Gene

KWMTBOMO07519  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005894

Annotation

PREDICTED:_retinoblastoma-binding_protein_5_homolog_[Papilio_xuthus]

Location

Bomo_Chr12(-):15379029-15386007      View in EpiBrowser

Full name

Phospholipid-transporting ATPase       + More
Retinoblastoma-binding protein 5 homolog      

Location in the cell

Cytoplasmic   Reliability : 1.141 Nuclear   Reliability : 1.542

CDS

ATGAATTTAGAGTTACTGGAATCGTTTGGACAAAATTATCCTGAGGAATTCGATGGTACCCTTGACTCAATTTCACTGGCTTCAACTTGCGCATTCAACAGACGAGGTACATTGCTGGCTGTAGGCTGCAATGATGGTAGGATTTTTATCTGGGATTTCCTGACTCGGGGCATTGCAAAGTCAATATCAGCTCATGTGTACCCTGTATGCAGCTTAAGTTGGTCAAGGAATTGTAAAAAGCTATTATCAGCATCAACAGATCATAATGTATGCATATGGGATGTACTGTCTGGTGAGTGTGAACAGACGTACAGATTCCCTACTTCAATATTACGTGTGCAATTTGATCCGAGGAATGACAAGAGATTTCTCGTGTGTCCCATGAGACATGCAGCCTTACTGGTCGATACTGATGGTGATCATAAAATACTTCCTATAGACGAAGATGGAGATGTAAATGTAATGGCTTCCTTCAACAGAAGAGGAGACTATGTTTATACAGGGAATGCCAAAGGAAAAATACTGATACTTGACTCGCAGACGTTGGCCGTAAAAGCCAGTTTTAAAATAACTGTAGGCACATCCAGTACAACTAGTATCAAGAGCATCGAATTTGCTAGAAGGGGAGATTGTTTCCTAGTGAACACGTCGGACCGCGTCATCCGGGTGTACGACACCAACACGGTGCTCCAGTGCGGGGTCAACGGTGAACCCGAACCCATACAGAAACTCCAGGACCTCATCAACAAAACAACGTGGAAGAAATGTTGTTTCTCCGGCGACGGCGAGTACATCTGCGCCGGGTCCGCGCGACAGCACGCGCTCTACATCTGGGAGAAGTCGATAGGGAACCTCGTCAAGATCCTGCACGGAACCAAGGGGGAGCTCCTGCTGGACGTCGTGTGGCACCCCATCCGCCCCATCATCGCCAGCATCAGCGCCGGTGTGGTATCGATATGGGCACAGAACCAAGTCGAGAACTGGTCAGCGTTCGCTCCCGACTTCAAGGAGCTGGACGAGAACGTGGAGTACGAGGAGCGAGAGAGCGAGTTCGACGTGGAGGACGAGGACCGCTCTGTGGACCAGGCCGGGGACACCAGGGACGACGAGGAAGTCGAGGTAGACGTGACTTCGTGCGAAGCGGTGGCGGCCTTCTGCAGCTCCGACGAGGAGGGCGAGGACGAGAACGTGCTGCTGTTCCTGCCCACCGCCCCCGAGATCGAGGACCCCGAGGATGGTTGGGCGGCGACTCAGGAGACGATCACGCCAGCCGAAACTCCAGAAAAATTGGAACCTGCAGCAAAGAGGCCTAAAAGCAAAACCTACGACATATCACTGAAGATTCCCCCGCCTGAACAATCATTGTCATTCGGAGGGAAAAACAAACAAGCTGCTGGAAATAAAAAAGTAGCGGGCAGGCCGAGGAAATAA

Protein

MNLELLESFGQNYPEEFDGTLDSISLASTCAFNRRGTLLAVGCNDGRIFIWDFLTRGIAKSISAHVYPVCSLSWSRNCKKLLSASTDHNVCIWDVLSGECEQTYRFPTSILRVQFDPRNDKRFLVCPMRHAALLVDTDGDHKILPIDEDGDVNVMASFNRRGDYVYTGNAKGKILILDSQTLAVKASFKITVGTSSTTSIKSIEFARRGDCFLVNTSDRVIRVYDTNTVLQCGVNGEPEPIQKLQDLINKTTWKKCCFSGDGEYICAGSARQHALYIWEKSIGNLVKILHGTKGELLLDVVWHPIRPIIASISAGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDVEDEDRSVDQAGDTRDDEEVEVDVTSCEAVAAFCSSDEEGEDENVLLFLPTAPEIEDPEDGWAATQETITPAETPEKLEPAAKRPKSKTYDISLKIPPPEQSLSFGGKNKQAAGNKKVAGRPRK

Description

Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'.

Catalytic Activity

ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Subunit

Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1. Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6.

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

Keywords

Chromatin regulator   Complete proteome   Nucleus   Reference proteome   Repeat   Transcription   Transcription regulation   WD repeat  

Feature

chain  Retinoblastoma-binding protein 5 homolog

Uniprot

H9J8Q2   A0A194PV58   A0A2A4J7P1   A0A0N0PBM4   A0A212EYA4   A0A2H1VSE5   + More
T1PK06   B4PFA7   A0A2J7R287   B3NIJ6   A0A0L0C3X6   A0A347ZJ83   B4QRX1   A0A1A9ZFY3   Q2M0V3   B4GR18   A0A182GZA4   W8C4P1   A0A1A9WPV6   A0A1I8PAV3   B4MLK6   Q9VPH8   Q17GA8   Q7Q8T2   B4LGF3   A0A0A1XID5   A0A3B0JRH8   A0A034VKM4   B3M974   A0A1A9V2Y3   A0A1B0ARA7   A0A1Q3F453   A0A1W4W5K5   A0A182S4X8   B0WTZ2   A0A026VXJ9   B4IWX6   A0A182JA02   A0A0M4EZK9   B4KY19   A0A182VKQ3   D6WGH2   A0A182LQ18   A0A1Y9GK61   A0A182TRM4   A0A182MYD8   A0A2M4AJL7   W5JDI7   A0A182MC05   A0A0K8WLX1   E2BCB0   A0A1Y1LIR5   F4X2E6   A0A182R137   A0A1B6G611   A0A182VTC1   N6THE0   A0A088AE91   N6UDR3   A0A1A9YL35   A0A182YA36   A0A2A3ERQ1   A0A084VKW5   A0A182X1U7   A0A0J7L8J5   A0A0C9RK96   A0A0L7R254   A0A182P8H0   A0A195CSA8   A0A151JYI6   E0VFH9   A0A1L8DNF0   A0A2R5LL22   A0A154P6C9   A0A224YQH2   A0A131YN32   A0A1S3CX87   A0A131XNU8   A0A131XZV1   L7MAM2   L7MAI9   A0A224YK23   A0A131YEG0   A0A067QXV9   A0A1E1XRD4   A0A182FUJ7   A0A1E1XF60   T1GDK4   A0A023GBU5   A0A0K8RHX0   A0A336MF23   A0A1B6MA67   K7INB4   A0A293MTH2   A0A1J1II07   A0A1B6E8W2   A0A232EYF4   A0A151WV00   A0A0P6IBQ3   A0A0P4ZRD7  

EC Number

7.6.2.1

Pubmed

19121390    26354079    22118469    25315136    17994087    17550304    + More
26108605    22936249    15632085    26483478    24495485    10731132    12537572    12537569    21694722    21875999    17510324    12364791    25830018    25348373    24508170    18362917    19820115    20966253    20920257    23761445    20798317    28004739    21719571    23537049    25244985    24438588    20566863    28797301    26830274    28049606    25576852    24845553    29209593    28503490    20075255    28648823   

EMBL

BABH01030362    BABH01030363    KQ459592    KPI96873.1    NWSH01002597    PCG67889.1    + More
KQ460954    KPJ10256.1    AGBW02011576    OWR46472.1    ODYU01004162    SOQ43739.1    KA648999    AFP63628.1    CM000159    EDW95193.1    NEVH01008200    PNF34932.1    CH954178    EDV52492.1    JRES01000936    KNC27053.1    FX985651    BBA84389.1    CM000363    CM002912    EDX11217.1    KMZ00744.1    CH379069    EAL30823.2    CH479188    EDW40203.1    JXUM01099203    KQ564476    KXJ72222.1    GAMC01005379    JAC01177.1    CH963847    EDW72862.1    AE014296    AY071120    BT032759    BT032765    AAF51573.2    AAL48742.1    ACD81773.1    CH477264    EAT45597.1    AAAB01008933    EAA09974.3    CH940647    EDW70482.1    GBXI01004044    JAD10248.1    OUUW01000009    SPP84735.1    GAKP01015918    JAC43034.1    CH902618    EDV40058.2    JXJN01002301    GFDL01012711    JAV22334.1    DS232096    EDS34699.1    KK107801    EZA47584.1    CH916366    EDV97377.1    CP012525    ALC44162.1    CH933809    EDW18721.1    KQ971321    EFA00179.1    APCN01005566    GGFK01007640    MBW40961.1    ADMH02001479    ETN62412.1    AXCM01002293    GDHF01000173    JAI52141.1    GL447257    EFN86646.1    GEZM01060786    JAV70917.1    GL888578    EGI59371.1    AXCN02001048    GECZ01011893    JAS57876.1    APGK01026531    KB740635    ENN79844.1    KB631992    ENN79845.1    ERL87749.1    KZ288192    PBC34370.1    ATLV01014310    KE524956    KFB38609.1    LBMM01000267    KMR02294.1    GBYB01007256    GBYB01007259    JAG77023.1    JAG77026.1    KQ414666    KOC64908.1    KQ977329    KYN03530.1    KQ981477    KYN41447.1    DS235112    EEB12135.1    GFDF01006143    JAV07941.1    GGLE01006100    MBY10226.1    KQ434827    KZC07496.1    GFPF01006863    MAA18009.1    GEDV01008579    JAP79978.1    GEFH01000686    JAP67895.1    GEFM01003033    JAP72763.1    GACK01004865    JAA60169.1    GACK01004866    JAA60168.1    GFPF01006862    MAA18008.1    GEDV01011707    JAP76850.1    KK852832    KDR15310.1    GFAA01001566    JAU01869.1    GFAC01001308    JAT97880.1    CAQQ02074621    GBBM01003727    JAC31691.1    GADI01003088    JAA70720.1    UFQT01001098    SSX28905.1    GEBQ01025684    GEBQ01007170    JAT14293.1    JAT32807.1    GFWV01019406    MAA44134.1    CVRI01000048    CRK98686.1    GEDC01002926    JAS34372.1    NNAY01001642    OXU23339.1    KQ982721    KYQ51666.1    GDIQ01023258    JAN71479.1    GDIP01213398    JAJ10004.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000007151    UP000095301    + More
UP000002282    UP000235965    UP000008711    UP000037069    UP000000304    UP000092445    UP000001819    UP000008744    UP000069940    UP000249989    UP000091820    UP000095300    UP000007798    UP000000803    UP000008820    UP000007062    UP000008792    UP000268350    UP000007801    UP000078200    UP000092460    UP000192221    UP000075900    UP000002320    UP000053097    UP000001070    UP000075880    UP000092553    UP000009192    UP000075903    UP000007266    UP000075882    UP000075840    UP000075902    UP000075884    UP000000673    UP000075883    UP000008237    UP000007755    UP000075886    UP000075920    UP000019118    UP000005203    UP000030742    UP000092443    UP000076408    UP000242457    UP000030765    UP000076407    UP000036403    UP000053825    UP000075885    UP000078542    UP000078541    UP000009046    UP000076502    UP000079169    UP000027135    UP000069272    UP000015102    UP000002358    UP000183832    UP000215335    UP000075809   

PRIDE

H9J8Q2    Q9VPH8    L7MAM2    L7MAI9   

Pfam

PF00400   WD40        + More
PF02037   SAP
PF16209   PhoLip_ATPase_N
PF16212   PhoLip_ATPase_C
PF12333   Ipi1_N
PF14904   FAM86
PF10294   Methyltransf_16
PF08385   DHC_N1

Interpro

IPR015943   WD40/YVTN_repeat-like_dom_sf        + More
IPR001680   WD40_repeat       
IPR036361   SAP_dom_sf       
IPR017986   WD40_repeat_dom       
IPR003034   SAP_dom       
IPR036322   WD40_repeat_dom_sf       
IPR037850   RBBP5/Swd1       
IPR019775   WD40_repeat_CS       
IPR032630   P_typ_ATPase_c       
IPR018303   ATPase_P-typ_P_site       
IPR008250   ATPase_P-typ_transduc_dom_A_sf       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR001757   P_typ_ATPase       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR006539   P-type_ATPase_IV       
IPR032631   P-type_ATPase_N       
IPR036412   HAD-like_sf       
IPR023214   HAD_sf       
IPR011990   TPR-like_helical_dom_sf       
IPR016024   ARM-type_fold       
IPR024679   Ipi1_N       
IPR019410   Methyltransf_16       
IPR029063   SAM-dependent_MTases       
IPR029426   FAM86       
IPR013594   Dynein_heavy_dom-1       
IPR001007   VWF_dom       
IPR003961   FN3_dom       
IPR013783   Ig-like_fold       
IPR036116   FN3_sf       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       

SUPFAM

SSF50978   SSF50978        + More
SSF56784   SSF56784       
SSF81653   SSF81653       
SSF81660   SSF81660       
SSF81665   SSF81665       
SSF48371   SSF48371       
SSF53335   SSF53335       
SSF49265   SSF49265       
SSF57667   SSF57667       

Gene 3D

1.10.720.30     2.130.10.10     3.40.1110.10     3.40.50.1000     1.25.40.10     2.60.40.10    

CDD

cd00063  FN3

ProteinModelPortal

H9J8Q2   A0A194PV58   A0A2A4J7P1   A0A0N0PBM4   A0A212EYA4   A0A2H1VSE5   + More
T1PK06   B4PFA7   A0A2J7R287   B3NIJ6   A0A0L0C3X6   A0A347ZJ83   B4QRX1   A0A1A9ZFY3   Q2M0V3   B4GR18   A0A182GZA4   W8C4P1   A0A1A9WPV6   A0A1I8PAV3   B4MLK6   Q9VPH8   Q17GA8   Q7Q8T2   B4LGF3   A0A0A1XID5   A0A3B0JRH8   A0A034VKM4   B3M974   A0A1A9V2Y3   A0A1B0ARA7   A0A1Q3F453   A0A1W4W5K5   A0A182S4X8   B0WTZ2   A0A026VXJ9   B4IWX6   A0A182JA02   A0A0M4EZK9   B4KY19   A0A182VKQ3   D6WGH2   A0A182LQ18   A0A1Y9GK61   A0A182TRM4   A0A182MYD8   A0A2M4AJL7   W5JDI7   A0A182MC05   A0A0K8WLX1   E2BCB0   A0A1Y1LIR5   F4X2E6   A0A182R137   A0A1B6G611   A0A182VTC1   N6THE0   A0A088AE91   N6UDR3   A0A1A9YL35   A0A182YA36   A0A2A3ERQ1   A0A084VKW5   A0A182X1U7   A0A0J7L8J5   A0A0C9RK96   A0A0L7R254   A0A182P8H0   A0A195CSA8   A0A151JYI6   E0VFH9   A0A1L8DNF0   A0A2R5LL22   A0A154P6C9   A0A224YQH2   A0A131YN32   A0A1S3CX87   A0A131XNU8   A0A131XZV1   L7MAM2   L7MAI9   A0A224YK23   A0A131YEG0   A0A067QXV9   A0A1E1XRD4   A0A182FUJ7   A0A1E1XF60   T1GDK4   A0A023GBU5   A0A0K8RHX0   A0A336MF23   A0A1B6MA67   K7INB4   A0A293MTH2   A0A1J1II07   A0A1B6E8W2   A0A232EYF4   A0A151WV00   A0A0P6IBQ3   A0A0P4ZRD7  

PDB

5OV3     E-value=6.14732e-149,     Score=1353

KEGG

101740999    K14961 COMPASS component SWD1 | (RefSeq) retinoblastoma-binding protein 5 homolog

GO

GO:0048188   GO:0004012   GO:0000287   GO:0016021   GO:0005524   GO:0044666   GO:0051568   GO:0044665   GO:0003676   GO:0005515   GO:0008270   GO:0015914   GO:0016020   GO:0003707   GO:0051537  

PANTHER

PTHR44040   PTHR24092  

Subcellular location

Membrane  
Nucleus  

Length:

476

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0355

Exp number, first 60 AAs:

0.00068

Total prob of N-in:

0.00042

outside

1  -  476

 

 

Pi

19.744297

Theta

18.39739

Tajima's D

-0.631767

CLR

0.587368

CSRT

0.215839208039598

Interpretation

Uncertain