Gene

KWMTBOMO07476

Pre Gene Modal

BGIBMGA005193

Annotation

predicted_carotinoid_oxygenase_[Bombyx_mori]

Location

Bomo_Chr12(+):14037352-14044590      View in EpiBrowser

Full name

Carotenoid isomerooxygenase      

Alternative Name

Beta-carotene 15,15'-monooxygenase and retinoid isomerase
Beta-carotene dioxygenase and retinoid isomerase
Neither inactivation nor afterpotential mutant B

Location in the cell

Cytoplasmic   Reliability : 1.202

CDS

ATGGCAACGAATTTAACTTTTCAGACGAACATAGTGCTGCTAAGCAGGAAAGACGGCAAGGAGTGGAAACGGTACCGCACTCAGACCCTCTTCTTCCTTCACATCATCAACTGCTTTGAGAAGAACGGGTCAGTGATAGTGGACCTGTGCGCGTATAAAGACCCCAAGGCCTTAGATGCTATGTACGTCCACGCCATCGAGACTATGCAAAGTAACGCTGACTACGCGGAATGGTTTCGTGGACGACCAAAGAGGCTTGAGCTGCCTCTAGACGCTCCGAGATTGGCGAAGGTGGTTCCAACTATACTGGCCGACCTCGGCTGTGAGACTCCGAGGATACACTATGACCTTTATAACGGAAAGCCTTATAGATACTTCTACGCTATCAGTTCGGATGTGGATGCAGAAAACCCTGGGACGGTCATCAAAGCGGACACGGTGACTGGCGTAACGAAGACTTGGTGTGAACCGAACTGCTACCCGAGCGAGCCCGTGTTCGTACCGACCCCGGACGCGAAGAATGAAGACGACGGCGTGCTGTTGTGCGCGCTCGTGTGGGGGGGCGACCGCGAGCACGAAGTGGCTCTTCTCGTGCTCGACGCACGAACGATGCTCGAGGTGGCTCGGGCACAGTTTCGCACCCCCTCCCCCGCGCCCAAGTGCTTGCACGGCTGTTCGAACTAG

Protein

MATNLTFQTNIVLLSRKDGKEWKRYRTQTLFFLHIINCFEKNGSVIVDLCAYKDPKALDAMYVHAIETMQSNADYAEWFRGRPKRLELPLDAPRLAKVVPTILADLGCETPRIHYDLYNGKPYRYFYAISSDVDAENPGTVIKADTVTGVTKTWCEPNCYPSEPVFVPTPDAKNEDDGVLLCALVWGGDREHEVALLVLDARTMLEVARAQFRTPSPAPKCLHGCSN

Description

Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development.

Catalytic Activity

all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal

Cofactor

Fe(2+)

Similarity

Belongs to the carotenoid oxygenase family.

Keywords

Iron   Metal-binding   Monooxygenase   Oxidoreductase  

Feature

chain  Carotenoid isomerooxygenase

Uniprot

H9J6Q1   I0DFX8   I0DFX7   A0A2H1X2B8   A0A2H1VBH9   A0A0N1PI86   + More
A0A194Q067   A0A2A4JI62   A8Y9I2   A0A212EY39   A0A0N1IEP3   A0A212F876   A0A067QUF9   A0A212EY42   A0A2J7RDY6   A0A0P5WS92   A0A0P5I931   A0A1Y1L6P7   E9FZ91   A0A0P5VNW2   A0A139WB29   A0A0N8D2P0   D6X3L2   A0A1B0GMU1   A0A164UF70   A0A0P6GJI7   A0A0K8T6W7   A0A194PTS0   A0A0P6AMK8   A0A2S2NXS0   A0A146LVX9   A0A0P5E643   C4WX86   A0A1Q3FPD8   A0A2H8TP50   A0A1Q3FNN0   A0A146M7F0   J9K9L7   A0A1B0GIS6   A0A0P5WA15   N6URL1   U4URC3   A0A2R7WVZ4   A0A0P5ZJ92   B0W216   A0A1B6DAC4   A0A2S2QIX8   A0A0A9YFS5   A0A0P5TTU8   A0A3Q0JGZ4   A0A182URE3   A0A182WU08   A0A151IIP5   A0A0P6I1X0   A0A023F2Z8   A0A1B6KT97   A0A0C9RK14   A0A1J1HQM1   A0A1B6LCW0   T1I140   A0A0P5Z7K2   A0A2S2P0R2   A0A1B6HMY0   A0A1D2N5H7   A0A310SLQ2   A0A1B0CCI0   A0A1D2MEG1   A0A1B6FKH8   A0A226DXQ4   A0A1D2MJU7   A0A1J1J759   A0A0K8TD31  

EC Number

1.13.11.65

Pubmed

19121390    26354079    19020100    22118469    24845553    28004739    + More
21292972    18362917    19820115    26823975    23537049    25401762    25474469    27289101   

EMBL

BABH01038129    JQ337860    AFH88674.1    JQ337859    AFH88673.1    ODYU01012851    + More
SOQ59356.1    ODYU01001645    SOQ38156.1    KQ460479    KPJ14364.1    KQ459592    KPI96810.1    NWSH01001487    PCG71102.1    AM778534    AGBW02011623    OWR46413.1    KPJ14365.1    AGBW02009791    OWR49918.1    KK853408    KDR07804.1    OWR46412.1    NEVH01005280    PNF39042.1    GDIP01082332    JAM21383.1    GDIQ01240272    JAK11453.1    GEZM01066223    GEZM01066222    JAV68050.1    GL732528    EFX87306.1    GDIP01097477    JAM06238.1    KQ971375    KYB25127.1    GDIP01074727    JAM28988.1    EEZ97644.2    AJVK01003755    LRGB01001581    KZS11306.1    GDIQ01034665    JAN60072.1    GBRD01004538    JAG61283.1    KPI96811.1    GDIP01028996    JAM74719.1    GGMR01009394    MBY22013.1    GDHC01006816    JAQ11813.1    GDIP01146541    JAJ76861.1    AK342506    BAH72506.1    GFDL01005576    JAV29469.1    GFXV01003213    MBW15018.1    GFDL01005845    JAV29200.1    GDHC01003414    JAQ15215.1    ABLF02039333    AJWK01015367    GDIP01089082    JAM14633.1    APGK01019264    KB740098    ENN81377.1    KB632331    ERL92615.1    KK855485    PTY22775.1    GDIP01046389    JAM57326.1    DS231824    EDS27452.1    GEDC01030378    GEDC01014655    JAS06920.1    JAS22643.1    GGMS01008491    MBY77694.1    GBHO01015239    JAG28365.1    GDIP01126968    JAL76746.1    KQ977459    KYN02559.1    GDIQ01018435    JAN76302.1    GBBI01003119    JAC15593.1    GEBQ01025320    JAT14657.1    GBYB01007191    JAG76958.1    CVRI01000010    CRK88774.1    GEBQ01018460    JAT21517.1    ACPB03016560    GDIP01047987    JAM55728.1    GGMR01010472    MBY23091.1    GECU01031751    JAS75955.1    LJIJ01000200    ODN00530.1    KQ762882    OAD55365.1    AJWK01006798    AJWK01006799    LJIJ01001565    ODM91398.1    GECZ01019077    JAS50692.1    LNIX01000009    OXA50242.1    LJIJ01001059    ODM93155.1    CVRI01000074    CRL08261.1    GBRD01002505    JAG63316.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000027135    + More
UP000235965    UP000000305    UP000007266    UP000092462    UP000076858    UP000007819    UP000092461    UP000019118    UP000030742    UP000002320    UP000079169    UP000075903    UP000076407    UP000078542    UP000183832    UP000015103    UP000094527    UP000198287   

PRIDE

H9J6Q1    I0DFX8    I0DFX7   

Pfam

PF03055   RPE65        + More
PF02866   Ldh_1_C
PF00056   Ldh_1_N

Interpro

IPR004294   Carotenoid_Oase        + More
IPR011047   Quinoprotein_ADH-like_supfam       
IPR000595   cNMP-bd_dom       
IPR036291   NAD(P)-bd_dom_sf       
IPR015955   Lactate_DH/Glyco_Ohase_4_C       
IPR001236   Lactate/malate_DH_N       
IPR022383   Lactate/malate_DH_C       

SUPFAM

SSF50998   SSF50998        + More
SSF51735   SSF51735       
SSF56327   SSF56327       

Gene 3D

3.90.110.10    

ProteinModelPortal

H9J6Q1   I0DFX8   I0DFX7   A0A2H1X2B8   A0A2H1VBH9   A0A0N1PI86   + More
A0A194Q067   A0A2A4JI62   A8Y9I2   A0A212EY39   A0A0N1IEP3   A0A212F876   A0A067QUF9   A0A212EY42   A0A2J7RDY6   A0A0P5WS92   A0A0P5I931   A0A1Y1L6P7   E9FZ91   A0A0P5VNW2   A0A139WB29   A0A0N8D2P0   D6X3L2   A0A1B0GMU1   A0A164UF70   A0A0P6GJI7   A0A0K8T6W7   A0A194PTS0   A0A0P6AMK8   A0A2S2NXS0   A0A146LVX9   A0A0P5E643   C4WX86   A0A1Q3FPD8   A0A2H8TP50   A0A1Q3FNN0   A0A146M7F0   J9K9L7   A0A1B0GIS6   A0A0P5WA15   N6URL1   U4URC3   A0A2R7WVZ4   A0A0P5ZJ92   B0W216   A0A1B6DAC4   A0A2S2QIX8   A0A0A9YFS5   A0A0P5TTU8   A0A3Q0JGZ4   A0A182URE3   A0A182WU08   A0A151IIP5   A0A0P6I1X0   A0A023F2Z8   A0A1B6KT97   A0A0C9RK14   A0A1J1HQM1   A0A1B6LCW0   T1I140   A0A0P5Z7K2   A0A2S2P0R2   A0A1B6HMY0   A0A1D2N5H7   A0A310SLQ2   A0A1B0CCI0   A0A1D2MEG1   A0A1B6FKH8   A0A226DXQ4   A0A1D2MJU7   A0A1J1J759   A0A0K8TD31  

PDB

5ULG     E-value=1.03424e-19,     Score=235

KEGG

101740058    K18048 carotenoid isomerooxygenase [EC:1.13.11.65] | (RefSeq) ninaB-1, ninaB-2; beta,beta-carotene 1

GO

GO:0046872   GO:0016702   GO:0004497   GO:0042572   GO:0004744   GO:0016121   GO:0003834   GO:0010436   GO:0042574   GO:0016616   GO:0005975   GO:0003824   GO:0016491   GO:0007165   GO:0005509   GO:0016042   GO:0016020   GO:0003707   GO:0051537   GO:0055114  

PANTHER

PTHR10543  

Length:

227

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.36615

Exp number, first 60 AAs:

0.36607

Total prob of N-in:

0.13190

outside

1  -  227

 

 

Pi

4.340557

Theta

13.768331

Tajima's D

-1.497544

CLR

2.565331

CSRT

0.0607469626518674

Interpretation

Uncertain