Gene

KWMTBOMO07494

Pre Gene Modal

BGIBMGA014556

Annotation

PREDICTED:_polypeptide_N-acetylgalactosaminyltransferase_2-like_isoform_X2_[Papilio_machaon]

Location

Bomo_Chr12(-):14512909-14545978      View in EpiBrowser

Full name

Polypeptide N-acetylgalactosaminyltransferase       + More
Polypeptide N-acetylgalactosaminyltransferase 2      

Alternative Name

Protein-UDP acetylgalactosaminyltransferase
Protein-UDP acetylgalactosaminyltransferase 2
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2

Location in the cell

Cytoplasmic   Reliability : 1.691 Mitochondrial   Reliability : 1.469

CDS

ATGGACACCTTCCAATACATCGGAGCGTCGGCGGACCTGCGAGGCGGTTTTGACTGGAACTTAGTCTTCAAGTGGGAATACTTATCGCATACGGAACGTAGCGCCCGTCTCACTGATCCCACTCAAGTAATCAGGACCCCTATGATAGCTGGTGGACTATTCAGCATGGACCGACTTTACTTCAACAAACTCGGGAAATACGATATGAAAATGGACGTGTGGGGAGGAGAGAACTTGGAAATTTCATTCAGAGTTTGGCAATGCGGAGGCTCCCTCGAAATCGTGCCTTGTTCCCGTGTGGGTCATGTCTTCAGGAAACGCCATCCGTATACATTCCCCGGCGGCTCCGGGGCGGTATTCGCGAGGAATACCAGAAGGGCGGCCGAAGTCTGGATGGACGATTACAAAGAACTATACTATAGATCTCAACCACTCGCGAAGCAAGTCGACTTTGGAGACATATCCGAGCGCGTCACTTTACGCGACAAACTACACTGCAAGCCGTTTCGTTGGTACTTACAACACGTGTACCCTGAACTCAAAATACCAGCCCAATTAGGGGGACCCCATCCTATAAAACAAGGAATAAGATGCCTAGACACCATGGGACATCTGGTCGACGGGACAATAGGAATGTATCCTTGCCATTACACGGGAGGCAATCAGGGGTGGCTCTTCGAAAACGGCCTCATCCGGCATCACAGTCTCTGCGTCTCCTTGTCCAACGAGGATCGTGTCACGGCAGTATTAGCACCCTGCGACCCTTCGGACGACGCCCAGCTCTGGACACGGAAGGGTCAACTCATAAGACACGAGAAACTGGACGCGTGCTTAGACACGGAACGCACTGATCTACATCTAGAACAATGCGACGAAGACAAACCGAGTCAGCAATTCACCTTTTAA

Protein

MDTFQYIGASADLRGGFDWNLVFKWEYLSHTERSARLTDPTQVIRTPMIAGGLFSMDRLYFNKLGKYDMKMDVWGGENLEISFRVWQCGGSLEIVPCSRVGHVFRKRHPYTFPGGSGAVFARNTRRAAEVWMDDYKELYYRSQPLAKQVDFGDISERVTLRDKLHCKPFRWYLQHVYPELKIPAQLGGPHPIKQGIRCLDTMGHLVDGTIGMYPCHYTGGNQGWLFENGLIRHHSLCVSLSNEDRVTAVLAPCDPSDDAQLWTRKGQLIRHEKLDACLDTERTDLHLEQCDEDKPSQQFTF

Catalytic Activity

L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP
L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

Keywords

Complete proteome   Disulfide bond   Glycosyltransferase   Golgi apparatus   Lectin   Manganese   Membrane   Metal-binding   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Polypeptide N-acetylgalactosaminyltransferase 2

Uniprot

A0A2A4JVU1   A0A2H1V7K7   A0A194PVS1   H9JYD6   A0A194REM4   I4DLJ5   + More
D2A0Q4   A0A232FKY8   T1I445   A0A195B151   F4WY07   A0A2A3EDA0   A0A088ANE0   A0A026WNX2   E2B4S0   A0A0N0BC47   A0A151J8G2   A0A023F4X4   A0A158NZ99   B4MWS9   A0A0M4E5A5   B3MNW1   A0A154PQG7   A0A1B6HAJ5   A0A1Y1LIC7   A0A151X933   B4KG89   A0A1B6L3A7   A0A195FV45   A0A3L8DW00   B4JDG8   A0A0K8VNP3   A0A3B0JZV2   A0A3B0K2J7   A0A1B6KJZ6   B4NXW1   B4G9P3   B3N316   Q29M65   A0A1W4UTS1   B4I2Z3   B4Q9J8   Q6WV19   A0A195CIK7   A0A1W4X6X2   B4LTQ9   A0A0L7RH75   A0A0J7KPE7   A0A0J9QV41   E2A7V1   A0A1S4EP92   A0A336LNH0   A0A0K8SYF1   A0A067R1I4   A0A0C9RCP2   A0A2R7W4N3   A0A0A9Y4T6   W8AN19   E9J4V7   A0A1B6C795   A0A1I8NIG4   A0A034V9M4   U4UH93   A0A1B0G2M0   A0A1B0A0V0   A0A1A9VTU0   A0A1A9Y369   A0A1B0BTJ8   A0A0L0BX46   A0A0K8V659   A0A0K8UCA0   A0A1I8NZS1   A0A1B6ISM0   A0A2P8Y6L9   A0A0K8WBU9   A0A0N7ZCW8   A0A1A9W0R7   Q16R35   E0W2D6   A0A182H3A2   B0WPN5   A0A0L7L238   A0A182V2F4   Q7Q0X9   A0A182XH81   A0A182PTI8   A0A182HR03   A0A182SZN9   A0A182TV63   A0A182Q6H4   A0A182JVQ3   A0A1Q3FPR8   A0A182LSH7   A0A1Q3FPW6   A0A210QER2   A0A182YQN2   A0A182NNR3   A0A182R1P7   W5JJQ0   A0A182W8H1  

EC Number

2.4.1.-
2.4.1.41

Pubmed

26354079    19121390    22651552    18362917    19820115    28648823    + More
21719571    24508170    20798317    25474469    21347285    17994087    18057021    28004739    30249741    17550304    15632085    23185243    22936249    10731132    12537572    12829714    16251381    24845553    25401762    26823975    24495485    21282665    25315136    25348373    23537049    26108605    29403074    17510324    20566863    26483478    26227816    12364791    28812685    25244985    20920257    23761445   

EMBL

NWSH01000544    PCG75754.1    ODYU01001071    SOQ36797.1    KQ459592    KPI96859.1    + More
BABH01043185    KQ460325    KPJ15740.1    AK402163    BAM18785.1    KQ971338    EFA01652.1    NNAY01000079    OXU31180.1    ACPB03003277    KQ976681    KYM78186.1    GL888434    EGI60888.1    KZ288276    PBC29725.1    KK107151    EZA57376.1    GL445595    EFN89299.1    KQ435944    KOX68172.1    KQ979528    KYN21147.1    GBBI01002658    JAC16054.1    ADTU01004134    ADTU01004135    ADTU01004136    ADTU01004137    ADTU01004138    ADTU01004139    ADTU01004140    ADTU01004141    ADTU01004142    ADTU01004143    CH963857    EDW76568.1    CP012523    ALC39246.1    CH902620    EDV32148.1    KPU73816.1    KQ435037    KZC14143.1    GECU01036013    JAS71693.1    GEZM01057944    JAV72080.1    KQ982392    KYQ56881.1    CH933807    EDW11076.1    KRG02521.1    GEBQ01021963    JAT18014.1    KQ981276    KYN43739.1    QOIP01000003    RLU24413.1    CH916368    EDW03338.1    GDHF01011810    JAI40504.1    OUUW01000004    SPP79229.1    SPP79231.1    GEBQ01028211    JAT11766.1    CM000157    EDW87532.1    CH479180    EDW29073.1    CH954177    EDV57615.1    CH379060    EAL33829.2    KRT04224.1    CH480820    EDW54138.1    CM000361    CM002910    EDX03609.1    KMY87884.1    AE014134    BT010030    AY268064    KQ977696    KYN00571.1    CH940649    EDW63960.1    KQ414596    KOC70061.1    LBMM01004751    KMQ92109.1    KMY87886.1    GL437408    EFN70488.1    UFQT01000093    SSX19622.1    GBRD01007886    GBRD01001372    JAG57935.1    KK852777    KDR16775.1    GBYB01004676    JAG74443.1    KK854326    PTY14687.1    GBHO01019049    GDHC01016936    JAG24555.1    JAQ01693.1    GAMC01020672    JAB85883.1    GL768119    EFZ12159.1    GEDC01027945    GEDC01011111    JAS09353.1    JAS26187.1    GAKP01020467    JAC38485.1    KB632299    ERL91738.1    CCAG010020175    JXJN01020204    JRES01001205    KNC24622.1    GDHF01017963    JAI34351.1    GDHF01028060    JAI24254.1    GECU01017809    JAS89897.1    PYGN01000865    PSN39900.1    GDHF01003678    JAI48636.1    GDRN01058336    JAI65608.1    CH477726    EAT36839.1    DS235877    EEB19792.1    JXUM01107019    JXUM01107020    JXUM01107021    JXUM01107022    JXUM01107023    JXUM01107024    JXUM01107025    KQ565104    KXJ71333.1    DS232027    EDS32438.1    JTDY01003479    KOB69495.1    AAAB01008980    EAA14535.4    APCN01001629    AXCN02001979    GFDL01005446    JAV29599.1    AXCM01000301    GFDL01005438    JAV29607.1    NEDP02003995    OWF47223.1    ADMH02001289    ETN63135.1   

Proteomes

UP000218220    UP000053268    UP000005204    UP000053240    UP000007266    UP000215335    + More
UP000015103    UP000078540    UP000007755    UP000242457    UP000005203    UP000053097    UP000008237    UP000053105    UP000078492    UP000005205    UP000007798    UP000092553    UP000007801    UP000076502    UP000075809    UP000009192    UP000078541    UP000279307    UP000001070    UP000268350    UP000002282    UP000008744    UP000008711    UP000001819    UP000192221    UP000001292    UP000000304    UP000000803    UP000078542    UP000192223    UP000008792    UP000053825    UP000036403    UP000000311    UP000079169    UP000027135    UP000095301    UP000030742    UP000092444    UP000092445    UP000078200    UP000092443    UP000092460    UP000037069    UP000095300    UP000245037    UP000091820    UP000008820    UP000009046    UP000069940    UP000249989    UP000002320    UP000037510    UP000075903    UP000007062    UP000076407    UP000075885    UP000075840    UP000075901    UP000075902    UP000075886    UP000075881    UP000075883    UP000242188    UP000076408    UP000075884    UP000075900    UP000000673    UP000075920   

PRIDE

H9JYD6    Q6WV19   

Pfam

PF00535   Glycos_transf_2        + More
PF00652   Ricin_B_lectin
PF02709   Glyco_transf_7C
PF00568   WH1

Interpro

IPR029044   Nucleotide-diphossugar_trans        + More
IPR001173   Glyco_trans_2-like       
IPR000772   Ricin_B_lectin       
IPR035992   Ricin_B-like_lectins       
IPR027791   Galactosyl_T_C       
IPR011993   PH-like_dom_sf       
IPR000697   WH1/EVH1_dom       

SUPFAM

SSF53448   SSF53448        + More
SSF50370   SSF50370       

Gene 3D

3.90.550.10     2.30.29.30    

CDD

cd00161  RICIN

ProteinModelPortal

A0A2A4JVU1   A0A2H1V7K7   A0A194PVS1   H9JYD6   A0A194REM4   I4DLJ5   + More
D2A0Q4   A0A232FKY8   T1I445   A0A195B151   F4WY07   A0A2A3EDA0   A0A088ANE0   A0A026WNX2   E2B4S0   A0A0N0BC47   A0A151J8G2   A0A023F4X4   A0A158NZ99   B4MWS9   A0A0M4E5A5   B3MNW1   A0A154PQG7   A0A1B6HAJ5   A0A1Y1LIC7   A0A151X933   B4KG89   A0A1B6L3A7   A0A195FV45   A0A3L8DW00   B4JDG8   A0A0K8VNP3   A0A3B0JZV2   A0A3B0K2J7   A0A1B6KJZ6   B4NXW1   B4G9P3   B3N316   Q29M65   A0A1W4UTS1   B4I2Z3   B4Q9J8   Q6WV19   A0A195CIK7   A0A1W4X6X2   B4LTQ9   A0A0L7RH75   A0A0J7KPE7   A0A0J9QV41   E2A7V1   A0A1S4EP92   A0A336LNH0   A0A0K8SYF1   A0A067R1I4   A0A0C9RCP2   A0A2R7W4N3   A0A0A9Y4T6   W8AN19   E9J4V7   A0A1B6C795   A0A1I8NIG4   A0A034V9M4   U4UH93   A0A1B0G2M0   A0A1B0A0V0   A0A1A9VTU0   A0A1A9Y369   A0A1B0BTJ8   A0A0L0BX46   A0A0K8V659   A0A0K8UCA0   A0A1I8NZS1   A0A1B6ISM0   A0A2P8Y6L9   A0A0K8WBU9   A0A0N7ZCW8   A0A1A9W0R7   Q16R35   E0W2D6   A0A182H3A2   B0WPN5   A0A0L7L238   A0A182V2F4   Q7Q0X9   A0A182XH81   A0A182PTI8   A0A182HR03   A0A182SZN9   A0A182TV63   A0A182Q6H4   A0A182JVQ3   A0A1Q3FPR8   A0A182LSH7   A0A1Q3FPW6   A0A210QER2   A0A182YQN2   A0A182NNR3   A0A182R1P7   W5JJQ0   A0A182W8H1  

PDB

2FFV     E-value=1.24926e-101,     Score=943

KEGG

101738869    K00710 polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41] | (RefSeq) polypeptide N-acetylga

PATHWAY

00512    Mucin type O-glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0000139   GO:0016021   GO:0030246   GO:0016757   GO:0006486   GO:0016740   GO:0005794   GO:0009312   GO:0004653   GO:0046872   GO:0005795  

Subcellular location

Golgi apparatus membrane  

Length:

301

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13556

Exp number, first 60 AAs:

0.12512

Total prob of N-in:

0.02676

outside

1  -  301

 

 

Pi

22.088294

Theta

20.953933

Tajima's D

-1.069017

CLR

0.549251

CSRT

0.125643717814109

Interpretation

Uncertain