Gene

KWMTBOMO07628  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000842

Annotation

PREDICTED:_elongation_of_very_long_chain_fatty_acids_protein_4-like_[Amyelois_transitella]

Location

Bomo_Chr13(+):2110691-2136177      View in EpiBrowser

Full name

Elongation of very long chain fatty acids protein       + More
Elongation of very long chain fatty acids protein 4      

Alternative Name

Very-long-chain 3-oxoacyl-CoA synthase
3-keto acyl-CoA synthase ELOVL4
ELOVL fatty acid elongase 4
Very long chain 3-ketoacyl-CoA synthase 4
Very long chain 3-oxoacyl-CoA synthase 4

Location in the cell

PlasmaMembrane   Reliability : 4.922

CDS

ATGGCCGATGTTATAGTGAATTCAACGCAGAGCGTTTTAAAAGACACATACGATTATTATATATGGACACTATCATTGTCAGATGATAGAACAAAAGGATGGCCACTGGTTGACTCGCCGCTGCCGACTGCGTTGTACACTTTAGCCTACCTCTTCATAGTGTGGATCGGTCCTAAGCTAATGAAAAACAGAAAGCCATTTCAATTAACATGGCTTTTAGTACCCTACAACTTAGCCATGGCTGCGCTAAATGCCTATATAGCTGTCAGGTTACTGACAGCCTCATTTAGATTAAGATATAGTTATATTTGTGAACCTTGCCGGCAGAAATATGACCCGGACGAATTGCAGATAGCAGATGCGGTATGGTGGTACTATTTTTCGAAGCTTCTGGAATTTTGTGATACCTTCTTCTTTATACTGAGGAAGAAGGATGAGCAGCTGACATTTTTGCATGTTTACCATCACTCGACCATGTTTTCGTTCTGGTGGATTGGAATCAAATGGGTGCCTAGTGGATCTACTTTCCTTCCCGCCATGGTGAACAGTGGAATCCACGTGCTGATGTACACTTACTATGGTCTTTCAGTTTTCGGTCCGACAGTCAGTCAGTATTTGTGGTGGAAGAAGTATCTCACGATCATGCAACTGATCCAGTTCACATGCGCTTTGATTCTCGGCATCAACGGAATCAGAACAGGCTGTGAGTTCCCGCTTTGGATGCACTACGTGCTGATCTTCTACATGATTTCCTTCATCATTCTGTTCGGTAACTTCTACATGAAGGCTTATATTGCAAAGGGAAGCAAGTGTATGGAAGTCAGATACGGGCAGTGTCTGGACGATGACGAAACGATAGCCGCCAAAAAACTTAAAGATTGCTAA

Protein

MADVIVNSTQSVLKDTYDYYIWTLSLSDDRTKGWPLVDSPLPTALYTLAYLFIVWIGPKLMKNRKPFQLTWLLVPYNLAMAALNAYIAVRLLTASFRLRYSYICEPCRQKYDPDELQIADAVWWYYFSKLLEFCDTFFFILRKKDEQLTFLHVYHHSTMFSFWWIGIKWVPSGSTFLPAMVNSGIHVLMYTYYGLSVFGPTVSQYLWWKKYLTIMQLIQFTCALILGINGIRTGCEFPLWMHYVLIFYMISFIILFGNFYMKAYIAKGSKCMEVRYGQCLDDDETIAAKKLKDC

Description

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Catalytic Activity

a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA

Subunit

Oligomer.

Similarity

Belongs to the ELO family.
Belongs to the ELO family. ELOVL4 subfamily.

Uniprot

A0A2A4JP92   I4DKN6   A0A194QKN5   A0A212F3R3   A0A2A4JNG6   A0A2H1X287   + More
D6X467   A0A1Y1N5G7   H9IUB2   A0A0M9A5S3   A0A1B0D768   A0A088A435   A0A2A3ELV1   F4WYE9   A0A151ID60   A0A026W109   A0A154NYA7   A0A195BNJ4   A0A151XGI5   A0A158N9L8   A0A0C9RV44   E2BVV2   A0A0C9QYU2   A0A195F9F3   A0A067RSL2   E0VTG7   A0A0L7R606   A0A232EEI2   A0A0J7KU83   E2AKD3   A0A3Q8FT87   A0A1B6DXW4   A0A1B6JRB1   K7J0V5   A0A151ISR3   A0A023F465   A0A084WNI0   W5JX27   A0A2C9GRX4   A0A3Q0JGU4   A0A182QFJ2   A0A1Q3FG49   B0WV69   A0A182UFW7   A0A1S4H4P2   A0A182YAC5   A0A182SNY1   A0A182WXY6   A0A182V0J6   A0A182KV07   A0A182FPL7   A0A182J5B5   A0A182HDP1   A0A182NPB3   A0A023ENL9   A0A182PV48   Q17E22   A0A3Q0JCZ7   A0A182RLU0   J9LV62   T1IFX7   A0A2H8TX96   A0A336M8W2   A0A2P8YRL0   A0A182WE72   A0A1J1I7U7   A0A182ILG8   A0A0P6JLN4   A0A0P4VZT1   A0A1B1LL02   A0A2P2I5L6   A0A0P5KIQ4   A0A0P5G581   A0A0P6IFK2   A0A0P5QAP8   A0A0N8E575   A0A3R7ML16   A0A0P4XV02   A0A0P5ZBH6   A0A0P6DRM9   A0A0N8C0Q8   A0A0P5S862   E9HK98   A0A0P6DHF4   A0A0N8DXG3   A0A0P5JYD0   A0A0P5C3R3   C3Y558   A0A0P5X0K4   G3NS06   A0A2I6SDK3   A0A1S3JK69   A0A1S3H7G0   A0A1S3HAB5   A0A1S3JK20   A0A3P8WYN6  

EC Number

2.3.1.199

Pubmed

22651552    26354079    22118469    18362917    19820115    28004739    + More
19121390    21719571    24508170    30249741    21347285    20798317    24845553    20566863    28648823    20075255    25474469    24438588    20920257    23761445    12364791    25244985    20966253    26483478    24945155    17510324    29403074    21292972    18563158    24487278   

EMBL

NWSH01000909    PCG73576.1    AK401854    KQ459606    BAM18476.1    KPI91094.1    + More
KQ461198    KPJ06087.1    AGBW02010520    OWR48353.1    PCG73577.1    ODYU01012855    SOQ59362.1    KQ971410    EEZ97311.1    GEZM01012215    JAV93094.1    BABH01001438    BABH01001439    KQ435728    KOX77795.1    AJVK01012348    AJVK01012349    KZ288219    PBC32252.1    GL888441    EGI60757.1    KQ977991    KYM98310.1    KK107502    QOIP01000014    EZA49698.1    RLU15120.1    KQ434772    KZC03860.1    KQ976428    KYM87792.1    KQ982169    KYQ59506.1    ADTU01009694    GBYB01011549    GBYB01011551    JAG81316.1    JAG81318.1    GL451029    EFN80181.1    GBYB01000885    JAG70652.1    KQ981727    KYN36679.1    KK852485    KDR22804.1    DS235765    EEB16673.1    KQ414648    KOC66254.1    NNAY01005326    OXU16753.1    LBMM01003204    KMQ93814.1    GL440262    EFN66075.1    MG573186    AWJ25048.1    GEDC01006801    JAS30497.1    GECU01005928    GECU01000011    JAT01779.1    JAT07696.1    KQ981064    KYN09912.1    GBBI01002412    JAC16300.1    ATLV01024612    KE525353    KFB51774.1    ADMH02000117    ETN67779.1    APCN01003542    AXCN02001819    GFDL01008530    JAV26515.1    DS232119    EDS35408.1    AAAB01008848    JXUM01034592    JXUM01034593    JXUM01034594    JXUM01034595    KQ561029    KXJ79972.1    GAPW01003067    JAC10531.1    CH477287    EAT44716.1    ABLF02017126    ABLF02017128    ACPB03011457    ACPB03011458    GFXV01006744    MBW18549.1    UFQS01000715    UFQT01000715    SSX06362.1    SSX26716.1    PYGN01000410    PSN46864.1    CVRI01000039    CRK94473.1    AXCP01006767    AXCP01006768    AXCP01006769    AXCP01006770    GDIQ01003382    JAN91355.1    GDRN01083877    JAI61594.1    KX454537    ANS53415.1    IACF01003696    LAB69307.1    GDIQ01183525    GDIQ01172979    GDIQ01172978    GDIQ01149233    GDIQ01124442    GDIQ01116687    GDIP01073217    GDIQ01044976    LRGB01001361    JAK68200.1    JAM30498.1    KZS12713.1    GDIQ01267966    JAJ83758.1    GDIQ01005888    JAN88849.1    GDIQ01138448    JAL13278.1    GDIQ01060668    JAN34069.1    QCYY01000534    ROT84478.1    GDIP01238647    GDIP01176406    JAI84754.1    GDIP01046275    JAM57440.1    GDIQ01074011    JAN20726.1    GDIQ01126195    JAL25531.1    GDIQ01097404    JAL54322.1    GL732667    EFX67847.1    GDIQ01077209    GDIQ01077208    JAN17529.1    GDIQ01082615    GDIQ01082364    JAN12373.1    GDIQ01197269    JAK54456.1    GDIP01176405    JAJ46997.1    GG666487    EEN64591.1    GDIP01079165    JAM24550.1    MF401207    AUO15655.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000007266    UP000005204    + More
UP000053105    UP000092462    UP000005203    UP000242457    UP000007755    UP000078542    UP000053097    UP000279307    UP000076502    UP000078540    UP000075809    UP000005205    UP000008237    UP000078541    UP000027135    UP000009046    UP000053825    UP000215335    UP000036403    UP000000311    UP000002358    UP000078492    UP000030765    UP000000673    UP000075840    UP000079169    UP000075886    UP000002320    UP000075902    UP000076408    UP000075901    UP000076407    UP000075903    UP000075882    UP000069272    UP000075880    UP000069940    UP000249989    UP000075884    UP000075885    UP000008820    UP000075900    UP000007819    UP000015103    UP000245037    UP000075920    UP000183832    UP000076858    UP000283509    UP000000305    UP000001554    UP000007635    UP000085678    UP000265120   

PRIDE

H9IUB2   

Pfam

PF01151   ELO        + More
PF00106   adh_short

Interpro

IPR030457   ELO_CS        + More
IPR002076   ELO_fam       
IPR020904   Sc_DH/Rdtase_CS       
IPR002347   SDR_fam       
IPR036291   NAD(P)-bd_dom_sf       
IPR033678   ELOVL4       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

A0A2A4JP92   I4DKN6   A0A194QKN5   A0A212F3R3   A0A2A4JNG6   A0A2H1X287   + More
D6X467   A0A1Y1N5G7   H9IUB2   A0A0M9A5S3   A0A1B0D768   A0A088A435   A0A2A3ELV1   F4WYE9   A0A151ID60   A0A026W109   A0A154NYA7   A0A195BNJ4   A0A151XGI5   A0A158N9L8   A0A0C9RV44   E2BVV2   A0A0C9QYU2   A0A195F9F3   A0A067RSL2   E0VTG7   A0A0L7R606   A0A232EEI2   A0A0J7KU83   E2AKD3   A0A3Q8FT87   A0A1B6DXW4   A0A1B6JRB1   K7J0V5   A0A151ISR3   A0A023F465   A0A084WNI0   W5JX27   A0A2C9GRX4   A0A3Q0JGU4   A0A182QFJ2   A0A1Q3FG49   B0WV69   A0A182UFW7   A0A1S4H4P2   A0A182YAC5   A0A182SNY1   A0A182WXY6   A0A182V0J6   A0A182KV07   A0A182FPL7   A0A182J5B5   A0A182HDP1   A0A182NPB3   A0A023ENL9   A0A182PV48   Q17E22   A0A3Q0JCZ7   A0A182RLU0   J9LV62   T1IFX7   A0A2H8TX96   A0A336M8W2   A0A2P8YRL0   A0A182WE72   A0A1J1I7U7   A0A182ILG8   A0A0P6JLN4   A0A0P4VZT1   A0A1B1LL02   A0A2P2I5L6   A0A0P5KIQ4   A0A0P5G581   A0A0P6IFK2   A0A0P5QAP8   A0A0N8E575   A0A3R7ML16   A0A0P4XV02   A0A0P5ZBH6   A0A0P6DRM9   A0A0N8C0Q8   A0A0P5S862   E9HK98   A0A0P6DHF4   A0A0N8DXG3   A0A0P5JYD0   A0A0P5C3R3   C3Y558   A0A0P5X0K4   G3NS06   A0A2I6SDK3   A0A1S3JK69   A0A1S3H7G0   A0A1S3HAB5   A0A1S3JK20   A0A3P8WYN6  

KEGG

101746391    K10249 elongation of very long chain fatty acids protein 4 [EC:2.3.1.199] | (RefSeq) elongation of v

PATHWAY

00062    Fatty acid elongation - Bombyx mori (domestic silkworm)
01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0102756   GO:0102338   GO:0016021   GO:0102336   GO:0102337   GO:0006633   GO:0030176   GO:0034625   GO:0009922   GO:0034626   GO:0030148   GO:0019367   GO:0042761   GO:0016491   GO:0006636   GO:0005789   GO:0035338   GO:0008270   GO:0033179   GO:0015450   GO:0005737   GO:0005488   GO:0022891   GO:0003707   GO:0051537  

PANTHER

PTHR11157  

Subcellular location

Endoplasmic reticulum membrane  

Length:

294

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

145.49304

Exp number, first 60 AAs:

20.52815

Total prob of N-in:

0.15279

POSSIBLE N-term signal

sequence

outside

1  -  33

TMhelix

34  -  56

inside

57  -  68

TMhelix

69  -  91

outside

92  -  121

TMhelix

122  -  141

inside

142  -  147

TMhelix

148  -  167

outside

168  -  176

TMhelix

177  -  199

inside

200  -  205

TMhelix

206  -  228

outside

229  -  237

TMhelix

238  -  260

inside

261  -  294

 

 

Pi

208.948375

Theta

156.877899

Tajima's D

0.335574

CLR

0.482838

CSRT

0.466476676166192

Interpretation

Uncertain