Gene

KWMTBOMO07629

Pre Gene Modal

BGIBMGA001298

Annotation

PREDICTED:_MORN_repeat-containing_protein_4_[Amyelois_transitella]

Location

Bomo_Chr13(-):2143294-2146580      View in EpiBrowser

Full name

Translation factor GUF1 homolog, mitochondrial       + More
MORN repeat-containing protein 4 homolog      

Alternative Name

Elongation factor 4 homolog
GTPase GUF1 homolog
Ribosomal back-translocase
Retinophilin
undertaker

Location in the cell

Cytoplasmic   Reliability : 1.316 Mitochondrial   Reliability : 1.247

CDS

ATGGTCGTGGATCCCGGTGTGGTGAAGACTGGAGCGTATAAATATGAAGACGGCACTCGCTACGTCGGAGAATGGAATGCTAAAGGCCAGAAACATGGGATGGGTCACTTGGTCCTACCCGACGGAACCAGATATGACGGAGCCCTGATCGGAGGATTGTGTTCTGGACTTGGGGTGATGGCGTTTCCTGATGGCGCAAAGTAA

Protein

MVVDPGVVKTGAYKYEDGTRYVGEWNAKGQKHGMGHLVLPDGTRYDGALIGGLCSGLGVMAFPDGAK

Description

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma (PubMed:22496551). Organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors (PubMed:20107052). The rtp/ninaC complex is required for stability of inad and inac and the normal termination of phototransduction in the retina (PubMed:20739554).

Catalytic Activity

GTP + H2O = GDP + H(+) + phosphate

Subunit

Interacts with ninaC.

Similarity

Belongs to the GTP-binding elongation factor family. LepA subfamily.

Keywords

Acetylation   Complete proteome   Membrane   Phosphoprotein   Reference proteome   Repeat   Sensory transduction   Vision  

Feature

chain  MORN repeat-containing protein 4 homolog

Uniprot

H9IVL8   A0A3S2L464   A0A212F3Q2   A0A194QM99   A0A194PDK6   A0A2A3EUI6   + More
A0A2P8Y895   A0A067RF44   A0A1B0CKH2   A0A182GVT9   A0A1B6FD29   A0A1B6MI08   A0A1J1IIZ5   A0A1B6I651   A0A084VB13   A0A1L8DCG9   T1DQ33   A0A1S3CYE0   Q17PB7   A0A084VB15   A0A182JDS1   A0A182F717   W5JU47   A0A182QRQ6   A0A182HZ81   A0A182V8T2   A0A182TW99   Q7PH89   A0A336LN76   A0A182M6J6   A0A182VS08   A0A310SK63   A0A182NSN3   A0A182WVV7   A0A182RZE1   A0A182KGR3   A0A182P0C9   A0A182T8H4   T1D558   A0A1Q3FRW4   B0WIW1   A0A088AF51   A0A182Y7F9   A0A0N0BEY7   A0A154PST9   A0A0J7KXG4   E2A8P4   A0A3L8D3G6   A0A026WVR0   E9J0W7   A0A151ICZ1   F4WTT2   A0A0K8SNN5   A0A146L576   A0A0A9XWF4   A0A0K8SMT0   E2BRK2   A0A232EZA8   A0A158N9N9   K7JBS3   A0A195BPQ8   B4JSP7   Q296A8   B4GFE9   A0A151XGK6   A0A1I8NX35   B4NI67   A0A034WE33   A0A0M4EQK6   B4KCM3   A0A1A9ZVL4   J9K3X1   A0A1A9Y8I5   A0A1A9VAD9   A0A1B0BLV0   A0A0K8W980   A0A1B0FQT6   B3M170   A0A0A1WJ59   A0A1A9WFS8   B4M4X8   A0A2H8TMD5   A0A2S2NRK1   D2NUK8   A0A1I8NF45   W8AYE1   A0A3B0KFU7   A0A2S2R0P9   B4QW88   B4I3X3   B3P2A4   Q9VN91   A0A1W4UWU5   B4PV68   A0A3M7TA09   E9HAI9   A0A0P4WW95   A0A0P5WN34   A0A0P5H1Y6   A0A0P6CJD3  

EC Number

3.6.5.n1

Pubmed

19121390    22118469    26354079    29403074    24845553    26483478    + More
24438588    17510324    20920257    23761445    12364791    14747013    17210077    24330624    25244985    20798317    30249741    24508170    21282665    21719571    26823975    25401762    28648823    21347285    20075255    17994087    15632085    25348373    25830018    25315136    24495485    17285308    10731132    12537572    12537569    20107052    20739554    22496551    25822849    17550304    30375419    21292972   

EMBL

BABH01001438    RSAL01000167    RVE45248.1    AGBW02010520    OWR48354.1    KQ461198    + More
KPJ06085.1    KQ459606    KPI91093.1    KZ288185    PBC34876.1    PYGN01000809    PSN40483.1    KK852508    KDR22397.1    AJWK01016269    AJWK01016270    AJWK01016271    AJWK01016272    JXUM01002529    JXUM01002530    JXUM01002531    KQ560140    KXJ84219.1    GECZ01021669    JAS48100.1    GEBQ01004446    JAT35531.1    CVRI01000054    CRL00195.1    GECU01025290    JAS82416.1    ATLV01004846    KE524243    KFB35157.1    GFDF01009921    JAV04163.1    GAMD01002809    JAA98781.1    CH477193    EAT48514.1    ATLV01004847    KFB35159.1    AXCP01002751    ADMH02000081    ETN67872.1    AXCN02000233    APCN01005504    AAAB01008888    EAA44640.4    EGK97065.1    UFQT01000091    SSX19532.1    AXCM01001479    KQ765222    OAD54065.1    GALA01000673    JAA94179.1    GFDL01004757    JAV30288.1    DS231953    EDS28787.1    KQ435821    KOX72291.1    KQ435180    KZC14979.1    LBMM01002304    KMQ95011.1    GL437663    EFN70123.1    QOIP01000014    RLU15047.1    KK107083    EZA60083.1    GL767538    EFZ13487.1    KQ977991    KYM98283.1    GL888344    EGI62397.1    GBRD01011404    GBRD01011403    GBRD01010999    JAG54420.1    GDHC01016332    JAQ02297.1    GBHO01020401    JAG23203.1    GBRD01011400    JAG54424.1    GL449965    EFN81694.1    NNAY01001541    OXU23637.1    ADTU01009725    AAZX01000360    AAZX01011714    AAZX01013565    AAZX01016629    AAZX01025833    KQ976428    KYM87825.1    CH916373    EDV94787.1    CM000070    EAL28550.2    CH479182    EDW34334.1    KQ982169    KYQ59534.1    CH964272    EDW84759.1    GAKP01005141    JAC53811.1    CP012526    ALC46635.1    CH933806    EDW15872.1    ABLF02035568    ABLF02035571    JXJN01016575    GDHF01004677    JAI47637.1    CCAG010014772    CH902617    EDV44340.1    GBXI01015869    JAC98422.1    CH940652    EDW59689.1    GFXV01003522    MBW15327.1    GGMR01007089    MBY19708.1    BT120151    ADB57072.1    GAMC01015415    GAMC01015413    JAB91142.1    OUUW01000008    SPP84616.1    GGMS01014366    MBY83569.1    CM000364    EDX11687.1    CH480821    EDW54916.1    CH954181    EDV47854.1    DQ333317    DQ324736    AE014297    AY060630    CM000160    EDW95737.1    REGN01000043    RNA44944.1    GL732612    EFX71189.1    GDIP01249903    JAI73498.1    GDIP01083969    LRGB01002121    JAM19746.1    KZS09027.1    GDIQ01255989    JAJ95735.1    GDIP01007450    JAM96265.1   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000053268    UP000242457    + More
UP000245037    UP000027135    UP000092461    UP000069940    UP000249989    UP000183832    UP000030765    UP000079169    UP000008820    UP000075880    UP000069272    UP000000673    UP000075886    UP000075840    UP000075903    UP000075902    UP000007062    UP000075883    UP000075920    UP000075884    UP000076407    UP000075900    UP000075881    UP000075885    UP000075901    UP000002320    UP000005203    UP000076408    UP000053105    UP000076502    UP000036403    UP000000311    UP000279307    UP000053097    UP000078542    UP000007755    UP000008237    UP000215335    UP000005205    UP000002358    UP000078540    UP000001070    UP000001819    UP000008744    UP000075809    UP000095300    UP000007798    UP000092553    UP000009192    UP000092445    UP000007819    UP000092443    UP000078200    UP000092460    UP000092444    UP000007801    UP000091820    UP000008792    UP000095301    UP000268350    UP000000304    UP000001292    UP000008711    UP000000803    UP000192221    UP000002282    UP000276133    UP000000305    UP000076858   

PRIDE

H9IVL8    D2NUK8    Q9VN91   

Pfam

PF02493   MORN        + More
PF14500   MMS19_N
PF12460   MMS19_C
PF00009   GTP_EFTU
PF00679   EFG_C
PF06421   LepA_C
PF11018   Cuticle_3

Interpro

IPR003409   MORN        + More
IPR029240   MMS19_N       
IPR024687   MMS19_C       
IPR011989   ARM-like       
IPR039920   MET18/MMS19       
IPR016024   ARM-type_fold       
IPR027417   P-loop_NTPase       
IPR006297   EF-4       
IPR035647   EFG_III/V       
IPR009000   Transl_B-barrel_sf       
IPR000795   TF_GTP-bd_dom       
IPR000640   EFG_V-like       
IPR038363   LepA_C_sf       
IPR005225   Small_GTP-bd_dom       
IPR031157   G_TR_CS       
IPR013842   LepA_CTD       
IPR022727   Cuticle_C1       

SUPFAM

SSF48371   SSF48371        + More
SSF54980   SSF54980       
SSF52540   SSF52540       
SSF50447   SSF50447       

Gene 3D

1.25.10.10     3.30.70.2570    

ProteinModelPortal

H9IVL8   A0A3S2L464   A0A212F3Q2   A0A194QM99   A0A194PDK6   A0A2A3EUI6   + More
A0A2P8Y895   A0A067RF44   A0A1B0CKH2   A0A182GVT9   A0A1B6FD29   A0A1B6MI08   A0A1J1IIZ5   A0A1B6I651   A0A084VB13   A0A1L8DCG9   T1DQ33   A0A1S3CYE0   Q17PB7   A0A084VB15   A0A182JDS1   A0A182F717   W5JU47   A0A182QRQ6   A0A182HZ81   A0A182V8T2   A0A182TW99   Q7PH89   A0A336LN76   A0A182M6J6   A0A182VS08   A0A310SK63   A0A182NSN3   A0A182WVV7   A0A182RZE1   A0A182KGR3   A0A182P0C9   A0A182T8H4   T1D558   A0A1Q3FRW4   B0WIW1   A0A088AF51   A0A182Y7F9   A0A0N0BEY7   A0A154PST9   A0A0J7KXG4   E2A8P4   A0A3L8D3G6   A0A026WVR0   E9J0W7   A0A151ICZ1   F4WTT2   A0A0K8SNN5   A0A146L576   A0A0A9XWF4   A0A0K8SMT0   E2BRK2   A0A232EZA8   A0A158N9N9   K7JBS3   A0A195BPQ8   B4JSP7   Q296A8   B4GFE9   A0A151XGK6   A0A1I8NX35   B4NI67   A0A034WE33   A0A0M4EQK6   B4KCM3   A0A1A9ZVL4   J9K3X1   A0A1A9Y8I5   A0A1A9VAD9   A0A1B0BLV0   A0A0K8W980   A0A1B0FQT6   B3M170   A0A0A1WJ59   A0A1A9WFS8   B4M4X8   A0A2H8TMD5   A0A2S2NRK1   D2NUK8   A0A1I8NF45   W8AYE1   A0A3B0KFU7   A0A2S2R0P9   B4QW88   B4I3X3   B3P2A4   Q9VN91   A0A1W4UWU5   B4PV68   A0A3M7TA09   E9HAI9   A0A0P4WW95   A0A0P5WN34   A0A0P5H1Y6   A0A0P6CJD3  

KEGG

101746252    no KO assigned | (RefSeq) MORN repeat-containing protein 4

GO

GO:0097428   GO:0005525   GO:0045727   GO:0043022   GO:0006412   GO:0003924   GO:0005759   GO:0005743   GO:0016021   GO:0033583   GO:0048678   GO:0007602   GO:1901555   GO:0007601   GO:0016028  

PANTHER

PTHR12891  

Subcellular location

Mitochondrion inner membrane  
Membrane   Co-localizes with ninaC in the rhabdomere membrane.   With evidence from 5 publications.

Length:

67

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.10503

Exp number, first 60 AAs:

2.5821

Total prob of N-in:

0.26471

outside

1  -  67

 

 

Pi

246.86557

Theta

121.992525

Tajima's D

3.163516

CLR

0.579061

CSRT

0.986150692465377

Interpretation

Uncertain