Gene

KWMTBOMO07473

Pre Gene Modal

BGIBMGA005190

Annotation

phospholipase_C_beta_1_[Bombyx_mori]

Location

Bomo_Chr12(+):13984432-13997696      View in EpiBrowser

Full name

Phosphoinositide phospholipase C       + More
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase      

Location in the cell

Nuclear   Reliability : 2.648

CDS

ATGTCATCGTTCGACGAGAAACAAGCGACCACGCTGCTGAAGGAACGTCCCATCGAGTTCGTGAACTACAACAAGCACCAGCTGTCCCGGGTGTACCCGGCCGGGACCAGGTTCGACTCGTCCAACTTCATGCCACAGGTCTTCTGGAACGCGGGTTGTCAATTAGTCGCTCTCAACTATCAAACTTTGGACCTCGCCATGCAGCTCAACCTAGGCACGTTCGAGTACAACAAGCGATGCGGATTCCTATTGAAACCTGAATTTATGAGGAGAAAGGATCGACGTTTGGATCCATTCGCGGAGAGCACCGTGGACGGCATCATAGCCGGCAGTCTCACCGTGACGGTTCTGTCCGGGCAGCTACTGACCGACAAGCGTTGCGGCACGTACGTGGAGGTGGACATGTTCGGTCTGCCGGCCGACACCGTCAGGAAGAAGTTCCGCACCAGGGTCGTGCCCAATAACGGAATCAATCCGATTTACGGAGACGAACCCTTCGAATTTAAGAAGGTGGTGCTGCCGGAGCTGGCGATGCTGCGGGTGGCGGCGCACGAGGAGGGCGGGCGGCTGCTGGGGCACCGCGTGGTGCCGGTGCGCGGGCTGCGGCCCGGCCTGCGCGCGCTGCCGCTGCGCACGGAGCGGGGCCTGCCGCTGCACGCCGCGCTGCTGCTGCACGTGCAGGTCAAGGACTACGTGCCGGACAAGCTGTCGGAGCTGGCGGAGGCCCTGGCCAACCCCATAAAGTACCAGAGCGAGCTGGACAAGCGCGAGCACCAGCTGGCCGTGCTCACCGACGGCACCGACGAGCCCGAGCAGGAGCCGCGCCGCTCCGTCGCGCAGCCGGTAAGACACGAGGCGGTGCCGGAGAGCAGTCCCAGTAAGTTGGCTTTGGAGACTAAGAAGTTAATAGAGACCGAGTCCATAGTGACCCTGCCGATACCGCCGCCGATTGATACTAAAGAGCAAGAGAAGAAAGCGAACGGCACGGACGAGAGCCTGGCCGAGACCCTAGAAACGTTGCTGAACTCGAAGCTGGTGCGGTTAAAAGAAGCCGAGCTGGCCCGCAAGCTGGACACGCTGCGTCGCAAGTTCGACAAGGACAAGAAGCCCTTCTCGGCCAAGTTCTACGTCAGCAACAAGCTCGTCAAGAAGCTCTCGTCCAATAACATGTGCGGTGAGGCGGGGGGCAGCGGCGCGGCGGAGGAGGGCGCGGCGGAGGAGCGCGCGCTGCGGCTGCGCTACCACCACGCCATCTACGCCGCGCTCGAGAAGCACGTGCGCGCCGACCACTCGCAGCAGATGAAGACGCTCAGCGATCTGTTAGAAGTCGAGAAGAAGGAAATATTAAATCGACTAGCAAACTCGCGGAAGGAAGACGTCAAAGCGCTCGCCAAAAAGACAAATCGAGATAAAGACGAGATACAGAGGATAAAGAGAGAGATCCACTCGCAGAGCGTGGAGCGCGGCGTGTCGGAATGTTGCCGGCTAGAGCAAGCCTACACCAAGCGGCGCGAGCAGCTCGCCCGCGACCACGAGAAGCTGCTGCAGATGCTGCTCAAACATCGAGATCAGGAGCTCGTGAAGCTGGACCGTCTGTGCGGGGGCACGCCGGAGGGCTAG

Protein

MSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRFDSSNFMPQVFWNAGCQLVALNYQTLDLAMQLNLGTFEYNKRCGFLLKPEFMRRKDRRLDPFAESTVDGIIAGSLTVTVLSGQLLTDKRCGTYVEVDMFGLPADTVRKKFRTRVVPNNGINPIYGDEPFEFKKVVLPELAMLRVAAHEEGGRLLGHRVVPVRGLRPGLRALPLRTERGLPLHAALLLHVQVKDYVPDKLSELAEALANPIKYQSELDKREHQLAVLTDGTDEPEQEPRRSVAQPVRHEAVPESSPSKLALETKKLIETESIVTLPIPPPIDTKEQEKKANGTDESLAETLETLLNSKLVRLKEAELARKLDTLRRKFDKDKKPFSAKFYVSNKLVKKLSSNNMCGEAGGSGAAEEGAAEERALRLRYHHAIYAALEKHVRADHSQQMKTLSDLLEVEKKEILNRLANSRKEDVKALAKKTNRDKDEIQRIKREIHSQSVERGVSECCRLEQAYTKRREQLARDHEKLLQMLLKHRDQELVKLDRLCGGTPEG

Description

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Feature

chain  Phosphoinositide phospholipase C

Uniprot

H9J6P8   D2XZ01   A0A3S2TQT2   A0A194PU19   A0A0N1I804   A0A0L7QY72   + More
A0A151XC94   A0A195B2D3   V9I905   A0A087ZZ32   A0A158NLC0   A0A195E7F7   V9IBA6   A0A151IH20   A0A195F2M4   A0A0M9A1B9   E2BMN6   A0A212EY45   E2AT88   F4X6N0   A0A310SIG3   Q16TV2   A0A067RK16   E9IZ80   A0A3L8DPC3   A0A026WZA0   A0A182HAM5   A0A154PD39   K7IWF5   A0A0C9RDF2   A0A0C9QNV9   A0A1B6CHB2   A0A2A3EDU3   U5EYK5   B0W1K0   A0A2R7WKJ7   A0A182T1K0   A0A182MUV3   A0A0A1XM90   A0A0A1WZX4   A0A182WH05   A0A3Q0IQI6   A0A1B0AP48   A0A2S2PTD7   A0A2H8TVM5   B4LUP2   A0A0Q9X7Z7   Q7PW25   A0A0K8W468   X1WJA8   E0W3C1   A0A1A9XW06   A0A0L0CID1   A0A1B0FLX0   A0A182KC59   A0A182R9N4   A0A034V484   A0A0Q9WME2   A0A0Q9XI68   A0A232F2V6   A0A0K8TX62   A0A023F3E7   A0A0K8TZ67   A0A182NEY3   A0A0Q9X0K2   A0A0Q9WKU7   A0A0Q9XCQ0   W8AH00   A0A0K8VX29   A0A1A9WKM0   B4KL19   A0A3F2Z1Y4   A0A0Q9X212   A0A0Q9W9U6   B4MTQ4   A0A3F2YUR1   A0A0M4EEF0   A0A1W4V2A1   B3MUI8   A0A3F2YSL3   A0A182R166   A0A1A9Z7Q2   A0A3F2YY95   A0A0Q9WRM6   A0A3F2Z0D3   A0A139WIL1   A0A1A9UXH0   A0A1W4UPU2   A0A1J1I203   B4JDA1   Q29N33   A0A3F2YUQ1   A0A3F2Z0E3   A0A3F2YSM6   A0A1S4H047   A0A2S2Q4C5   A0A1I8NX92   B3G506   A0A1I8NX64   A0A0L7KPR1  

EC Number

3.1.4.11

Pubmed

19121390    26354079    21347285    20798317    22118469    21719571    + More
17510324    24845553    21282665    30249741    24508170    26483478    20075255    25830018    17994087    12364791    20566863    26108605    25348373    28648823    25474469    24495485    18057021    20966253    18362917    19820115    15632085    26227816   

EMBL

BABH01038133    BABH01038134    GU266210    ADB25313.1    RSAL01000020    RVE52618.1    + More
KQ459592    KPI96812.1    KQ460479    KPJ14367.1    KQ414697    KOC63504.1    KQ982314    KYQ58001.1    KQ976662    KYM78452.1    JR037088    AEY57573.1    ADTU01019314    ADTU01019315    KQ979568    KYN20792.1    JR037089    AEY57574.1    KQ977647    KYN00837.1    KQ981864    KYN34344.1    KQ435765    KOX75330.1    GL449275    EFN83054.1    AGBW02011623    OWR46416.1    GL442545    EFN63333.1    GL888818    EGI57812.1    KQ759870    OAD62421.1    CH477639    EAT37940.1    KK852424    KDR24186.1    GL767119    EFZ14136.1    QOIP01000005    RLU22284.1    KK107063    EZA61123.1    JXUM01122973    JXUM01122974    JXUM01122975    JXUM01122976    JXUM01122977    KQ566663    KXJ69931.1    KQ434875    KZC09772.1    GBYB01006290    JAG76057.1    GBYB01005249    JAG75016.1    GEDC01024506    GEDC01011531    GEDC01011062    GEDC01002558    JAS12792.1    JAS25767.1    JAS26236.1    JAS34740.1    KZ288269    PBC29897.1    GANO01001949    JAB57922.1    DS231822    EDS25798.1    KK854992    PTY20163.1    AXCM01002116    GBXI01001858    JAD12434.1    GBXI01010349    JAD03943.1    JXJN01001137    JXJN01001138    GGMR01019975    MBY32594.1    GFXV01006046    MBW17851.1    CH940649    EDW64228.2    CH933807    KRG03417.1    AAAB01008984    EAA14708.4    GDHF01006457    JAI45857.1    ABLF02022835    ABLF02022837    DS235882    EEB20128.1    JRES01000438    KNC31249.1    CCAG010020618    GAKP01021638    JAC37314.1    KRF81520.1    KRG03416.1    NNAY01001186    OXU24820.1    GDHF01033267    JAI19047.1    GBBI01002884    JAC15828.1    GDHF01032582    JAI19732.1    CH963852    KRF98251.1    KRF81518.1    KRG03418.1    GAMC01021628    JAB84927.1    GDHF01008878    JAI43436.1    EDW12769.2    KRG03419.1    KRF98252.1    KRF81517.1    EDW75493.1    CP012523    ALC38505.1    CH902624    EDV33517.2    APCN01003744    APCN01003745    AXCN02000839    KRF98253.1    KQ971338    KYB27786.1    CVRI01000037    CRK93620.1    CH916368    EDW03274.1    CH379060    EAL33510.3    GGMS01003371    MBY72574.1    EU649777    ACD69415.1    JTDY01007365    KOB65267.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000053825    UP000075809    + More
UP000078540    UP000005203    UP000005205    UP000078492    UP000078542    UP000078541    UP000053105    UP000008237    UP000007151    UP000000311    UP000007755    UP000008820    UP000027135    UP000279307    UP000053097    UP000069940    UP000249989    UP000076502    UP000002358    UP000242457    UP000002320    UP000075901    UP000075883    UP000075920    UP000079169    UP000092460    UP000008792    UP000009192    UP000007062    UP000007819    UP000009046    UP000092443    UP000037069    UP000092444    UP000075881    UP000075900    UP000215335    UP000075884    UP000007798    UP000091820    UP000076407    UP000075882    UP000092553    UP000192221    UP000007801    UP000075840    UP000075886    UP000092445    UP000075903    UP000007266    UP000078200    UP000183832    UP000001070    UP000001819    UP000095300    UP000037510   

PRIDE

H9J6P8    D2XZ01   

Pfam

PF09279   EF-hand_like        + More
PF00387   PI-PLC-Y
PF08703   PLC-beta_C
PF00388   PI-PLC-X
PF17787   PH_14
PF00089   Trypsin

Interpro

IPR001192   PI-PLC_fam        + More
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR015359   PLC_EF-hand-like       
IPR011992   EF-hand-dom_pair       
IPR000008   C2_dom       
IPR016280   PLC-beta       
IPR014815   PLC-beta_C       
IPR035892   C2_domain_sf       
IPR037862   PLC-beta_PH       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR009003   Peptidase_S1_PA       

SUPFAM

SSF51695   SSF51695        + More
SSF47473   SSF47473       
SSF50494   SSF50494       

Gene 3D

2.60.40.150     3.20.20.190    

CDD

cd13361  PH_PLC_beta
cd00190  Tryp_SPc

ProteinModelPortal

H9J6P8   D2XZ01   A0A3S2TQT2   A0A194PU19   A0A0N1I804   A0A0L7QY72   + More
A0A151XC94   A0A195B2D3   V9I905   A0A087ZZ32   A0A158NLC0   A0A195E7F7   V9IBA6   A0A151IH20   A0A195F2M4   A0A0M9A1B9   E2BMN6   A0A212EY45   E2AT88   F4X6N0   A0A310SIG3   Q16TV2   A0A067RK16   E9IZ80   A0A3L8DPC3   A0A026WZA0   A0A182HAM5   A0A154PD39   K7IWF5   A0A0C9RDF2   A0A0C9QNV9   A0A1B6CHB2   A0A2A3EDU3   U5EYK5   B0W1K0   A0A2R7WKJ7   A0A182T1K0   A0A182MUV3   A0A0A1XM90   A0A0A1WZX4   A0A182WH05   A0A3Q0IQI6   A0A1B0AP48   A0A2S2PTD7   A0A2H8TVM5   B4LUP2   A0A0Q9X7Z7   Q7PW25   A0A0K8W468   X1WJA8   E0W3C1   A0A1A9XW06   A0A0L0CID1   A0A1B0FLX0   A0A182KC59   A0A182R9N4   A0A034V484   A0A0Q9WME2   A0A0Q9XI68   A0A232F2V6   A0A0K8TX62   A0A023F3E7   A0A0K8TZ67   A0A182NEY3   A0A0Q9X0K2   A0A0Q9WKU7   A0A0Q9XCQ0   W8AH00   A0A0K8VX29   A0A1A9WKM0   B4KL19   A0A3F2Z1Y4   A0A0Q9X212   A0A0Q9W9U6   B4MTQ4   A0A3F2YUR1   A0A0M4EEF0   A0A1W4V2A1   B3MUI8   A0A3F2YSL3   A0A182R166   A0A1A9Z7Q2   A0A3F2YY95   A0A0Q9WRM6   A0A3F2Z0D3   A0A139WIL1   A0A1A9UXH0   A0A1W4UPU2   A0A1J1I203   B4JDA1   Q29N33   A0A3F2YUQ1   A0A3F2Z0E3   A0A3F2YSM6   A0A1S4H047   A0A2S2Q4C5   A0A1I8NX92   B3G506   A0A1I8NX64   A0A0L7KPR1  

PDB

4GNK     E-value=3.98811e-87,     Score=821

KEGG

100329153    K05858 phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] | (RefSeq) PLCb1; phospholipase C be

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04745    Phototransduction - fly - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0016042   GO:0004435   GO:0005509   GO:0035556   GO:0007165   GO:0032959   GO:0048015   GO:0051209   GO:0005623   GO:0004252   GO:0016021   GO:0006629   GO:0008081   GO:0005515   GO:0016020   GO:0003707   GO:0051537  

PANTHER

PTHR10336  

Length:

539

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.35812

Exp number, first 60 AAs:

0.03989

Total prob of N-in:

0.01812

outside

1  -  539

 

 

Pi

24.46809

Theta

24.627171

Tajima's D

-0.609783

CLR

0.795143

CSRT

0.216789160541973

Interpretation

Uncertain