Gene

KWMTBOMO07474

Pre Gene Modal

BGIBMGA005192

Annotation

PREDICTED:_malate_dehydrogenase?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr12(+):14008292-14013506      View in EpiBrowser

Full name

Malate dehydrogenase      

Location in the cell

Extracellular   Reliability : 1.53 PlasmaMembrane   Reliability : 1.907

CDS

ATGAGCTGGTGTCGGTGTCATTTGACCCCCATAGTCGGCGCTGGTAGTGACATTGGTCGAATAGCAGCTTTGTTCCTAAAACAGCAGAAAGTCGTGAAAACCCTTGCCTTGTATGATGATGTACCCGAACGATACGTATTGGGAATAGCCAACGACTTAGCACATATTGATACTAGCACTGAGATCGAAGCGTTTCAAGGAAGAGTTTTCTTAAAACCAGCGCTATATAACTCTGACGTGGTGTTAATTTGTGGAGGATGCTACGTGCTCCCTCCGTGTTGTAGCGTCGAGGACCGAGAGCTCTTTTTTCAGAACATGGCTTATGTTCGCACAGTTACATTGGCTATTGCTCAATTCTGTCCTCAAGCTATTGTGGCCATACAAACTCCGCCCGTGGACTGTAACTTCGCACTGTGTATGCATACCTTGAAAATGGCGGGAGTTTACAATAAGAGACGCGTTCTCGGTGTGAACTCGGTAAACGCGATGCGAGCGAATCAGCTGTTTAGCGCGATGACGGGCACTGACCCCGCTGCGCGCACTACGCCGGTCGTCTGCGGCACCGGACGCTGTACTCGAGTTCCCGTGTTCTCCGCTGGTAAAGCTGGCAATGTTCCCAGGTCGCAAGTGGAGTGTCTCACGCGTCTCATACGGGAAGCTGATGATATTATCTGCAAAGTAAAAAGCAACAACGGACAAGGACACCTTTCCATTGGGTTTTCTACTGCACGATTTGTCGTTAATATTATGAAAGGTCTTTTCCAAAAGCCGACATTTATCGATAGTGCTTTAGTGGAACAACGTGATCCCGGGAAATGTTACAATATGGCTGTTTGCGCGACACCAGTCACAATAGGGAAAGGCGGCATTGTGGAATACGTGGTGCCGCAATTGAATGAAGCTGAAACTAAACTATTGGAAGACAGCAAGTGCGACCTAGAGGATATGCTGAACCTCGGCAGATGTTATGCTGTGGGTGATGAATACTGCATCCACTCATGCAAGTGTCCAGCTCCTCCTTCTTGCAAGACCTCCAGAAATAATCTGATCTTAAGCAGTGTAGCTAAATCCATATTTGTGAAGGTAACTTGGAACTGCAACTTGGTAACAAGGCGGAAAGTGGCAACTTTGGTCCCGCTGCGCTAA

Protein

MSWCRCHLTPIVGAGSDIGRIAALFLKQQKVVKTLALYDDVPERYVLGIANDLAHIDTSTEIEAFQGRVFLKPALYNSDVVLICGGCYVLPPCCSVEDRELFFQNMAYVRTVTLAIAQFCPQAIVAIQTPPVDCNFALCMHTLKMAGVYNKRRVLGVNSVNAMRANQLFSAMTGTDPAARTTPVVCGTGRCTRVPVFSAGKAGNVPRSQVECLTRLIREADDIICKVKSNNGQGHLSIGFSTARFVVNIMKGLFQKPTFIDSALVEQRDPGKCYNMAVCATPVTIGKGGIVEYVVPQLNEAETKLLEDSKCDLEDMLNLGRCYAVGDEYCIHSCKCPAPPSCKTSRNNLILSSVAKSIFVKVTWNCNLVTRRKVATLVPLR

Description

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic Activity

(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate

Cofactor

Fe(2+)

Subunit

Homodimer.

Similarity

Belongs to the LDH/MDH superfamily.
Belongs to the carotenoid oxygenase family.
Belongs to the LDH/MDH superfamily. MDH type 1 family.

Keywords

Complete proteome   NAD   Oxidoreductase   Tricarboxylic acid cycle  

Feature

chain  Malate dehydrogenase

Uniprot

A0A2A4JGJ5   A0A3S2P542   A0A0N1PGW7   A0A2H1VBF7   A0A194PTS0   A0A0L7L654   + More
V5SJ21   A0A1L8E0M4   A0A1L8EI00   H9JU51   B3MTR2   B3NZ92   B4M0W4   A0A1Y1MKR1   B4JI52   B4IB85   Q9VEB1   A0A1W4U941   B4PL86   A0A0L0BXC1   B4K7H4   B4NG95   A0A1Z5LBZ6   A0A2U8I2I6   A0A1B6DH64   A0A0K8TPD6   T1PH40   A0A1B0D3T4   A0A1B0CP43   A0A383KSF0   A0A1Z1SPZ3   B4F2A1   A0A1L8EEK1   A0A1L8EEQ2   A0A140NN07   B2Q4U7   A0A335E6L1   A0A379HHV1   Q4PP90   A0A0M9CZC5   A0A023FKC0   A0A154PN63   A0A023FWQ5   A0A310SPT5   V9IKY6   A0A0M4EPV2   A0A293LJK1   A0A131XGD2   A0A1I8PUI8   A0A2A3E6L2   A0A1B6GIT9   A0A2C6DJG2   W8BVV6   A0A3B0KCD1   A0A0K8VWB8   A0A0C9QFA6   A0A034VDU0   A0A0C9S2L6   A0A023FJ07   A0A1B6GA36   A0A1I9WLG5   A0A158NR67   L7M8Y4   A0A1B6CB81   E2B525   A0A131Y2D8   A0A094K5W9   E0W2E5   B4QUH7   A0A195E5P6   B7PH44   A0A195C8W5   A0A0K8RNA0   A0A1B6J8X6   A0A379F7W1   A0A091L2M8   A0A0G4QBC9   A0A2J9L5I6   A0A2A4K4Z0   A0A0A1XDJ4   A0A366N9J7   A0A336KS61   A0A1B7JNA6   A0A3D2BI27   A0A2R5LL11   A0A3D9U8N3   Q6B4U5   A0A379EHN9   A0A0G4QEA1   A0A224Z2B3   A0A131Z2S2   A0A023FKR5   A0A292C4T0   D2A663   A0A094L1E7   V6MEP9   A0A091RKN9  

EC Number

1.1.1.37

Pubmed

26354079    26227816    19121390    17994087    28004739    10731132    + More
12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    26108605    28528879    26369729    25315136    18375554    22740665    28049606    24495485    25348373    26131772    27538518    21347285    25576852    20798317    20566863    25830018    30148503    16235119    27762356    28797301    26830274    18362917    19820115    24435854   

EMBL

NWSH01001487    PCG71101.1    RSAL01000020    RVE52617.1    KQ460479    KPJ14366.1    + More
ODYU01001645    SOQ38157.1    KQ459592    KPI96811.1    JTDY01002773    KOB70759.1    KF647639    AHB50501.1    GFDF01001804    JAV12280.1    GFDG01000570    JAV18229.1    BABH01004084    BABH01004085    CH902623    EDV30193.1    CH954181    EDV48634.1    CH940650    EDW68423.1    GEZM01028449    JAV86301.1    CH916369    EDV92933.1    CH480827    EDW44643.1    AE014297    AY119152    BT029274    AAF55516.1    AAM51012.1    ABK30911.1    CM000160    EDW95868.1    JRES01001197    KNC24655.1    CH933806    EDW15318.1    CH964251    EDW83312.1    GFJQ02002048    JAW04922.1    CP021659    AWK13336.1    GEDC01012275    JAS25023.1    GDAI01001597    JAI16006.1    KA647450    AFP62079.1    AJVK01011042    AJWK01021413    UIRA01000030    SVJ57987.1    CP021694    ARX32649.1    AM942759    GFDG01001652    JAV17147.1    GFDG01001643    JAV17156.1    CP003488    AFH94263.1    ABJD02000102    EDU58179.1    UFMN01000005    SST03734.1    UGUB01000002    UGUC01000004    SUC43993.1    SUC78682.1    DQ062223    AAY63978.1    LJCS01000021    KOY62223.1    GBBK01002903    JAC21579.1    KQ434960    KZC12660.1    GBBL01001391    JAC25929.1    KQ761246    OAD57934.1    JR049934    AEY61131.1    CP012526    ALC47877.1    GFWV01003318    MAA28048.1    GEFH01002017    JAP66564.1    KZ288351    PBC27350.1    GECZ01015347    GECZ01007546    JAS54422.1    JAS62223.1    PDDX01000001    PHI28961.1    GAMC01003193    JAC03363.1    OUUW01000008    SPP83849.1    GDHF01009138    JAI43176.1    GBYB01013203    JAG82970.1    GAKP01018685    GAKP01018684    JAC40267.1    GBZX01001486    JAG91254.1    GBBK01002880    JAC21602.1    GECZ01014690    GECZ01010479    JAS55079.1    JAS59290.1    KU932349    APA33985.1    ADTU01023767    GACK01005436    JAA59598.1    GEDC01026556    JAS10742.1    GL445685    EFN89233.1    GEFM01003154    JAP72642.1    KL342034    KFZ53514.1    DS235877    EEB19801.1    CM000364    EDX12477.1    KQ979608    KYN20488.1    ABJB010476585    ABJB010859688    ABJB011055278    ABJB011116435    DS711115    EEC05916.1    KQ978081    KYM97140.1    GADI01001415    JAA72393.1    GECU01012127    JAS95579.1    UGTW01000001    SUC15690.1    KK764223    KFP45870.1    CVRZ01000007    CRL62936.1    NJFA02000001    PNL48752.1    NWSH01000176    PCG78732.1    GBXI01004828    JAD09464.1    UFQS01000662    UFQT01000490    UFQT01000662    SSX05893.1    SSX24725.1    DPFJ01000054    HCH49930.1    GGLE01006002    MBY10128.1    QTUB01000001    REF25838.1    BC106695    AY681346    AH014673    AY924294    AY924295    AY924296    AY924297    CM004468    AAI06696.1    AAT85637.1    OCT95004.1    UGTQ01000009    SUB98883.1    CVRY01000006    CRL64208.1    GFPF01009557    MAA20703.1    GEDV01002858    JAP85699.1    GBBK01002902    JAC21580.1    CP023965    ATM98694.1    KQ971346    EFA04972.1    KL269186    KFZ63322.1    AWXP01000023    EST57006.1    KK821814    KFQ40408.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000053268    UP000037510    UP000005204    + More
UP000007801    UP000008711    UP000008792    UP000001070    UP000001292    UP000000803    UP000192221    UP000002282    UP000037069    UP000009192    UP000007798    UP000095301    UP000092462    UP000092461    UP000258067    UP000195540    UP000008319    UP000005012    UP000004506    UP000262355    UP000254419    UP000254690    UP000037727    UP000076502    UP000092553    UP000095300    UP000242457    UP000224974    UP000268350    UP000005205    UP000008237    UP000009046    UP000000304    UP000078492    UP000001555    UP000078542    UP000254331    UP000181932    UP000197103    UP000256294    UP000186698    UP000254361    UP000183920    UP000222988    UP000007266    UP000018077   

PRIDE

H9JU51    B3MTR2    Q9VEB1    B4F2A1    L7M8Y4    B7PH44    + More
Q6B4U5   

Pfam

PF02866   Ldh_1_C        + More
PF00056   Ldh_1_N
PF03055   RPE65

Interpro

IPR015955   Lactate_DH/Glyco_Ohase_4_C        + More
IPR022383   Lactate/malate_DH_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR001236   Lactate/malate_DH_N       
IPR001557   L-lactate/malate_DH       
IPR004294   Carotenoid_Oase       
IPR010097   Malate_DH_type1       
IPR001252   Malate_DH_AS       
IPR023958   Malate_DH_type1_bac       

SUPFAM

SSF51735   SSF51735        + More
SSF56327   SSF56327       

Gene 3D

3.90.110.10    

ProteinModelPortal

A0A2A4JGJ5   A0A3S2P542   A0A0N1PGW7   A0A2H1VBF7   A0A194PTS0   A0A0L7L654   + More
V5SJ21   A0A1L8E0M4   A0A1L8EI00   H9JU51   B3MTR2   B3NZ92   B4M0W4   A0A1Y1MKR1   B4JI52   B4IB85   Q9VEB1   A0A1W4U941   B4PL86   A0A0L0BXC1   B4K7H4   B4NG95   A0A1Z5LBZ6   A0A2U8I2I6   A0A1B6DH64   A0A0K8TPD6   T1PH40   A0A1B0D3T4   A0A1B0CP43   A0A383KSF0   A0A1Z1SPZ3   B4F2A1   A0A1L8EEK1   A0A1L8EEQ2   A0A140NN07   B2Q4U7   A0A335E6L1   A0A379HHV1   Q4PP90   A0A0M9CZC5   A0A023FKC0   A0A154PN63   A0A023FWQ5   A0A310SPT5   V9IKY6   A0A0M4EPV2   A0A293LJK1   A0A131XGD2   A0A1I8PUI8   A0A2A3E6L2   A0A1B6GIT9   A0A2C6DJG2   W8BVV6   A0A3B0KCD1   A0A0K8VWB8   A0A0C9QFA6   A0A034VDU0   A0A0C9S2L6   A0A023FJ07   A0A1B6GA36   A0A1I9WLG5   A0A158NR67   L7M8Y4   A0A1B6CB81   E2B525   A0A131Y2D8   A0A094K5W9   E0W2E5   B4QUH7   A0A195E5P6   B7PH44   A0A195C8W5   A0A0K8RNA0   A0A1B6J8X6   A0A379F7W1   A0A091L2M8   A0A0G4QBC9   A0A2J9L5I6   A0A2A4K4Z0   A0A0A1XDJ4   A0A366N9J7   A0A336KS61   A0A1B7JNA6   A0A3D2BI27   A0A2R5LL11   A0A3D9U8N3   Q6B4U5   A0A379EHN9   A0A0G4QEA1   A0A224Z2B3   A0A131Z2S2   A0A023FKR5   A0A292C4T0   D2A663   A0A094L1E7   V6MEP9   A0A091RKN9  

PDB

2DFD     E-value=1.49338e-32,     Score=348

KEGG

101740191    K00026 malate dehydrogenase [EC:1.1.1.37] | (RefSeq) malate dehydrogenase, mitochondrial-like

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016616   GO:0005975   GO:0019752   GO:0016702   GO:0046872   GO:0030060   GO:0006099   GO:0006108   GO:0035096   GO:0035071   GO:0005739   GO:0006919   GO:0035209   GO:0043068   GO:0016615   GO:0043067   GO:0005759   GO:0055114   GO:0035070   GO:0005737   GO:0003824   GO:0016491   GO:0007165   GO:0005509   GO:0016042   GO:0016020   GO:0003707   GO:0051537  

PANTHER

PTHR10543   PTHR11540:SF22  

Length:

381

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.3446

Exp number, first 60 AAs:

0.06431

Total prob of N-in:

0.02890

outside

1  -  381

 

 

Pi

4.251441

Theta

17.603326

Tajima's D

-2.286426

CLR

285.64487

CSRT

0.00264986750662467

Interpretation

Uncertain