Gene
KWMTBOMO07475
Pre Gene Modal
BGIBMGA005193
Annotation
beta?beta-carotene_15?15'-monooxygenase-like_[Bombyx_mori]
Full name
Carotenoid isomerooxygenase
Alternative Name
Beta-carotene 15,15'-monooxygenase and retinoid isomerase
Beta-carotene dioxygenase and retinoid isomerase
Neither inactivation nor afterpotential mutant B
Beta-carotene dioxygenase and retinoid isomerase
Neither inactivation nor afterpotential mutant B
Location in the cell
Cytoplasmic Reliability : 0.979
Sequence
CDS
ATGGCTGCGGAAACACAGAACTTGTACCCGAACTGCGATTCGAGTGTTTGGTTGAGATCCTGCGAAGAGGAAGTCACCGAACCTCTAGACGGAAATATTACAGGCACATTGCCACCTTGGCTTCGTGGTACACTGCTTCGCAACGGGCCGGGATCTCTGAAGGTCGGAGCGATGCGATTCAAACATTTGTTTGACAGCTCAGCGCTTTTACACAGGTTTGCGATACACGACGGTATAGTTACATACCAATGTCAGTTTCTCAAGTCCAATACGCTGAAGAAGAACAGGGCGGCTAACAGGATTGTCGTCACGGAATTCGGAACCAAATCAGTGCACGATCCGTGTCATACTATCTTCGATAGGGTGGCGGCTATTTTCAAACCGGGCGACTCCATGTCGGACAACGCTATGATATCCTTGTACCCGTTCGGGGATGAAATATACGCATTTACAGAGGGTCCTATTATTCATAGGATAGATCCGGTGACTTTGGATACCCTGGATCGAAAGAATATGACGGACTGCATCGCTCTTGTCAATCACACGTCACATCCGCACGTAATGCCCAACGGTGACGTTTACAACGTAGGAATGTCGATAGTAAAGGGCGGACTCAGGCATGTCGTGGTGAAATTTCCTTACACGGAGAAAGGAGACATGTTCGAGCGCGCCAAAGTTGTGGCGAGTTTGAAACCAAGATGGCCGCTGCATCCCGCTTACATGCATACGTTTGGTACGAATTTGACAAGACAGCTTTTCTTAACCTCTTCTTTTTCAAACTGGTAA
Protein
MAAETQNLYPNCDSSVWLRSCEEEVTEPLDGNITGTLPPWLRGTLLRNGPGSLKVGAMRFKHLFDSSALLHRFAIHDGIVTYQCQFLKSNTLKKNRAANRIVVTEFGTKSVHDPCHTIFDRVAAIFKPGDSMSDNAMISLYPFGDEIYAFTEGPIIHRIDPVTLDTLDRKNMTDCIALVNHTSHPHVMPNGDVYNVGMSIVKGGLRHVVVKFPYTEKGDMFERAKVVASLKPRWPLHPAYMHTFGTNLTRQLFLTSSFSNW
Summary
Description
Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development.
Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception.
Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception.
Catalytic Activity
all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
Cofactor
Fe(2+)
Similarity
Belongs to the carotenoid oxygenase family.
Keywords
Iron
Metal-binding
Monooxygenase
Oxidoreductase
Complete proteome
Reference proteome
Feature
chain Carotenoid isomerooxygenase
Uniprot
I0DFX7
A8Y9I2
A0A2A4JI62
A0A2H1VBH9
A0A194Q067
I0DFX8
+ More
A0A0N1PI86 A0A212EY39 Q17FY3 A0A182H5Q0 A0A2J7RDY6 A0A0N1IDH1 A0A1B6DAC4 A0A1Q3FNN0 A0A1Q3FPD8 B0W216 W5J3D8 A0A1Y9GLE5 A0A182SJU9 Q7Q411 A0A182URE3 A0A182WU08 A0A1S4GXE0 A0A182Y0A2 A0A182L1F0 A0A182RCT2 A0A182LRC9 A0A1B6KT97 A0A182Q6V3 A0A182F4X0 A0A182JU85 A0A182JI63 A0A034V7D3 A0A034V7D0 A0A182PPK6 A0A232EWH8 A0A1A9XM81 A0A182W715 A0A1B0BNS4 A0A1B6EZD3 A0A1B0GIS6 A0A1A9WDL0 A0A1A9V8V6 A0A1B0GMU1 A0A154P3Y5 A0A182NUF8 A0A0K8UAS6 A0A0L0BQD9 A0A1B0A7T0 A0A1I8NE16 A0A1B0FGT0 A0A212EY42 A0A1I8NE15 W8AFR2 A0A1I8QDN2 A0A1I8QDQ1 A0A1I8QDQ5 A0A336K6N6 A0A1I8QDQ2 A0A3B0K9S8 K7J6E4 A0A3B0K2Y2 Q299Z6 B4KBR0 B4NH74 A0A0Q9WZH1 B4G3J1 A0A084W867 B4R162 A0A0M3QXZ7 Q9VFS2 B4HFP5 B4PQH9 B4MBL2 Q9NKW9 V9II87 A0A088AMG3 U4URC3 A0A2A3EHF1 A0A0L7RCH1 N6URL1 A0A194PTS0 A0A212F876 B4JYB7 E2C3F4 A0A2A3EHF9 B3P415 A0A0M9A8U9 B3LWV8 A0A195EZ02 A0A026W0P0 A0A1W4V4X0 A0A195DNI6 A0A310SLQ2 A0A336K788 A0A195BNB4 A0A158P2X6 A0A0J7L236 A0A151WYK1 A0A2S2QIX8
A0A0N1PI86 A0A212EY39 Q17FY3 A0A182H5Q0 A0A2J7RDY6 A0A0N1IDH1 A0A1B6DAC4 A0A1Q3FNN0 A0A1Q3FPD8 B0W216 W5J3D8 A0A1Y9GLE5 A0A182SJU9 Q7Q411 A0A182URE3 A0A182WU08 A0A1S4GXE0 A0A182Y0A2 A0A182L1F0 A0A182RCT2 A0A182LRC9 A0A1B6KT97 A0A182Q6V3 A0A182F4X0 A0A182JU85 A0A182JI63 A0A034V7D3 A0A034V7D0 A0A182PPK6 A0A232EWH8 A0A1A9XM81 A0A182W715 A0A1B0BNS4 A0A1B6EZD3 A0A1B0GIS6 A0A1A9WDL0 A0A1A9V8V6 A0A1B0GMU1 A0A154P3Y5 A0A182NUF8 A0A0K8UAS6 A0A0L0BQD9 A0A1B0A7T0 A0A1I8NE16 A0A1B0FGT0 A0A212EY42 A0A1I8NE15 W8AFR2 A0A1I8QDN2 A0A1I8QDQ1 A0A1I8QDQ5 A0A336K6N6 A0A1I8QDQ2 A0A3B0K9S8 K7J6E4 A0A3B0K2Y2 Q299Z6 B4KBR0 B4NH74 A0A0Q9WZH1 B4G3J1 A0A084W867 B4R162 A0A0M3QXZ7 Q9VFS2 B4HFP5 B4PQH9 B4MBL2 Q9NKW9 V9II87 A0A088AMG3 U4URC3 A0A2A3EHF1 A0A0L7RCH1 N6URL1 A0A194PTS0 A0A212F876 B4JYB7 E2C3F4 A0A2A3EHF9 B3P415 A0A0M9A8U9 B3LWV8 A0A195EZ02 A0A026W0P0 A0A1W4V4X0 A0A195DNI6 A0A310SLQ2 A0A336K788 A0A195BNB4 A0A158P2X6 A0A0J7L236 A0A151WYK1 A0A2S2QIX8
EC Number
1.13.11.65
Pubmed
19020100
26354079
22118469
17510324
26483478
20920257
+ More
23761445 12364791 25244985 20966253 25348373 28648823 26108605 25315136 24495485 20075255 15632085 17994087 24438588 10766819 10731132 12537572 12537569 11158606 14982930 17452532 17344064 19889630 17550304 23537049 20798317 24508170 30249741 21347285
23761445 12364791 25244985 20966253 25348373 28648823 26108605 25315136 24495485 20075255 15632085 17994087 24438588 10766819 10731132 12537572 12537569 11158606 14982930 17452532 17344064 19889630 17550304 23537049 20798317 24508170 30249741 21347285
EMBL
JQ337859
AFH88673.1
AM778534
NWSH01001487
PCG71102.1
ODYU01001645
+ More
SOQ38156.1 KQ459592 KPI96810.1 JQ337860 AFH88674.1 KQ460479 KPJ14364.1 AGBW02011623 OWR46413.1 CH477267 EAT45491.1 JXUM01112251 KQ565576 KXJ70865.1 NEVH01005280 PNF39042.1 LADI01009561 KPJ20706.1 GEDC01030378 GEDC01014655 JAS06920.1 JAS22643.1 GFDL01005845 JAV29200.1 GFDL01005576 JAV29469.1 DS231824 EDS27452.1 ADMH02002111 ETN58862.1 APCN01002465 AAAB01008964 EAA12399.4 AXCM01015462 GEBQ01025320 JAT14657.1 AXCN02000761 GAKP01021484 JAC37468.1 GAKP01021489 GAKP01021486 JAC37463.1 NNAY01001856 OXU22702.1 JXJN01017585 GECZ01026430 JAS43339.1 AJWK01015367 AJVK01003755 KQ434796 KZC05840.1 GDHF01028595 GDHF01015782 JAI23719.1 JAI36532.1 JRES01001623 KNC21419.1 CCAG010004028 OWR46412.1 GAMC01019445 GAMC01019443 JAB87110.1 UFQS01000137 UFQT01000137 SSX00339.1 SSX20719.1 OUUW01000005 SPP80308.1 SPP80309.1 CM000070 EAL27555.2 CH933806 EDW14737.1 CH964272 EDW84571.1 KRG01165.1 CH479179 EDW24999.1 ATLV01021376 KE525317 KFB46411.1 CM000364 EDX13039.1 CP012526 ALC46793.1 AJ276682 AE014297 AY121617 CH480815 EDW42280.1 CM000160 EDW97275.1 CH940656 EDW58483.1 AB041507 BAA94508.1 JR045699 AEY60034.1 KB632331 ERL92615.1 KZ288248 PBC31147.1 KQ414615 KOC68687.1 APGK01019264 KB740098 ENN81377.1 KPI96811.1 AGBW02009791 OWR49918.1 CH916377 EDV90679.1 GL452320 EFN77492.1 PBC31148.1 CH954181 EDV49189.1 KQ435711 KOX79605.1 CH902617 EDV42746.1 KQ981905 KYN33448.1 KK107538 QOIP01000005 EZA49146.1 RLU22972.1 KQ980713 KYN14396.1 KQ762882 OAD55365.1 SSX00337.1 SSX20717.1 KQ976432 KYM87520.1 ADTU01007642 LBMM01001130 KMQ96862.1 KQ982649 KYQ52972.1 GGMS01008491 MBY77694.1
SOQ38156.1 KQ459592 KPI96810.1 JQ337860 AFH88674.1 KQ460479 KPJ14364.1 AGBW02011623 OWR46413.1 CH477267 EAT45491.1 JXUM01112251 KQ565576 KXJ70865.1 NEVH01005280 PNF39042.1 LADI01009561 KPJ20706.1 GEDC01030378 GEDC01014655 JAS06920.1 JAS22643.1 GFDL01005845 JAV29200.1 GFDL01005576 JAV29469.1 DS231824 EDS27452.1 ADMH02002111 ETN58862.1 APCN01002465 AAAB01008964 EAA12399.4 AXCM01015462 GEBQ01025320 JAT14657.1 AXCN02000761 GAKP01021484 JAC37468.1 GAKP01021489 GAKP01021486 JAC37463.1 NNAY01001856 OXU22702.1 JXJN01017585 GECZ01026430 JAS43339.1 AJWK01015367 AJVK01003755 KQ434796 KZC05840.1 GDHF01028595 GDHF01015782 JAI23719.1 JAI36532.1 JRES01001623 KNC21419.1 CCAG010004028 OWR46412.1 GAMC01019445 GAMC01019443 JAB87110.1 UFQS01000137 UFQT01000137 SSX00339.1 SSX20719.1 OUUW01000005 SPP80308.1 SPP80309.1 CM000070 EAL27555.2 CH933806 EDW14737.1 CH964272 EDW84571.1 KRG01165.1 CH479179 EDW24999.1 ATLV01021376 KE525317 KFB46411.1 CM000364 EDX13039.1 CP012526 ALC46793.1 AJ276682 AE014297 AY121617 CH480815 EDW42280.1 CM000160 EDW97275.1 CH940656 EDW58483.1 AB041507 BAA94508.1 JR045699 AEY60034.1 KB632331 ERL92615.1 KZ288248 PBC31147.1 KQ414615 KOC68687.1 APGK01019264 KB740098 ENN81377.1 KPI96811.1 AGBW02009791 OWR49918.1 CH916377 EDV90679.1 GL452320 EFN77492.1 PBC31148.1 CH954181 EDV49189.1 KQ435711 KOX79605.1 CH902617 EDV42746.1 KQ981905 KYN33448.1 KK107538 QOIP01000005 EZA49146.1 RLU22972.1 KQ980713 KYN14396.1 KQ762882 OAD55365.1 SSX00337.1 SSX20717.1 KQ976432 KYM87520.1 ADTU01007642 LBMM01001130 KMQ96862.1 KQ982649 KYQ52972.1 GGMS01008491 MBY77694.1
Proteomes
UP000218220
UP000053268
UP000053240
UP000007151
UP000008820
UP000069940
+ More
UP000249989 UP000235965 UP000002320 UP000000673 UP000075840 UP000075901 UP000007062 UP000075903 UP000076407 UP000076408 UP000075882 UP000075900 UP000075883 UP000075886 UP000069272 UP000075881 UP000075880 UP000075885 UP000215335 UP000092443 UP000075920 UP000092460 UP000092461 UP000091820 UP000078200 UP000092462 UP000076502 UP000075884 UP000037069 UP000092445 UP000095301 UP000092444 UP000095300 UP000268350 UP000002358 UP000001819 UP000009192 UP000007798 UP000008744 UP000030765 UP000000304 UP000092553 UP000000803 UP000001292 UP000002282 UP000008792 UP000005203 UP000030742 UP000242457 UP000053825 UP000019118 UP000001070 UP000008237 UP000008711 UP000053105 UP000007801 UP000078541 UP000053097 UP000279307 UP000192221 UP000078492 UP000078540 UP000005205 UP000036403 UP000075809
UP000249989 UP000235965 UP000002320 UP000000673 UP000075840 UP000075901 UP000007062 UP000075903 UP000076407 UP000076408 UP000075882 UP000075900 UP000075883 UP000075886 UP000069272 UP000075881 UP000075880 UP000075885 UP000215335 UP000092443 UP000075920 UP000092460 UP000092461 UP000091820 UP000078200 UP000092462 UP000076502 UP000075884 UP000037069 UP000092445 UP000095301 UP000092444 UP000095300 UP000268350 UP000002358 UP000001819 UP000009192 UP000007798 UP000008744 UP000030765 UP000000304 UP000092553 UP000000803 UP000001292 UP000002282 UP000008792 UP000005203 UP000030742 UP000242457 UP000053825 UP000019118 UP000001070 UP000008237 UP000008711 UP000053105 UP000007801 UP000078541 UP000053097 UP000279307 UP000192221 UP000078492 UP000078540 UP000005205 UP000036403 UP000075809
Pfam
Interpro
IPR004294
Carotenoid_Oase
+ More
IPR000595 cNMP-bd_dom
IPR011047 Quinoprotein_ADH-like_supfam
IPR022761 Fumarate_lyase_N
IPR020557 Fumarate_lyase_CS
IPR009049 Argininosuccinate_lyase
IPR000362 Fumarate_lyase_fam
IPR024083 Fumarase/histidase_N
IPR008948 L-Aspartase-like
IPR029419 Arg_succ_lyase_C
IPR036291 NAD(P)-bd_dom_sf
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001236 Lactate/malate_DH_N
IPR022383 Lactate/malate_DH_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000595 cNMP-bd_dom
IPR011047 Quinoprotein_ADH-like_supfam
IPR022761 Fumarate_lyase_N
IPR020557 Fumarate_lyase_CS
IPR009049 Argininosuccinate_lyase
IPR000362 Fumarate_lyase_fam
IPR024083 Fumarase/histidase_N
IPR008948 L-Aspartase-like
IPR029419 Arg_succ_lyase_C
IPR036291 NAD(P)-bd_dom_sf
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001236 Lactate/malate_DH_N
IPR022383 Lactate/malate_DH_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
Gene 3D
ProteinModelPortal
I0DFX7
A8Y9I2
A0A2A4JI62
A0A2H1VBH9
A0A194Q067
I0DFX8
+ More
A0A0N1PI86 A0A212EY39 Q17FY3 A0A182H5Q0 A0A2J7RDY6 A0A0N1IDH1 A0A1B6DAC4 A0A1Q3FNN0 A0A1Q3FPD8 B0W216 W5J3D8 A0A1Y9GLE5 A0A182SJU9 Q7Q411 A0A182URE3 A0A182WU08 A0A1S4GXE0 A0A182Y0A2 A0A182L1F0 A0A182RCT2 A0A182LRC9 A0A1B6KT97 A0A182Q6V3 A0A182F4X0 A0A182JU85 A0A182JI63 A0A034V7D3 A0A034V7D0 A0A182PPK6 A0A232EWH8 A0A1A9XM81 A0A182W715 A0A1B0BNS4 A0A1B6EZD3 A0A1B0GIS6 A0A1A9WDL0 A0A1A9V8V6 A0A1B0GMU1 A0A154P3Y5 A0A182NUF8 A0A0K8UAS6 A0A0L0BQD9 A0A1B0A7T0 A0A1I8NE16 A0A1B0FGT0 A0A212EY42 A0A1I8NE15 W8AFR2 A0A1I8QDN2 A0A1I8QDQ1 A0A1I8QDQ5 A0A336K6N6 A0A1I8QDQ2 A0A3B0K9S8 K7J6E4 A0A3B0K2Y2 Q299Z6 B4KBR0 B4NH74 A0A0Q9WZH1 B4G3J1 A0A084W867 B4R162 A0A0M3QXZ7 Q9VFS2 B4HFP5 B4PQH9 B4MBL2 Q9NKW9 V9II87 A0A088AMG3 U4URC3 A0A2A3EHF1 A0A0L7RCH1 N6URL1 A0A194PTS0 A0A212F876 B4JYB7 E2C3F4 A0A2A3EHF9 B3P415 A0A0M9A8U9 B3LWV8 A0A195EZ02 A0A026W0P0 A0A1W4V4X0 A0A195DNI6 A0A310SLQ2 A0A336K788 A0A195BNB4 A0A158P2X6 A0A0J7L236 A0A151WYK1 A0A2S2QIX8
A0A0N1PI86 A0A212EY39 Q17FY3 A0A182H5Q0 A0A2J7RDY6 A0A0N1IDH1 A0A1B6DAC4 A0A1Q3FNN0 A0A1Q3FPD8 B0W216 W5J3D8 A0A1Y9GLE5 A0A182SJU9 Q7Q411 A0A182URE3 A0A182WU08 A0A1S4GXE0 A0A182Y0A2 A0A182L1F0 A0A182RCT2 A0A182LRC9 A0A1B6KT97 A0A182Q6V3 A0A182F4X0 A0A182JU85 A0A182JI63 A0A034V7D3 A0A034V7D0 A0A182PPK6 A0A232EWH8 A0A1A9XM81 A0A182W715 A0A1B0BNS4 A0A1B6EZD3 A0A1B0GIS6 A0A1A9WDL0 A0A1A9V8V6 A0A1B0GMU1 A0A154P3Y5 A0A182NUF8 A0A0K8UAS6 A0A0L0BQD9 A0A1B0A7T0 A0A1I8NE16 A0A1B0FGT0 A0A212EY42 A0A1I8NE15 W8AFR2 A0A1I8QDN2 A0A1I8QDQ1 A0A1I8QDQ5 A0A336K6N6 A0A1I8QDQ2 A0A3B0K9S8 K7J6E4 A0A3B0K2Y2 Q299Z6 B4KBR0 B4NH74 A0A0Q9WZH1 B4G3J1 A0A084W867 B4R162 A0A0M3QXZ7 Q9VFS2 B4HFP5 B4PQH9 B4MBL2 Q9NKW9 V9II87 A0A088AMG3 U4URC3 A0A2A3EHF1 A0A0L7RCH1 N6URL1 A0A194PTS0 A0A212F876 B4JYB7 E2C3F4 A0A2A3EHF9 B3P415 A0A0M9A8U9 B3LWV8 A0A195EZ02 A0A026W0P0 A0A1W4V4X0 A0A195DNI6 A0A310SLQ2 A0A336K788 A0A195BNB4 A0A158P2X6 A0A0J7L236 A0A151WYK1 A0A2S2QIX8
PDB
5ULG
E-value=2.03361e-43,
Score=440
Ontologies
GO
GO:0046872
GO:0016702
GO:0042572
GO:0004497
GO:0016787
GO:0042574
GO:0010436
GO:0003834
GO:0016121
GO:0004744
GO:0004056
GO:0042450
GO:0016021
GO:0016063
GO:0007603
GO:0035238
GO:0016119
GO:0007604
GO:0055114
GO:0007602
GO:0009110
GO:0016616
GO:0005975
GO:0003824
GO:0016491
GO:0007165
GO:0005509
GO:0016042
GO:0016020
GO:0003707
GO:0051537
PANTHER
Topology
Length:
261
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.01397
Exp number, first 60 AAs:
0
Total prob of N-in:
0.04370
outside
1 - 261
Population Genetic Test Statistics
Pi
2.358496
Theta
12.990861
Tajima's D
-2.231671
CLR
589.088448
CSRT
0.00444977751112444
Interpretation
Possibly Positive selection
