Gene

KWMTBOMO07527

Pre Gene Modal

BGIBMGA005886

Annotation

hypothetical_protein_KGM_22692_[Danaus_plexippus]

Location

Bomo_Chr12(+):15936374-15939582      View in EpiBrowser

Full name

Parkin coregulated gene protein       + More
DNA-directed RNA polymerase subunit      

Alternative Name

Molecular chaperone/chaperonin-binding protein
PARK2 coregulated gene protein

Location in the cell

Nuclear   Reliability : 1.09

CDS

ATGATTGTGACGGGGTCTGATAGGGTTGGTGAAGCCCTTGTCCCTTACTACAGACAGATCCTACCGGTATTAAACTTGTTTAAGGACAGAAATCGAAACATGGGGTCCGGTATCGATCACACGACGACGAGGGGCGAGAACGTTGGCGACCTCATCGAGGACACGCTGCAGATATTGGAACGCTACGGTGGTCCGGACGCATTCATAAACATTAAATACATGATACCGACCTACGAGTCTTGCGTTTTGAATTAG

Protein

MIVTGSDRVGEALVPYYRQILPVLNLFKDRNRNMGSGIDHTTTRGENVGDLIEDTLQILERYGGPDAFINIKYMIPTYESCVLN

Description

Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic Activity

a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)

Subunit

Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PRKN, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 (By similarity).

Miscellaneous

Linked to PRKN in a head-to-head arrangement on opposite DNA strands and share a common 5'-flanking promoter region.

Similarity

Belongs to the RNA polymerase beta' chain family.

Keywords

Alternative splicing   Complete proteome   Reference proteome  

Feature

chain  Parkin coregulated gene protein
splice variant  In isoform 2.

Uniprot

A0A3S2NFB9   A0A2A4K6M3   H9J8P4   A0A212EVQ4   A0A0N1INV9   A0A2H1X2S1   + More
W4YW26   A0A2U3W010   A0A2Y9HI62   A7RV01   A0A3Q1JR10   A0A2B4T1S6   A0A3M6UMM7   A0A151M2E9   A0A1Y1LUQ6   A5PK71   A0A384BWS8   A0A3Q7XEL5   U6CTK6   A0A2Y9KSA0   A0A3Q7TPS3   A0A2I2V0T8   A0A1S3A5I7   A0JPP9   A0A2K6EVL2   A0A0P6JEU6   I3MFD7   A0A287AL41   U3DZF3   A0A1S3FTV5   A0A183SX25   A0A3Q3AB62   A0A232ER16   K7IYK7   A7RV02   J9IC37   A0A078AI15   A0A2Y9SIY0   A0A2K6V7T5   A0A2U4CNM9   A0A384AFM0   A0A2K5C935   A0A2Y9MLJ7   A0A1V4JL56   A0A1D2M9M2   A0A2R8Z640   Q96M98-2   A0A2I2Y7G1   A0A2J8K072   A0A2J8T972   A0A2K6DRQ1   A0A2K6JQ03   A0A2K5WXD8   A0A2K5ZVE6   A0A2I3LWK7   A0A2K6QPD7   A0A2K5ML33   F6U142   A0A1R2C2S2   A0A2I3GEX7   A0A2I0MV49   A0A2P6NE04   A0A3Q1BSW9   A0A3P8TJ37   A0A2K5RVB9   A0A2K5I6W2   A0A0N0U4D9   A0A183AKW1   R1C2J4   A0A3Q7Q238   A0A158NXU4   A0A0V0R3I2   A0A2A3EAP2   E2C1V3   A0A0M9GB55   A0A087ZRC3   K1QZ29   A0A0L7QKD4   D6WD92   X2C4Z0   A0A3L8DZ67   A0A2P8XGI5   E0VI64   A0A026X4E6   E9JCW9   E4Y293   A0A151JME0   E2B160   A0A151WIN0   R7V706   A0A0S4IYX0   E7FDS1   Q5U3Q1   A0A310SPC7   A0A0B6ZED5   A0A3Q7T454   W5UCD8   A0A0B6ZCP7   A0A1B6G4I2   A0A0J7NV06  

EC Number

2.7.7.6

Pubmed

19121390    22118469    26354079    17615350    30382153    22293439    + More
28004739    19393038    17975172    15489334    30723633    25243066    28648823    20075255    23382650    27289101    22722832    12547187    14702039    14574404    14532270    14737177    22398555    16136131    25362486    17431167    25319552    23371554    29378020    23760476    21347285    26486372    20798317    22992520    18362917    19820115    24012313    30249741    29403074    20566863    24508170    21282665    21097902    23254933    23594743    23127152   

EMBL

RSAL01000060    RVE49634.1    NWSH01000124    PCG79310.1    BABH01030300    AGBW02012150    + More
OWR45563.1    KQ460954    KPJ10262.1    ODYU01012973    SOQ59542.1    AAGJ04145293    DS469542    EDO44659.1    LSMT01000003    PFX34617.1    RCHS01001178    RMX54859.1    AKHW03006780    KYO18689.1    GEZM01049356    JAV75990.1    BC142383    AAI42384.1    HAAF01001351    CCP73177.1    AANG04000169    BC127534    AAI27535.1    GEBF01001573    JAO02060.1    AGTP01022095    AGTP01022096    AGTP01022097    AGTP01022098    AGTP01022099    AGTP01022100    AEMK02000001    DQIR01027149    HCZ82624.1    GAMS01004415    GAMR01008312    JAB18721.1    JAB25620.1    UYSU01034843    VDL95158.1    NNAY01002687    OXU20772.1    EDO44660.1    AMCR01018581    EJY68690.1    CCKQ01009656    CDW81157.1    LSYS01006902    OPJ72834.1    LJIJ01002462    ODM89668.1    AJFE02069348    AJFE02069349    AJFE02069350    AJFE02069351    AJFE02069352    AJFE02069353    AJFE02069354    AJFE02069355    AJFE02069356    AJFE02069357    AF546872    AK057286    AL031121    AL137182    AL354942    AP001576    AL078585    AL590286    AL603788    CH471051    BC030642    BC044227    BK001670    CABD030048866    CABD030048867    CABD030048868    CABD030048869    CABD030048870    CABD030048871    CABD030048872    CABD030048873    CABD030048874    CABD030048875    AACZ04028762    NBAG03000405    PNI28382.1    PNI28383.1    ABGA01224050    ABGA01224051    ABGA01224052    ABGA01224053    ABGA01224054    ABGA01224055    ABGA01224056    ABGA01224057    ABGA01224058    ABGA01224059    NDHI03003515    PNJ29560.1    PNJ29561.1    AQIA01049284    AQIA01049285    AQIA01049286    AHZZ02026040    AHZZ02026041    AHZZ02026042    AHZZ02026043    AHZZ02026044    JSUE03032586    JSUE03032587    JSUE03032588    JSUE03032589    JSUE03032590    JSUE03032591    JSUE03032592    JSUE03032593    JU320398    JV045526    AFE64154.1    AFI35597.1    MPUH01000308    OMJ83318.1    ADFV01068177    ADFV01068178    ADFV01068179    ADFV01068180    ADFV01068181    ADFV01068182    ADFV01068183    ADFV01068184    ADFV01068185    ADFV01068186    AKCR02000002    PKK33558.1    MDYQ01000109    PRP82165.1    KQ435827    KOX71971.1    UZAN01044822    VDP81536.1    KB866687    EOD16768.1    ADTU01003549    LDAU01000055    KRX09037.1    KZ288322    PBC28131.1    GL452008    EFN78065.1    LGTL01000001    KPA86579.1    JH816987    EKC36429.1    KQ414954    KOC59074.1    KQ971321    EEZ99529.1    KC543636    AGG11648.1    QOIP01000003    RLU25098.1    PYGN01002220    PSN31095.1    DS235184    EEB13070.1    KK107013    EZA62906.1    GL771866    EFZ09334.1    FN653788    CBY15987.1    KQ978931    KYN27460.1    GL444789    EFN60584.1    KQ983089    KYQ47684.1    AMQN01004920    KB294684    ELU14217.1    CYKH01000900    CUG61013.1    BX927104    BX936463    BC085440    BC165063    AAH85440.1    AAI65063.1    KQ762196    OAD56128.1    HACG01019361    CEK66226.1    JT411686    AHH39555.1    HACG01019362    CEK66227.1    GECZ01012432    JAS57337.1    LBMM01001488    KMQ96225.1   

Proteomes

UP000283053    UP000218220    UP000005204    UP000007151    UP000053240    UP000007110    + More
UP000245340    UP000248481    UP000001593    UP000265040    UP000225706    UP000275408    UP000050525    UP000009136    UP000261680    UP000286642    UP000248482    UP000286640    UP000011712    UP000079721    UP000233160    UP000005215    UP000008227    UP000008225    UP000081671    UP000050788    UP000275846    UP000264800    UP000215335    UP000002358    UP000248484    UP000233220    UP000245320    UP000261681    UP000233020    UP000248483    UP000190648    UP000094527    UP000240080    UP000005640    UP000001519    UP000002277    UP000001595    UP000233120    UP000233180    UP000233100    UP000233140    UP000028761    UP000233200    UP000233060    UP000006718    UP000001073    UP000053872    UP000241769    UP000257160    UP000265080    UP000233040    UP000233080    UP000053105    UP000050740    UP000013827    UP000286641    UP000005205    UP000242457    UP000008237    UP000005203    UP000005408    UP000053825    UP000007266    UP000279307    UP000245037    UP000009046    UP000053097    UP000078492    UP000000311    UP000075809    UP000014760    UP000000437    UP000221080    UP000036403   

PRIDE

H9J8P4    A0JPP9    Q96M98   

Pfam

PF10274   ParcG        + More
PF00454   PI3_PI4_kinase
PF00623   RNA_pol_Rpb1_2
PF04997   RNA_pol_Rpb1_1
PF04998   RNA_pol_Rpb1_5
PF04983   RNA_pol_Rpb1_3
PF05000   RNA_pol_Rpb1_4

Interpro

IPR019399   Parkin_co-regulated_protein        + More
IPR016024   ARM-type_fold       
IPR039756   Lsb6/PI4K2       
IPR000403   PI3/4_kinase_cat_dom       
IPR018936   PI3/4_kinase_CS       
IPR007083   RNA_pol_Rpb1_4       
IPR035697   RNAP_III_RPC1_N       
IPR042102   RNA_pol_Rpb1_3_sf       
IPR007066   RNA_pol_Rpb1_3       
IPR006592   RNA_pol_N       
IPR000722   RNA_pol_asu       
IPR038120   Rpb1_funnel_sf       
IPR007081   RNA_pol_Rpb1_5       
IPR007080   RNA_pol_Rpb1_1       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.10.132.30     1.10.274.100    

CDD

cd02583  RNAP_III_RPC1_N

ProteinModelPortal

A0A3S2NFB9   A0A2A4K6M3   H9J8P4   A0A212EVQ4   A0A0N1INV9   A0A2H1X2S1   + More
W4YW26   A0A2U3W010   A0A2Y9HI62   A7RV01   A0A3Q1JR10   A0A2B4T1S6   A0A3M6UMM7   A0A151M2E9   A0A1Y1LUQ6   A5PK71   A0A384BWS8   A0A3Q7XEL5   U6CTK6   A0A2Y9KSA0   A0A3Q7TPS3   A0A2I2V0T8   A0A1S3A5I7   A0JPP9   A0A2K6EVL2   A0A0P6JEU6   I3MFD7   A0A287AL41   U3DZF3   A0A1S3FTV5   A0A183SX25   A0A3Q3AB62   A0A232ER16   K7IYK7   A7RV02   J9IC37   A0A078AI15   A0A2Y9SIY0   A0A2K6V7T5   A0A2U4CNM9   A0A384AFM0   A0A2K5C935   A0A2Y9MLJ7   A0A1V4JL56   A0A1D2M9M2   A0A2R8Z640   Q96M98-2   A0A2I2Y7G1   A0A2J8K072   A0A2J8T972   A0A2K6DRQ1   A0A2K6JQ03   A0A2K5WXD8   A0A2K5ZVE6   A0A2I3LWK7   A0A2K6QPD7   A0A2K5ML33   F6U142   A0A1R2C2S2   A0A2I3GEX7   A0A2I0MV49   A0A2P6NE04   A0A3Q1BSW9   A0A3P8TJ37   A0A2K5RVB9   A0A2K5I6W2   A0A0N0U4D9   A0A183AKW1   R1C2J4   A0A3Q7Q238   A0A158NXU4   A0A0V0R3I2   A0A2A3EAP2   E2C1V3   A0A0M9GB55   A0A087ZRC3   K1QZ29   A0A0L7QKD4   D6WD92   X2C4Z0   A0A3L8DZ67   A0A2P8XGI5   E0VI64   A0A026X4E6   E9JCW9   E4Y293   A0A151JME0   E2B160   A0A151WIN0   R7V706   A0A0S4IYX0   E7FDS1   Q5U3Q1   A0A310SPC7   A0A0B6ZED5   A0A3Q7T454   W5UCD8   A0A0B6ZCP7   A0A1B6G4I2   A0A0J7NV06  

KEGG

101740861    no KO assigned | (RefSeq) parkin coregulated gene protein homolog

GO

GO:0043005   GO:0031982   GO:0060548   GO:0030544   GO:0005829   GO:0051879   GO:0051087   GO:0043014   GO:0031625   GO:0048487   GO:0007286   GO:0003779   GO:0044297   GO:0097225   GO:0001664   GO:0005524   GO:0004430   GO:0034620   GO:0005634   GO:0031072   GO:0003677   GO:0003899   GO:0006351  

PANTHER

PTHR21207   PTHR12865  

Length:

84

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01272

Exp number, first 60 AAs:

0.0123

Total prob of N-in:

0.28478

outside

1  -  84

 

 

Pi

27.707754

Theta

30.33345

Tajima's D

-0.739016

CLR

0.228423

CSRT

0.184590770461477

Interpretation

Uncertain