SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07724
Pre Gene Modal
BGIBMGA000880
Annotation
PREDICTED:_ATP-dependent_RNA_helicase_SUV3_homolog?_mitochondrial_[Bombyx_mori]
Full name
ATP-dependent RNA helicase SUV3 homolog, mitochondrial      
Location in the cell
Cytoplasmic   Reliability : 1.478 Nuclear   Reliability : 2.068
 

Sequence

CDS
ATGTATAAAGGGTTTTCCAGAATATTAGCCCTTCATAATGTAGAAAAATTACAACTTAATGTATCAAATCTCAGATGTAATATCTTGTGCGCCCGTAAACTCAAACCCGCCGGTATAGGTTATATTTTGGTAAGAACTAAAAAACATGATCGGAATCCTTCTGCTTTATTTGTGCCAGTGCCAGTGAAACCAAACTCCGATGACATAAACATTGGTGAAGAATTTACAGGACGTCTAAAAAAACAAGACTTGTTAAAAATTCTTAACAAATTTTACCAAAAACCTGAAATCAGAGTGCTTGCTTCAGAAAATGGATTGGATGATCAATTGTTACATCAAGCTTTCCTTTCATTCAGACGGCATTGTTTAGAACATGATTTACCACCAGACTTACATATTACGATCAGTGATATACTTCAAGGTGCAGGACATGTTGATGATTTGTTTCCATACTTCTTGAGGCATGCAAGACGAGCATTTCCGCACCTTGACTGCTTGGAAGACTTGAAAAAGATATCAGATTTGAGAACACCAGCAAACTGGTATCCTGAAGCTCGAAGTATGGATCGCAAAATTATATTTCATGCAGGTCCCACAAATTCAGGAAAAACTTATCATGCAATGGAGAGATTCTTAAAATCGAAATCTGGTGTGTACTGTGGTCCCTTAAAGTTACTAGCAACTGAGATATATCATAAATCGAATAAAAGTGGCACACCCTGCGATCTAGTAACAGGAGAAGAAAGAAGGCACGCTTCATTATACAACACCTTAATAAATGGTACAGATGATAATGACATAGAAACATCAGATGTCGAACCTTATTTGTTAGAAGAAACCGAATTAACACCGTCTGGTCATGTTGCATGTACAGTTGAAATGACTTCTCTAAATAATAAATATGAAGTGGCAATCATAGATGAAATACAAATGATAGGAGATAGAGGAAGAGGGTGGGCATGGACTCGAGCTATATTAGGTTTACAAGCAGATGAAATACATTTATGTGGGGAGGCAGGTGCAATAAATCTCATTGAAGAAATTTGTAACACAACCGGTGAAGTAATGGAGGTTCGTTCGTACAAAAGATTAACACAGCTAAAAGTCGAAGATACCGCTTTAGGATCATTAGACAATGTTCAGCCCGGAGACTGTATTGTGTGTTTCAATAAAAACGACATTTACAGTGTAAGTCGAGCCATTGAACAGAGAGGACATGAGGTAGCAGTTATCTATGGCAGTTTACCACCTGGTACTAAGCTAGCTCAGGCAAACAAGTTCAACGATCCGGAGAGTTCGTGTAAAGTTATGGTTGCGACAGACGCCATTGGACTCGGTATAAATTTGAGCATCCGGCGGATAATCTTTTACTCATTAATCAAACCGGTAATTAATGAAGACGGTGAGAAAGAGATGGACGTTATTAGTATATCACAAGCGTTGCAGATTGCAGGTCGGGCCGGTCGTTACGGCAGCGCGTGGGAGACCGGCCACGTGACCTCGTACCGGCCCGAAGACCTCGCGACGCTGAAGACGCTGCTGTCCCAGCCGCCCGAGCCGGTCACGCAGGCCGGCCTGCACCCCACCTCCGAGCAGATGGAGCTGTACGCCTACCATCTGCCCCACGCCACTCTCAGCAGTCTCATGGACATATTCGTTCACTTGTGCACGGTCGACGATTCGCTTTACTTCATGTGCAACACGGAGGGGTTCAAGTTCTTAGCGGAGATGATACAGCACGTTCCGTTGCCGCTGCGGGCGCGCTACGTGTTCTGTTGCGCGCCCATCAATAACAAGCTACCGTTCGTTTGTGCTACCTTCCTGAAAATGGTGAGACAGTACAGTCGCAACGAGCCCATCACCCGGAACTGGCTGAGCGGCACAGTGGAGTGGCCGCTGCCCTCTCCTAGGACCATACTGGACCTCGTGCACTTGGAATCTGTCTTTGACGTCCTAGAGCTTTACTTGTGGTTAAGCTATCGATTTCCGGACATGTTTCCGGACGTGAAATTAGTTCGTGACATGGAGACTGAATTAGATGCTATCATTCAACAAGGAATTTTCCAAATAACTAGGTTACTAAGAAATTCTGAACAGATGATCCGCGATGAGGACAGCGGCTTTGCGATCGGCCACGGCAGCAAGAGGGTCAATAAGATGCTGGCCGGACAATCAATGGGCGAGGAGAAGGGAAAATTGTCGGAATTACTAGTTGCCAGGGGACTCATAACGCCGCAGATGCTGAAGAAACTTCAGCAAGAACTCTCCACGGACAAGAAGATAGACAGAACGAAAAAGAATAGGAACAGAAGGAAATAA
Protein
MYKGFSRILALHNVEKLQLNVSNLRCNILCARKLKPAGIGYILVRTKKHDRNPSALFVPVPVKPNSDDINIGEEFTGRLKKQDLLKILNKFYQKPEIRVLASENGLDDQLLHQAFLSFRRHCLEHDLPPDLHITISDILQGAGHVDDLFPYFLRHARRAFPHLDCLEDLKKISDLRTPANWYPEARSMDRKIIFHAGPTNSGKTYHAMERFLKSKSGVYCGPLKLLATEIYHKSNKSGTPCDLVTGEERRHASLYNTLINGTDDNDIETSDVEPYLLEETELTPSGHVACTVEMTSLNNKYEVAIIDEIQMIGDRGRGWAWTRAILGLQADEIHLCGEAGAINLIEEICNTTGEVMEVRSYKRLTQLKVEDTALGSLDNVQPGDCIVCFNKNDIYSVSRAIEQRGHEVAVIYGSLPPGTKLAQANKFNDPESSCKVMVATDAIGLGINLSIRRIIFYSLIKPVINEDGEKEMDVISISQALQIAGRAGRYGSAWETGHVTSYRPEDLATLKTLLSQPPEPVTQAGLHPTSEQMELYAYHLPHATLSSLMDIFVHLCTVDDSLYFMCNTEGFKFLAEMIQHVPLPLRARYVFCCAPINNKLPFVCATFLKMVRQYSRNEPITRNWLSGTVEWPLPSPRTILDLVHLESVFDVLELYLWLSYRFPDMFPDVKLVRDMETELDAIIQQGIFQITRLLRNSEQMIRDEDSGFAIGHGSKRVNKMLAGQSMGEEKGKLSELLVARGLITPQMLKKLQQELSTDKKIDRTKKNRNRRK

Summary

Description
Major helicase player in mitochondrial RNA metabolism and maintenance (PubMed:26152302). Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction (By similarity). Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts (PubMed:26152302).
Major helicase player in mitochondrial RNA metabolism and maintenance. Likely component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Regulates mRNA stability and is required for the correct processing and maturation of mitochondrial transcripts.
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
Similarity
Belongs to the helicase family.
Keywords
ATP-binding   Complete proteome   Helicase   Hydrolase   Mitochondrion   Nucleotide-binding   Reference proteome   Transit peptide  
Feature
chain  ATP-dependent RNA helicase SUV3 homolog, mitochondrial
EC Number
3.6.4.13
EMBL
ODYU01002500    SOQ40060.1    KQ459606    KPI91178.1    AGBW02011630    OWR46402.1    + More
KZ149983    PZC75759.1    KQ459700    KPJ20408.1    NWSH01003023    PCG67094.1    BABH01001167    KK853179    KDR10211.1    NEVH01024949    PNF16463.1    GEZM01026090    JAV87252.1    KQ971371    EFA10159.1    KB630054    KB632237    ERL83363.1    ERL90465.1    APGK01043589    KB741015    ENN75346.1    UFQS01000350    UFQT01000350    SSX03081.1    SSX23447.1    KI208369    ERL95848.1    PNF16458.1    CH933806    EDW14595.2    KI210459    ERL96274.1    NNAY01000743    OXU26724.1    GGFK01006834    MBW40155.1    CP012526    ALC45255.1    GEBQ01000339    JAT39638.1    ATLV01011796    KE524723    KFB36135.1    GAMC01007460    JAB99095.1    ADMH02002130    ETN58541.1    CH940652    KRF78736.1    EDW59175.1    GEDC01028125    GEDC01018024    JAS09173.1    JAS19274.1    CH477445    EAT40781.1    DS231872    EDS41418.1    JRES01000310    KNC32404.1    AXCM01002011    JXUM01059133    KQ562037    KXJ76843.1    AXCN02000234    GFXV01002522    MBW14327.1    GFDL01008968    JAV26077.1    ABLF02038337    GGMR01016258    MBY28877.1    CCAG010004727    CH964232    EDW81570.1    CH916369    EDV92967.1    CM000160    EDW95639.2    AAAB01008820    EAA05399.5    AE014297    AY058527    BT133067    AEX93152.1    OUUW01000014    SPP88300.1    GECZ01030465    JAS39304.1    CM000070    CH479185    EDW37929.1    CM000364    EDX11581.1    CH954181    EDV47761.1    JXJN01008576    KQ976423    KYM88740.1    CVRI01000070    CRL07148.1    ADTU01000904    ADTU01000905    GFJQ02007031    JAV99938.1    QOIP01000005    RLU22620.1    GL436716    EFN71602.1    KQ981855    KYN34951.1    GL761812    EFZ22765.1    GL445549    EFN89463.1    KK107293    EZA53186.1    GFWV01018580    MAA43308.1    GDIQ01076142    JAN18595.1    GDIQ01110840    JAL40886.1    GDIQ01078644    LRGB01000005    JAN16093.1    KZS22089.1    GGLE01005556    MBY09682.1    KQ982231    KYQ58864.1    MWRG01004014    PRD30914.1    GDIQ01253232    JAJ98492.1    GDIP01143172    JAJ80230.1    GDIP01133330    JAL70384.1    KQ979039    KYN23320.1    GDIQ01244998    JAK06727.1    GL732665    EFX67971.1    GDIQ01021130    JAN73607.1    GBBM01000609    JAC34809.1    JO844461    AEO36078.1    GANP01000526    JAB83942.1    ABJB011085262    DS734517    EEC07128.1   
Pfam
PF00271   Helicase_C        + More
PF18147   Suv3_C_1
PF18114   Suv3_N
PF12513   SUV3_C
Interpro
IPR022192   SUV3_C        + More
IPR041082   Suv3_C_1       
IPR027417   P-loop_NTPase       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR041453   Suv3_N       
SUPFAM
SSF52540   SSF52540       
PDB
3RC8     E-value=0,     Score=2125

Ontologies

Topology

Subcellular location
Mitochondrion   Unlike in mammals, does not localize to the nucleus.   With evidence from 5 publications.
Length:
772
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.15001
Exp number, first 60 AAs:
0.00079
Total prob of N-in:
0.00060
outside
1  -  772
 
 

Population Genetic Test Statistics

Pi
197.647878
Theta
151.733461
Tajima's D
0.973468
CLR
0.464288
CSRT
0.657417129143543
Interpretation
Uncertain
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