Gene

KWMTBOMO07744

Pre Gene Modal

BGIBMGA001259

Annotation

PREDICTED:_otopetrin-2_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr13(-):6094814-6133625      View in EpiBrowser

Full name

Proton channel OtopLc      

Alternative Name

Otopetrin-Lc

Location in the cell

PlasmaMembrane   Reliability : 4.725

CDS

ATGTCTGGTGGCTCTCATGTGTCGCGAACTACATTCGGCGGAGCCGACTCCGAGATGTCCAGTGGTAGTGCTCCACCGCTTCCCAGTCCAGCATCGGCTGGAGCCGCACTAGTCTCGCCAGAAACTTTAAGCAGACACAGCAGTCCGCCCCCGCTACCTCCTCATCCGTCGCACCAGCATCCGGCGCCATCTTGTTCTTCTCATCGGGTACATATGGAGTCGCCCTTACGGATGTCCAGTGCTCCATCAATGAACTTGGGTGGTTCATTGTCGCTACAACCCATGCTGTACGGAGCTGCGAGCGCTGGTTCGGCTCACGTTCCTCTGCCGCCAACAAGACGCTCACCACGACCTTCCAACACTATACAGCAGATGCACGTTATAAGCGCAAGCGATGCATTAGCGACCACGTTGTCCGCTCTCTACGGGAAGCTGTTGGTGGTCATGGGTGTCGCCTTTCCCATGGCCGAAGTCATATCAACGTACATTCCACCCTCGTTTTATGAGGGTTTCTATTTGTACCTGTACATCGGCAGCATGGTGTTCCTTTTGTATATGTACGCCGCTCTCGTAAGGGACAGAACGCGATCTGGAAAGGAAACCGCTATTGTTGCAAAGTCAGAATCTAGTTCGACGCCATCCGAATCGGATTCGTGTTCATCGCACGAACAAAGTACTACGACAACGACACACGCGATCCCACAGTTACCCGCCAAGAGATTATCCCTCGGATTTGCATTGGCCACCCGGACGCATCACTACGGAAGTTTTTATTTGCGAATGGGAGCTGTTGCTTTTGGTATCGGATCAATGATATACTCCGGGCTGGAATTTGGTCAGTACTGGGAACTGGAGAGGAACACTAATTGTCACAACGTCCTGCTGGCGCTGACACCCGCCACCAGAATGGCCTTCATCTTCATACAGATGTACTTTATCTTTCTCAACAACGAGATGAAAGTATACAAACACAAGATTGTGGCCAGGTTCGGTTTAATGCACATGGTTGGAACTAACCTCAGCGTGTGGTTGAATGTATTGGTTCAGGAAACGAAACACGAGATACTGACCTTCTACGACCCGGAAAATAAGACCATTGGACTCTCGCATAGACTAGCATTCCAAAAGGCCTTCGCTTCTTTAGCTACTGAGGTGCCTCCGTCACATCCGGCAGCGGCACATCTCCGCGTTCCGAGAGGGCTGAAAGGACCGCATCACATTTTCGAATGTAGACGTACTAACATAATGGGTACTCTCGTTCAAGATGCATCGCCTTTTCTGTTTCCTTGTACAATTGAGTATTCACTTATCTGTGCGGCTATACTTTACGTCATGTGGAAAAATATCTCGAAATATCCATCTAAAGACGTAGCGGCAGCAATCGCCAAAGCTCGCATACTCGAAGGCCTAGCTTACAAGAAGTCCCCACATTTGTACAGCGTCGACTGCGCTAGAGCTCACAAGGGACTGTTTTTTGGAATTCTCGTATTAGTTCTAACGATTATATCACTGATCTTGTTCTTCGTTTTAGTATCCAAAAAGGAATACGCATCATTGGCGGTTGTCGAAGTGAACATGTGTGAATTGGCTCTTTACGCTATGACGACTTTAGCTAGTTTGGCCGGAATGTTTTGTGTAAGAAATCTAAAGTATGACGGAAACCGAAATCTCGAACTCGATAACATACTTCTTGTTGGAGCTCAAACTGGCATGTTCATTTATGGTACGTTTACCATCATCGGAGGGCACTTCACTATAGAAAAGAACACGATTCTGATCTTGATCACTGCTTTATCTTCGTTAATCCAAACAACATGCCAGACGATGTTCATATTGGATGCGAGTCGTCGGTCGGCTAAGACTCCTGAACAATTGAGAAAAAAGCCTGGCAGGGAAATAGTGACGTTCTTATTGGTAACCAACTTAGCCATGTGGGCGATCAACACACTGGAGAAATCGCGCGCCGAATCTCACCCAGTCCAGTTGCACTTTTACGGACTCTGGGCTTGGACGATCATAACGCATGTCTCAATGCCGCTAGCGATTTTCTACAGATTCCACTCGACCGTTTGCTTGTGTGAGATTTGGAAGCGCGCTTACAAAATGAAACCTGCCTACATGTAG

Protein

MSGGSHVSRTTFGGADSEMSSGSAPPLPSPASAGAALVSPETLSRHSSPPPLPPHPSHQHPAPSCSSHRVHMESPLRMSSAPSMNLGGSLSLQPMLYGAASAGSAHVPLPPTRRSPRPSNTIQQMHVISASDALATTLSALYGKLLVVMGVAFPMAEVISTYIPPSFYEGFYLYLYIGSMVFLLYMYAALVRDRTRSGKETAIVAKSESSSTPSESDSCSSHEQSTTTTTHAIPQLPAKRLSLGFALATRTHHYGSFYLRMGAVAFGIGSMIYSGLEFGQYWELERNTNCHNVLLALTPATRMAFIFIQMYFIFLNNEMKVYKHKIVARFGLMHMVGTNLSVWLNVLVQETKHEILTFYDPENKTIGLSHRLAFQKAFASLATEVPPSHPAAAHLRVPRGLKGPHHIFECRRTNIMGTLVQDASPFLFPCTIEYSLICAAILYVMWKNISKYPSKDVAAAIAKARILEGLAYKKSPHLYSVDCARAHKGLFFGILVLVLTIISLILFFVLVSKKEYASLAVVEVNMCELALYAMTTLASLAGMFCVRNLKYDGNRNLELDNILLVGAQTGMFIYGTFTIIGGHFTIEKNTILILITALSSLIQTTCQTMFILDASRRSAKTPEQLRKKPGREIVTFLLVTNLAMWAINTLEKSRAESHPVQLHFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEIWKRAYKMKPAYM

Description

Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.

Similarity

Belongs to the synaptobrevin family.
Belongs to the otopetrin family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Glycoprotein   Hydrogen ion transport   Ion channel   Ion transport   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Proton channel OtopLc
splice variant  In isoform E.

Uniprot

A0A2W1BL98   A0A194RSM4   A0A212FL14   A0A3S2NW75   H9IVH9   A0A2A4JFV7   + More
D2A139   A0A2J7R2L2   A0A182QWY1   A0A0L7R7U6   A0A182RYU7   A0A0J7KQZ6   E2BVD7   A0A182MZX8   A0A182I9T7   A0A182UPD9   A0A182XY96   A0A182KK37   Q7QED6   A0A182PV14   A0A182MN77   A0A182X7J8   A0A084VGP7   F4X8Q0   E1ZZ69   A0A182TED6   A0A195DR75   A0A182W669   A0A088AUK5   V9IDZ6   A0A182SUD8   A0A182IW95   A0A182K9Q0   A0A182H3A5   A0A151IGX4   T1IC16   U4U5Z9   A0A158NBH1   A0A026W3F3   A0A1B6CS77   A0A1S4FER5   A0A1S4FEP3   A0A154NXD9   A0A1J1I405   A0A0K8UBX2   A0A232EUU7   A0A0K8VW96   Q174P9   A0A182FIF6   B4L407   K7IZA3   B0WWI4   A0A1W4VRK9   A0A0Q9WC09   A0A0R1ECV6   A0A0Q5T3I0   B7Z0W9-2   A0A1I8M6U8   A0A0M4EUV9   B7Z0W9   A0A3B0JDC8   A0A3B0JEK2   A0A146LN45   B7Z0W9-3   A0A1I8PUA9   A0A0P8XJU4   E0VXM8   A0A0C9S038   A0A0R3P453   A0A1A9X582   E9J190   W5JWD4   W8AWC5   A0A2R7WDC1   A0A0Q9WX90   A0A2S2NND9   A0A336KMM7   A0A3B0K0R2   X1X228   A0A1B0FL34   A0A1A9XRT5   A0A1A9UUQ5   A0A1B0AK69   A0A1B0AP93   B4I0M4   B4JLH0   B4R502   B4GWD2   J9JR25   A0A0L0BTM5   A0A2A3ETA9  

Pubmed

28756777    26354079    22118469    19121390    18362917    19820115    + More
20798317    25244985    20966253    12364791    24438588    21719571    26483478    23537049    21347285    24508170    30249741    17510324    28648823    17994087    20075255    17550304    10731132    12537572    29371428    25315136    26823975    20566863    15632085    21282665    20920257    23761445    24495485    26108605   

EMBL

KZ149987    PZC75668.1    KQ459700    KPJ20394.1    AGBW02007913    OWR54427.1    + More
RSAL01000049    RVE50377.1    BABH01001086    NWSH01001609    PCG70709.1    KQ971338    EFA02602.1    NEVH01007828    PNF35079.1    AXCN02001343    KQ414638    KOC66914.1    LBMM01004191    KMQ92716.1    GL450828    EFN80313.1    APCN01001049    AAAB01008847    EAA06870.5    AXCM01002007    ATLV01013047    KE524836    KFB37141.1    GL888932    EGI57319.1    GL435311    EFN73484.1    KQ980581    KYN15415.1    JR039392    JR039393    AEY58671.1    AEY58672.1    JXUM01024640    JXUM01024641    JXUM01024642    KQ560697    KXJ81233.1    KQ977661    KYN00685.1    ACPB03019762    KB632166    ERL89314.1    ADTU01011104    ADTU01011105    ADTU01011106    KK107453    QOIP01000004    EZA50595.1    RLU24169.1    GEDC01021123    JAS16175.1    KQ434778    KZC04336.1    CVRI01000036    CRK93105.1    GDHF01028243    JAI24071.1    NNAY01002084    OXU22132.1    GDHF01009509    JAI42805.1    CH477407    EAT41549.1    CH933810    EDW07285.2    DS232147    EDS36076.1    CH940651    KRF82211.1    CM000162    KRK05955.1    CH954180    KQS29759.1    AE014298    CP012528    ALC49626.1    OUUW01000003    SPP78613.1    SPP78612.1    GDHC01010417    JAQ08212.1    CH902622    KPU75104.1    DS235833    EEB18134.1    GBYB01013776    JAG83543.1    CH379063    KRT06293.1    GL767586    EFZ13432.1    ADMH02000170    ETN67515.1    GAMC01021459    GAMC01021458    JAB85096.1    KK854651    PTY17646.1    CH963851    KRF98206.1    GGMR01005657    MBY18276.1    UFQS01000677    UFQT01000677    SSX06116.1    SSX26472.1    SPP78611.1    ABLF02028005    ABLF02028012    CCAG010011710    JXJN01001277    JXJN01001278    JXJN01001279    CH480819    EDW53055.1    CH916370    EDW00423.1    CM000366    EDX17151.1    CH479194    EDW27016.1    ABLF02004943    ABLF02028010    ABLF02048961    JRES01001480    KNC22579.1    KZ288192    PBC34281.1   

Proteomes

UP000053240    UP000007151    UP000283053    UP000005204    UP000218220    UP000007266    + More
UP000235965    UP000075886    UP000053825    UP000075900    UP000036403    UP000008237    UP000075884    UP000075840    UP000075903    UP000076408    UP000075882    UP000007062    UP000075885    UP000075883    UP000076407    UP000030765    UP000007755    UP000000311    UP000075902    UP000078492    UP000075920    UP000005203    UP000075901    UP000075880    UP000075881    UP000069940    UP000249989    UP000078542    UP000015103    UP000030742    UP000005205    UP000053097    UP000279307    UP000076502    UP000183832    UP000215335    UP000008820    UP000069272    UP000009192    UP000002358    UP000002320    UP000192221    UP000008792    UP000002282    UP000008711    UP000000803    UP000095301    UP000092553    UP000268350    UP000095300    UP000007801    UP000009046    UP000001819    UP000091820    UP000000673    UP000007798    UP000007819    UP000092444    UP000092443    UP000078200    UP000092445    UP000092460    UP000001292    UP000001070    UP000000304    UP000008744    UP000037069    UP000242457   

PRIDE

H9IVH9    B7Z0W9   

Pfam

PF03189   Otopetrin        + More
PF00957   Synaptobrevin
PF13774   Longin

Interpro

IPR004878   Otopetrin        + More
IPR010908   Longin_dom       
IPR011012   Longin-like_dom_sf       
IPR001388   Synaptobrevin       

SUPFAM

SSF64356   SSF64356       

ProteinModelPortal

A0A2W1BL98   A0A194RSM4   A0A212FL14   A0A3S2NW75   H9IVH9   A0A2A4JFV7   + More
D2A139   A0A2J7R2L2   A0A182QWY1   A0A0L7R7U6   A0A182RYU7   A0A0J7KQZ6   E2BVD7   A0A182MZX8   A0A182I9T7   A0A182UPD9   A0A182XY96   A0A182KK37   Q7QED6   A0A182PV14   A0A182MN77   A0A182X7J8   A0A084VGP7   F4X8Q0   E1ZZ69   A0A182TED6   A0A195DR75   A0A182W669   A0A088AUK5   V9IDZ6   A0A182SUD8   A0A182IW95   A0A182K9Q0   A0A182H3A5   A0A151IGX4   T1IC16   U4U5Z9   A0A158NBH1   A0A026W3F3   A0A1B6CS77   A0A1S4FER5   A0A1S4FEP3   A0A154NXD9   A0A1J1I405   A0A0K8UBX2   A0A232EUU7   A0A0K8VW96   Q174P9   A0A182FIF6   B4L407   K7IZA3   B0WWI4   A0A1W4VRK9   A0A0Q9WC09   A0A0R1ECV6   A0A0Q5T3I0   B7Z0W9-2   A0A1I8M6U8   A0A0M4EUV9   B7Z0W9   A0A3B0JDC8   A0A3B0JEK2   A0A146LN45   B7Z0W9-3   A0A1I8PUA9   A0A0P8XJU4   E0VXM8   A0A0C9S038   A0A0R3P453   A0A1A9X582   E9J190   W5JWD4   W8AWC5   A0A2R7WDC1   A0A0Q9WX90   A0A2S2NND9   A0A336KMM7   A0A3B0K0R2   X1X228   A0A1B0FL34   A0A1A9XRT5   A0A1A9UUQ5   A0A1B0AK69   A0A1B0AP93   B4I0M4   B4JLH0   B4R502   B4GWD2   J9JR25   A0A0L0BTM5   A0A2A3ETA9  

PDB

6NF6     E-value=5.17519e-14,     Score=191

KEGG

101740010    no KO assigned | (RefSeq) otopetrin-2-like

GO

GO:0016021   GO:0016192   GO:0015252   GO:0005886   GO:1902600  

PANTHER

PTHR21522  

Subcellular location

Cell membrane  

Length:

707

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

259.45628

Exp number, first 60 AAs:

0.00177

Total prob of N-in:

0.97719

inside

1  -  133

TMhelix

134  -  156

outside

157  -  170

TMhelix

171  -  191

inside

192  -  255

TMhelix

256  -  278

outside

279  -  292

TMhelix

293  -  315

inside

316  -  326

TMhelix

327  -  349

outside

350  -  423

TMhelix

424  -  446

inside

447  -  488

TMhelix

489  -  511

outside

512  -  525

TMhelix

526  -  548

inside

549  -  560

TMhelix

561  -  580

outside

581  -  589

TMhelix

590  -  612

inside

613  -  632

TMhelix

633  -  650

outside

651  -  664

TMhelix

665  -  687

inside

688  -  707

 

 

Pi

226.36172

Theta

176.802984

Tajima's D

0.847423

CLR

0.457882

CSRT

0.616819159042048

Interpretation

Uncertain