Silkworm Genome Informatics Database

Gene

KWMTBOMO07708

Pre Gene Modal

BGIBMGA000872

Annotation

PREDICTED:_TBC_domain-containing_protein_kinase-like_protein_[Amyelois_transitella]

Location

Bomo_Chr13(+):4915006-4929083 View in EpiBrowser

Full name

TBC domain-containing protein kinase-like protein

Location in the cell

Cytoplasmic Reliability : 1.448 Peroxisomal Reliability : 1.034 PlasmaMembrane Reliability : 1.388

CDS

ATGACATATGGAGGTAGTGAAGTTGCATTTCCACTTGGTCAACCAAGATACCTAAGTCCAGAAACAATATTGAACAGTGGTGGTCCTACAGCAGACATTTGGACATTTGGTGTCATTTTGTTAGAGTTGTGTATCGGAAAGCTTTGGGCTAAATTAAAACCAGGTCCAATATTGAGAAGAATACTTGGCTTGGTGCATGTTAATGACCCTGCTAAAAGAATTGCAAGAGAGCATAACAGCATTGAGGAATATGAACAATTACCTAAATACCTTCAGACCTTAATAGAAAAATGCCTCCAAATTTGCCCTAGTAAAAGAGCGACAATCACCGAAATACTCCAGGACTTGTCTAATGTTGATACCAAGGAAATGTGTGCTGTGAAACCGCCGCGAGGATTGATGGGCTGTAAATTACAGTATCTCTATCATTGGTGGCAACTGGCCGGTGGTGATATACAAGTTGAGTTGAAGAGAAATGGTTTGATCAAAAACAGTCCACCCATACTGTCTATACCTGTCGCTATCCTCCTCGACGGTTGTACTATAGGCGGTAAAACTGGAGTCCTATATGATCGCCGCATCGCGAAATACAGCATCGAGCTGCTGCAGTCCAGACTCAGTCATGTATCAGCCCACGACTACTATCCGCTCATGCACGAACGAAAGAAACAAAATGACGCCGTCACGTTACCGAAAACAATACGAGAGAGGGATACGGAATACCAATTCTATAGATTGCTATGGTTCCAGAGACTGTTGCATGGCTATCCATATACAGCTCCATATATAAGAGCAGAAGCAGAAATCGATATCCCACCATTAGTGCGCGGCGATGTGTGGGCAGCCCTACTGGGTGTTGTCGGAGATATAGAAGAACAGTACGAGAGGATTGATAAAGAGACACCCACGCCTACCGACAGACAGATAGATGTGGACATACCGCGTTGTCATCAGTACTGTTGGTTGCTATGCGGCTCGGCTGGCCACAGAACGCTCAAGAGGCTCCTCAAGGCGTGGCTACTGACCAACCCTCAATACGTGTATTGGCAAGGACTCGATTCTCTGACGGCACCATTCATGTACCTTAACTTCTGTAATGAAGCTCGGGCATTCGCGTGCCTCAGTGCGTTCGTGCCGAAGTTCTTGCACAAGTTCTTTTTGAAGGACAATAGTGCCGTCATAAAGGAGTACCTTGCGAAGTTCTGGCAGATGGCGGCCTTCCACGAGCCCCGACTCGCGACCCACCTCCACGACATCAACTTCGTGCCGGAACTCTTCGCCATACCTTGGTTCCTCACTATGTTCTCGCATGTTTTTCCGCTACACAAAATAGTTCATCTATGGGACGCCTTTCTGGTCGAAGGTCCCTCGTTGCCTTTATTTATGGGTGTCGGAATATTGAGGCAATTGCGTGACACTTTACTAGAATCCGGATTCAACGAATGTATATTGTTGTTCTCCGATTTACCCGAAATCGACATAGGAGAATGTGTCAAGGAAGCTATAGATATGTGTCGTAGCTCGCCAAGAAGCATCAGTTACAGAAGATTCACGAATGACACTGTTAAAAAAGACTCTATGGATCAAGTAGAAATTCCAATGGAAGTACTGTTCGTCGAGATCTGTCCCAGGATAAGTCTCTCAGATTTTTTCTCGTTGATCTGCGAAGACAAATGCTGCGTCGTCGATATAAGGTCCAATCTCCTTTACGAGAAGAGCTGCATAGACGGCAGTGTAAACGTGCCGTACAGTGGCGTCCATCTCGGTCGGCATGAGCTCCGCGCTCTCGGTCCTCAGCCCGAGCGCGCCTTGCAGCAAGCTATCAAGATGAAGAGGAACGTTGTAATTGCCTCGGCTGAAGACGAGACCGCGCAATTGTTCAGTGATTATTTAGTGAAATGCGGTGTACCTAGAGTCTGCATTCTGCACGGAGGCATCGCCGCTCTGCAAACTCATATACCTTCGCTCTTCATAACACCACCCACCGGGAACACAGGAAAATGA

Protein

MTYGGSEVAFPLGQPRYLSPETILNSGGPTADIWTFGVILLELCIGKLWAKLKPGPILRRILGLVHVNDPAKRIAREHNSIEEYEQLPKYLQTLIEKCLQICPSKRATITEILQDLSNVDTKEMCAVKPPRGLMGCKLQYLYHWWQLAGGDIQVELKRNGLIKNSPPILSIPVAILLDGCTIGGKTGVLYDRRIAKYSIELLQSRLSHVSAHDYYPLMHERKKQNDAVTLPKTIRERDTEYQFYRLLWFQRLLHGYPYTAPYIRAEAEIDIPPLVRGDVWAALLGVVGDIEEQYERIDKETPTPTDRQIDVDIPRCHQYCWLLCGSAGHRTLKRLLKAWLLTNPQYVYWQGLDSLTAPFMYLNFCNEARAFACLSAFVPKFLHKFFLKDNSAVIKEYLAKFWQMAAFHEPRLATHLHDINFVPELFAIPWFLTMFSHVFPLHKIVHLWDAFLVEGPSLPLFMGVGILRQLRDTLLESGFNECILLFSDLPEIDIGECVKEAIDMCRSSPRSISYRRFTNDTVKKDSMDQVEIPMEVLFVEICPRISLSDFFSLICEDKCCVVDIRSNLLYEKSCIDGSVNVPYSGVHLGRHELRALGPQPERALQQAIKMKRNVVIASAEDETAQLFSDYLVKCGVPRVCILHGGIAALQTHIPSLFITPPTGNTGK

Description

Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and growth. Involved in the control of actin-cytoskeleton organization.

Similarity

Belongs to the STXBP/unc-18/SEC1 family.
Belongs to the protein kinase superfamily.

Keywords

Complete proteome Cytoplasm Cytoskeleton Reference proteome

Feature

chain TBC domain-containing protein kinase-like protein

Uniprot

H9IUE2 A0A2A4JDM2 A0A194PDR3 A0A194QYE9 A0A2W1BSZ5 A0A212EZG9 + More
D6W9B1 E2AVT0 A0A026WTJ4 A0A3L8DGU8 E2BT09 A0A151XIB5 A0A151J8F7 A0A158NF89 F4WYM8 K7J4K4 A0A087ZPX1 A0A2A3EKG8 A0A1Y1JR89 A0A0C9QH08 A0A1Y1JR93 A0A151K043 A0A0L7RJT4 A0A195BSL7 A0A154PUC6 A0A232F1D4 A0A1B0GKB9 A0A1B6JBH7 A0A151IAI6 N6UKV6 U4TXT5 E9IDM7 A0A034VWN7 A0A0K8W405 W8BFN5 A0A0K8VIN9 A0A0A1WJH9 A0A067QJ52 B0XCS3 A0A182MIA1 A0A182RBH5 A0A182P7W9 A0A182QL28 A0A182W4P2 A0A336N1J6 B4JK52 B4NED1 A0A1I8JSQ4 Q29GZ5 A0A182IA83 Q7QFL6 B4H0P4 A0A182LGX6 A0A182TUX2 A0A182SJP3 A0A1Q3F703 A0A182K495 A0A182Y7J2 A0A182HAQ4 A0A1S4FAJ6 A0A1I8PXM4 B4I0T9 A0A3B0K3G3 A0A2M4BEA6 Q9W4F8 Q17A25 A0A2M4BDC4 A0A1I8M218 W5JCG5 E0VBG5 A0A1W4WBU6 A0A182IL75 A0A0M8ZQJ6 B3MPZ6 B3NV08 B4L691 A0A3B0KS91 B4PZU1 B4R4R4 A0A084VQJ8 A0A1A9UY20 A0A182N117 A0A1B0AHB8 A0A1A9YHE2 A0A1B0FY85 A0A182G1Y1 A0A1B0FNQ3 B4MAH4 A0A1J1I890 A0A2J7RG10 A0A093GNT6 A0A1B0AMN4 A0A3Q3FHY0 A0A3Q3FHJ7 A0A310S9H0 A0A3Q2DFS7 U3IC26 Q5F361 F1NLC9

Pubmed

19121390 26354079 28756777 22118469 18362917 19820115 + More
20798317 24508170 30249741 21347285 21719571 20075255 28004739 28648823 23537049 21282665 25348373 24495485 25830018 24845553 17994087 15632085 12364791 14747013 17210077 20966253 25244985 26483478 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 17510324 25315136 20920257 23761445 20566863 17550304 24438588 23749191 15642098 15592404

EMBL

BABH01001193 BABH01001194 BABH01001195 NWSH01001976 PCG69520.1 KQ459606 + More
KPI91158.1 KQ460947 KPJ10563.1 KZ149946 PZC76755.1 AGBW02011306 OWR46851.1 KQ971312 EEZ98186.1 GL443213 EFN62352.1 KK107109 EZA59278.1 QOIP01000008 RLU19536.1 GL450325 EFN81139.1 KQ982080 KYQ60139.1 KQ979533 KYN21116.1 ADTU01014037 GL888454 EGI60691.1 AAZX01002348 KZ288227 PBC31742.1 GEZM01102907 JAV51729.1 GBYB01013923 JAG83690.1 GEZM01102911 JAV51724.1 KQ981319 KYN42727.1 KQ414579 KOC71099.1 KQ976417 KYM89658.1 KQ435191 KZC15044.1 NNAY01001324 OXU24363.1 AJWK01028650 GECU01011076 JAS96630.1 KQ978221 KYM96278.1 APGK01029192 KB740727 ENN79317.1 KB631815 ERL86404.1 GL762454 EFZ21476.1 GAKP01011246 JAC47706.1 GDHF01006366 GDHF01001661 JAI45948.1 JAI50653.1 GAMC01010803 GAMC01010802 JAB95753.1 GDHF01019970 GDHF01013591 JAI32344.1 JAI38723.1 GBXI01015724 JAC98567.1 KK853449 KDR07552.1 DS232716 EDS45090.1 AXCM01001654 AXCN02001386 UFQS01003282 UFQT01003282 SSX15444.1 SSX34813.1 CH916370 EDV99954.1 CH964239 EDW82100.2 CH379064 EAL31964.2 APCN01001132 AAAB01008846 EAA06291.5 CH479200 EDW29839.1 GFDL01011705 JAV23340.1 JXUM01031636 KQ560930 KXJ80300.1 CH480819 EDW53120.1 OUUW01000016 SPP88777.1 GGFJ01002231 MBW51372.1 AE014298 BT031268 AAF45995.4 ABY20509.1 CH477341 EAT43081.1 GGFJ01001901 MBW51042.1 ADMH02001918 ETN60519.1 DS235030 EEB10721.1 KQ435966 KOX67936.1 CH902621 EDV44422.1 CH954180 EDV45856.1 CH933812 EDW05887.1 SPP88776.1 CM000162 EDX01158.1 CM000366 EDX17111.1 ATLV01015219 KE525003 KFB40242.1 AJVK01000801 JXUM01039558 JXUM01039559 KQ561209 KXJ79341.1 CCAG010023313 CH940655 EDW66233.1 CVRI01000044 CRK96501.1 NEVH01004406 PNF39774.1 KL216275 KFV68677.1 JXJN01000507 KQ763209 OAD55153.1 ADON01074655 ADON01074656 ADON01074657 AJ851789 CAH65423.1 AADN05000017

Proteomes

UP000005204 UP000218220 UP000053268 UP000053240 UP000007151 UP000007266 + More
UP000000311 UP000053097 UP000279307 UP000008237 UP000075809 UP000078492 UP000005205 UP000007755 UP000002358 UP000005203 UP000242457 UP000078541 UP000053825 UP000078540 UP000076502 UP000215335 UP000092461 UP000078542 UP000019118 UP000030742 UP000027135 UP000002320 UP000075883 UP000075900 UP000075885 UP000075886 UP000075920 UP000001070 UP000007798 UP000069272 UP000001819 UP000075840 UP000007062 UP000008744 UP000075882 UP000075902 UP000075901 UP000075881 UP000076408 UP000069940 UP000249989 UP000095300 UP000001292 UP000268350 UP000000803 UP000008820 UP000095301 UP000000673 UP000009046 UP000192221 UP000075880 UP000053105 UP000007801 UP000008711 UP000009192 UP000002282 UP000000304 UP000030765 UP000078200 UP000075884 UP000092445 UP000092443 UP000092462 UP000092444 UP000008792 UP000183832 UP000235965 UP000053875 UP000092460 UP000261660 UP000265020 UP000016666 UP000000539

PRIDE

H9IUE2 Q9W4F8 Q5F361

Pfam

PF00566   RabGAP-TBC        + More
PF00069   Pkinase
PF00581   Rhodanese
PF00995   Sec1

Interpro

IPR035969   Rab-GTPase_TBC_sf        + More
IPR011009   Kinase-like_dom_sf
IPR000719   Prot_kinase_dom
IPR036873   Rhodanese-like_dom_sf
IPR000195   Rab-GTPase-TBC_dom
IPR001763   Rhodanese-like_dom
IPR027121   VPS33
IPR027482   Sec-1-like_dom2
IPR036045   Sec1-like_sf
IPR001619   Sec1-like

SUPFAM

SSF47923   SSF47923        + More
SSF52821   SSF52821
SSF56112   SSF56112
SSF56815   SSF56815

Gene 3D

3.40.250.10 3.40.50.1910

ProteinModelPortal

H9IUE2 A0A2A4JDM2 A0A194PDR3 A0A194QYE9 A0A2W1BSZ5 A0A212EZG9 + More
D6W9B1 E2AVT0 A0A026WTJ4 A0A3L8DGU8 E2BT09 A0A151XIB5 A0A151J8F7 A0A158NF89 F4WYM8 K7J4K4 A0A087ZPX1 A0A2A3EKG8 A0A1Y1JR89 A0A0C9QH08 A0A1Y1JR93 A0A151K043 A0A0L7RJT4 A0A195BSL7 A0A154PUC6 A0A232F1D4 A0A1B0GKB9 A0A1B6JBH7 A0A151IAI6 N6UKV6 U4TXT5 E9IDM7 A0A034VWN7 A0A0K8W405 W8BFN5 A0A0K8VIN9 A0A0A1WJH9 A0A067QJ52 B0XCS3 A0A182MIA1 A0A182RBH5 A0A182P7W9 A0A182QL28 A0A182W4P2 A0A336N1J6 B4JK52 B4NED1 A0A1I8JSQ4 Q29GZ5 A0A182IA83 Q7QFL6 B4H0P4 A0A182LGX6 A0A182TUX2 A0A182SJP3 A0A1Q3F703 A0A182K495 A0A182Y7J2 A0A182HAQ4 A0A1S4FAJ6 A0A1I8PXM4 B4I0T9 A0A3B0K3G3 A0A2M4BEA6 Q9W4F8 Q17A25 A0A2M4BDC4 A0A1I8M218 W5JCG5 E0VBG5 A0A1W4WBU6 A0A182IL75 A0A0M8ZQJ6 B3MPZ6 B3NV08 B4L691 A0A3B0KS91 B4PZU1 B4R4R4 A0A084VQJ8 A0A1A9UY20 A0A182N117 A0A1B0AHB8 A0A1A9YHE2 A0A1B0FY85 A0A182G1Y1 A0A1B0FNQ3 B4MAH4 A0A1J1I890 A0A2J7RG10 A0A093GNT6 A0A1B0AMN4 A0A3Q3FHY0 A0A3Q3FHJ7 A0A310S9H0 A0A3Q2DFS7 U3IC26 Q5F361 F1NLC9

PDB

4NC6 E-value=5.19882e-16, Score=208

KEGG

101743643 K17544 TBC domain-containing protein kinase-like protein | (RefSeq) TBC domain-containing protein ki

GO

GO:0004672 GO:0005524 GO:0090630 GO:0005096 GO:0017137 GO:0006886 GO:0005623 GO:0006904 GO:0007030 GO:0006468 GO:0043087 GO:0030496 GO:0032006 GO:0030036 GO:0005737 GO:0008283 GO:0072686 GO:0005819 GO:0050353 GO:0016491 GO:0016573 GO:0008270 GO:0022891 GO:0003707 GO:0051537

PANTHER

PTHR11679 PTHR11679:SF56

Subcellular location

Cytoplasm   Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody.   With evidence from 1 publications.
Cytoskeleton   Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody.   With evidence from 1 publications.
Spindle   Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody.   With evidence from 1 publications.
Midbody   Mainly localized in the cytoplasm during interphase. During metaphase, TBCK accumulates at the mitotic spindle. At the end of mitosis, it is detected at the midbody.   With evidence from 1 publications.

Length:

667

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.715049999999999

Exp number, first 60 AAs:

0.16215

Total prob of N-in:

0.00460

outside

1 - 667

Pi

36.321415

Theta

152.565619

Tajima's D

-0.796232

CLR

177.535421

CSRT

0.176341182940853

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics