Gene
KWMTBOMO07477
Pre Gene Modal
BGIBMGA005208
Annotation
PREDICTED:_retinol_dehydrogenase_12-like_[Anolis_carolinensis]
Full name
Retinol dehydrogenase 11
+ More
Retinol dehydrogenase 12
Retinol dehydrogenase 12
Alternative Name
Androgen-regulated short-chain dehydrogenase/reductase 1
Cell line MC/9.IL4-derived protein 1
M42C60
Prostate short-chain dehydrogenase/reductase 1
Retinal reductase 1
Short-chain aldehyde dehydrogenase
HCV core-binding protein HCBP12
Short chain dehydrogenase/reductase family 7C member 1
Double substrate specificity short-chain dehydrogenase/reductase 2
Cell line MC/9.IL4-derived protein 1
M42C60
Prostate short-chain dehydrogenase/reductase 1
Retinal reductase 1
Short-chain aldehyde dehydrogenase
HCV core-binding protein HCBP12
Short chain dehydrogenase/reductase family 7C member 1
Double substrate specificity short-chain dehydrogenase/reductase 2
Location in the cell
PlasmaMembrane Reliability : 2.859
Sequence
CDS
ATGTGCGATCAGAATGTTTCTATGGTCGGCAGAGTTGTTATAGTGACGGGAGCCAATTCGGGAATTGGTTTTCAGACCGCTAAAGATTTAGCTCGACGGGGCGCCAGAGTGATACTTGGGTGCAGGAGCGTCGATCGAGGCACCAAAGCCAGAGACGAGATCATATCCGTTACAAACAACAAAAACGTTGTGTTCAAACAAATCGATTTATCATCGTTAAGATCTGTGAGGGAGTTCGCGAAAGATATCATCGAGACGGAGAATGAGCTTCATGTATTGATCAACAACGCGGGAATGTTTAGCAGCGAGAAGAGCTACACAGAAGACGGAATAGATACGGTGATGCAAGTCAACTATTTTGGGCCGTTCTTACTGACGCGACTGCTTTTACCGCTGCTAAAAAAATCTCAACCGAGCCGAATTGTCAACGTCAGTTCAATATTTAATTTATTCGGTACAATTAATTTTAAGGATGATAACCACAAATCTTTCTATAACGGTATTCTCACGTATTGTAACAGCAAGCTGTGCAATTTGATTTTTACGATAGAATTGTCGGAAAGGCTGCGCGATACGGGCGTTGTCGTTAACGCTGTCCATCCCGGTATCATCTTGACTAATATAACGAATGGCTGTTCGAATTTACTGTACAGAGTTGGATTCGCTGTCCTCTGTTGGTTCAACAACTTAACAGACGAAGACGGTGCTCAAACTCCGCTCCATTTAGCGACTAGTGATATAGGAGGGAACGCTACAGGTAAATTCTTTATCAATTGTTCAGAATCTTCACTCGTGTCTCCAAAAACACGGAATGAAGTTCTCCGAAAGAAATTGTGGGAGCACTCAAATAAATTAATACGATTCGATGAAAGTTCTGTGCAATTATAA
Protein
MCDQNVSMVGRVVIVTGANSGIGFQTAKDLARRGARVILGCRSVDRGTKARDEIISVTNNKNVVFKQIDLSSLRSVREFAKDIIETENELHVLINNAGMFSSEKSYTEDGIDTVMQVNYFGPFLLTRLLLPLLKKSQPSRIVNVSSIFNLFGTINFKDDNHKSFYNGILTYCNSKLCNLIFTIELSERLRDTGVVVNAVHPGIILTNITNGCSNLLYRVGFAVLCWFNNLTDEDGAQTPLHLATSDIGGNATGKFFINCSESSLVSPKTRNEVLRKKLWEHSNKLIRFDESSVQL
Summary
Description
Retinol dehydrogenase with a clear preference for NADP (PubMed:12807874, PubMed:29567832). Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (By similarity) (PubMed:12807874). Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal (PubMed:12807874). Has no dehydrogenase activity towards steroid (PubMed:12807874). Seems to be required for homeostasis of retinol in liver and testis (PubMed:29567832).
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids.
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids.
Catalytic Activity
all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH
11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH
9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH
13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH
a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH
(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH
(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH
(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH
heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH
hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH
decan-1-ol + NADP(+) = decanal + H(+) + NADPH
NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal
NADP(+) + octan-1-ol = H(+) + NADPH + octanal
(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH
a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH
11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH
9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH
13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH
a medium-chain primary fatty alcohol + NADP(+) = a medium-chain fatty aldehyde + H(+) + NADPH
(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH
(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH
(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH
heptan-1-ol + NADP(+) = H(+) + heptanal + NADPH
hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH
decan-1-ol + NADP(+) = decanal + H(+) + NADPH
NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal
NADP(+) + octan-1-ol = H(+) + NADPH + octanal
(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH
a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH
Biophysicochemical Properties
57 uM for all-trans-retinal
14 uM for 9-cis-retinal
30 uM for nonan-1-ol
20 uM for NADPH
0.23 uM for NADPH
0.8 uM for NADP
0.5 uM for all-trans-retinal
0.62 uM for 13-cis-retinal
0.19 uM for 9-cis-retinal
1.3 uM for all-trans-retinol
5 uM for (Z)-non-6-enol
14 uM for 9-cis-retinal
30 uM for nonan-1-ol
20 uM for NADPH
0.23 uM for NADPH
0.8 uM for NADP
0.5 uM for all-trans-retinal
0.62 uM for 13-cis-retinal
0.19 uM for 9-cis-retinal
1.3 uM for all-trans-retinol
5 uM for (Z)-non-6-enol
Subunit
Interacts with SELENOF.
Miscellaneous
Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Keywords
Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
NADP
Oxidoreductase
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Cataract
Dwarfism
Sensory transduction
Vision
Feature
chain Retinol dehydrogenase 11
splice variant In isoform 2.
splice variant In isoform 2.
Uniprot
H9J6R6
A0A293LWC1
A0A293MVK9
A0A2C9K9F2
A0A0L7KVJ8
A0A0L7KV18
+ More
A0A0N0PAY2 G3WGM2 G3WGM3 A0A2A4ITG8 A0A2H1VAE5 I4DQA1 A0A1Q3G5J0 A0A1Y1NCI4 H9JSR3 D6X0B0 A0A1Y1LAJ4 A0A1Y1N8N2 A0A1Z5LCY1 V9KU50 A0A2W1BZE1 A0A212F5B7 A0A1S2ZX06 A0A2H1W6X7 A0A2A4JJH1 H9GAM3 A0A2J7PGU9 A0A2A4IXN8 R4GC18 F6URR5 H9GAK1 A0A2H1W7C7 H2NLK8 A0A0N0PAY1 A0A2P6L863 Q9R1R9 Q9R1R8 A0A0N0PB70 A0A087TBA3 A0A2J7PGY1 Q9QYF1 A0A1Q3G5G7 H9JSL6 A0A0N0PC61 A0A0L7LKJ0 A0A250YFJ1 A0A3F2YU01 H0X3M1 A0A2Y9DAF6 A0A1Y1KEI4 B4N651 A0A212FMV5 A0A194Q6L5 C3YDD9 R4GAG6 A0A2J7PGT7 A0A067QUP0 A0A0N0PAN9 G3TEF7 F7BRU6 A0A2K6TDH4 A0A1W4WGA3 A0A3Q2TZ83 A0A384CV50 A0A3Q7W598 A0A3Q2NS51 A0A146NMV4 Q5R763 J3JYB7 A0A2K5F7C7 K7BJ49 G3QS80 A0A1U7TKA1 A0A2R9BIG4 K7DJ39 A0A0S2Z583 Q8TC12 G9KKN7 H0UUU1 G1LN50 A0A0P4W6I9 A0A096NVQ7 A0A2K6RH31 A0A2K5P068 H3BEA6 A0A0D9RLD9 G1SDM3 A0A1W4WGK2 K7FV47 F1MD39 A0A2K6EE83 M3Y738 P59837 A0A151IL06 A0A1S3F032 A0A2K5QRF4 A0A1S3S0C8 A0A2K6GQX0 A0A2K5ZHR2 M3Y753
A0A0N0PAY2 G3WGM2 G3WGM3 A0A2A4ITG8 A0A2H1VAE5 I4DQA1 A0A1Q3G5J0 A0A1Y1NCI4 H9JSR3 D6X0B0 A0A1Y1LAJ4 A0A1Y1N8N2 A0A1Z5LCY1 V9KU50 A0A2W1BZE1 A0A212F5B7 A0A1S2ZX06 A0A2H1W6X7 A0A2A4JJH1 H9GAM3 A0A2J7PGU9 A0A2A4IXN8 R4GC18 F6URR5 H9GAK1 A0A2H1W7C7 H2NLK8 A0A0N0PAY1 A0A2P6L863 Q9R1R9 Q9R1R8 A0A0N0PB70 A0A087TBA3 A0A2J7PGY1 Q9QYF1 A0A1Q3G5G7 H9JSL6 A0A0N0PC61 A0A0L7LKJ0 A0A250YFJ1 A0A3F2YU01 H0X3M1 A0A2Y9DAF6 A0A1Y1KEI4 B4N651 A0A212FMV5 A0A194Q6L5 C3YDD9 R4GAG6 A0A2J7PGT7 A0A067QUP0 A0A0N0PAN9 G3TEF7 F7BRU6 A0A2K6TDH4 A0A1W4WGA3 A0A3Q2TZ83 A0A384CV50 A0A3Q7W598 A0A3Q2NS51 A0A146NMV4 Q5R763 J3JYB7 A0A2K5F7C7 K7BJ49 G3QS80 A0A1U7TKA1 A0A2R9BIG4 K7DJ39 A0A0S2Z583 Q8TC12 G9KKN7 H0UUU1 G1LN50 A0A0P4W6I9 A0A096NVQ7 A0A2K6RH31 A0A2K5P068 H3BEA6 A0A0D9RLD9 G1SDM3 A0A1W4WGK2 K7FV47 F1MD39 A0A2K6EE83 M3Y738 P59837 A0A151IL06 A0A1S3F032 A0A2K5QRF4 A0A1S3S0C8 A0A2K6GQX0 A0A2K5ZHR2 M3Y753
EC Number
1.1.1.300
Pubmed
19121390
15562597
26227816
26354079
21709235
22651552
+ More
28004739 18362917 19820115 28528879 24402279 28756777 22118469 21881562 17495919 19468303 21183079 8018917 12137953 12807874 16141072 15489334 15790565 29567832 28087693 17994087 18563158 24845553 25243066 22516182 16136131 22398555 22722832 26871637 11245473 10810093 14702039 16303743 12508121 17286855 12036956 12226107 15865448 19608861 21269460 24916380 24275569 25944712 29410696 23236062 21993624 20010809 25362486 9215903 17381049 19393038
28004739 18362917 19820115 28528879 24402279 28756777 22118469 21881562 17495919 19468303 21183079 8018917 12137953 12807874 16141072 15489334 15790565 29567832 28087693 17994087 18563158 24845553 25243066 22516182 16136131 22398555 22722832 26871637 11245473 10810093 14702039 16303743 12508121 17286855 12036956 12226107 15865448 19608861 21269460 24916380 24275569 25944712 29410696 23236062 21993624 20010809 25362486 9215903 17381049 19393038
EMBL
BABH01038129
GFWV01013038
MAA37767.1
GFWV01019263
MAA43991.1
JTDY01005329
+ More
KOB67106.1 KOB67107.1 KQ461133 KPJ08901.1 AEFK01013795 AEFK01013796 NWSH01008708 PCG62440.1 ODYU01001508 SOQ37815.1 AK404009 BAM20091.1 GEYN01000179 JAV44810.1 GEZM01009785 JAV94305.1 BABH01032245 KQ971372 EFA10517.1 GEZM01063043 JAV69350.1 GEZM01009786 JAV94304.1 GFJQ02001830 JAW05140.1 JW869425 AFP01943.1 KZ149935 PZC77183.1 AGBW02010210 OWR48927.1 ODYU01006737 SOQ48855.1 NWSH01001250 PCG71979.1 AAWZ02022819 AAWZ02022820 NEVH01025161 PNF15560.1 NWSH01005060 PCG64471.1 SOQ48856.1 ABGA01093527 KPJ08898.1 MWRG01001082 PRD34763.1 AB030503 BAA82656.1 AC154585 AB030504 BAA82657.1 KPJ08899.1 KK114425 KFM62392.1 PNF15592.1 AB035959 AY039032 AF474027 AK004413 AK135443 BC018261 GEYN01000196 JAV44793.1 BABH01032240 KQ460651 KPJ13037.1 JTDY01000784 KOB75884.1 GFFW01002474 JAV42314.1 AAQR03134912 AAQR03134913 AAQR03134914 GEZM01085981 GEZM01085980 GEZM01085979 GEZM01085978 GEZM01085977 GEZM01085976 JAV59859.1 CH964154 EDW79840.2 AGBW02007651 OWR55082.1 KQ459582 KPI99040.1 GG666503 EEN61750.1 PNF15542.1 KK853387 KDR07942.1 KQ458665 KPJ05596.1 GAMT01009928 GAMT01009927 GAMS01009975 GAMR01010243 GAMR01010242 GAMR01010241 GAMQ01007668 GAMQ01007667 GAMP01004616 GAMP01004615 JAB01933.1 JAB13161.1 JAB23689.1 JAB34183.1 JAB48139.1 GCES01153264 JAQ33058.1 CR860255 CAH92397.1 BT128242 AEE63202.1 AACZ04008467 GABF01010096 GABF01010095 GABD01000533 NBAG03000214 JAA12050.1 JAA32567.1 PNI83925.1 CABD030092947 CABD030092948 AJFE02084691 AJFE02084692 GABC01000020 GABE01002795 JAA11318.1 JAA41944.1 KU178627 ALQ34085.1 AF167438 AF395068 AF151840 CR457180 AK289427 AK293355 AK314465 AK074749 AL049779 CH471061 BC000112 BC011727 BC026274 BC037302 BC051291 DQ426886 JP016868 AES05466.1 AAKN02025212 ACTA01033695 GDRN01096942 GDRN01096940 JAI59223.1 AHZZ02032337 AFYH01034444 AFYH01034445 AQIB01054775 AAGW02057621 AGCU01021282 AEYP01004114 AEYP01004115 AY115489 KQ977151 KYN05278.1 AEYP01004120
KOB67106.1 KOB67107.1 KQ461133 KPJ08901.1 AEFK01013795 AEFK01013796 NWSH01008708 PCG62440.1 ODYU01001508 SOQ37815.1 AK404009 BAM20091.1 GEYN01000179 JAV44810.1 GEZM01009785 JAV94305.1 BABH01032245 KQ971372 EFA10517.1 GEZM01063043 JAV69350.1 GEZM01009786 JAV94304.1 GFJQ02001830 JAW05140.1 JW869425 AFP01943.1 KZ149935 PZC77183.1 AGBW02010210 OWR48927.1 ODYU01006737 SOQ48855.1 NWSH01001250 PCG71979.1 AAWZ02022819 AAWZ02022820 NEVH01025161 PNF15560.1 NWSH01005060 PCG64471.1 SOQ48856.1 ABGA01093527 KPJ08898.1 MWRG01001082 PRD34763.1 AB030503 BAA82656.1 AC154585 AB030504 BAA82657.1 KPJ08899.1 KK114425 KFM62392.1 PNF15592.1 AB035959 AY039032 AF474027 AK004413 AK135443 BC018261 GEYN01000196 JAV44793.1 BABH01032240 KQ460651 KPJ13037.1 JTDY01000784 KOB75884.1 GFFW01002474 JAV42314.1 AAQR03134912 AAQR03134913 AAQR03134914 GEZM01085981 GEZM01085980 GEZM01085979 GEZM01085978 GEZM01085977 GEZM01085976 JAV59859.1 CH964154 EDW79840.2 AGBW02007651 OWR55082.1 KQ459582 KPI99040.1 GG666503 EEN61750.1 PNF15542.1 KK853387 KDR07942.1 KQ458665 KPJ05596.1 GAMT01009928 GAMT01009927 GAMS01009975 GAMR01010243 GAMR01010242 GAMR01010241 GAMQ01007668 GAMQ01007667 GAMP01004616 GAMP01004615 JAB01933.1 JAB13161.1 JAB23689.1 JAB34183.1 JAB48139.1 GCES01153264 JAQ33058.1 CR860255 CAH92397.1 BT128242 AEE63202.1 AACZ04008467 GABF01010096 GABF01010095 GABD01000533 NBAG03000214 JAA12050.1 JAA32567.1 PNI83925.1 CABD030092947 CABD030092948 AJFE02084691 AJFE02084692 GABC01000020 GABE01002795 JAA11318.1 JAA41944.1 KU178627 ALQ34085.1 AF167438 AF395068 AF151840 CR457180 AK289427 AK293355 AK314465 AK074749 AL049779 CH471061 BC000112 BC011727 BC026274 BC037302 BC051291 DQ426886 JP016868 AES05466.1 AAKN02025212 ACTA01033695 GDRN01096942 GDRN01096940 JAI59223.1 AHZZ02032337 AFYH01034444 AFYH01034445 AQIB01054775 AAGW02057621 AGCU01021282 AEYP01004114 AEYP01004115 AY115489 KQ977151 KYN05278.1 AEYP01004120
Proteomes
UP000005204
UP000076420
UP000037510
UP000053240
UP000007648
UP000218220
+ More
UP000007266 UP000007151 UP000079721 UP000001646 UP000235965 UP000002280 UP000001595 UP000000589 UP000054359 UP000075881 UP000005225 UP000248480 UP000007798 UP000053268 UP000001554 UP000027135 UP000007646 UP000008225 UP000233220 UP000192223 UP000265000 UP000261680 UP000286642 UP000233020 UP000002277 UP000001519 UP000189704 UP000240080 UP000005640 UP000005447 UP000008912 UP000028761 UP000233200 UP000233060 UP000008672 UP000029965 UP000001811 UP000007267 UP000009136 UP000233160 UP000000715 UP000078542 UP000081671 UP000233040 UP000087266 UP000233140
UP000007266 UP000007151 UP000079721 UP000001646 UP000235965 UP000002280 UP000001595 UP000000589 UP000054359 UP000075881 UP000005225 UP000248480 UP000007798 UP000053268 UP000001554 UP000027135 UP000007646 UP000008225 UP000233220 UP000192223 UP000265000 UP000261680 UP000286642 UP000233020 UP000002277 UP000001519 UP000189704 UP000240080 UP000005640 UP000005447 UP000008912 UP000028761 UP000233200 UP000233060 UP000008672 UP000029965 UP000001811 UP000007267 UP000009136 UP000233160 UP000000715 UP000078542 UP000081671 UP000233040 UP000087266 UP000233140
Pfam
PF00106 adh_short
SUPFAM
SSF51735
SSF51735
ProteinModelPortal
H9J6R6
A0A293LWC1
A0A293MVK9
A0A2C9K9F2
A0A0L7KVJ8
A0A0L7KV18
+ More
A0A0N0PAY2 G3WGM2 G3WGM3 A0A2A4ITG8 A0A2H1VAE5 I4DQA1 A0A1Q3G5J0 A0A1Y1NCI4 H9JSR3 D6X0B0 A0A1Y1LAJ4 A0A1Y1N8N2 A0A1Z5LCY1 V9KU50 A0A2W1BZE1 A0A212F5B7 A0A1S2ZX06 A0A2H1W6X7 A0A2A4JJH1 H9GAM3 A0A2J7PGU9 A0A2A4IXN8 R4GC18 F6URR5 H9GAK1 A0A2H1W7C7 H2NLK8 A0A0N0PAY1 A0A2P6L863 Q9R1R9 Q9R1R8 A0A0N0PB70 A0A087TBA3 A0A2J7PGY1 Q9QYF1 A0A1Q3G5G7 H9JSL6 A0A0N0PC61 A0A0L7LKJ0 A0A250YFJ1 A0A3F2YU01 H0X3M1 A0A2Y9DAF6 A0A1Y1KEI4 B4N651 A0A212FMV5 A0A194Q6L5 C3YDD9 R4GAG6 A0A2J7PGT7 A0A067QUP0 A0A0N0PAN9 G3TEF7 F7BRU6 A0A2K6TDH4 A0A1W4WGA3 A0A3Q2TZ83 A0A384CV50 A0A3Q7W598 A0A3Q2NS51 A0A146NMV4 Q5R763 J3JYB7 A0A2K5F7C7 K7BJ49 G3QS80 A0A1U7TKA1 A0A2R9BIG4 K7DJ39 A0A0S2Z583 Q8TC12 G9KKN7 H0UUU1 G1LN50 A0A0P4W6I9 A0A096NVQ7 A0A2K6RH31 A0A2K5P068 H3BEA6 A0A0D9RLD9 G1SDM3 A0A1W4WGK2 K7FV47 F1MD39 A0A2K6EE83 M3Y738 P59837 A0A151IL06 A0A1S3F032 A0A2K5QRF4 A0A1S3S0C8 A0A2K6GQX0 A0A2K5ZHR2 M3Y753
A0A0N0PAY2 G3WGM2 G3WGM3 A0A2A4ITG8 A0A2H1VAE5 I4DQA1 A0A1Q3G5J0 A0A1Y1NCI4 H9JSR3 D6X0B0 A0A1Y1LAJ4 A0A1Y1N8N2 A0A1Z5LCY1 V9KU50 A0A2W1BZE1 A0A212F5B7 A0A1S2ZX06 A0A2H1W6X7 A0A2A4JJH1 H9GAM3 A0A2J7PGU9 A0A2A4IXN8 R4GC18 F6URR5 H9GAK1 A0A2H1W7C7 H2NLK8 A0A0N0PAY1 A0A2P6L863 Q9R1R9 Q9R1R8 A0A0N0PB70 A0A087TBA3 A0A2J7PGY1 Q9QYF1 A0A1Q3G5G7 H9JSL6 A0A0N0PC61 A0A0L7LKJ0 A0A250YFJ1 A0A3F2YU01 H0X3M1 A0A2Y9DAF6 A0A1Y1KEI4 B4N651 A0A212FMV5 A0A194Q6L5 C3YDD9 R4GAG6 A0A2J7PGT7 A0A067QUP0 A0A0N0PAN9 G3TEF7 F7BRU6 A0A2K6TDH4 A0A1W4WGA3 A0A3Q2TZ83 A0A384CV50 A0A3Q7W598 A0A3Q2NS51 A0A146NMV4 Q5R763 J3JYB7 A0A2K5F7C7 K7BJ49 G3QS80 A0A1U7TKA1 A0A2R9BIG4 K7DJ39 A0A0S2Z583 Q8TC12 G9KKN7 H0UUU1 G1LN50 A0A0P4W6I9 A0A096NVQ7 A0A2K6RH31 A0A2K5P068 H3BEA6 A0A0D9RLD9 G1SDM3 A0A1W4WGK2 K7FV47 F1MD39 A0A2K6EE83 M3Y738 P59837 A0A151IL06 A0A1S3F032 A0A2K5QRF4 A0A1S3S0C8 A0A2K6GQX0 A0A2K5ZHR2 M3Y753
PDB
3RD5
E-value=1.02928e-27,
Score=305
Ontologies
GO
Topology
Subcellular location
Endoplasmic reticulum membrane
Length:
295
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
2.49619
Exp number, first 60 AAs:
2.30142
Total prob of N-in:
0.15440
outside
1 - 295
Population Genetic Test Statistics
Pi
26.350893
Theta
25.092776
Tajima's D
0.125136
CLR
0
CSRT
0.411629418529074
Interpretation
Uncertain
