Gene

KWMTBOMO07685  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014607

Annotation

translocase_of_inner_mitochondrial_membrane_8_homolog_b_[Bombyx_mori]

Location

Bomo_Chr13(-):4389524-4390080      View in EpiBrowser

Full name

Mitochondrial import inner membrane translocase subunit Tim8      

Location in the cell

Cytoplasmic   Reliability : 1.678 Nuclear   Reliability : 1.401

CDS

ATGAGCGACATTGATTTTCCTAGTCCAAAAGGTGCAGATTCCGAACTTCAGGATTTCTTAATACAAGAAAAACAAAAGGCACAGTTCCAAGCACAGATACACGAATTCAATAGTTTCTGTTGGGACAAGTGTATTGAAAAACCTGGAGCTAAGCTGGACTCTCGGACCGAAACATGTATCACAAACTGTGTGGAAAGATTCATTGATACCTCACTATTAATAACAAATAGATTTGCACAGATGCTAGAAAAGGGAGGCGGAATGCATTGA

Protein

MSDIDFPSPKGADSELQDFLIQEKQKAQFQAQIHEFNSFCWDKCIEKPGAKLDSRTETCITNCVERFIDTSLLITNRFAQMLEKGGGMH

Description

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The Tim8-Tim13 complex mediates the import of some proteins while the predominant Tim9-Tim10 70 kDa complex mediates the import of much more proteins (By similarity).

Subunit

Heterohexamer; composed of 3 copies of Tim8 and 3 copies of Tim13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of Tim22 (By similarity).

Similarity

Belongs to the small Tim family.

Keywords

Chaperone   Complete proteome   Disulfide bond   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Protein transport   Reference proteome   Translocation   Transport   Zinc  

Feature

chain  Mitochondrial import inner membrane translocase subunit Tim8

Uniprot

Q2F5V6   A0A2H1WSH8   A0A2A4JT37   A0A2W1BR18   A0A194PCV5   A0A194R3Y0   + More
A0A212EKJ8   J3JW55   A0A154PE47   A0A0K8TQU0   A0A023ECC3   Q1HRI2   A0A0M9A616   A0A1J1J0F2   A0A0L7QK92   A0A026WI36   A0A088AI79   A0A2P8XN33   A0A0P4VIS7   R4G2V9   A0A1Q3FD63   T1DFV4   N6TAJ0   A0A1W4XPE1   B3MZR8   B0XF40   A0A2R7VPT9   A0A067R284   A0A023FDQ2   T1IQX1   B4IE17   X2JB87   Q9Y1A3   A0A1E1XU72   B5M730   A0A023FG02   A0A023FW22   A0A1E1X1S4   A0A1L8DFM4   B4PYB9   A0A151XGM4   A0A151IC46   A0A310SCG8   A0A195BQ81   A0A158N9Q2   A0A023EEA7   A0A224YZ32   A0A131YVB9   G3MRZ2   A0A1I8M6E2   F4WRI2   A0A131X8D5   L7M332   A0A139WJ95   B4MCY3   B4L4A1   A0A1B6JYD4   A0A1I8QA90   A0A1L8EEE6   A0A182HFN6   A0A182VK93   A0A182XPC3   Q7Q8R2   A0A1W4Z3C2   A0A1B6KJN9   B3NUE2   W5JDR8   A0A182STM5   A0A195F866   B0XF39   A0A2M3ZCZ1   A0A2M4C4S0   A0A182YA64   A0A1B6FG41   A0A0L0CFK6   A0A182TDM9   A0A3B3Q8A3   A0A0V0G9M4   A0A2M4AKS7   A0A023F7M0   A0A0E9X9E5   A0A224Y362   A0A1W4V0L7   A0A3B5KM03   A0A3B4C4J1   A0A182M2Q3   A0A182P8E4   A0A069DNN9   B4H0H5   A0A182J673   A0A182JWS4   A0A2R5LFJ9   A6NA11   B3DGI9   Q29H23   A0A2A3EB92   E0VHD2   A0A182QTD2   A0A1D2AJ50   A0A3Q3XM10  

Pubmed

19121390    28756777    26354079    22118469    22516182    23537049    + More
26369729    24945155    17204158    17510324    24508170    30249741    29403074    27129103    24330624    17994087    24845553    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10611480    12537569    29209593    19320755    28503490    17550304    21347285    26483478    28797301    26830274    22216098    25315136    21719571    28049606    25576852    18362917    19820115    18057021    12364791    14747013    17210077    20920257    23761445    25244985    26108605    29240929    25474469    25613341    21551351    26334808    18070662    23594743    15632085    20566863   

EMBL

BABH01043858    DQ311317    ABD36261.1    ODYU01010667    SOQ55926.1    NWSH01000677    + More
PCG74858.1    KZ149946    PZC76771.1    KQ459606    KPI91141.1    KQ460947    KPJ10546.1    AGBW02014249    OWR42019.1    BT127473    KB632390    AEE62435.1    ERL94516.1    KQ434886    KZC10139.1    GDAI01000876    JAI16727.1    GAPW01006635    JAC06963.1    DQ440112    CH477204    ABF18145.1    EAT47987.1    KQ435742    KOX76663.1    CVRI01000063    CRL04321.1    KQ414982    KOC59029.1    KK107211    QOIP01000005    EZA55336.1    RLU22692.1    PYGN01001679    PSN33396.1    GDKW01002672    JAI53923.1    ACPB03011331    GAHY01002246    JAA75264.1    GFDL01009548    JAV25497.1    GALA01000422    JAA94430.1    APGK01045222    KB741032    ENN74758.1    CH902635    EDV33869.1    DS232895    EDS26453.1    KK854015    PTY09396.1    KK852761    KDR17009.1    GBBK01004456    JAC20026.1    AFFK01018409    CH480830    EDW45825.1    AE014298    KX532093    AHN59590.1    ANY27903.1    AF142424    AY118649    GFAA01000590    JAU02845.1    EZ000213    ACG76198.1    GBBK01004457    JAC20025.1    GBBL01002405    JAC24915.1    GFAC01005981    JAT93207.1    GFDF01008950    JAV05134.1    CM000162    EDX01981.1    KQ982169    KYQ59546.1    KQ978067    KYM97652.1    KQ770716    OAD52626.1    KQ976428    KYM87838.1    ADTU01009732    JXUM01127899    GAPW01006643    GAPW01006642    KQ567248    JAC06955.1    KXJ69528.1    GFPF01009823    MAA20969.1    GEDV01006451    JAP82106.1    JO844643    AEO36260.1    GL888287    EGI63199.1    GEFH01004847    JAP63734.1    GACK01006574    JAA58460.1    KQ971338    KYB27877.1    CH940660    EDW58055.1    CH933810    EDW07379.1    KRF94011.1    GECU01003475    JAT04232.1    GFDG01001830    JAV16969.1    APCN01005544    AAAB01008933    EAA09982.3    GEBQ01028332    JAT11645.1    CH954180    EDV46057.1    ADMH02001513    ETN62236.1    KQ981727    KYN36638.1    EDS26452.1    GGFM01005587    MBW26338.1    GGFJ01011171    MBW60312.1    GECZ01020593    JAS49176.1    JRES01000457    KNC31025.1    GECL01002061    JAP04063.1    GGFK01008074    MBW41395.1    GBBI01001346    JAC17366.1    GBXM01009491    JAH99086.1    GFTR01001485    JAW14941.1    AXCM01004073    GBGD01003613    JAC85276.1    CH479200    EDW29770.1    GGLE01004160    MBY08286.1    EF633977    ABR23494.1    CU467998    BC162413    BC162426    AAI62413.1    CH379064    EAL31936.2    KZ288293    PBC29043.1    DS235168    EEB12788.1    AXCN02001045    GETE01000194    JAT79217.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000030742    + More
UP000076502    UP000008820    UP000053105    UP000183832    UP000053825    UP000053097    UP000279307    UP000005203    UP000245037    UP000015103    UP000019118    UP000192223    UP000007801    UP000002320    UP000027135    UP000001292    UP000000803    UP000002282    UP000075809    UP000078542    UP000078540    UP000005205    UP000069940    UP000249989    UP000095301    UP000007755    UP000007266    UP000008792    UP000009192    UP000095300    UP000075840    UP000075903    UP000076407    UP000007062    UP000192224    UP000008711    UP000000673    UP000075901    UP000078541    UP000076408    UP000037069    UP000075902    UP000261540    UP000192221    UP000005226    UP000261440    UP000075883    UP000075885    UP000008744    UP000075880    UP000075881    UP000000437    UP000001819    UP000242457    UP000009046    UP000075886    UP000261620   

PRIDE

Q2F5V6    A0A088AI79    X2JB87    Q9Y1A3   

Pfam

PF02953   zf-Tim10_DDP

Interpro

IPR039238   Tim8/13        + More
IPR004217   Tim10-like       
IPR035427   Tim10-like_dom_sf       
IPR032675   LRR_dom_sf       
IPR006553   Leu-rich_rpt_Cys-con_subtyp       

SUPFAM

SSF144122   SSF144122       

Gene 3D

1.10.287.810     3.80.10.10    

ProteinModelPortal

Q2F5V6   A0A2H1WSH8   A0A2A4JT37   A0A2W1BR18   A0A194PCV5   A0A194R3Y0   + More
A0A212EKJ8   J3JW55   A0A154PE47   A0A0K8TQU0   A0A023ECC3   Q1HRI2   A0A0M9A616   A0A1J1J0F2   A0A0L7QK92   A0A026WI36   A0A088AI79   A0A2P8XN33   A0A0P4VIS7   R4G2V9   A0A1Q3FD63   T1DFV4   N6TAJ0   A0A1W4XPE1   B3MZR8   B0XF40   A0A2R7VPT9   A0A067R284   A0A023FDQ2   T1IQX1   B4IE17   X2JB87   Q9Y1A3   A0A1E1XU72   B5M730   A0A023FG02   A0A023FW22   A0A1E1X1S4   A0A1L8DFM4   B4PYB9   A0A151XGM4   A0A151IC46   A0A310SCG8   A0A195BQ81   A0A158N9Q2   A0A023EEA7   A0A224YZ32   A0A131YVB9   G3MRZ2   A0A1I8M6E2   F4WRI2   A0A131X8D5   L7M332   A0A139WJ95   B4MCY3   B4L4A1   A0A1B6JYD4   A0A1I8QA90   A0A1L8EEE6   A0A182HFN6   A0A182VK93   A0A182XPC3   Q7Q8R2   A0A1W4Z3C2   A0A1B6KJN9   B3NUE2   W5JDR8   A0A182STM5   A0A195F866   B0XF39   A0A2M3ZCZ1   A0A2M4C4S0   A0A182YA64   A0A1B6FG41   A0A0L0CFK6   A0A182TDM9   A0A3B3Q8A3   A0A0V0G9M4   A0A2M4AKS7   A0A023F7M0   A0A0E9X9E5   A0A224Y362   A0A1W4V0L7   A0A3B5KM03   A0A3B4C4J1   A0A182M2Q3   A0A182P8E4   A0A069DNN9   B4H0H5   A0A182J673   A0A182JWS4   A0A2R5LFJ9   A6NA11   B3DGI9   Q29H23   A0A2A3EB92   E0VHD2   A0A182QTD2   A0A1D2AJ50   A0A3Q3XM10  

PDB

3CJH     E-value=1.32933e-06,     Score=118

KEGG

692908    K17780 mitochondrial import inner membrane translocase subunit TIM8 | (RefSeq) translocase of inner

GO

GO:0005758   GO:0072321   GO:0046872   GO:0008566   GO:0006626   GO:0005744   GO:0005739   GO:0015450   GO:0015031  

PANTHER

PTHR19338  

Subcellular location

Mitochondrion inner membrane  

Length:

89

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00051

Exp number, first 60 AAs:

2e-05

Total prob of N-in:

0.10755

outside

1  -  89

 

 

Pi

351.908577

Theta

200.895416

Tajima's D

2.366143

CLR

0

CSRT

0.931753412329384

Interpretation

Uncertain