Gene

KWMTBOMO07690

Pre Gene Modal

BGIBMGA000868

Annotation

cytochrome_P450_CYP4L6_precursor_[Bombyx_mori]

Location

Bomo_Chr13(+):4426361-4439500      View in EpiBrowser

Full name

Cytochrome P450 4d2      

Alternative Name

CYPIVD2

Location in the cell

Mitochondrial   Reliability : 1.288 PlasmaMembrane   Reliability : 1.635

CDS

ATGTTAAATCGCATATGTAAAAGCAATGTACCTGGACCATTTCCACTGCCGATCATTGGAAATGCTCATCAGTTCGTAGTGAGATCCACGGAATTTCTGGGACTTCTCAAAAGTTTCACGGATAAATACGGTGACGTCTTCAGAGTACATTTCTTTAGCTATCCCTATGTATTAATATCCCATCCAAAGTATGCCGAGGCTTTGGTTTCAAGTGCCGATTTGATAACAAAAGGACGATCGTACTCATTTTTGAAAGCCTGGCTGGGTGAAGGTCTCCTTACAGCTTCAGGCCCCAGGTGGAGACTACATCGCAAATTCTTGACGCCGGCCTTCCATTTCAACATATTGCAGAATTTTCTGCCTGTGTTCTGCAAAAAATCGGAGATATTACGAGACAAAATACGACGTCTCGCTGATGGACAACCCATCGATTTGTTTCCCATTACCGCTTTGGCAGCTCTTGATAATGTTGCAGAGTCAATTATGGGGGTGTCAGTGAATGCTCAACAAAACAGCGAATCCGAATATGTTCGCGCTATCGAAACTTTATCACAAATAACAACATTACGTATGCAAATTCCATTGCTGGGCGAGGATTTCATCTTTAATCTGACATCGTATAAGAAGAAACAGAATATCGCCTTGGAGGTGGTACATGGACAGACAAAAAAAGTTATTGAAGCGAGACGTTGCGAACTTGAAAAAAATAATAAAACAAATATCAGTGGAACCAACGAATATGGTATAAAAAATAAACATGCATTTTTGGATCTTCTGCTTTTGGCCGAAATTGACGGCAAACTAATTGATGAACAGAGTGTCAGAGAAGAAGTAGATACTTTCATGTTTGAGGGTCATGATACAACAACTTCTGGTATTGTGTACACATTATTTTGTCTTTCGAAGCATCCTGATATACAAGAGAAATTGTATGAAGAGCAACTAACCATTTTCGGCGAAGAAATGGACCGGACTCCTGCGTACAATGAACTGGCACAAATGAAGGTTCTGGAGTTGGTCATCAAGGAATCGTTGCGGATGTATCCATCGGTACCGCTGATCGAACGTTTGATCACAAAGGATGCTGAGGTTGGAGGTCTGAAACTATCTAAAGGAACATCGGTCGTGTTAAACATATTCCAGATGCATCGAAATCCAGAAGTGTTCGAGAAGCCCCTGGAATTCATTCCTGAACGATTCGATTCATTAGAACACAAAAATCCTTTCAGCTGGCTCGCTTTCAGCGCTGGCCCGAGGAATTGCATTGGTCAAAAGTTTGCAATGATGGAGATGAAAGTGACGCTATCAACATTAGTAAGAAATTTTAAACTGGTACCGGTCGATATAGAACCGATATTATGTGCAGATCTTATACTCCGTTCCCAGAATGGCGTCAAAGTTGGATTTTTACCAAGAACTCAATCGAATTCAAAAACGTAA

Protein

MLNRICKSNVPGPFPLPIIGNAHQFVVRSTEFLGLLKSFTDKYGDVFRVHFFSYPYVLISHPKYAEALVSSADLITKGRSYSFLKAWLGEGLLTASGPRWRLHRKFLTPAFHFNILQNFLPVFCKKSEILRDKIRRLADGQPIDLFPITALAALDNVAESIMGVSVNAQQNSESEYVRAIETLSQITTLRMQIPLLGEDFIFNLTSYKKKQNIALEVVHGQTKKVIEARRCELEKNNKTNISGTNEYGIKNKHAFLDLLLLAEIDGKLIDEQSVREEVDTFMFEGHDTTTSGIVYTLFCLSKHPDIQEKLYEEQLTIFGEEMDRTPAYNELAQMKVLELVIKESLRMYPSVPLIERLITKDAEVGGLKLSKGTSVVLNIFQMHRNPEVFEKPLEFIPERFDSLEHKNPFSWLAFSAGPRNCIGQKFAMMEMKVTLSTLVRNFKLVPVDIEPILCADLILRSQNGVKVGFLPRTQSNSKT

Description

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Keywords

Complete proteome   Endoplasmic reticulum   Heme   Iron   Membrane   Metal-binding   Microsome   Monooxygenase   Oxidoreductase   Polymorphism   Reference proteome  

Feature

chain  Cytochrome P450 4d2

Uniprot

B1AAB4   L0N6G7   A0A068EU53   Q8ISJ7   A0A248QEZ4   A0A1W5X9Y4   + More
A0A248QEI6   A0A248QG71   A0A2I6RJL3   A0A2W1BU71   A0A068EVJ8   A0A194RST1   A0A212EY40   A0A2H1VS16   A0A0K8TUK7   A0A1V0D9C3   C1LZ56   A0A286MXL9   X5D9E0   A0A286MXM0   D2JLK1   A0A194PCY8   A0A182II59   A0A182VPL4   A0A084VSF3   A0A182XUF1   A0A182S5C2   Q7PGG9   A0A182LF91   A0A182VPL5   A0A2M4BL07   A0A182PZ13   A0A182IQV8   A0A2M4BL09   T1E891   A0A1Q3FL09   A0A1Q3FL53   B0WRU2   A0A1Q3FKR8   A0A0U3YU82   A0A2M4CZE3   D6WKN7   A0A2M4CZ71   W5JTN5   Q170T4   A0A1I8NB38   A0A1I8PVI0   A0A1I8P933   A0A2M4ARG5   A0A1B0DB94   U5EUK9   A0A067QYE8   Q170T1   A0A1W7R8X8   B0XLC1   A0A067R367   A0A1I8Q7V5   D6WKD5   D6WYC3   A0A182S5C4   A0A182G610   A0A084VSF0   A0A182JL16   B0WRT9   A0A2J7QZP4   Q695H3   A0A1J1I2S3   A0A182PZ11   A0A1W4VRX6   A0A068FC40   A0A1Q3FLN2   A0A1I8MHR1   A0A182FZV1   Q170T2   A0A182VX83   A0A1W4W6L8   Q2PZV9   A0A182GW83   Q27589   B4R3F3   B3MYR6   X2JI29   A0A2M4ASZ7   O16806   A0A1Y1NM17   A0A1L8E438   A0A2J7QZQ8   A0A1I8MHR3   A0A0L0C064   A0A182II60   A0ND41   A0A182V6X9   A0A1I8N0B4   D6WKD3   A0A182XUF3   A0A0K0LBB5   B4I9Q8   A8DY22  

EC Number

1.14.-.-

Pubmed

28756777    12000647    28881445    28390075    26354079    22118469    + More
26017144    19954531    25299618    24361403    24438588    12364791    14747013    17210077    20966253    18362917    19820115    20920257    23761445    17510324    25315136    24845553    26483478    15277687    25880816    17201768    8024706    10731132    12537572    10731137    12537569    17994087    12537568    12537573    12537574    16110336    17569856    17569867    28004739    26108605    18817570   

EMBL

EU435135    ABZ81071.1    AK289279    AK289280    BAM73806.1    BAM73807.1    + More
KM016727    KZ149946    AID54879.1    PZC76748.1    AY063501    AAL48300.1    KX443465    ASO98040.1    KX961726    ARH52654.1    KX443464    ASO98039.1    KX443463    ASO98038.1    KY304473    AUN86404.1    PZC76747.1    KM016726    AID54878.1    KQ459700    KPJ20405.1    AGBW02011630    OWR46405.1    ODYU01004098    SOQ43610.1    GCVX01000051    JAI18179.1    KY212036    ARA91600.1    FN356973    CAX94851.1    MF684337    ASX93971.1    KF701162    AHW57332.1    MF684338    ASX93972.1    GQ915317    ACZ97411.2    KQ459606    KPI91181.1    APCN01000417    ATLV01015933    KE525044    KFB40897.1    AAAB01008859    EAA44936.4    GGFJ01004618    MBW53759.1    GGFJ01004619    MBW53760.1    GAMD01002382    JAA99208.1    GFDL01006889    JAV28156.1    GFDL01006726    JAV28319.1    DS232059    EDS33501.1    GFDL01006844    JAV28201.1    KT071008    ALX81393.1    GGFL01006499    MBW70677.1    KQ971342    EFA04535.1    GGFL01006454    MBW70632.1    ADMH02000178    ETN67486.1    CH477468    EAT40472.2    GGFK01009867    MBW43188.1    AJVK01004718    AJVK01004719    GANO01002276    JAB57595.1    KK853107    KDR11277.1    EAT40475.1    GEHC01000054    JAV47591.1    DS234406    EDS33837.1    KK853035    KDR12227.1    EFA04616.1    KQ971356    EFA09279.1    JXUM01044527    JXUM01044528    JXUM01044529    JXUM01044530    KQ561405    KXJ78680.1    KFB40894.1    EDS33498.1    NEVH01009068    PNF34047.1    AY605086    AAT38512.1    CVRI01000039    CRK94499.1    KJ702272    AID61426.1    GFDL01006526    JAV28519.1    EAT40474.1    DQ279461    ABB86762.2    JXUM01092957    JXUM01092958    JXUM01092959    KQ564023    KXJ72909.1    X75955    Z23005    AE014298    AL009194    AY118763    AF017006    AF017007    AF017008    AF017009    AF017010    AF017011    AF017012    AF017013    AF017014    AF017015    AF017016    AF017017    AF017018    CM000366    EDX16905.1    CH902632    EDV32760.1    AHN59277.1    GGFK01010604    MBW43925.1    AF017019    AAB71182.1    GEZM01002343    JAV97316.1    GFDF01000658    JAV13426.1    PNF34044.1    JRES01001093    KNC25631.1    APCN01000420    EAU77127.3    EFA04665.2    KM217034    AIW79997.1    CH480825    EDW43939.1    EF615001    KA645267    ABV48807.1    AFP59896.1   

Proteomes

UP000053240    UP000007151    UP000053268    UP000075840    UP000075903    UP000030765    + More
UP000076407    UP000075900    UP000007062    UP000075882    UP000075885    UP000075880    UP000002320    UP000007266    UP000000673    UP000008820    UP000095301    UP000095300    UP000092462    UP000027135    UP000069940    UP000249989    UP000235965    UP000183832    UP000192221    UP000069272    UP000075920    UP000192223    UP000000803    UP000000304    UP000007801    UP000037069    UP000001292   

PRIDE

B1AAB4    L0N6G7    Q27589    X2JI29   

Pfam

PF00067   p450

Interpro

IPR002401   Cyt_P450_E_grp-I        + More
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR036396   Cyt_P450_sf       
IPR002403   Cyt_P450_E_grp-IV       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

B1AAB4   L0N6G7   A0A068EU53   Q8ISJ7   A0A248QEZ4   A0A1W5X9Y4   + More
A0A248QEI6   A0A248QG71   A0A2I6RJL3   A0A2W1BU71   A0A068EVJ8   A0A194RST1   A0A212EY40   A0A2H1VS16   A0A0K8TUK7   A0A1V0D9C3   C1LZ56   A0A286MXL9   X5D9E0   A0A286MXM0   D2JLK1   A0A194PCY8   A0A182II59   A0A182VPL4   A0A084VSF3   A0A182XUF1   A0A182S5C2   Q7PGG9   A0A182LF91   A0A182VPL5   A0A2M4BL07   A0A182PZ13   A0A182IQV8   A0A2M4BL09   T1E891   A0A1Q3FL09   A0A1Q3FL53   B0WRU2   A0A1Q3FKR8   A0A0U3YU82   A0A2M4CZE3   D6WKN7   A0A2M4CZ71   W5JTN5   Q170T4   A0A1I8NB38   A0A1I8PVI0   A0A1I8P933   A0A2M4ARG5   A0A1B0DB94   U5EUK9   A0A067QYE8   Q170T1   A0A1W7R8X8   B0XLC1   A0A067R367   A0A1I8Q7V5   D6WKD5   D6WYC3   A0A182S5C4   A0A182G610   A0A084VSF0   A0A182JL16   B0WRT9   A0A2J7QZP4   Q695H3   A0A1J1I2S3   A0A182PZ11   A0A1W4VRX6   A0A068FC40   A0A1Q3FLN2   A0A1I8MHR1   A0A182FZV1   Q170T2   A0A182VX83   A0A1W4W6L8   Q2PZV9   A0A182GW83   Q27589   B4R3F3   B3MYR6   X2JI29   A0A2M4ASZ7   O16806   A0A1Y1NM17   A0A1L8E438   A0A2J7QZQ8   A0A1I8MHR3   A0A0L0C064   A0A182II60   A0ND41   A0A182V6X9   A0A1I8N0B4   D6WKD3   A0A182XUF3   A0A0K0LBB5   B4I9Q8   A8DY22  

PDB

6C94     E-value=4.1833e-66,     Score=639

KEGG

100141436    K15001 cytochrome P450 family 4 [EC:1.14.-.-] | (RefSeq) Cyp4l6; cytochrome P450 CYP4L6

GO

GO:0016705   GO:0005506   GO:0020037   GO:0004497   GO:0016021   GO:0070330   GO:0005789   GO:0046983   GO:0015935   GO:0016573   GO:0008270   GO:0022891   GO:0003707   GO:0051537   GO:0055114  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

479

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.149170000000001

Exp number, first 60 AAs:

0.09086

Total prob of N-in:

0.01722

outside

1  -  479

 

 

Pi

202.551988

Theta

174.32098

Tajima's D

-1.180992

CLR

135.621066

CSRT

0.109494525273736

Interpretation

Uncertain