGAAGCGGCGGGCTGGACGCCGCCCCCCGCCCCCCCGCACGACAAGGCGCACAGTAACGCCGCCACACCCACCGACGTCAGAGATGTACACTTCTAA

Protein

MLCIIIWTPSNGRNLRAGLTGTALPPRRAAPIILLCSVGGRVSHRPLTATRALVVVATLRATLRRSLPTDQLSSTPRRTNHILRDAYVTVRINMELLCAERVSPGSGEGAPRLPQAAAPDPVLLRRRVLDNLLRTEERYAVTANYFGTVQTEITPHMRRLVAEWMLEVCEDRGCQEEVFPLAISFLDRFLSICAVGKSQVQLLGTACLLLASKLREPGSCALPADLLVFYTANSITLTDLCSWELLVLSKLKWDVAGVTAHDFLPLLLSRLPIRGLVNVEMVQRHAKTFISLAARDYEFTLYSSSTLAACSIAAALRGLEHDGYLSRLQELTRIDLDCLQTCLEQIEDMVQSLIVERDSCPPNGQAREAAGWTPPPAPPHDKAHSNAATPTDVRDVHF

Description

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Subunit

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K (By similarity).

Similarity

Belongs to the cyclin family.
Belongs to the cyclin family. Cyclin D subfamily.

Keywords

Cell cycle   Cell division   Complete proteome   Cyclin   Cytoplasm   Membrane   Nucleus   Phosphoprotein   Reference proteome   Ubl conjugation  

Feature

chain  G1/S-specific cyclin-D3

Uniprot

A0A2A4J6D0   A0A2H1W4P5   A0A3S2L901   A0A212FHZ1   A0A0L7LMZ4   A0A1B6EAC8   + More
A0A195BRG8   A0A158NF65   A0A154P9A9   A0A195FAP4   A0A291S6V8   A0A026W033   A0A1Y1LH73   A0A195E872   T1JB92   A0A151WHW8   A0A151NBN3   A0A218UEB0   K7FR66   M3YPT8   A0A3P4S0T0   A0A091EEC5   I3NGA5   A0A3M0JKI9   A0A0Q3WS63   A0A1Q3EVE5   Q007T4   B2KIE0   A0A250YEW6   A0A2Y9JPU4   B2MVY3   A0A341D4T4   A0A3Q2GV07   A0A340XA32   A0A2Y9FDC1   A0A2Y9NR31   F1MV86   A0A2U3WHA3   A0A384BF96   K7GLC1   A0A2I2V351   G3HR48   A0A131Y267   A0A1S3A5R5   A0A2F0AUW0   A0A3Q7QKW9   A0A1U7QEU9   G1PP55   Q3MHH5   A0A061IIM4   A0A2P4TGD2   A0A1S3FEF6   B0X5M7   F1PC17   A0A2B4RC26   A0A1A6GIQ8   I3QUJ2   Q5U321   Q3TSW4   P30282   A0A1W4X6M2   A0A2K5TJJ8   G3RGP1   A0A0D9RFX8   A0A2K6R312   A0A2K5NJ80   H2PJ14   F7GU42   A8MN33   A0A2I3RXN8   V5H9K8   A0A1V4KWQ2  

Pubmed

22118469    26227816    21347285    28992199    24508170    30249741    + More
28004739    22293439    17381049    28087693    19892987    19393038    17975172    21804562    21993624    23929341    29704459    16341006    23473789    15489334    15057822    15632090    22673903    10349636    11042159    11076861    11217851    12466851    12040188    16141073    21183079    1827757    8661116    22398555    25362486    17431167    22002653    25319552    16136131    25765539   

EMBL

NWSH01003070    PCG67000.1    ODYU01006254    SOQ47926.1    RSAL01000084    RVE48399.1    + More
AGBW02008449    OWR53350.1    JTDY01000551    KOB76709.1    GEDC01002428    JAS34870.1    KQ976417    KYM89600.1    ADTU01013876    ADTU01013877    ADTU01013878    ADTU01013879    ADTU01013880    ADTU01013881    KQ434829    KZC07760.1    KQ981720    KYN37282.1    MF432989    ATL75340.1    KK107519    QOIP01000009    EZA49413.1    RLU18521.1    GEZM01055679    JAV72984.1    KQ979479    KYN21410.1    JH432010    KQ983106    KYQ47431.1    AKHW03003562    KYO34238.1    MUZQ01000400    OWK51752.1    AGCU01135433    AGCU01135434    AGCU01135435    AGCU01135436    AGCU01135437    AEYP01006169    CYRY02044493    VCX39468.1    KK718210    KFO55017.1    AGTP01010841    QRBI01000149    RMB99209.1    LMAW01000447    KQL52034.1    GFDL01015772    JAV19273.1    DQ915494    ABJ09399.1    DP000721    ACC68848.1    GFFW01002698    JAV42090.1    EU626222    ACC93617.1    AEMK02000055    AANG04003966    JH000627    EGW06812.1    GEFM01002819    JAP72977.1    NTJE010004242    MBV94530.1    AAPE02051467    BC105236    KE665325    RAZU01000030    ERE88913.1    RLQ78640.1    PPHD01000474    POI35419.1    DS232387    EDS40964.1    AAEX03008324    LSMT01000869    PFX13927.1    LZPO01089559    OBS65635.1    JQ700064    AFK15626.1    AABR07066759    BC085763    BC089819    CH473987    AAH85763.1    AAH89819.1    EDM18888.1    AK161758    AK168290    CH466559    BAE36561.1    BAE40235.1    EDL23569.1    M86183    U43844    BC004076    BC005605    AQIA01051882    CABD030044660    AQIB01159909    ABGA01105595    ABGA01105596    NDHI03003283    PNJ89056.1    JSUE03030859    JSUE03030860    JSUE03030861    JSUE03030862    JSUE03030863    JSUE03030864    JSUE03030865    JSUE03030866    JU322013    JV048616    CM001256    AFE65769.1    AFI38687.1    EHH18323.1    AHZZ02024652    DP000458    ABW05542.1    AACZ04022870    GABC01000298    GABF01009951    GABD01007458    GABE01006785    NBAG03000221    JAA11040.1    JAA12194.1    JAA25642.1    JAA37954.1    PNI77284.1    GANP01010594    JAB73874.1    LSYS01001493    OPJ88919.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000037510    UP000078540    UP000005205    + More
UP000076502    UP000078541    UP000053097    UP000279307    UP000078492    UP000075809    UP000050525    UP000197619    UP000007267    UP000000715    UP000052976    UP000005215    UP000269221    UP000051836    UP000248482    UP000252040    UP000002281    UP000265300    UP000248484    UP000248483    UP000009136    UP000245340    UP000261681    UP000008227    UP000011712    UP000001075    UP000079721    UP000286641    UP000189706    UP000001074    UP000030759    UP000273346    UP000081671    UP000002320    UP000002254    UP000225706    UP000092124    UP000002494    UP000000589    UP000192223    UP000233100    UP000001519    UP000029965    UP000233200    UP000233060    UP000001595    UP000006718    UP000028761    UP000002277    UP000190648   

PRIDE

Q007T4    K7GLC1    G3HR48    Q3MHH5    P30282   

Pfam

PF00134   Cyclin_N        + More
PF02984   Cyclin_C

Interpro

IPR004367   Cyclin_C-dom        + More
IPR039361   Cyclin       
IPR006671   Cyclin_N       
IPR013763   Cyclin-like       
IPR036915   Cyclin-like_sf       
IPR015451   Cyclin_D       

SUPFAM

SSF47954   SSF47954       

CDD

cd00043  CYCLIN

ProteinModelPortal

A0A2A4J6D0   A0A2H1W4P5   A0A3S2L901   A0A212FHZ1   A0A0L7LMZ4   A0A1B6EAC8   + More
A0A195BRG8   A0A158NF65   A0A154P9A9   A0A195FAP4   A0A291S6V8   A0A026W033   A0A1Y1LH73   A0A195E872   T1JB92   A0A151WHW8   A0A151NBN3   A0A218UEB0   K7FR66   M3YPT8   A0A3P4S0T0   A0A091EEC5   I3NGA5   A0A3M0JKI9   A0A0Q3WS63   A0A1Q3EVE5   Q007T4   B2KIE0   A0A250YEW6   A0A2Y9JPU4   B2MVY3   A0A341D4T4   A0A3Q2GV07   A0A340XA32   A0A2Y9FDC1   A0A2Y9NR31   F1MV86   A0A2U3WHA3   A0A384BF96   K7GLC1   A0A2I2V351   G3HR48   A0A131Y267   A0A1S3A5R5   A0A2F0AUW0   A0A3Q7QKW9   A0A1U7QEU9   G1PP55   Q3MHH5   A0A061IIM4   A0A2P4TGD2   A0A1S3FEF6   B0X5M7   F1PC17   A0A2B4RC26   A0A1A6GIQ8   I3QUJ2   Q5U321   Q3TSW4   P30282   A0A1W4X6M2   A0A2K5TJJ8   G3RGP1   A0A0D9RFX8   A0A2K6R312   A0A2K5NJ80   H2PJ14   F7GU42   A8MN33   A0A2I3RXN8   V5H9K8   A0A1V4KWQ2  

PDB

3G33     E-value=5.79746e-53,     Score=525

KEGG

101738852    no KO assigned | (RefSeq) G1/S-specific cyclin-D3-like

GO

GO:0005634   GO:0046626   GO:0007165   GO:0000122   GO:0042127   GO:0019901   GO:0045737   GO:0005737   GO:0042098   GO:0000307   GO:0004693   GO:0044772   GO:0016538   GO:0000079   GO:1900087   GO:0006468   GO:0016020   GO:0051301   GO:0001934   GO:0043434   GO:0030213   GO:0008284   GO:0051726   GO:0016849   GO:0004890   GO:0005216   GO:0006811   GO:0016021   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR10177   PTHR10177:SF66   PTHR10177:SF65  

Subcellular location

Nucleus   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.   With evidence from 1 publications.
Cytoplasm   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.   With evidence from 1 publications.
Membrane   Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.   With evidence from 1 publications.

Length:

398

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.07537

Exp number, first 60 AAs:

0.00266

Total prob of N-in:

0.00419

outside

1  -  398

 

 

Pi

22.566757

Theta

186.010385

Tajima's D

-1.469695

CLR

250.142528

CSRT

0.064396780160992

Interpretation

Uncertain