Gene

KWMTBOMO07619  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA001302

Annotation

vacuolar_H+_ATP_synthase_16_kDa_proteolipid_subunit_[Bombyx_mori]

Location

Bomo_Chr13(-):1809828-1813599      View in EpiBrowser

Full name

V-type proton ATPase proteolipid subunit       + More
V-type proton ATPase 16 kDa proteolipid subunit      

Alternative Name

Ductin
Vacuolar H+ ATPase subunit 16-1
Vacuolar proton pump 16 kDa proteolipid subunit
V-ATPase subunit C

Location in the cell

PlasmaMembrane   Reliability : 3.285

CDS

ATGGCTGAAAATAATCCAATCTACGGACCCTTCTTTGGAGTTATGGGGGCGGCGTCTGCTATCATCTTCAGCGCCTTGGGAGCTGCCTATGGAACTGCCAAGTCAGGAACTGGTATTGCCGCCATGTCGGTGATGAGGCCTGAGCTGATCATGAAGTCGATCATTCCTGTCGTCATGGCGGGTATTATTGCCATCTACGGTCTGGTCGTGGCTGTCCTGATTGCTGGTGCCCTCCAGGAGCCAGCCAACTACCCCCTTTACAAAGGGTTCATCCACTTGGGTGCTGGTTTGGCTGTAGGATTCTCTGGTCTGGCTGCCGGTTTCGCCATAGGCATCGTGGGAGATGCAGGCGTGCGTGGTACTGCTCAGCAGCCTAGGAGAGAACATTTCTTTTGCGATTTCTATCGACATATCAGTTTTATTTGCGCGTCACATCCTCCGCAACATCCGAAGATATCAATTTAG

Protein

MAENNPIYGPFFGVMGAASAIIFSALGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIAGALQEPANYPLYKGFIHLGAGLAVGFSGLAAGFAIGIVGDAGVRGTAQQPRREHFFCDFYRHISFICASHPPQHPKISI

Description

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore).

Similarity

Belongs to the V-ATPase proteolipid subunit family.

Keywords

Complete proteome   Hydrogen ion transport   Ion transport   Membrane   Reference proteome   Transmembrane   Transmembrane helix   Transport   Vacuole  

Feature

chain  V-type proton ATPase 16 kDa proteolipid subunit

Uniprot

Q1HQ99   H9IVM2   A0A0P6ILY8   C4WUM0   A0A2H8TS11   D3TLH1   + More
A0A1B0B1W5   A0A1B0AG93   B4MNV1   A0A2S2P2C6   A0A2M3ZZD6   A0A2M3ZZN9   A0A212F2W5   C4N183   A0A1L8EC69   B4HPV5   B4QD96   A0A1W4VEK7   B3NB54   Q6XI23   P23380   A0A0C9R1H6   I3SJ61   A0A1A9WR00   T1PLX2   X2JC18   A0A3S2M6Z7   A0A2M4A0G7   B3MJ49   W8BRX6   A0A0L0BTS7   T1EAH2   A0A1L8EBZ1   W5JPD7   A0A182J6H0   A0A0K8W669   A0A2M3ZFE7   A0A2M4CJ79   B4LIM5   A0A182P7K6   A0A1Q3FGG5   B0WV62   A0A3B0JL22   A0A1L8DEL5   A8CW60   A0A084WUD4   A0A0A1WRA4   Q28WX5   B4H648   K7J0V3   A0A182YAC2   A0A1S4HCY4   A0A182MKJ3   A0A182QUX3   A0A182WE75   A0A182WXZ1   A0A182FKH1   A0A182RLU4   A0A182I611   A0A182KV05   A0A0M3QVN1   A0A0V0G4Y9   A0A023EFX1   O16110   A0A182NPA9   B4KUH4   A0A232F3Y2   T1DFC6   B4JVQ7   A0A2A4K4J7   A0A2H1VDA2   P55277   A0A1J1IVZ0   A0A2P8ZLX1   R4WNW2   A0A2A3EM58   V9IJP6   Q7YU97   A0A1Y1MP75   P31403   A0A0F7R686   A0A1B1UZP2   A0A1B6MT49   A0A161MMG9   A6YPQ9   A0A2R7X2K5   U5EUW8   A0A164R4R3   I4DM45   A0A194QRB6   A0A0P5I7A0   A0A0P5I961   A0A0N7Z9I6   R4FMV1   A0A069DP10   I4DIU8   Q5QBF6   A0A0P6B0I0   A0A146MBB5   D6X4W4  

Pubmed

19121390    20353571    17994087    22118469    19576987    22936249    + More
18057021    14525923    17550304    2147478    7983150    10731132    12537572    25315136    24528536    24495485    26108605    20920257    23761445    18194529    24438588    25830018    15632085    20075255    25244985    12364791    20966253    24945155    9397516    17510324    28648823    24330624    8353524    29403074    23691247    28004739    1283142    25937057    18207082    22651552    26354079    27129103    26334808    26823975    18362917    19820115   

EMBL

DQ443153    EU082222    ABF51242.1    ABU62758.1    BABH01001468    GDIQ01002357    + More
JAN92380.1    ABLF02023936    AK341125    BAH71590.1    GFXV01004577    MBW16382.1    EZ422273    ADD18549.1    JXJN01007356    CH963848    EDW73790.1    GGMR01010915    MBY23534.1    GGFK01000603    MBW33924.1    GGFK01000599    MBW33920.1    AGBW02010668    OWR48076.1    EZ048856    ACN69148.1    GFDG01002676    JAV16123.1    CH480816    EDW46624.1    CM000362    CM002911    EDX05883.1    KMY91746.1    CH954177    EDV59819.1    AY232009    CM000157    AAR10032.1    EDW89055.1    X55979    X77936    AE013599    BT012440    GBYB01006717    JAG76484.1    BT140508    AFK40303.1    KA649782    KA649787    AFP64411.1    KJ135006    AHN55086.1    RSAL01000017    RVE52907.1    GGFK01000928    MBW34249.1    CH902619    EDV38143.1    KPU77290.1    GAMC01010544    JAB96011.1    JRES01001352    KNC23406.1    GAMD01001038    JAB00553.1    GFDG01002677    JAV16122.1    ADMH02000484    ETN66257.1    AXCP01005913    GDHF01005752    JAI46562.1    GGFM01006454    MBW27205.1    GGFL01001209    MBW65387.1    CH940648    EDW60395.1    GFDL01008397    JAV26648.1    DS232119    EDS35401.1    OUUW01000001    SPP73341.1    GFDF01009198    JAV04886.1    AJWK01011218    EU124586    ABV60304.1    ATLV01027079    KE525423    KFB53828.1    GBXI01012950    JAD01342.1    CM000071    EAL26541.1    CH479213    EDW33272.1    AAAB01008848    AXCM01001138    AXCN02001819    APCN01003544    APCN01003545    CP012524    ALC42683.1    GECL01003682    JAP02442.1    GAPW01005356    GEHC01001278    JAC08242.1    JAV46367.1    AF008924    CH477190    CH933808    EDW10761.1    NNAY01001086    OXU25188.1    GALA01000672    JAA94180.1    CH916375    EDV98045.1    NWSH01000168    PCG78834.1    ODYU01001899    SOQ38756.1    L16884    CVRI01000063    CRL04443.1    PYGN01000019    PSN57498.1    AK417356    BAN20571.1    KZ288219    PBC32249.1    JR049151    AEY60877.1    AY343324    AAQ21381.1    GEZM01025401    JAV87473.1    X65051    LC026147    BAR72392.1    KU550965    GDQN01003206    ANW09711.1    JAT87848.1    GEBQ01000912    JAT39065.1    GEMB01004294    JAR98978.1    EF639070    ABR27955.1    KK856546    PTY25996.1    GANO01002140    JAB57731.1    LRGB01002230    KZS08322.1    AK402363    BAM18985.1    KQ461198    KPJ06076.1    GDIQ01216823    JAK34902.1    GDIQ01216822    JAK34903.1    GDKW01000443    JAI56152.1    ACPB03011456    GAHY01000823    JAA76687.1    GBGD01003304    JAC85585.1    AK401216    KQ459606    BAM17838.1    KPI91084.1    AY752855    UFQS01000292    UFQT01000292    AAV84268.1    SSX02511.1    SSX22885.1    GDIP01022184    JAM81531.1    GDHC01001558    JAQ17071.1    KQ971381    EEZ97227.1   

Proteomes

UP000005204    UP000007819    UP000092460    UP000092445    UP000007798    UP000007151    + More
UP000095300    UP000001292    UP000000304    UP000192221    UP000008711    UP000002282    UP000000803    UP000091820    UP000095301    UP000283053    UP000007801    UP000037069    UP000000673    UP000075880    UP000008792    UP000075885    UP000002320    UP000268350    UP000092461    UP000030765    UP000001819    UP000008744    UP000002358    UP000076408    UP000075883    UP000075886    UP000075920    UP000076407    UP000069272    UP000075900    UP000075840    UP000075882    UP000092553    UP000008820    UP000075884    UP000009192    UP000215335    UP000001070    UP000218220    UP000183832    UP000245037    UP000242457    UP000005203    UP000076858    UP000053240    UP000015103    UP000053268    UP000007266   

PRIDE

Q1HQ99    H9IVM2    P23380   

Pfam

PF00137   ATP-synt_C

Interpro

IPR002379   ATPase_proteolipid_c-like_dom        + More
IPR011555   ATPase_proteolipid_su_C_euk       
IPR000245   ATPase_proteolipid_csu       
IPR035921   F/V-ATP_Csub_sf       

SUPFAM

SSF81333   SSF81333       

ProteinModelPortal

Q1HQ99   H9IVM2   A0A0P6ILY8   C4WUM0   A0A2H8TS11   D3TLH1   + More
A0A1B0B1W5   A0A1B0AG93   B4MNV1   A0A2S2P2C6   A0A2M3ZZD6   A0A2M3ZZN9   A0A212F2W5   C4N183   A0A1L8EC69   B4HPV5   B4QD96   A0A1W4VEK7   B3NB54   Q6XI23   P23380   A0A0C9R1H6   I3SJ61   A0A1A9WR00   T1PLX2   X2JC18   A0A3S2M6Z7   A0A2M4A0G7   B3MJ49   W8BRX6   A0A0L0BTS7   T1EAH2   A0A1L8EBZ1   W5JPD7   A0A182J6H0   A0A0K8W669   A0A2M3ZFE7   A0A2M4CJ79   B4LIM5   A0A182P7K6   A0A1Q3FGG5   B0WV62   A0A3B0JL22   A0A1L8DEL5   A8CW60   A0A084WUD4   A0A0A1WRA4   Q28WX5   B4H648   K7J0V3   A0A182YAC2   A0A1S4HCY4   A0A182MKJ3   A0A182QUX3   A0A182WE75   A0A182WXZ1   A0A182FKH1   A0A182RLU4   A0A182I611   A0A182KV05   A0A0M3QVN1   A0A0V0G4Y9   A0A023EFX1   O16110   A0A182NPA9   B4KUH4   A0A232F3Y2   T1DFC6   B4JVQ7   A0A2A4K4J7   A0A2H1VDA2   P55277   A0A1J1IVZ0   A0A2P8ZLX1   R4WNW2   A0A2A3EM58   V9IJP6   Q7YU97   A0A1Y1MP75   P31403   A0A0F7R686   A0A1B1UZP2   A0A1B6MT49   A0A161MMG9   A6YPQ9   A0A2R7X2K5   U5EUW8   A0A164R4R3   I4DM45   A0A194QRB6   A0A0P5I7A0   A0A0P5I961   A0A0N7Z9I6   R4FMV1   A0A069DP10   I4DIU8   Q5QBF6   A0A0P6B0I0   A0A146MBB5   D6X4W4  

PDB

6O7X     E-value=7.64276e-37,     Score=380

KEGG

778463    K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit | (RefSeq) VATPc; vacuolar H+ ATP syn

PATHWAY

00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)
04145    Phagosome - Bombyx mori (domestic silkworm)

GO

GO:0015991   GO:0016021   GO:0033179   GO:0015078   GO:0005774   GO:0033227   GO:0033181   GO:0045169   GO:0000220   GO:0016787   GO:0046961   GO:0033177   GO:0015450   GO:0005737   GO:0005488   GO:0022891   GO:0003707   GO:0051537  

Subcellular location

Vacuole membrane  

Length:

154

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

68.75188

Exp number, first 60 AAs:

30.22545

Total prob of N-in:

0.06610

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  52

TMhelix

53  -  75

outside

76  -  89

TMhelix

90  -  112

inside

113  -  154

 

 

Pi

187.176465

Theta

171.733007

Tajima's D

-0.911383

CLR

0.088495

CSRT

0.151442427878606

Interpretation

Uncertain