Gene

KWMTBOMO07753

Pre Gene Modal

BGIBMGA007598

Annotation

PREDICTED:_gamma-aminobutyric_acid_receptor_subunit_beta-like_[Bombyx_mori]

Location

Bomo_Chr13(-):6241758-6245165      View in EpiBrowser

Full name

Gamma-aminobutyric acid receptor subunit beta-like      

Alternative Name

GABA(A) receptor

Location in the cell

PlasmaMembrane   Reliability : 2.915

CDS

ATGTTATTATTTCCAGGAGATCCGCTGTACGTTGGAATGGACTTGACTATTGCTAGTTTCGACGCAATCTCTGAAGTCAATATGGATTATACCATTACACTCTACTTAAATCAATATTGGAAAGATGAAAGACTAGCCTTCGGATTGCCGGAGGAGGTTTTGACGTTGTCCGGAGATTTCGCGGATAAGATCTGGGTTCCGGACACCTTCTTCGCAAATGACAAAAATAGTTTTCTCCACGACGTGACAGAGAGGAATAAGCTGGTTCGCCTGGGAGGTGACGGCAGCATCACATACGGGATGCGTTTCACAGCGACGTTGGCTTGCATGATGGATCTACACTACTATCCACTCGACAGCCAGAACTGCACCGTCGAGATTGAAAGCTATGGCTACACGGTATCTGACGTGGTCATGTACTGGAAGAACACCCCGGTACGCGGCGTCGAAGACGCTGAACTACCCCAGTTCACAATTTTAGGCCACGAAACGAATGATAGAAAGGAAAAGCTGGCGACAGGAGTGTACCAGCGTTTATCTCTTAGTTTCAAATTACGAAGGAATATAGGATATTTCGTATTTCAAACATATTTGCCGAGTATTTTGATAGTGATGCTATCTTGGGTGTCCTTCTGGATAAACCACGAAGCAACTTCAGCTAGAGTTGCATTAGGTATGTGA

Protein

MLLFPGDPLYVGMDLTIASFDAISEVNMDYTITLYLNQYWKDERLAFGLPEEVLTLSGDFADKIWVPDTFFANDKNSFLHDVTERNKLVRLGGDGSITYGMRFTATLACMMDLHYYPLDSQNCTVEIESYGYTVSDVVMYWKNTPVRGVEDAELPQFTILGHETNDRKEKLATGVYQRLSLSFKLRRNIGYFVFQTYLPSILIVMLSWVSFWINHEATSARVALGM

Description

GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Combines with the ligand-gated ion channel subunit GRD to form cation-selective GABA-gated ion channels when coexpressed in Xenopus laevis oocytes.

Subunit

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with Grd (alpha chain).

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.

Keywords

Cell junction   Cell membrane   Chloride   Chloride channel   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Gamma-aminobutyric acid receptor subunit beta-like

Uniprot

H9JDK1   A0A0U5AGK6   A0A3G1J4Z3   A0A2W1BV77   A0A3S2L9G8   A0A212FHX4   + More
A0A2H1VBG3   A0A2A4JWK9   A0A2A3E3B9   A0A1S3D1I9   E0X9H6   T1HYN8   A0A067RWI3   A0A1B6C9D9   A0A0C9QCI6   Q0GQR5   A0A0B5EHU3   E2BUR7   A0A026VVK9   A0A0J7KNV5   A0A154PC31   A0A0L7R7A8   A8DMU3   A0A2H4G327   A0A3L8DUE8   A0A1B6F9E5   A0A1C9HM79   A0A1B6DDZ0   A0A1B6E0U6   A0A1A9VSW7   A0A194RW19   A0A1A9WIP1   A0A1I8MLG2   B4NUH8   B3NXH4   B4L419   B4NPE8   A0A0Q9WP23   B4PX94   A0A1I8PT20   F4WHV8   A0A0M4EZJ5   Q08832   A0A1W4V464   A0A2J7RFP1   B4JLF9   A0A158NBY7   B4M3E6   A0A232FF21   D3UAF7   K7IYR9   Q16S42   A0A182JG57   A0A0K8VK36   A0A1B0BT41   A0A182PNS6   Q7QEL0   A0A182N0V2   F7IWD1   A0A182R203   A0A182VVK3   A0A182KY18   A0A182Q7U1   A0A182K5B4   A0A1D2N7W2   A0A2J7RFP3   A0A0N0BBV9   A0A1B0CGC2   A0A034WF54   A0A0A1XC77   A0A195C9H9   A0A195BFV1   A0A0P5EGF8   A0A1J0FAT9   A0A182FK44   A0A195FL86   A0A0P5ZF36   A0A0P5LU31   A0A182MSX1   A0A336LUK1   A0A0P6A7B7   A0A194PD82   A0A1J1IX20   A0A0P6ABB4   A0A0P6IA95   A0A226DEW5   A0A0N7ZMF0   A0A182UT51   E9FT88   A0A1J0FAT0   E0VY07   A0A0P6IR87   A0A0P4W899   A0A226E8S9   A0A1D2MAT4   A0A0P6CUT4   A0A0P6F4T8   A0A343W7U0   A0A0P5D6V0   A0A1B0G1E7  

Pubmed

19121390    28756777    22118469    20924418    24845553    16902773    + More
20798317    24508170    17880682    18362917    19820115    30249741    26354079    25315136    17994087    18057021    17550304    21719571    7685594    10731132    12537572    12537569    8025558    15148245    21347285    28648823    20087392    20075255    17510324    12364791    20966253    27289101    25348373    25830018    21292972    20566863   

EMBL

BABH01003359    BABH01003360    AB278156    BAT57341.1    KX856968    ASY91960.1    + More
KZ149987    PZC75663.1    RSAL01000392    RVE41992.1    AGBW02008449    OWR53343.1    ODYU01001638    SOQ38141.1    NWSH01000440    PCG76407.1    KZ288449    PBC25591.1    GQ890660    ADM88005.1    ACPB03022461    KK852422    KDR24264.1    GEDC01027227    JAS10071.1    GBYB01012148    JAG81915.1    DQ667184    ABG75736.1    KJ485712    AJE68943.1    GL450743    EFN80572.1    KK107785    EZA47792.1    LBMM01004999    KMQ91924.1    KQ434869    KZC09373.1    KQ414642    KOC66723.1    EF545120    KQ971338    ABU63598.1    EFA02804.1    KX505305    API80736.1    QOIP01000004    RLU23529.1    GECZ01022922    GECZ01003692    JAS46847.1    JAS66077.1    KX355312    AOO87782.1    GEDC01013385    JAS23913.1    GEDC01005791    JAS31507.1    KQ459700    KPJ20386.1    CH984013    EDX16625.1    CH954180    EDV46933.1    KQS30269.1    CH933810    EDW07297.1    CH964291    EDW86388.1    KRF93989.1    KRF93990.1    KRF93991.1    KRF93992.1    KRF93993.1    KRF93994.1    KRF93995.1    CM000162    EDX01857.1    KRK06383.1    KRK06384.1    GL888170    EGI66187.1    CP012528    ALC49630.1    L17436    S62717    AE014298    AY060660    NEVH01004410    PNF39647.1    CH916370    EDW00412.1    ADTU01011489    ADTU01011490    CH940651    EDW65321.1    NNAY01000335    OXU29120.1    FJ851096    ACZ51428.1    CH477684    EAT37282.1    AXCP01007151    AXCP01007152    GDHF01013080    JAI39234.1    JXJN01019976    JXJN01019977    AAAB01008846    EAA06524.3    AY805323    AAV66543.1    AXCN02001227    LJIJ01000157    ODN01349.1    PNF39648.1    KQ435951    KOX68118.1    AJWK01011011    GAKP01005623    JAC53329.1    GBXI01005273    JAD09019.1    KQ978068    KYM97477.1    KQ976500    KYM83084.1    GDIP01160343    JAJ63059.1    KU986878    APC26107.1    KQ981491    KYN41027.1    GDIP01046309    JAM57406.1    GDIQ01165578    JAK86147.1    AXCM01015593    UFQS01000005    UFQT01000005    SSW96941.1    SSX17328.1    GDIP01046308    JAM57407.1    KQ459606    KPI91197.1    CVRI01000063    CRL04827.1    GDIP01031993    JAM71722.1    GDIQ01033173    JAN61564.1    LNIX01000020    OXA44115.1    GDIP01231137    JAI92264.1    GL732524    EFX89331.1    KU986871    APC26100.1    DS235842    EEB18263.1    GDIQ01002784    JAN91953.1    GDRN01065213    JAI64715.1    LNIX01000006    OXA53271.1    LJIJ01002165    ODM90108.1    GDIQ01087049    JAN07688.1    GDIQ01055099    JAN39638.1    KY748055    AVY53074.1    GDIP01162136    JAJ61266.1    CCAG010015964    CCAG010015965   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000242457    UP000079169    + More
UP000015103    UP000027135    UP000008237    UP000053097    UP000036403    UP000076502    UP000053825    UP000007266    UP000279307    UP000078200    UP000053240    UP000091820    UP000095301    UP000000304    UP000008711    UP000009192    UP000007798    UP000002282    UP000095300    UP000007755    UP000092553    UP000000803    UP000192221    UP000235965    UP000001070    UP000005205    UP000008792    UP000215335    UP000002358    UP000008820    UP000075880    UP000092460    UP000075885    UP000007062    UP000075884    UP000075900    UP000075920    UP000075882    UP000075886    UP000075881    UP000094527    UP000053105    UP000092461    UP000078542    UP000078540    UP000069272    UP000078541    UP000075883    UP000053268    UP000183832    UP000198287    UP000075903    UP000000305    UP000009046    UP000092444   

PRIDE

H9JDK1    E0X9H6    Q08832   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb
PF00057   Ldl_recept_a
PF00058   Ldl_recept_b
PF07645   EGF_CA

Interpro

IPR006201   Neur_channel        + More
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR036719   Neuro-gated_channel_TM_sf       
IPR006202   Neur_chan_lig-bd       
IPR006028   GABAA/Glycine_rcpt       
IPR006029   Neurotrans-gated_channel_TM       
IPR036734   Neur_chan_lig-bd_sf       
IPR002289   GABAAb_rcpt       
IPR001390   GABAAa_rcpt       
IPR023415   LDLR_class-A_CS       
IPR002172   LDrepeatLR_classA_rpt       
IPR036055   LDL_receptor-like_sf       
IPR005437   GABBAg_rcpt       
IPR016024   ARM-type_fold       
IPR001881   EGF-like_Ca-bd_dom       
IPR000033   LDLR_classB_rpt       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR018097   EGF_Ca-bd_CS       
IPR013032   EGF-like_CS       
IPR011042   6-blade_b-propeller_TolB-like       
IPR000742   EGF-like_dom       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       
SSF57424   SSF57424       
SSF48371   SSF48371       
SSF57184   SSF57184       

Gene 3D

2.70.170.10     4.10.400.10     2.120.10.30    

CDD

cd00112  LDLa

ProteinModelPortal

H9JDK1   A0A0U5AGK6   A0A3G1J4Z3   A0A2W1BV77   A0A3S2L9G8   A0A212FHX4   + More
A0A2H1VBG3   A0A2A4JWK9   A0A2A3E3B9   A0A1S3D1I9   E0X9H6   T1HYN8   A0A067RWI3   A0A1B6C9D9   A0A0C9QCI6   Q0GQR5   A0A0B5EHU3   E2BUR7   A0A026VVK9   A0A0J7KNV5   A0A154PC31   A0A0L7R7A8   A8DMU3   A0A2H4G327   A0A3L8DUE8   A0A1B6F9E5   A0A1C9HM79   A0A1B6DDZ0   A0A1B6E0U6   A0A1A9VSW7   A0A194RW19   A0A1A9WIP1   A0A1I8MLG2   B4NUH8   B3NXH4   B4L419   B4NPE8   A0A0Q9WP23   B4PX94   A0A1I8PT20   F4WHV8   A0A0M4EZJ5   Q08832   A0A1W4V464   A0A2J7RFP1   B4JLF9   A0A158NBY7   B4M3E6   A0A232FF21   D3UAF7   K7IYR9   Q16S42   A0A182JG57   A0A0K8VK36   A0A1B0BT41   A0A182PNS6   Q7QEL0   A0A182N0V2   F7IWD1   A0A182R203   A0A182VVK3   A0A182KY18   A0A182Q7U1   A0A182K5B4   A0A1D2N7W2   A0A2J7RFP3   A0A0N0BBV9   A0A1B0CGC2   A0A034WF54   A0A0A1XC77   A0A195C9H9   A0A195BFV1   A0A0P5EGF8   A0A1J0FAT9   A0A182FK44   A0A195FL86   A0A0P5ZF36   A0A0P5LU31   A0A182MSX1   A0A336LUK1   A0A0P6A7B7   A0A194PD82   A0A1J1IX20   A0A0P6ABB4   A0A0P6IA95   A0A226DEW5   A0A0N7ZMF0   A0A182UT51   E9FT88   A0A1J0FAT0   E0VY07   A0A0P6IR87   A0A0P4W899   A0A226E8S9   A0A1D2MAT4   A0A0P6CUT4   A0A0P6F4T8   A0A343W7U0   A0A0P5D6V0   A0A1B0G1E7  

PDB

6I53     E-value=1.59558e-78,     Score=742

KEGG

100500929    K05181 gamma-aminobutyric acid receptor subunit beta | (RefSeq) lcch3; ligand-gated chloride channel

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0004890   GO:0005886   GO:0005230   GO:0016021   GO:0006811   GO:0004888   GO:0007165   GO:0042391   GO:0007268   GO:0034220   GO:0050877   GO:0005887   GO:1902711   GO:0045202   GO:0043005   GO:0022851   GO:0034707   GO:0045211   GO:0030054   GO:0007214   GO:0006821   GO:0005509   GO:0060828   GO:0030509   GO:0048513   GO:0006810   GO:0016020   GO:0016573   GO:0008270   GO:0022891   GO:0003707   GO:0051537   GO:0005216  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

Length:

226

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.07223

Exp number, first 60 AAs:

0.41751

Total prob of N-in:

0.02234

outside

1  -  190

TMhelix

191  -  213

inside

214  -  226

 

 

Pi

206.040407

Theta

154.04908

Tajima's D

1.011197

CLR

0.003991

CSRT

0.661816909154542

Interpretation

Uncertain