Gene

KWMTBOMO07718

Pre Gene Modal

BGIBMGA000878

Annotation

PREDICTED:_uncharacterized_protein_LOC101742063_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr13(+):5173196-5186224      View in EpiBrowser

Full name

Pyruvate dehydrogenase E1 component subunit alpha      

Location in the cell

Nuclear   Reliability : 2.851

CDS

ATGGAGCAAGTCATTCTAGTCTCTATAGACATTGATAACAATTTAATAACGGATAAATGTGTCTTGGACCAGGCCATGGACGATATTGAGTTCCTGGCTGACTACCCACAGTACACCGGCAACCGTCACATAGTTTGGCTATTCCTGATGGAGTTAGCGAGACGTCGCTGGGAGGCCAGACCAAGGGCAGAGCAAGAACGCGCTACACAACTATTGGAAGGCGCTGGACAACCATTTAAGGAAATGGAGAACGTTGTCTGGGAACAAAGAGTACACTTCGCAGCTGCCATCGCTAGGATTCGTATAAAAAATAAGGCTCTCTCGTTGTCGGACCTATTGCCGCCACATTTGCGTGAGGAACGCATATCAGCGTGTGTCAATAAGGACATAATCACGGGTTGGGTTAACACTTTTAAAGCCAAAAAAATTGCATTGCTGGTTAAAAAATTACACGAACTAGGATACTCTTACAGCAGCTCACGACAGCTTTGCGCCGGCGAATACAGATTTGATAGAGTTTGTCCGAGATTCATAACGCTACGACCTCCGGCCAGTATCAGCATTGGGAAATTGGATTTAGTACAAGAAGGAATTATTGTTCTTCAGGAACGCGAGTTTTGCGAGGGAGCTTCTACGCTTTGTCGAGCCCTTCGCGCGAACTCTCTTCAAGGAGTGGTGGCCCAGACCCACGCGTCGTCCCCCCGTTGCTCAGCGTACCTCGCGGCTCAGCTGAAGGAACTGGCCGCAGTGCTGAAGGCCCAGACTCCTCCTGCACCAGCTATACCGGAACTCGGTCGACTGGTTGTGTTCGGAGCAGGAGATAAAGCCGAAAGTTATGTTTTAGCTCTTCGGGAGCTCGGCATAGAGGCCTCAGAGGCGCCTCACTCGGGAGCGCCAGTATGCGTCCTTAGCGAACCTGTACATTGCGACACTCCGACTGTGACCAACGCGTTAGACGGAGTGGTAGCAGCCTTGGCAACTCCACCCAACTCTTACTCCGCAGTCACGGATCCCATTGATCTTGTGTGCGGTCGTGGAGGAGATTTGGCAATGCTAGAGGTTTTAACCGAATCGGAGATTGACAGTAAAGGTAAAGCTAGAGTGCAATCAATTCTCGAGGAACAAAAGAAAACATTGAAGACCTTAATGTCTAAGCCTCAAATCCAGTTGATATTGTACGAAACACATTCTGCATTAGAAGCCGAAAATCAAGCGCAAGTGACAAGAGCCGTCGCAGAAGCGAACAGATTGGCTCGGGAACGACACGCGTTGCTGAAAAGGAAACATCGCCAATCCAGTCCATTAAAGCACGGAATAGAAAACATTGAGTCCTTAACAACATTAGACAACACAATCTCTGAGGGAGACAGAGATGACCAAACGGATGATGAATTTGATTCAATTTCACCAAAGCGACGCACGTCTGGACCGTCGCCGCCAAGACGGAGATCTCAGACCGACGATACAGTGTTAAGAAAACAAGCGGATTCATCTCGTCCCGGATCAAGGCCTGGGACTAACAAAGCCCGACCTATACCTGCAGTACCCGATGACGCCGTCCCCGGAGATCCCGACAAGGATAATCCGGATATTTTTGTACCGAATTGCGATTTGTTCGAAATCGCGACGTTGCCTAATTTAGGGAATGGTTTAGATATTAACTACATACTGGATCGAGACGGTTGTTATCTCGGCCTCATCCAAAGGAAGGAGATAACCCGTTTGGACGCAAAGTATATGATCCGTATGGCGGAGGAGCGTGGGCTTTTCGGCGCGAGCGCGGCCGCCGCGTCCCCCCCGCGGCGGAGGCGCGCCGACACCGCGCCCTCGCGACACAAGCGGGCCCGCAGGAGAACCAGCTTTGAGGTAGAACGTATAGCCGCTCCGACGTACGCGTCGCTGTGCCGATCGTCGCGTCGCGGCAGCGCGCCTGCCTGTCTACAAGACGCGCCCCCCGAGCAACAGTTGCTCGAGTGTCAGCGGCACGCGCGGCGACAGGCGGCCGCGGCGGCAATTACTGCCGCGGCCTGTAACTGTGACGCCAGGCACAGAACGCCATACCGTCGGGCATCAGCTGATGTGACGGTCACAGCGCGACCCGCCTCGCCCCCGTGCCGACGACCCTTCCCACTGGTAGTACACGATCTTAGACTCAAGTCTATACCTATGACTACCCACAAAATATTCGCTTGA

Protein

MEQVILVSIDIDNNLITDKCVLDQAMDDIEFLADYPQYTGNRHIVWLFLMELARRRWEARPRAEQERATQLLEGAGQPFKEMENVVWEQRVHFAAAIARIRIKNKALSLSDLLPPHLREERISACVNKDIITGWVNTFKAKKIALLVKKLHELGYSYSSSRQLCAGEYRFDRVCPRFITLRPPASISIGKLDLVQEGIIVLQEREFCEGASTLCRALRANSLQGVVAQTHASSPRCSAYLAAQLKELAAVLKAQTPPAPAIPELGRLVVFGAGDKAESYVLALRELGIEASEAPHSGAPVCVLSEPVHCDTPTVTNALDGVVAALATPPNSYSAVTDPIDLVCGRGGDLAMLEVLTESEIDSKGKARVQSILEEQKKTLKTLMSKPQIQLILYETHSALEAENQAQVTRAVAEANRLARERHALLKRKHRQSSPLKHGIENIESLTTLDNTISEGDRDDQTDDEFDSISPKRRTSGPSPPRRRSQTDDTVLRKQADSSRPGSRPGTNKARPIPAVPDDAVPGDPDKDNPDIFVPNCDLFEIATLPNLGNGLDINYILDRDGCYLGLIQRKEITRLDAKYMIRMAEERGLFGASAAAASPPRRRRADTAPSRHKRARRRTSFEVERIAAPTYASLCRSSRRGSAPACLQDAPPEQQLLECQRHARRQAAAAAITAAACNCDARHRTPYRRASADVTVTARPASPPCRRPFPLVVHDLRLKSIPMTTHKIFA

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Uniprot

A0A2W1BQ72   A0A2H1VGU1   A0A194PEP8   A0A194RSU1   A0A2A4JXD9   A0A212EY68   + More
A0A0L7L6H2   A0A1Y1L1J0   A0A1Y1KWR6   A0A1Y1L414   A0A2J7PZE4   A0A2J7PZE5   A0A2J7PZE7   A0A2J7PZE6   A0A1W4XEB5   A0A336MCW3   A0A336M9L1   A0A182M5F0   A0A182WZQ6   A0A2C9GQX1   A0A182U1B0   A0A182VCJ2   Q7Q0B2   A0A084WIE2   A0A182JNV3   A0A182WG36   A0A1Y9HEP9   W5JW12   Q29EI6   A0A182FB97   A0A0R3P940   N6UDB2   A0A151JP29   A0A151X9U6   A0A195CV24  

EC Number

1.2.4.1

Pubmed

28756777    26354079    22118469    26227816    28004739    12364791    + More
14747013    17210077    24438588    20920257    23761445    15632085    17994087    23537049   

EMBL

KZ149983    PZC75764.1    ODYU01002500    SOQ40065.1    KQ459606    KPI91169.1    + More
KQ459700    KPJ20415.1    NWSH01000400    PCG76681.1    AGBW02011630    OWR46394.1    JTDY01002656    KOB71000.1    GEZM01071410    JAV65815.1    GEZM01071411    JAV65814.1    GEZM01071409    GEZM01071405    JAV65817.1    NEVH01020335    PNF21708.1    PNF21706.1    PNF21705.1    PNF21707.1    UFQT01000782    SSX27191.1    UFQS01000758    UFQT01000758    SSX06688.1    SSX27034.1    AXCM01004871    APCN01003303    AAAB01008986    EAA00406.4    ATLV01023929    KE525347    KFB49986.1    ADMH02000120    ETN67688.1    CH379070    EAL30074.3    KRT08630.1    APGK01039344    APGK01039345    APGK01039346    APGK01039347    APGK01039348    KB740970    ENN76642.1    KQ978820    KYN28138.1    KQ982365    KYQ57133.1    KQ977279    KYN04377.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000007151    UP000037510    UP000235965    + More
UP000192223    UP000075883    UP000076407    UP000075840    UP000075902    UP000075903    UP000007062    UP000030765    UP000075881    UP000075920    UP000075900    UP000000673    UP000001819    UP000069272    UP000019118    UP000078492    UP000075809    UP000078542   

Pfam

PF00632   HECT        + More
PF16558   AZUL
PF01553   Acyltransferase
PF16076   Acyltransf_C
PF00676   E1_dh

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR032353   AZUL       
IPR000569   HECT_dom       
IPR035983   Hect_E3_ubiquitin_ligase       
IPR032098   Acyltransf_C       
IPR002123   Plipid/glycerol_acylTrfase       
IPR029061   THDP-binding       
IPR001017   DH_E1       
IPR017597   Pyrv_DH_E1_asu_subgrp-y       

SUPFAM

SSF53335   SSF53335        + More
SSF56204   SSF56204       
SSF52518   SSF52518       

CDD

cd00078  HECTc

ProteinModelPortal

A0A2W1BQ72   A0A2H1VGU1   A0A194PEP8   A0A194RSU1   A0A2A4JXD9   A0A212EY68   + More
A0A0L7L6H2   A0A1Y1L1J0   A0A1Y1KWR6   A0A1Y1L414   A0A2J7PZE4   A0A2J7PZE5   A0A2J7PZE7   A0A2J7PZE6   A0A1W4XEB5   A0A336MCW3   A0A336M9L1   A0A182M5F0   A0A182WZQ6   A0A2C9GQX1   A0A182U1B0   A0A182VCJ2   Q7Q0B2   A0A084WIE2   A0A182JNV3   A0A182WG36   A0A1Y9HEP9   W5JW12   Q29EI6   A0A182FB97   A0A0R3P940   N6UDB2   A0A151JP29   A0A151X9U6   A0A195CV24  

KEGG

101742063    no KO assigned | (RefSeq) uncharacterized LOC101742063

GO

GO:0004842   GO:0016021   GO:0016746   GO:0016624   GO:0004739   GO:0006086   GO:0043231  

Length:

730

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00049

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00008

outside

1  -  730

 

 

Pi

212.836716

Theta

155.233257

Tajima's D

1.50258

CLR

0.30449

CSRT

0.783360831958402

Interpretation

Uncertain