Gene

KWMTBOMO07521

Pre Gene Modal

BGIBMGA005885

Annotation

PREDICTED:_poly(ADP-ribose)_glycohydrolase_[Bombyx_mori]

Location

Bomo_Chr12(+):15389508-15398721      View in EpiBrowser

Full name

Poly(ADP-ribose) glycohydrolase      

Location in the cell

Nuclear   Reliability : 3.504

CDS

ATGAGTACAGTAACTAAAAGCTGGCTCGGAGTACCCATTAGCGAAATACGCGGTTCCCAATCGCCGTGGGGTGCTCCAGAATTTCCGTTAGTGGTGCCAGCATACAATCATTCCGTTTTGTATCACGTGCAGAACGGTAGACCGATTGATGGAGACAGACCGCCAAAACCGCAGATAGGACGTGATAAGTGGGATCATGAGTTTGTAAGGATGCCGTGTTCAAATCAGAGCCTTTATCCATTTGAAGATAGCAACGGTGATTGCCACTTGAAAAAGAGATGGGAGGTTATAGAGAGTAGTCTCTGGAAACCTATCAGGGACAGTCGGGAACTGGCTAACACTATACTCAGCTACAATACAAAGTTTAAGAAAATATGGAAATTCAAAGCCTTACACAAATTGTTCAGTGAATATCTAGATGAAGAAGAAACACAATACTTCTTTGATGTTACATTACCTGAGATAGCGAAGTTAGCGTTGGCATTGCCAAAATTGATTCAGTCACCCATACCACTACTGAAACAACACAAGAACTATTCTATATCGTTGTCACAACAACAAATAGCAAGTATCCTTGCGAATGCTTTTTTCTGTACTTTTCCACGACGGAATACAAAAAAGAAATCATCTGAATACTCATCTTATCCACACATCAATTTTTATACATTGTACGAGACAGATGGTTCTGAATCAGTGTTAGAAAAGTTAAAATGTTTGTGTCACTACTTTCGAAGAGTGTGCACTAAAGTCCCGGGCGGCGTAGTGACTTGGACCCGGCGCAGCGTGCCGCCGCGGGGCTGCCCCGCGTGGGGCTCCAGTGGGTCTCCGCTGTCGTCCCTCCCACTGCACGTAGACTCCGACACCACTATAGAGGATGCTCACGGACTCATACAGGTCGACTTCGCTAACAAGTACTTAGGTGGTGGTGTATTGAACTATGGTTGCGTGCAAGAAGAGATAAGATTCGTGATATGTCCAGAGCTGATGGTGTCGATGCTGTTCACGGAAGTGCTGAGGCCCAATGAAGCATTGTTAATTGTTGGCTGTGAAAGGTACAGCAGGTACACGGGCTACGCGAGCACGTTCCAGTGGGCCGGGGACTACCGGGACGAGACGCCCCTGGACTCGTCCGGGCGGCGGCGCTGCGCCGTGCTGGCCATAGACGCGCTGCCCTACCCCAGCACCGTCCAGGAGTACAGGGAGGAAATGTTGACCAGGGAACTTAATAAGGCCTGGATAGGTTTTACGTTTCACGCGGACCCAGAGTCCAGTACGCTGCAGTACCCGGGCGTGGCGACCGGCAACTGGGGCTGCGGCGCCTTCGGGGGCTCCCCGCGGCTCAAGGGTCTCCTGCAGGCGATGGCGGCCGCGCAGGCCGGGCGGCCCCTCGCTTACTTTACGTTCGGCGACGCGGAGCTCAGGGACCACATCGTAGACGTGTACAACGCGCTGGCCAAGTGTGGCGTCACCGTCGGTCAGCTGTACCGACTCATTGTTCGTTTCTCAAAAACGAATGTACTCAGGTCGGACCTTTACGATTTTTTGCATCAGGTGTTGAGAGACGGGGAGGTGGATAAGCTCAGGGGAACTCAGCACGAGCGCATGGAGACCGACTCAACACCGGGCACGTCGACAATGGAACTGTCCGACTCCCTACAGACGGAATTACTCAAAGAGTTTACATCGACCGATTCACCGGACCTATTCTCGACTGACGAAAGTTTAATCGAGATTAAAATCGATAAGAGCGATCCGAGTGACAACACTGGCTGTCACTCGCAGCTGTCAAACTGTACGTCAAAGTTGTTTGACGAGATGCAGAAGCTGGATGAGGAAGACGGGCTGACGAGCTTGTCTATGCCCCAAGAGTCGCCTCTGGAACAGAACGCGAGTTGCGACGGCGATCTGCCCAAGCGACCCGCAGATGCGACTTCGGAATTGAAGGCCAGAGTCAATAGGAAAATAACAGATTATTTTAGCAGAAAACCTGTTTAA

Protein

MSTVTKSWLGVPISEIRGSQSPWGAPEFPLVVPAYNHSVLYHVQNGRPIDGDRPPKPQIGRDKWDHEFVRMPCSNQSLYPFEDSNGDCHLKKRWEVIESSLWKPIRDSRELANTILSYNTKFKKIWKFKALHKLFSEYLDEEETQYFFDVTLPEIAKLALALPKLIQSPIPLLKQHKNYSISLSQQQIASILANAFFCTFPRRNTKKKSSEYSSYPHINFYTLYETDGSESVLEKLKCLCHYFRRVCTKVPGGVVTWTRRSVPPRGCPAWGSSGSPLSSLPLHVDSDTTIEDAHGLIQVDFANKYLGGGVLNYGCVQEEIRFVICPELMVSMLFTEVLRPNEALLIVGCERYSRYTGYASTFQWAGDYRDETPLDSSGRRRCAVLAIDALPYPSTVQEYREEMLTRELNKAWIGFTFHADPESSTLQYPGVATGNWGCGAFGGSPRLKGLLQAMAAAQAGRPLAYFTFGDAELRDHIVDVYNALAKCGVTVGQLYRLIVRFSKTNVLRSDLYDFLHQVLRDGEVDKLRGTQHERMETDSTPGTSTMELSDSLQTELLKEFTSTDSPDLFSTDESLIEIKIDKSDPSDNTGCHSQLSNCTSKLFDEMQKLDEEDGLTSLSMPQESPLEQNASCDGDLPKRPADATSELKARVNRKITDYFSRKPV

Description

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.

Catalytic Activity

[(1''->2')-ADP-alpha-D-ribose]n + H2O = [(1''->2')-ADP-alpha-D-ribose]n-1 + ADP-D-ribose

Similarity

Belongs to the poly(ADP-ribose) glycohydrolase family.

Keywords

Complete proteome   Hydrolase   Phosphoprotein   Reference proteome  

Feature

chain  Poly(ADP-ribose) glycohydrolase

Uniprot

H9J8P3   A0A3S2NV82   A0A2A4J6Y6   A0A194PU76   A0A212ER22   B0WST7   + More
A0A1Q3F4V3   A0A1I8P7Y8   Q17L69   A0A0L0C4D8   A0A0A1WZR8   A0A182GTV7   B4R467   A0A212FBJ9   A0A034W105   O46043   A0A1A9W8L6   A0A1W4VSH3   A0A0K8UU75   A0A1B0ADR4   A0A1A9VY97   A0A0K8UFZ1   W8AQL3   A0A1B0FJ80   B3NSQ9   A0A1I8NDE2   B4Q0I7   A0A182GBX4   A0A1I8NDE8   U5EQC3   B4NPN3   B4I158   A0A1L8DL32   B4M1L2   A0A3B0JWQ9   B4H0U9   A0A3B0JRR4   Q29GN0   A0A1B0GHX2   B3MW84   A0A0M4F7R8   K7J0P1   B4JN37   B4L4V6   A0A0C9QWZ8   A0A232F6A4   A0A3L8DI25   A0A2J7PYB3   A0A2J7PY66   E2BI70   A0A1B0DM96   A0A2J7PY95   A0A158NCD2   A0A088AIJ7   F4WWX1   A0A1B6KY88   A0A2J7PY76   A0A336MPT7   A0A1B6HT42   A0A026VX02   A0A1B6HAF6   A0A1J1HID5   D6W990   E2B1V8   A0A067RFC3   A0A2P8Z7V8   A0A2A3EK29   A0A1W4WD06   A0A0P5Y1S9   A0A0P5Q659   A0A195FAJ8   A0A0P5NMJ0   A0A195BY71   A0A151WS21   A0A151ITL5   A0A0N8BQQ5   A0A0P5QQE3   A0A069DVA2   A0A0P6K040   A0A2S2QZC1   E9GAG4   A0A2G8K0Z3   A0A151IG65   A0A1Y1KZH8   A0A154PFY3   A0A2D4MHK1   H9GUD9   A0A210PSB1   A0A3Q7RU58   J9NTQ1   A0A2U3X9T8   A0A2U3X9S9   A0A2Y9HZM2   A0A340WI96   A0A3Q7PSD1   A0A340WBF8   A0A0F7ZDZ9   K9IUD8  

EC Number

3.2.1.143

Pubmed

19121390    26354079    22118469    17510324    26108605    25830018    + More
26483478    17994087    25348373    10731132    12537572    10731137    12537569    14676324    18327897    30100084    24495485    25315136    17550304    15632085    20075255    28648823    30249741    20798317    21347285    21719571    24508170    18362917    19820115    24845553    29403074    26334808    21292972    29023486    28004739    21881562    28812685    16341006   

EMBL

BABH01030360    BABH01030361    RSAL01000060    RVE49636.1    NWSH01002597    PCG67887.1    + More
KQ459592    KPI96872.1    AGBW02013163    OWR43927.1    DS232076    EDS34047.1    GFDL01012478    JAV22567.1    CH477218    EAT47426.1    JRES01000996    KNC26314.1    GBXI01009723    JAD04569.1    JXUM01087914    KQ563665    KXJ73521.1    CM000366    EDX17009.1    AGBW02009309    OWR51110.1    GAKP01010925    JAC48027.1    AF079556    AE014298    Z98254    AY051955    AAC28734.1    AAK93379.1    CAB10913.1    GDHF01022090    JAI30224.1    GDHF01026831    JAI25483.1    GAMC01015445    JAB91110.1    CCAG010011096    CH954180    EDV45739.2    CM000162    EDX01271.2    JXUM01053377    KQ561774    KXJ77584.1    GANO01003331    JAB56540.1    CH964291    EDW86473.2    CH480819    EDW53239.1    GFDF01006915    JAV07169.1    CH940651    EDW65566.2    OUUW01000003    SPP78169.1    CH479201    EDW30014.1    SPP78170.1    CH379064    EAL32079.3    AJWK01006336    CH902625    EDV35229.1    CP012528    ALC48287.1    CH916371    EDV92130.1    CH933810    EDW07584.2    GBYB01000215    JAG69982.1    NNAY01000903    OXU26003.1    QOIP01000008    RLU19976.1    NEVH01020850    PNF21290.1    PNF21289.1    GL448457    EFN84601.1    AJVK01006914    PNF21292.1    ADTU01011818    GL888417    EGI61214.1    GEBQ01023753    JAT16224.1    PNF21291.1    UFQS01001383    UFQT01001383    SSX10624.1    SSX30307.1    GECU01029885    JAS77821.1    KK107648    EZA48323.1    GECU01036079    JAS71627.1    CVRI01000004    CRK87314.1    KQ971312    EEZ98465.1    GL444981    EFN60314.1    KK852722    KDR17705.1    PYGN01000157    PSN52583.1    KZ288222    PBC32050.1    GDIP01065195    LRGB01000389    JAM38520.1    KZS19345.1    GDIQ01121524    JAL30202.1    KQ981727    KYN37069.1    GDIQ01147230    JAL04496.1    KQ976396    KYM92888.1    KQ982796    KYQ50618.1    KQ981004    KYN10390.1    GDIQ01154219    JAK97506.1    GDIQ01117442    JAL34284.1    GBGD01000886    JAC88003.1    GDIQ01001081    JAN93656.1    GGMS01013896    MBY83099.1    GL732537    EFX83529.1    MRZV01001001    PIK41639.1    KQ977728    KYN00259.1    GEZM01068670    GEZM01068669    JAV66813.1    KQ434896    KZC10773.1    IACM01100102    LAB32246.1    AAWZ02012964    AAWZ02012965    NEDP02005529    OWF39385.1    AAEX03015370    GBEX01000128    JAI14432.1    GABZ01000620    JAA52905.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000002320    + More
UP000095300    UP000008820    UP000037069    UP000069940    UP000249989    UP000000304    UP000000803    UP000091820    UP000192221    UP000092445    UP000078200    UP000092444    UP000008711    UP000095301    UP000002282    UP000007798    UP000001292    UP000008792    UP000268350    UP000008744    UP000001819    UP000092461    UP000007801    UP000092553    UP000002358    UP000001070    UP000009192    UP000215335    UP000279307    UP000235965    UP000008237    UP000092462    UP000005205    UP000005203    UP000007755    UP000053097    UP000183832    UP000007266    UP000000311    UP000027135    UP000245037    UP000242457    UP000192223    UP000076858    UP000078541    UP000078540    UP000075809    UP000078492    UP000000305    UP000230750    UP000078542    UP000076502    UP000001646    UP000242188    UP000286640    UP000002254    UP000245341    UP000248481    UP000265300    UP000286641   

PRIDE

H9J8P3    O46043   

Pfam

PF05028   PARG_cat        + More
PF10477   EIF4E-T
PF02138   Beach
PF01363   FYVE
PF15787   DUF4704
PF14844   PH_BEACH
PF00400   WD40

Interpro

IPR007724   Poly_GlycHdrlase        + More
IPR018862   eIF4E-T       
IPR036322   WD40_repeat_dom_sf       
IPR013320   ConA-like_dom_sf       
IPR000306   Znf_FYVE       
IPR019775   WD40_repeat_CS       
IPR000409   BEACH_dom       
IPR031570   DUF4704       
IPR036372   BEACH_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011011   Znf_FYVE_PHD       
IPR001680   WD40_repeat       
IPR017455   Znf_FYVE-rel       
IPR016024   ARM-type_fold       
IPR017986   WD40_repeat_dom       
IPR023362   PH-BEACH_dom       
IPR013083   Znf_RING/FYVE/PHD       

SUPFAM

SSF81837   SSF81837        + More
SSF57903   SSF57903       
SSF49899   SSF49899       
SSF48371   SSF48371       
SSF50978   SSF50978       

Gene 3D

1.10.1540.10     2.130.10.10     3.30.40.10    

CDD

cd01201  PH_BEACH
cd06071  Beach

ProteinModelPortal

H9J8P3   A0A3S2NV82   A0A2A4J6Y6   A0A194PU76   A0A212ER22   B0WST7   + More
A0A1Q3F4V3   A0A1I8P7Y8   Q17L69   A0A0L0C4D8   A0A0A1WZR8   A0A182GTV7   B4R467   A0A212FBJ9   A0A034W105   O46043   A0A1A9W8L6   A0A1W4VSH3   A0A0K8UU75   A0A1B0ADR4   A0A1A9VY97   A0A0K8UFZ1   W8AQL3   A0A1B0FJ80   B3NSQ9   A0A1I8NDE2   B4Q0I7   A0A182GBX4   A0A1I8NDE8   U5EQC3   B4NPN3   B4I158   A0A1L8DL32   B4M1L2   A0A3B0JWQ9   B4H0U9   A0A3B0JRR4   Q29GN0   A0A1B0GHX2   B3MW84   A0A0M4F7R8   K7J0P1   B4JN37   B4L4V6   A0A0C9QWZ8   A0A232F6A4   A0A3L8DI25   A0A2J7PYB3   A0A2J7PY66   E2BI70   A0A1B0DM96   A0A2J7PY95   A0A158NCD2   A0A088AIJ7   F4WWX1   A0A1B6KY88   A0A2J7PY76   A0A336MPT7   A0A1B6HT42   A0A026VX02   A0A1B6HAF6   A0A1J1HID5   D6W990   E2B1V8   A0A067RFC3   A0A2P8Z7V8   A0A2A3EK29   A0A1W4WD06   A0A0P5Y1S9   A0A0P5Q659   A0A195FAJ8   A0A0P5NMJ0   A0A195BY71   A0A151WS21   A0A151ITL5   A0A0N8BQQ5   A0A0P5QQE3   A0A069DVA2   A0A0P6K040   A0A2S2QZC1   E9GAG4   A0A2G8K0Z3   A0A151IG65   A0A1Y1KZH8   A0A154PFY3   A0A2D4MHK1   H9GUD9   A0A210PSB1   A0A3Q7RU58   J9NTQ1   A0A2U3X9T8   A0A2U3X9S9   A0A2Y9HZM2   A0A340WI96   A0A3Q7PSD1   A0A340WBF8   A0A0F7ZDZ9   K9IUD8  

PDB

6HMN     E-value=3.83495e-97,     Score=908

KEGG

101743876    K07759 poly(ADP-ribose) glycohydrolase [EC:3.2.1.143] | (RefSeq) poly(ADP-ribose) glycohydrolase

GO

GO:0005975   GO:0004649   GO:0005634   GO:0043484   GO:0036099   GO:0006342   GO:0005654   GO:0051457   GO:0030576   GO:0009408   GO:0035065   GO:0046872   GO:1990966   GO:0009225   GO:0005737   GO:0006282   GO:0016021   GO:0005829   GO:0016787   GO:0000287   GO:0004012   GO:0005524   GO:0015914   GO:0016020   GO:0003707   GO:0051537  

PANTHER

PTHR12837  

Length:

664

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02189

Exp number, first 60 AAs:

0.00061

Total prob of N-in:

0.00045

outside

1  -  664

 

 

Pi

26.546791

Theta

24.107553

Tajima's D

0.13042

CLR

0.532711

CSRT

0.409579521023949

Interpretation

Uncertain