Gene

KWMTBOMO07739

Annotation

PREDICTED:_craniofacial_development_protein_2-like_[Bombyx_mori]

Location

Bomo_Chr13(-):5847275-5852433      View in EpiBrowser

Full name

Queuine tRNA-ribosyltransferase accessory subunit 2      

Alternative Name

Queuine tRNA-ribosyltransferase domain-containing protein 1

Location in the cell

Nuclear   Reliability : 2.131

CDS

ATGCGCAGCTACAAACTTGAGATTCTTGGCATTTCAGAAACTAGATGGAAGGGTTTTGGAGAACACCAAGAAGATGATATGACTTTCATTTATTCAGGCAAAGATATCACTGATAACCATGAATCAGGCGTGGGTATTTTAATGACCACCAACGCTAAGAGCAGTTTGCTCGACTGGCATCCTGTTTCGGACCGAATAATAATGGCACGTTTTTACTCAAGAGTGCGGAACATCTCAGTCATACAATGCTATGCGCCTACAAATGCAGCGAGTTCAGTCACAAAAGCAAAGTTCTACAGTCACTTGCAATCGACTCTGCAGAAGATAAAGCGCCAAGATATTGTTATCTGCATGGGAGACTTCAACGCCCAACTGGGATCAGACAACACGAACATTGAGCCTTGGCTAGGTAGACACGCGATGGGACGGAGATCTGAAAACGGTGATATGCTCATAGATCTCTGCTGTCAAAATGACCTCATAGTGGGGGGATCTATTTTCCCTCATAAGAGTTGTCACAAAGTTACATGGGTTTCACCTGACCGTATCACAGAGAACCACATCGACCATGTGTTGATAAGTCGCAAGTGGAGAAGATCCCTTCTAGACGTTCGCAATAAAAGAGGTGCGGACATAAACAGCGACCACCACCTGGTTGTGGCAAAGATAAAACTAAAAGTAGCGAAAATCCAGCGGACTGCCAAAACAGCAAGTAGGAACTTTGATACAGAGAAGCTTCGGAATCCAACCACAAAACAAAATTTCCAAGACGACCTCCGTAATCGTACTGTTAACATTAGCTGTGAAGAAGGGACTATCGAAGATCATTGGGAGTCTGTTAGAGGCGCATTCCGTGAAAGCTGCCAGTCTGTGCTTGGTTACAAATGCACGCCTAAAAAGAAATGGATCTCAGGAACCACTTGGGACATGATCCAGGCAAGGCAGCAAAAGAAAGAGCAGATCAACTCTGCACAAACTCTGGAAGCCAAAGAAGAACTAGCTTATGAGTACTACATTTGTGAGTCAAAGATCAAACTCAACCTAAAGAAAGACAAACGAGCTTGGACTGAAGCTATAGCACAGAAAGCAGAGCTGGCGGCATATTCTGGAAACATGTCAGAGTTACATAAATCAGCAAAAATCCTCTGCAATAAACCAATCGCTGATAAACCACTGAGGGATGACGCCGGAAATCTACTAGTTACCTTAGAGCAACAACTGGTTGGATGGCGTGAGCACTTTGCTAAGGTCTTCGAAGCTCGGCCCACGGCGACTATCGTTGGACACGAGCCTTCTCAGAAACTACTCGATATTGAAGTGGGCCCTCCAGTCGTAACCGAGATTAAAAAGGCAATCACATCTCTAAAATCTGGCAAGGCTCCCGGTGGCGATGGCATTACGGCTGAAGAGATGCAGTGTGAAGTTTTCACATTGTTTATCGACTTCGAAAAGGCCTTTGACAGTGTCAGTTGGTCCAGCATTTGGACTGTTTTGAAGAAAAAAGGCGTGCCCGACAAGCTCATAAATGTCATAAAAGCGCTTTACTATGGATCGTCGTGTAGAGTGCTCCACAGGGGAAAACTCACGGATAATATCGTGGTCACCGCAGGCGTCAAGCAAGGTTGCTTGCTGTCTCCCCTGCTGTTTATAATGGTGCTTGATGTTGTGATGCGCAGAGTCACCTATGATCTAGTAGATGAAGCTGAAAAAGCAGGGCTGCGTATTAATTTCTCAAAAACAAAAGAAATGCGCATAAATACCACCGATTCGGCTCCTATGTCGATCAAAGGGAGGCACATCGAGCGGGTGGGAAGCTTCTGTTACCTGGGCAGCATTGTGGATGATAGGGGAGGCACCGAGGCAGACATTGCGGCTCGTATAAATAAAGCCAGAGCCGCGTTTAGTCAACTTAGGCCAGTAGAAAATGAAACAATCGGTGTTACTATTTATGGCGTAGGATTAACGAGCGAATGCACAGGAGACTCGGCTAATTTGTCACGGCCAGTCGCGTAG

Protein

MRSYKLEILGISETRWKGFGEHQEDDMTFIYSGKDITDNHESGVGILMTTNAKSSLLDWHPVSDRIIMARFYSRVRNISVIQCYAPTNAASSVTKAKFYSHLQSTLQKIKRQDIVICMGDFNAQLGSDNTNIEPWLGRHAMGRRSENGDMLIDLCCQNDLIVGGSIFPHKSCHKVTWVSPDRITENHIDHVLISRKWRRSLLDVRNKRGADINSDHHLVVAKIKLKVAKIQRTAKTASRNFDTEKLRNPTTKQNFQDDLRNRTVNISCEEGTIEDHWESVRGAFRESCQSVLGYKCTPKKKWISGTTWDMIQARQQKKEQINSAQTLEAKEELAYEYYICESKIKLNLKKDKRAWTEAIAQKAELAAYSGNMSELHKSAKILCNKPIADKPLRDDAGNLLVTLEQQLVGWREHFAKVFEARPTATIVGHEPSQKLLDIEVGPPVVTEIKKAITSLKSGKAPGGDGITAEEMQCEVFTLFIDFEKAFDSVSWSSIWTVLKKKGVPDKLINVIKALYYGSSCRVLHRGKLTDNIVVTAGVKQGCLLSPLLFIMVLDVVMRRVTYDLVDEAEKAGLRINFSKTKEMRINTTDSAPMSIKGRHIERVGSFCYLGSIVDDRGGTEADIAARINKARAAFSQLRPVENETIGVTIYGVGLTSECTGDSANLSRPVA

Description

Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

Cofactor

Zn(2+)

Subunit

Heterodimer of a catalytic subunit and an accessory subunit.

Similarity

Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.

Uniprot

A0A183LFM6   A0A183MS45   A0A183MMG7   A0A146MF87   A0A183LTL8   A0A1B0GLA1   + More
D7F173   A0A336MSP8   A0A183NCM3   A0A183MX41   A0A3B1KH88   H9IZE7   A0A183MP16   A0A3S0Z3I7   A0A183LTH6   Q4QQE8   A0A336M488   A0A183L9Y2   A0A2G8LPK9   A0A183ME56   A0A2T7PJY8   A0A183MVQ1   A0A183MYH2   A0A183N5W2   A0A3P7XAK8   A0A183LGK5   A0A2T7NHE8   C7C207   A0A2B4R8E3   A0A2B4RLZ4   A0A183L9X8   A0A183ML31   A0A183MTT9   A0A183MC01   A0A183N4V7   W4XQE1   A0A183NAE6   A0A183KHV6   A0A183K1M3   A0A1S3ISC1   A0A182FVE7   A0A0B7BT32   A0A183N4N7   W5JEC3  

Pubmed

26823975    20470440    25329095    19121390    15939396    29023486    + More
20920257    23761445   

EMBL

UZAI01000669    VDO55444.1    UZAI01017784    VDP29476.1    UZAI01017324    VDP23363.1    + More
GDHC01000226    JAQ18403.1    UZAI01002818    VDO74918.1    AJWK01034673    FJ265558    ADI61826.1    UFQT01001780    SSX31783.1    UZAI01022444    VDP57962.1    UZAI01018385    VDP36481.1    BABH01014180    BABH01014181    BABH01014182    BABH01014183    UZAI01017464    VDP25179.1    RQTK01002506    RUS68506.1    UZAI01002797    VDO74729.1    BN000794    CAJ00236.1    UFQS01000142    UFQT01000142    SSX00428.1    SSX20808.1    UZAI01000113    VDO48731.1    MRZV01000018    PIK62110.1    UZAI01016773    VDP15570.1    PZQS01000003    PVD33720.1    UZAI01018190    VDP34363.1    UZAI01018571    VDP38269.1    UZAI01019871    VDP48262.1    UZAI01000793    VDO56507.1    PZQS01000012    PVD20578.1    FN356221    CAX83710.1    LSMT01001244    PFX12648.1    LSMT01000478    PFX17357.1    UZAI01000112    VDO48722.1    UZAI01017217    VDP21932.1    UZAI01017973    VDP31675.1    UZAI01010461    VDP07114.1    UZAI01019647    VDP46800.1    AAGJ04045270    UZAI01021135    VDP54563.1    UZAK01036860    VDP56899.1    UZAK01032956    VDP33068.1    HACG01049283    CEK96148.1    UZAI01019607    VDP46489.1    ADMH02001629    ETN61698.1   

Proteomes

UP000050790    UP000277204    UP000092461    UP000018467    UP000005204    UP000271974    + More
UP000230750    UP000245119    UP000225706    UP000007110    UP000050789    UP000085678    UP000069272    UP000000673   

PRIDE

D7F173    H9IZE7   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF00069   Pkinase
PF03372   Exo_endo_phos
PF01702   TGT

Interpro

IPR005135   Endo/exonuclease/phosphatase        + More
IPR027124   Swc5/CFDP2       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR000477   RT_dom       
IPR000719   Prot_kinase_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR011009   Kinase-like_dom_sf       
IPR036511   TGT-like_sf       
IPR028592   QTRTD1       
IPR002616   tRNA_ribo_trans-like       

SUPFAM

SSF56219   SSF56219        + More
SSF56112   SSF56112       
SSF51713   SSF51713       

Gene 3D

3.60.10.10     3.20.20.105    

ProteinModelPortal

A0A183LFM6   A0A183MS45   A0A183MMG7   A0A146MF87   A0A183LTL8   A0A1B0GLA1   + More
D7F173   A0A336MSP8   A0A183NCM3   A0A183MX41   A0A3B1KH88   H9IZE7   A0A183MP16   A0A3S0Z3I7   A0A183LTH6   Q4QQE8   A0A336M488   A0A183L9Y2   A0A2G8LPK9   A0A183ME56   A0A2T7PJY8   A0A183MVQ1   A0A183MYH2   A0A183N5W2   A0A3P7XAK8   A0A183LGK5   A0A2T7NHE8   C7C207   A0A2B4R8E3   A0A2B4RLZ4   A0A183L9X8   A0A183ML31   A0A183MTT9   A0A183MC01   A0A183N4V7   W4XQE1   A0A183NAE6   A0A183KHV6   A0A183K1M3   A0A1S3ISC1   A0A182FVE7   A0A0B7BT32   A0A183N4N7   W5JEC3  

PDB

1AKO     E-value=0.00233562,     Score=99

KEGG

101740371    no KO assigned | (RefSeq) craniofacial development protein 2-like

GO

GO:0004672   GO:0005524   GO:0004519   GO:0003964   GO:0008479   GO:0101030   GO:0005737   GO:0046872  

PANTHER

PTHR23227  

Subcellular location

Cytoplasm  

Length:

670

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.92385

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.00070

outside

1  -  670

 

 

Pi

287.595399

Theta

183.303809

Tajima's D

1.195749

CLR

17.243949

CSRT

0.710064496775161

Interpretation

Uncertain