Gene

KWMTBOMO07552

Annotation

PREDICTED:_acetylcholine_receptor_subunit_beta-like_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr12(+):17314307-17316131      View in EpiBrowser

Full name

Neuronal acetylcholine receptor subunit beta-3      

Location in the cell

PlasmaMembrane   Reliability : 3.658

CDS

ATGTCGACGACTTATATTATTCTGTTACCGTTTCTCCTCACTTGTGCTATAGCTAGTGCGGCAGAATGCGAAAACGCAACATCACTGTCCCTCATGATCGACTCGCTCCTCGCAACGTACGATCGGGAGTCTCCCCCCGACTCCAAAATCGTAGTCAACCTGACCCTGCATTTGAGACATGCTAACATTCGTGAGTCCGAGTCCACCGTGCGGATACTGGCAGATCTTCAAATGAATTGGATCGACAAACGACTGAGTTGGAACGCAGGGGAGTGGGGCTGCAGCACTTGGCTGGTGTCCTCGGAACGCTTGTGGAGGCCTGACGTGGTACTGCTAAACGCGGCTGCAACCACCGCCGGGGACTACGCTCTCCGCGCCCGTGTATCTAATAACGGCTCCGTCTCCTGGATAAAGCGCTTGGACATTAGCACTCCAATTTCTATGCAGTTAGACAATTGGCCCAACGACATGCAGACTTGCACGTTCAAGTTCGGTTCTAGGATGCACAATAGTGACGAAATGGATTTCGTGATTGACAAAAGAATATACAGTATGTTCGAGTCAGGAGCGTGGGATGTGACGGATCTGTCCAGTGCGGTGCAGAGCCAGGACCGTGGCGAGGTGGAAGCTCGCGTGGCAATGTTCCAGATGTCTTTCCGGAGACGCGCCCCGGCACACGCGCTGGCGGCCGGCGCCGTGTTCGCCGTGGTGCTCCTGCTTCTGCTCTCCGCGGCTGCTTTGCCGCCCGCCACTAGACCACCACTAGCTGCGGTTTCCGCGTTCATCTCTATATTATGGTAA

Protein

MSTTYIILLPFLLTCAIASAAECENATSLSLMIDSLLATYDRESPPDSKIVVNLTLHLRHANIRESESTVRILADLQMNWIDKRLSWNAGEWGCSTWLVSSERLWRPDVVLLNAAATTAGDYALRARVSNNGSVSWIKRLDISTPISMQLDNWPNDMQTCTFKFGSRMHNSDEMDFVIDKRIYSMFESGAWDVTDLSSAVQSQDRGEVEARVAMFQMSFRRRAPAHALAAGAVFAVVLLLLLSAAALPPATRPPLAAVSAFISILW

Subunit

Neuronal AChR seems to be composed of two different type of subunits: alpha and beta.

Similarity

Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily.

Keywords

Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Membrane   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Neuronal acetylcholine receptor subunit beta-3

Uniprot

A0A2A4JFJ2   A0A2W1BVW0   A0A2H1WEZ3   A0A0N1PJ48   A0A194Q0G4   A0A212F671   + More
A0A1Y1NJU4   A0A1Y1NKW9   A0A1Y1NMS6   A0A1Y1NPL4   A0A1W0XDC2   A0A1L8HVH3   A0A1L8HMK0   Q7SY88   F6SXB7   A0A1V4IPX5   A0A3L8S724   A0A091ET85   H0YPN6   F7ERN7   A0A0N8EUK3   A0A3M0LBB1   U3JRK0   A0A0P5ZWE4   A0A218U9E0   A0A0P5DV07   A0A0P5DY03   A0A0P6EYJ8   A0A0P6DDZ3   A0A162RQU1   A0A0P5VZZ8   A0A0P6C4D2   A0A0P5MM38   A0A0P5P565   P43679   A0A0P5TWZ0   A0A093KC27   A0A3Q1ENF7   A0A2R7WVN7   A0A226NZR0   F1NKI4   A0A3Q3AFM3   A0A093H1D7   A0A091LIL1   A0A3Q3FQK2   E4X6V2   A0A091SJK1   A0A2T7NKI4   A0A091G9F5   R0JWV6   A0A2I0UNG1   A0A087V9P6   U3IZH8   A0A093BZJ4   A0A3B4UQK9   A0A091WGP0   H3D6I8   Q4S3I3   H3C655   A0A091J8V6   A0A091NGN2   A0A099ZJ61   A0A093TLB2   H3D6I7   F6STM8  

Pubmed

28756777    26354079    22118469    28004739    27762356    20431018    + More
30282656    20360741    7852408    24621616    15592404    21097902    23749191    15496914   

EMBL

NWSH01001652    PCG70536.1    KZ149931    PZC77337.1    ODYU01008237    SOQ51655.1    + More
KQ460642    KPJ13338.1    KQ459592    KPI96905.1    AGBW02010072    OWR49240.1    GEZM01001091    GEZM01001090    JAV98161.1    GEZM01001086    JAV98168.1    GEZM01001089    JAV98165.1    GEZM01001087    JAV98167.1    MTYJ01000002    OQV25479.1    CM004466    OCU00097.1    CM004467    OCT97323.1    BC054966    AAH54966.1    AAMC01130387    LSYS01009690    OPJ61976.1    QUSF01000046    RLV98058.1    KK718913    KFO59807.1    ABQF01041674    ABQF01041675    ABQF01041676    AAMC01035410    AAMC01035411    AAMC01035412    GEBF01001339    JAO02294.1    QRBI01000092    RMC22326.1    AGTO01011095    GDIP01038451    JAM65264.1    MUZQ01000560    OWK50377.1    GDIP01168234    JAJ55168.1    GDIP01167383    JAJ56019.1    GDIQ01063743    JAN30994.1    GDIQ01078599    JAN16138.1    LRGB01000117    KZS20709.1    GDIP01093733    JAM09982.1    GDIP01007171    JAM96544.1    GDIQ01156202    JAK95523.1    GDIQ01143405    JAL08321.1    X83739    GDIP01123270    JAL80444.1    KL206979    KFV87829.1    KK855707    PTY23614.1    AWGT02000249    OXB72840.1    AC186840    KL217254    KFV75476.1    KK753910    KFP42696.1    FN653027    CBY08040.1    KK473233    KFQ58190.1    PZQS01000011    PVD21671.1    KL447973    KFO79005.1    KB743048    EOB01747.1    KZ505675    PKU47567.1    KL485114    KFO09338.1    ADON01069214    ADON01069215    ADON01069216    ADON01069217    ADON01069218    ADON01069219    ADON01069220    ADON01069221    ADON01069222    ADON01069223    KL455804    KFV09095.1    KK735479    KFR14310.1    CAAE01014749    CAG04799.1    KK501561    KFP16155.1    KL382304    KFP88147.1    KL893558    KGL80978.1    KL444379    KFW95029.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000186698    UP000008143    + More
UP000190648    UP000276834    UP000052976    UP000007754    UP000269221    UP000016665    UP000197619    UP000076858    UP000000539    UP000053584    UP000257200    UP000198419    UP000264800    UP000053875    UP000245119    UP000053760    UP000016666    UP000261420    UP000053605    UP000007303    UP000053119    UP000053641    UP000008225   

Pfam

PF02931   Neur_chan_LBD        + More
PF02932   Neur_chan_memb

Interpro

IPR006202   Neur_chan_lig-bd        + More
IPR036734   Neur_chan_lig-bd_sf       
IPR006201   Neur_channel       
IPR036719   Neuro-gated_channel_TM_sf       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006029   Neurotrans-gated_channel_TM       
IPR002394   Nicotinic_acetylcholine_rcpt       

SUPFAM

SSF63712   SSF63712        + More
SSF90112   SSF90112       

Gene 3D

2.70.170.10    

ProteinModelPortal

A0A2A4JFJ2   A0A2W1BVW0   A0A2H1WEZ3   A0A0N1PJ48   A0A194Q0G4   A0A212F671   + More
A0A1Y1NJU4   A0A1Y1NKW9   A0A1Y1NMS6   A0A1Y1NPL4   A0A1W0XDC2   A0A1L8HVH3   A0A1L8HMK0   Q7SY88   F6SXB7   A0A1V4IPX5   A0A3L8S724   A0A091ET85   H0YPN6   F7ERN7   A0A0N8EUK3   A0A3M0LBB1   U3JRK0   A0A0P5ZWE4   A0A218U9E0   A0A0P5DV07   A0A0P5DY03   A0A0P6EYJ8   A0A0P6DDZ3   A0A162RQU1   A0A0P5VZZ8   A0A0P6C4D2   A0A0P5MM38   A0A0P5P565   P43679   A0A0P5TWZ0   A0A093KC27   A0A3Q1ENF7   A0A2R7WVN7   A0A226NZR0   F1NKI4   A0A3Q3AFM3   A0A093H1D7   A0A091LIL1   A0A3Q3FQK2   E4X6V2   A0A091SJK1   A0A2T7NKI4   A0A091G9F5   R0JWV6   A0A2I0UNG1   A0A087V9P6   U3IZH8   A0A093BZJ4   A0A3B4UQK9   A0A091WGP0   H3D6I8   Q4S3I3   H3C655   A0A091J8V6   A0A091NGN2   A0A099ZJ61   A0A093TLB2   H3D6I7   F6STM8  

PDB

2BG9     E-value=1.30591e-11,     Score=166

KEGG

101737252    no KO assigned | (RefSeq) uncharacterized LOC101737252

GO

GO:0005230   GO:0004888   GO:0016021   GO:0030054   GO:0045211   GO:0022848   GO:0005887   GO:0045202   GO:0035094   GO:0043005   GO:0005892   GO:0007165   GO:0042391   GO:0007274   GO:0007271   GO:0007268   GO:0034220   GO:0050877   GO:0006811   GO:0015464   GO:2000300   GO:0098691   GO:0060084   GO:0006810   GO:0016020   GO:0004190   GO:0006508   GO:0015914   GO:0003707   GO:0051537  

PANTHER

PTHR18945  

Subcellular location

Cell junction  
Synapse  
Postsynaptic cell membrane  
Cell membrane  

SignalP

Position:   1 - 20,         Likelihood:  0.992066

 

 

Length:

266

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

32.63657

Exp number, first 60 AAs:

10.15126

Total prob of N-in:

0.31790

POSSIBLE N-term signal

sequence

inside

1  -  224

TMhelix

225  -  247

outside

248  -  266

 

 

Pi

13.443146

Theta

13.415815

Tajima's D

0.035118

CLR

0.075769

CSRT

0.388530573471326

Interpretation

Uncertain