Gene

KWMTBOMO07622

Pre Gene Modal

BGIBMGA000840

Annotation

PREDICTED:_transmembrane_protease_serine_9-like_[Bombyx_mori]

Location

Bomo_Chr13(+):1913320-1920181      View in EpiBrowser

Full name

Trypsin-1       + More
Trypsin-3      
Trypsin-2      
Trypsin-7      
Trypsin 5G1      
Trypsin 3A1      
Trypsin-4      

Alternative Name

Antryp1
Antryp2

Location in the cell

Extracellular   Reliability : 2.248

CDS

ATGGAGTCTTCTGAGCATTTCGTGATTTTCTTTGGATTAACTCTACTATATTCACAACTTGCGTACGGTCTAGATTTCTCCAATTTCCCAACTTTGGAAGAGTTCCTCAAGGAGCCCATGGTAAACGATGACAGAATCGTGGGGGGACAGGAGGCCTTCATCGATGATTACCCCCACCAAGTATCGTTTGTGGTGAACAATACGTATTTTTGCGGCGGCTCGATCATCAGCGAGAACTGGATATTGACTGCAGCCCATTGCTCTCAGAACGTCGACCCCTCGACAGTGGTCTTAAGAGGTGGAAGTTCATGGCGGAAGAATGGTACTATCATTCCCATTGAAAAAGTGATAGCGCATCCAGAGTATGACAACCCTGCGTTCGACAAGGATGTCGCTGTTATGAAGACCAAAGAACCTATACAATTTAGTGACACAATGCAGCCTATAGGGCTACCTTCAATGGATAGAGCAATGAGAGGTGGAACGGAGGTATCGGTCAGCGGGTGGGGACGTACTAAGCAAGGAGCCGCTTCGATTCCCGAAAGACTGATGGACGTGCGTATACCAGTCGTGTCGTATCCGGAGTGTTTCCTGTCGTACTTTTCAGTCCTCACGAGGAACATGTGGTGCGGCGGGAACTTCTTCTTGGGTGGTCAGGGAACTTGCCAGGGCGATTCTGGAGGATCAGCAGTTCAAGACGGTATGGCAGTTGGCATCGTGTCTTTTGGACGTGGTTGTGGCCAGTCTTTCGCTCCAAGTGTGTTCGCCAATATTGCCGCACCTCCCATCAGGAACTTCATCAAAGAACACACAGATCTTTAA

Protein

MESSEHFVIFFGLTLLYSQLAYGLDFSNFPTLEEFLKEPMVNDDRIVGGQEAFIDDYPHQVSFVVNNTYFCGGSIISENWILTAAHCSQNVDPSTVVLRGGSSWRKNGTIIPIEKVIAHPEYDNPAFDKDVAVMKTKEPIQFSDTMQPIGLPSMDRAMRGGTEVSVSGWGRTKQGAASIPERLMDVRIPVVSYPECFLSYFSVLTRNMWCGGNFFLGGQGTCQGDSGGSAVQDGMAVGIVSFGRGCGQSFAPSVFANIAAPPIRNFIKEHTDL

Description

Major function may be to aid in digestion of the blood meal.
Constitutive trypsin that is expressed 2 days after emergence, coinciding with host seeking behavior of the female.

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Complete proteome   Digestion   Disulfide bond   Hydrolase   Protease   Reference proteome   Secreted   Serine protease   Signal   Zymogen   Alternative splicing  

Feature

propeptide  Activation peptide
chain  Trypsin-1
splice variant  In isoform A.

Uniprot

H9IUB0   A0A2H1WLN2   A0A2A4K471   A0A3S2LFV6   A0A2A4K3K4   A0A2A4K3J2   + More
H9IUB1   A0A194PDK1   A0A0N1PJX5   A0A212FPE2   A0A0L7KY81   A0A194PEH2   A0A194PCY4   A0A194QL10   A0A0N1IQS6   A0A212EWZ2   A0A2H1X0F7   A0A194PDG5   A0A1Y9J180   P35035   A0A0A1TPQ4   A0A194RI37   A0A2C9GTY9   A0A182U9U3   A0A1Y9GKU7   A0A182TKI7   P35037   A0A1Y9GLX5   A0A182VG56   A0A1S4GXU9   H9JW07   A0A182T760   A0A182V8D5   A0A182TJQ8   A0A1Y9J0J4   A0A1Y9GKV0   P35036   A0A1Y9J184   A0A182VGJ0   A0A2C9GTQ1   L0ATN6   A0A182KHH7   A0A240PL34   A0A0A1T583   P35041   A0A2P0XIZ8   F6JSA6   A0A182V8R1   A0A182ICF6   A0A182T724   A0A182XL71   Q16TM1   A0A182U4C7   A0A0A1TJ15   A0A2C9GTS0   A0A182L0V6   Q5QBF4   A0A182M8Z6   B4KK96   A0A0L7LAG0   Q1M0X9   C8CGF6   C5IBE8   A0A1Y9HES5   Q17086   A0A0A1TC23   A0A182MJH4   A0A1Y9GLA7   A0A1Y9J0S1   O16133   A0A2C9GTS6   P29787   P29786-2   P35038   A0A1V1G554   A0A1Y9IS50   A0A240PM69   A0A240PKC7   F4MI42   A0A084VY03   A0A084VY04   A0A084VY00   A0A2K7P6D6   A0A154PBT0   Q5QBG0   A0A2P0XIE9   C5IBF3   A0A182HBG3   P29786   A0A2M9M4T8   A0A240PL37   D2A2R7   Q16TL9   A0A182G5M7   C5IBF5   K7J8G1   B4LRU7   B4KK93   A0A0B7KIN4  

EC Number

3.4.21.4

Pubmed

19121390    26354079    22118469    26227816    8335004    7498434    + More
12364791    20966253    22727120    17510324    15796745    17994087    20100490    19204376    11016929    9087545    28410430    21569254    24438588    26483478    18362917    19820115    20075255   

EMBL

BABH01001460    BABH01001461    ODYU01009503    SOQ53993.1    NWSH01000168    PCG78826.1    + More
RSAL01000017    RVE52910.1    PCG78837.1    PCG78825.1    BABH01001457    BABH01001458    KQ459606    KPI91088.1    LADJ01066212    KPJ21686.1    AGBW02003040    OWR55583.1    JTDY01004566    KOB68004.1    KPI91089.1    KPI91087.1    KQ461198    KPJ06079.1    KPJ21685.1    AGBW02011879    OWR45991.1    ODYU01012498    SOQ58840.1    KPI91053.1    Z18889    Z22930    AAAB01008964    CDHN01000005    CEJ92817.1    KQ460205    KPJ17099.1    APCN01000798    BABH01036516    Z18890    JX915894    AFZ78860.1    CDHN01000004    CEJ92321.1    KY661301    AVA17388.1    GU187072    ADQ53625.1    CH477645    EAT37856.1    CDHN01000003    CEJ90625.1    AY752857    AAV84270.1    AXCM01021675    CH933807    EDW12627.1    JTDY01001944    KOB72483.1    AY792954    AAX33734.1    GQ398048    ACV07665.1    FJ839338    ACR61319.1    U52359    AAA97479.1    CEJ92324.1    AXCM01007963    AF012809    AAB66878.1    CH478086    X64363    AF487426    AF508783    X64362    CH477469    FX985313    BAX07326.1    EZ933290    ADJ57671.1    ATLV01018235    KE525226    KFB42847.1    KFB42848.1    ATLV01018234    KFB42844.1    KQ434869    KZC09267.1    AY752851    AAV84264.1    KY661306    AVA17393.1    FJ839343    ACR61324.1    JXUM01032511    KQ560958    KXJ80213.1    NNBP01000013    PJN38624.1    KQ971339    EFA02919.1    EAT37858.1    JXUM01043731    KQ561373    KXJ78808.1    FJ839345    ACR61326.1    CH940649    EDW64699.1    EDW12624.1    CDPU01000050    CEO55277.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    + More
UP000037510    UP000076407    UP000007062    UP000039046    UP000075882    UP000075902    UP000075840    UP000075903    UP000075901    UP000075881    UP000075885    UP000008820    UP000075883    UP000009192    UP000075900    UP000030765    UP000076502    UP000069940    UP000249989    UP000231976    UP000007266    UP000002358    UP000008792   

PRIDE

H9IUB1    P35035    H9JW07    P35036    P35041    P29787    + More
P29786   

Pfam

PF00089   Trypsin

Interpro

IPR001254   Trypsin_dom        + More
IPR018114   TRYPSIN_HIS       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR012224   Pept_S1A_FX       
IPR033116   TRYPSIN_SER       

SUPFAM

SSF50494   SSF50494       

CDD

cd00190  Tryp_SPc

ProteinModelPortal

H9IUB0   A0A2H1WLN2   A0A2A4K471   A0A3S2LFV6   A0A2A4K3K4   A0A2A4K3J2   + More
H9IUB1   A0A194PDK1   A0A0N1PJX5   A0A212FPE2   A0A0L7KY81   A0A194PEH2   A0A194PCY4   A0A194QL10   A0A0N1IQS6   A0A212EWZ2   A0A2H1X0F7   A0A194PDG5   A0A1Y9J180   P35035   A0A0A1TPQ4   A0A194RI37   A0A2C9GTY9   A0A182U9U3   A0A1Y9GKU7   A0A182TKI7   P35037   A0A1Y9GLX5   A0A182VG56   A0A1S4GXU9   H9JW07   A0A182T760   A0A182V8D5   A0A182TJQ8   A0A1Y9J0J4   A0A1Y9GKV0   P35036   A0A1Y9J184   A0A182VGJ0   A0A2C9GTQ1   L0ATN6   A0A182KHH7   A0A240PL34   A0A0A1T583   P35041   A0A2P0XIZ8   F6JSA6   A0A182V8R1   A0A182ICF6   A0A182T724   A0A182XL71   Q16TM1   A0A182U4C7   A0A0A1TJ15   A0A2C9GTS0   A0A182L0V6   Q5QBF4   A0A182M8Z6   B4KK96   A0A0L7LAG0   Q1M0X9   C8CGF6   C5IBE8   A0A1Y9HES5   Q17086   A0A0A1TC23   A0A182MJH4   A0A1Y9GLA7   A0A1Y9J0S1   O16133   A0A2C9GTS6   P29787   P29786-2   P35038   A0A1V1G554   A0A1Y9IS50   A0A240PM69   A0A240PKC7   F4MI42   A0A084VY03   A0A084VY04   A0A084VY00   A0A2K7P6D6   A0A154PBT0   Q5QBG0   A0A2P0XIE9   C5IBF3   A0A182HBG3   P29786   A0A2M9M4T8   A0A240PL37   D2A2R7   Q16TL9   A0A182G5M7   C5IBF5   K7J8G1   B4LRU7   B4KK93   A0A0B7KIN4  

PDB

1UTM     E-value=1.80857e-27,     Score=303

KEGG

101746664    K09640 transmembrane protease serine 9 [EC:3.4.21.-] | (RefSeq) transmembrane protease serine 9-like

GO

GO:0004252   GO:0007596   GO:0005509   GO:0016021   GO:0005576   GO:0007586   GO:0008236   GO:0005615   GO:0006508   GO:0033177   GO:0033179   GO:0015450   GO:0005737   GO:0005488   GO:0022891   GO:0003707   GO:0051537  

Subcellular location

Secreted  
  

SignalP

Position:   1 - 23,         Likelihood:  0.943490

 

 

Length:

273

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

15.9279

Exp number, first 60 AAs:

15.68355

Total prob of N-in:

0.77176

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  273

 

 

Pi

189.503383

Theta

160.047429

Tajima's D

1.265117

CLR

0

CSRT

0.729713514324284

Interpretation

Uncertain