Gene

KWMTBOMO07716

Pre Gene Modal

BGIBMGA001268

Annotation

PREDICTED:_phosphatidylinositol_4-phosphate_3-kinase_C2_domain-containing_subunit_alpha_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr13(-):5132822-5159715      View in EpiBrowser

Location in the cell

Nuclear   Reliability : 2.585

CDS

ATGTCTGACTACGATCTTCAGTTTCAAGCGGATTTAGAAAAGGCGCAGGCTTTGAGTTTAGAAAGTCTCGCGCTAGAACAATTTCGAAGGCAGAAGCTTCTTTCTAGCACAGATAATGGACGGGAGTTGGGCACTGTCAATTATCGTCGCAGAGAGGACGAGGGGCCCCCGCCAGCGCTGCCGCCACCTCCGCGGAAACCACCTCGTGGACGATCCAATTCCGAAACTCCAAGGTCATCTGAGGCGAGTCCCACCAGGGACGAGAGCAGCGACCTGATCTCGTTTGCAAGTCCAACCAGCAAGGCAGCACCGCAAGATCCACATGCGTCACTCAAAGAATATATAGACCAGATCAACAAACTAGGTCAAAAAACTGAAGACTTGACAGAACAATCGCCTGTAATCATGAATAATCATCCGTACAACCAAAGGCCCGGTTATCCTTACGCGCCGCAATACAACTACAACTATCCCCCTTACAACGTGATGCCTCCATATCCGTCTTCCGCGCCCTACGGCATGCCATCACCCATGCCGAATTATTCGTATTACACGCCGCCCATAGCTGCACCACCGGAGACGCCGCCCGCATACGTGCCAGGGAACCCGGCGATGTATTCCGTTCCATACAGCCAAACGCGGATGTCAGCTCCCGTCACTCCCAACTATGGATATCCACCGGCGTACAATTACAACACGACGAACATGATATCTCGTCCGCCGATGCCTATTTCGAACTTGTACCCGCAGCTGAGTCAGGCCCACGCTTACCCGCCGAACTCGAACCAGCCGCAAAACAAAAGCAACGACACCACACAGACGATCGTTAAAACGGAACCGTCAAGGGACAGCATGGACAGTAATAGCTCGAGGAAATCGTCTGAAGTTAGCATAGGGTCCAACGAATCAAACGACACAGTAGGAAGTCTCCCTAAATCAATGAACCTGATCGACTTTGGTGGTCGAAACCCGAACGGCAGTCAAGAATATGCGGTGGGCAGCGAATGTTCGAGTAGCGTCTACGAAGAGTACGACCCGCTGGATTTCCTGTACGGGGAGACTGAGATGCGTGAGACGCCCGTATACGGTACCGTCGGCAAGCGCGAGCCTGCCGTCATGCCGTCGCCGCCGCCAAAGGCAATGCCCTCCGTGCCCGCCGTCGCGCTCAGATCCACCACGAACAAACTTTACGATAGCATAGTTAAGATCAGAACAAGAAATTACGACAGCGAACACAAAGCGTTTCTTAAAATGGCTCTTGACGTTCGAAAAAAGTTCGTGTACACTGATGAGAGGACGAACCCAGGGCACGTCATAGCAGCCAGGTCCGGCGGCAAGTACCCGCCCAACACGAGCATCAAGATACTAGTTCATCACGCTCACTCCGATGAACCCATCACTTTCACGTCCGATGTGGAATCTAAAGTCGAACACGTGATATTAACAGTAGTCTGTTCACTGGATGAAGACATCAGGGAGGACATGTCTGGATATATGTTAAGGGTGCGGGGAGCCAAAGAGTATCTGACGCCCGGCAGCTCGCTGAGCGAATACGATTACATACGCGAGTGCGTGCGCTTGGAGAAGGACGTGACGCTGTGTCTGCACGAAGGGAGGGACAGCACGCTGGCCAGGACCGAGAGGGACGACGCGAAGGACTCGCACCTCACGCTCGACGACCTGTTCCCGGCGCAGGGAGCCACGCCGATGCTATCGTTCGATAATTTATCGATATTGCTCGAAACTTTAGAAGGCGAGCTGTCGCGTGCTATCGGTGTGACCAGCGCTGAGGGCAGCTGCTCCCCGAAGGCGGTGTTCCAAGCCGTCAAGGCTATCTGCGCTCTGGCGGGCGGCGTGGAGACTCTGCACGTCACTCACACGCTCAACGCGTTCGCGCAGGCCTGCACCGCGCAGGGAGCGAACAACGTGGTCCGCCCGGAGATAGAGCGCGAACAGGGCGCGTACTGCTCGGTGTCGCTGGCGGCGGGCTCGCGGCGCGACTGCGTGTCGCTGCAGGGCGGGCGCGTGCGCGACGCCGTGCGGGCGCTGCTCGCGCTCTATACGCGCACGCGCCTGCTCGACTTCCGCCTCGCCGACGCGCACTACCAGGCGCCCGCCAACCCCGCCAAAGCAGTACCGGCGCACACAATATCAGAAACGACACTGTTTTGTATAGAGGCGGTGCACTGTTTGCCTCTGTGCTGGAGCCACGACGAGTACATGTTCCATGCGCAAATCTACCACGGAACAAGACCTTTGAAAACATTACGGTTCACACAAGCTTCGAAGATTGAATGCGGCGGGTTTTATCCTCGAATCATATTTGATACTTGGCTGAACCTCGAGGATTTACCAGTAAACACGTTACCAAGAGAATCTCGTCTCGTTCTGACGCTGCACGGCAGGACGCAGCGCACCATCGACAGCCAGCATCCGAACGAGAACAGCCCGCCCAGCAGCCAGGAGGCCGAGGACAGCGGCGACGTGCTGTACGAGCAGGTCGAGCTGGGCTGGGCCGCCCTGCAACTCTTCGACTTTGATGGGATGCTATCGTCCGGTAATTACGTTTTACCATTGTGGCCGACTAGCTGCGACCGGCGGACCGGCCCGGCTCCTCATCCCATGCACACACCTACAACACCATATCCCGTTGTCAATATTGAAATTCCTTTATACGCACACACCGGGGTCAAGTGGACCAGCGGAGAAGAAGACAAACAGAAGAATATATCTCTGAAGGATCTTCCATCGTTCGACAGTTTGGATGGACACACACAGTCTCAACTGCTACACCTCATCGAGCAGGGCGCTTATCAGAGGATGCCTACAGAATGTAGAGAGGTCATGTGGGAGAAACGGCAGTACCTGGTACAGATCCCAGGCGCTTTGCCTCTGGTGTTGCTAGCAGCTACAAATTGGTACGGAGACCATAGAGAACAATTGATAGGTCTACTCCGACTGTGGGAGAAACCTTCACCTTTAAACGCTATGCATTTGCTGTTGCCTTGTTTCCCGGATGTCGCCGTAAGAGAAACAGCAGCCAAGCTGTTGAACGAGATGTCTGACGACGACCTGTGCCGCGTGTTGCCGCAGCTCACGCAGGCGCTGCGACACGAGACGTACGAACCCAGTCCTTTAGCCGAGCTACTCCTCTCGCGAGCGCTAGCGGCTCCGGCTGTTGCTCACAGACTGTTTTGGCTTTTAGTGCATTCCCTGCCTAATATACCACAGGCGCCACATCAAGAGTTCCTCGGGATAAATTTAGAAGATAATGCTTCTGAAAACGCCGAAACTGATGCATCGATGAGCGCCTCGTGGCGCTACACGCTGATGCTGCGCGCCTTACTCGTTATATGCGGAGAAAATCTCAACAAGACGCTGCTTCGACAACAGTTACTCGTCAAGAGTCTGTGCGAGATGGCGGTGTCGGTGAAGTGCGCGAAGGAGTGCGCCCGCGGACGCGCGCTGTGTGCGGGCGGCACGGCGCTGGCGGGCGCGCTGCGTGCCCAGCCCACCGCACTGCCTCTCGCACTCCATAAATACGTACACGATCTCGACGTCAAATCATGTACCTACTTCTCATCAAACACACTTCCGCTGAAAATAAATTTTATTGGAACAGATAATGCAGTAATTCCAGCTATGTTCAAGGTTGGAGATGATTTACGACAAGATGCTCTAGTGTTGCAAGTGATAAAAATAATGGATACATTATGGTTGAAAGCTGGCTTAGATCTGAGGATGGTTACTTTCCAAGCTCTACCCACAAGTAATAGTAAAGGTATGATAGAAATAGTGACAGAAGCGGAGACGCTGCGGGCCATACAAACCGAGTGGGGTCTGACCGGCTCGTTCAAGGACAAGCCCATAGCCGAGTGGCTCGCCAAACACAATCCCTCCGAACTCGAATACCAACGCGCCAGAGACAATTTCACAGCTTCGTGCGCCGGGTACAGCGTGGCGACGTACCTGCTGGGGATCTGCGACCGGCACAACGACAACATCATGCTGAAGACCTCCGGCCACCTGTTCCACATCGACTTCGGGAAGTTCCTGGGAGACGCGCAAATGCAAACGAGCATACCGCCCACCTGA

Protein

MSDYDLQFQADLEKAQALSLESLALEQFRRQKLLSSTDNGRELGTVNYRRREDEGPPPALPPPPRKPPRGRSNSETPRSSEASPTRDESSDLISFASPTSKAAPQDPHASLKEYIDQINKLGQKTEDLTEQSPVIMNNHPYNQRPGYPYAPQYNYNYPPYNVMPPYPSSAPYGMPSPMPNYSYYTPPIAAPPETPPAYVPGNPAMYSVPYSQTRMSAPVTPNYGYPPAYNYNTTNMISRPPMPISNLYPQLSQAHAYPPNSNQPQNKSNDTTQTIVKTEPSRDSMDSNSSRKSSEVSIGSNESNDTVGSLPKSMNLIDFGGRNPNGSQEYAVGSECSSSVYEEYDPLDFLYGETEMRETPVYGTVGKREPAVMPSPPPKAMPSVPAVALRSTTNKLYDSIVKIRTRNYDSEHKAFLKMALDVRKKFVYTDERTNPGHVIAARSGGKYPPNTSIKILVHHAHSDEPITFTSDVESKVEHVILTVVCSLDEDIREDMSGYMLRVRGAKEYLTPGSSLSEYDYIRECVRLEKDVTLCLHEGRDSTLARTERDDAKDSHLTLDDLFPAQGATPMLSFDNLSILLETLEGELSRAIGVTSAEGSCSPKAVFQAVKAICALAGGVETLHVTHTLNAFAQACTAQGANNVVRPEIEREQGAYCSVSLAAGSRRDCVSLQGGRVRDAVRALLALYTRTRLLDFRLADAHYQAPANPAKAVPAHTISETTLFCIEAVHCLPLCWSHDEYMFHAQIYHGTRPLKTLRFTQASKIECGGFYPRIIFDTWLNLEDLPVNTLPRESRLVLTLHGRTQRTIDSQHPNENSPPSSQEAEDSGDVLYEQVELGWAALQLFDFDGMLSSGNYVLPLWPTSCDRRTGPAPHPMHTPTTPYPVVNIEIPLYAHTGVKWTSGEEDKQKNISLKDLPSFDSLDGHTQSQLLHLIEQGAYQRMPTECREVMWEKRQYLVQIPGALPLVLLAATNWYGDHREQLIGLLRLWEKPSPLNAMHLLLPCFPDVAVRETAAKLLNEMSDDDLCRVLPQLTQALRHETYEPSPLAELLLSRALAAPAVAHRLFWLLVHSLPNIPQAPHQEFLGINLEDNASENAETDASMSASWRYTLMLRALLVICGENLNKTLLRQQLLVKSLCEMAVSVKCAKECARGRALCAGGTALAGALRAQPTALPLALHKYVHDLDVKSCTYFSSNTLPLKINFIGTDNAVIPAMFKVGDDLRQDALVLQVIKIMDTLWLKAGLDLRMVTFQALPTSNSKGMIEIVTEAETLRAIQTEWGLTGSFKDKPIAEWLAKHNPSELEYQRARDNFTASCAGYSVATYLLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMQTSIPPT

Similarity

Belongs to the PI3/PI4-kinase family.

Uniprot

H9IVI8   A0A2W1BRJ4   A0A194PJA3   A0A2H1VGX9   A0A212EY28   A0A2A4JZ40   + More
A0A232FL80   K7IW81   A0A151IFN4   E2ABJ5   A0A1B6CT28   F4WQ66   A0A1B6D833   A0A195BML6   A0A151WKS4   A0A158NXE4   E9IVV7   A0A195ECF4   A0A0J7NVG0   A0A195FG44   A0A154PSM0   A0A3L8E4C0   E2BVU7   A0A2P8ZDS3   A0A088AC41   A0A2A3EGV0   T1HF92   A0A310SA10   A0A0N0U690   A0A0L7RKB3   A0A0C9PVJ8   A0A0C9RM03   A0A023F2W8   E0VBF9   A0A1Y1L4Z2   A0A1L8DL86   A0A1B0CCJ7   W4VRG7   Q0IGF6   A0A182GNH9   A0NBA9   A0A1Q3F7H7   A0A1Q3F7G5   A0A182QRR1   B0W7X6   A0A182FTM6   A0A2M4B8C5   A0A336MPB8   A0A2M3YZF9   A0A336LRK7   J9JP72   A0A2M4CHI7   A0A2M4CHG7   A0A2M4CHI5   A0A2M4B8D1   A0A182RUL2   A0A2S2NPJ6   A0A182KKM4   A0A2M4B8A2   W5JEA5   A0A182V420   A0A182MQA5   A0A1A9YEL9   A0A0K8VEC8   A0A1B0B1B1   A0A1B0A2K1   A0A2M4A4J6   A0A1B0FDB1   A0A2M3Z0P3   A0A2M4A4C5   A0A2M4A4P5   A0A1A9VMZ6   A0A034V3S2   A0A182WDV0   A0A182N318   W8BAJ7   A0A182YBJ8   A0A182PSA9   A0A2M4A771   A0A2S2QGW6   A0A0A1WPZ0   A0A182JVT2   A0A1A9X0C7   A0A1I8M8C7   A0A1I8NM56   A0A0L0CCG5   A0A139WA97   A0A084VU08   A0A139WAA5   A0A182IQY2   A0A0Q9WM38   B4LCS5   T1PAR1  

Pubmed

19121390    28756777    26354079    22118469    28648823    20075255    + More
20798317    21719571    21347285    21282665    30249741    29403074    25474469    20566863    28004739    17510324    26483478    12364791    20966253    20920257    23761445    25348373    24495485    25244985    25830018    25315136    26108605    18362917    19820115    24438588    17994087    18057021   

EMBL

BABH01001177    BABH01001178    BABH01001179    BABH01001180    BABH01001181    KZ149983    + More
PZC75767.1    KQ459606    KPI91165.1    ODYU01002500    SOQ40067.1    AGBW02011630    OWR46390.1    NWSH01000400    PCG76680.1    NNAY01000053    OXU31504.1    KQ977780    KYM99950.1    GL438292    EFN69190.1    GEDC01020678    GEDC01012952    JAS16620.1    JAS24346.1    GL888262    EGI63689.1    GEDC01029021    GEDC01015563    GEDC01005018    JAS08277.1    JAS21735.1    JAS32280.1    KQ976441    KYM86393.1    KQ983001    KYQ48479.1    ADTU01003040    ADTU01003041    GL766449    EFZ15298.1    KQ979074    KYN22898.1    LBMM01001404    KMQ96380.1    KQ981610    KYN39363.1    KQ435053    KZC14258.1    QOIP01000001    RLU27580.1    GL451029    EFN80176.1    PYGN01000086    PSN54649.1    KZ288258    PBC30512.1    ACPB03015469    ACPB03015470    ACPB03015471    KQ762659    OAD55550.1    KQ435735    KOX77152.1    KQ414574    KOC71253.1    GBYB01005478    JAG75245.1    GBYB01014407    JAG84174.1    GBBI01003159    JAC15553.1    DS235030    EEB10715.1    GEZM01070994    JAV66147.1    GFDF01006855    JAV07229.1    AJWK01006860    AJWK01006861    AJWK01006862    GANO01003076    JAB56795.1    CH477192    EAT48581.1    JXUM01000533    JXUM01000534    AAAB01008804    EAU77730.2    GFDL01011566    JAV23479.1    GFDL01011576    JAV23469.1    AXCN02001143    DS231856    EDS38438.1    GGFJ01000145    MBW49286.1    UFQT01001941    SSX32186.1    GGFM01000903    MBW21654.1    UFQS01000052    UFQT01000052    SSW98661.1    SSX19047.1    ABLF02039321    ABLF02039331    GGFL01000629    MBW64807.1    GGFL01000624    MBW64802.1    GGFL01000628    MBW64806.1    GGFJ01000146    MBW49287.1    GGMR01006057    MBY18676.1    GGFJ01000144    MBW49285.1    ADMH02001385    ETN62687.1    AXCM01006030    GDHF01015414    JAI36900.1    JXJN01007040    JXJN01007041    GGFK01002350    MBW35671.1    CCAG010006850    GGFM01001351    MBW22102.1    GGFK01002343    MBW35664.1    GGFK01002371    MBW35692.1    GAKP01022532    JAC36420.1    GAMC01019691    JAB86864.1    GGFK01003308    MBW36629.1    GGMS01007775    MBY76978.1    GBXI01013809    JAD00483.1    JRES01000610    KNC29902.1    KQ971410    KYB24843.1    ATLV01016620    KE525097    KFB41452.1    KYB24844.1    CH940647    KRF85222.1    EDW70967.1    KRF85218.1    KRF85219.1    KRF85220.1    KRF85221.1    KA645003    AFP59632.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000215335    UP000002358    + More
UP000078542    UP000000311    UP000007755    UP000078540    UP000075809    UP000005205    UP000078492    UP000036403    UP000078541    UP000076502    UP000279307    UP000008237    UP000245037    UP000005203    UP000242457    UP000015103    UP000053105    UP000053825    UP000009046    UP000092461    UP000008820    UP000069940    UP000007062    UP000075886    UP000002320    UP000069272    UP000007819    UP000075900    UP000075882    UP000000673    UP000075903    UP000075883    UP000092443    UP000092460    UP000092445    UP000092444    UP000078200    UP000075920    UP000075884    UP000076408    UP000075885    UP000075881    UP000091820    UP000095301    UP000095300    UP000037069    UP000007266    UP000030765    UP000075880    UP000008792   

PRIDE

H9IVI8   

Pfam

PF00794   PI3K_rbd        + More
PF00792   PI3K_C2
PF00613   PI3Ka
PF00454   PI3_PI4_kinase
PF00168   C2
PF00787   PX
PF00067   p450

Interpro

IPR036940   PI3/4_kinase_cat_sf        + More
IPR001263   PI3K_accessory_dom       
IPR036871   PX_dom_sf       
IPR016024   ARM-type_fold       
IPR035892   C2_domain_sf       
IPR015433   PI_Kinase       
IPR002420   PI3K_C2_dom       
IPR042236   PI3K_accessory_sf       
IPR000341   PI3K_Ras-bd_dom       
IPR029071   Ubiquitin-like_domsf       
IPR018936   PI3/4_kinase_CS       
IPR000403   PI3/4_kinase_cat_dom       
IPR011009   Kinase-like_dom_sf       
IPR001683   Phox       
IPR000008   C2_dom       
IPR002402   Cyt_P450_E_grp-II       
IPR036396   Cyt_P450_sf       
IPR001128   Cyt_P450       

SUPFAM

SSF56112   SSF56112        + More
SSF48371   SSF48371       
SSF54236   SSF54236       
SSF64268   SSF64268       
SSF48264   SSF48264       

Gene 3D

1.10.1070.11     1.25.40.70     2.60.40.150     3.30.1520.10     1.10.630.10    

ProteinModelPortal

H9IVI8   A0A2W1BRJ4   A0A194PJA3   A0A2H1VGX9   A0A212EY28   A0A2A4JZ40   + More
A0A232FL80   K7IW81   A0A151IFN4   E2ABJ5   A0A1B6CT28   F4WQ66   A0A1B6D833   A0A195BML6   A0A151WKS4   A0A158NXE4   E9IVV7   A0A195ECF4   A0A0J7NVG0   A0A195FG44   A0A154PSM0   A0A3L8E4C0   E2BVU7   A0A2P8ZDS3   A0A088AC41   A0A2A3EGV0   T1HF92   A0A310SA10   A0A0N0U690   A0A0L7RKB3   A0A0C9PVJ8   A0A0C9RM03   A0A023F2W8   E0VBF9   A0A1Y1L4Z2   A0A1L8DL86   A0A1B0CCJ7   W4VRG7   Q0IGF6   A0A182GNH9   A0NBA9   A0A1Q3F7H7   A0A1Q3F7G5   A0A182QRR1   B0W7X6   A0A182FTM6   A0A2M4B8C5   A0A336MPB8   A0A2M3YZF9   A0A336LRK7   J9JP72   A0A2M4CHI7   A0A2M4CHG7   A0A2M4CHI5   A0A2M4B8D1   A0A182RUL2   A0A2S2NPJ6   A0A182KKM4   A0A2M4B8A2   W5JEA5   A0A182V420   A0A182MQA5   A0A1A9YEL9   A0A0K8VEC8   A0A1B0B1B1   A0A1B0A2K1   A0A2M4A4J6   A0A1B0FDB1   A0A2M3Z0P3   A0A2M4A4C5   A0A2M4A4P5   A0A1A9VMZ6   A0A034V3S2   A0A182WDV0   A0A182N318   W8BAJ7   A0A182YBJ8   A0A182PSA9   A0A2M4A771   A0A2S2QGW6   A0A0A1WPZ0   A0A182JVT2   A0A1A9X0C7   A0A1I8M8C7   A0A1I8NM56   A0A0L0CCG5   A0A139WA97   A0A084VU08   A0A139WAA5   A0A182IQY2   A0A0Q9WM38   B4LCS5   T1PAR1  

PDB

4A55     E-value=1.09809e-52,     Score=528

KEGG

101742216    K00923 phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154] | (RefSeq) phosphatidylinositol 4-ph

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0048015   GO:0016301   GO:0046854   GO:0035091   GO:0016021   GO:0020037   GO:0016705   GO:0005506   GO:0005524   GO:0004497   GO:0035005   GO:0036092   GO:0005737   GO:0016477   GO:0016303   GO:0005886   GO:0016020   GO:0014065   GO:0005942   GO:0017137   GO:0017124   GO:0042059   GO:0030866   GO:0010008   GO:0005515   GO:0005488   GO:0006508   GO:0016573   GO:0008270   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR10048  

Length:

1364

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.09305

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00001

outside

1  -  1364

 

 

Pi

217.417029

Theta

159.626552

Tajima's D

0.852472

CLR

0.425479

CSRT

0.623868806559672

Interpretation

Uncertain