Gene

KWMTBOMO07472

Pre Gene Modal

BGIBMGA005190

Annotation

phospholipase_C_beta_1_[Bombyx_mori]

Location

Bomo_Chr12(+):13890082-13981154      View in EpiBrowser

Full name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase       + More
Phosphoinositide phospholipase C      
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II      

Alternative Name

Phosphoinositide phospholipase C

Location in the cell

Cytoplasmic   Reliability : 2.02 Nuclear   Reliability : 2.358

CDS

ATGAGTGCTAGCACGAGATCAGCCAAAGTTAGCTTAAAGTCCATCGAAGTGCCGAAAGCTTTGCAGGATGGAGAAAAATTTATTAAATGGGATGAGGATTCCGGGACAGGCCTTCCAGTTACCTTGAGGGTTGATCCTAATGGCTTCTACCTGTACTGGACTGATCAGAACATGGAGGTGGAGTTGCTAGACATTGTCACCATCAGAGATGTCAGAACTGGAGTTCATGCTAAAGTGCCAAAAGATCCGAAAATCCGCAACGTCGTCCTCATCGGGAGCCAAGGGTCGCTCGAGGAGAAGACGGTCACGGTTTGTCACGGCACGGACTTCGTCAACGTGAATTTCATTAACTTCTGCTGCACTAGGAAGGAAATTGCACAGTTATGGACCGAAGAGTTGTTTGCGTTGGCTTACAACTTGAACCAGTTCAACAATCCAACGGTGAAGTTTCTAGAGAAATTGCACACGAAGATAACGTTAAAGGCTGACAAATCGGGGAAAATTCTCGTCAAGAACATTGTCCGCCAATTCGCGCAGAACAAGGAAGACAAGAAGCGTGTGGAGAAAGCGCTCAGTGAGTCTGGTCTCCCGACGGGCAAAAACGATACCATCAGCCAGTCCAAGTTCCAGTTCGAAGACTTCTTCGCTTTCTACAAGAGTCTCACGCAGAGAACCGAAGTACAGAAGATATTTAACGGACTAACGGACGGAAAACCTTATCTATCAGCGACTCAATTAGTAGACTTTTTAAACGACGTGCAAAGGGACCCACGTCTCAATGAGATATTGCATCCGTACGCTGATCTCCAGCGAGCGAAAGACCTCATAAAAGCTTACGAACACAATAAGTATCATCAGCAAAGATCGCAGCTTACCTTCGATGGATTCCTCAGGTTCCTAATGTCTGAAGACAATCCTATAGTGGCACCAAACAAGTTGGATTTGTGTGACGATATGGATCAGCCATTAGCTCATTATTTCATCAACAGCTCACACAACACGTATCTAACCGGCCATCAGATAACTGGCAAGTCTAGCGTCGAGATATACAGGCAGAGCTTGCTAGCCGGGTGCAGATGCGTGGAGTTGGACTTCTGGAATGGTCGAACCGAAGAGCCGGTCATCGTTCACGGTTACACGTTCGTGCCGGAGATAAGCGCCAGGGAAGTGTTGGAGGCGATAGCGGAAAGCGCTTTCAAGACTTCCGATTTTCCGGTTATTTTGAGTTTCGAGAACCACTGCAACCCGCGCCAGCAGGCGAAGATAGCCAACTACTGTAGAGAGATTTTCGGGGACATGCTGCTCGATAAGCCTCTGGACTCGCACCAGTTGGAACCAGGAGGTGAACTTCCACCGCCTTCGTTGCTACGGCACAAAATAATAATTAAGAACAAAAAGAAGCACCATCACCATCACAAGAAGGAGGACACACCGCCGATAGAGGAGTGCGAGCAGAGAGCCGAGCTGACAACGCAGGGGAACGGCGAGATGACCCACGCCACAACATTAATCAACTGA

Protein

MSASTRSAKVSLKSIEVPKALQDGEKFIKWDEDSGTGLPVTLRVDPNGFYLYWTDQNMEVELLDIVTIRDVRTGVHAKVPKDPKIRNVVLIGSQGSLEEKTVTVCHGTDFVNVNFINFCCTRKEIAQLWTEELFALAYNLNQFNNPTVKFLEKLHTKITLKADKSGKILVKNIVRQFAQNKEDKKRVEKALSESGLPTGKNDTISQSKFQFEDFFAFYKSLTQRTEVQKIFNGLTDGKPYLSATQLVDFLNDVQRDPRLNEILHPYADLQRAKDLIKAYEHNKYHQQRSQLTFDGFLRFLMSEDNPIVAPNKLDLCDDMDQPLAHYFINSSHNTYLTGHQITGKSSVEIYRQSLLAGCRCVELDFWNGRTEEPVIVHGYTFVPEISAREVLEAIAESAFKTSDFPVILSFENHCNPRQQAKIANYCREIFGDMLLDKPLDSHQLEPGGELPPPSLLRHKIIIKNKKKHHHHHKKEDTPPIEECEQRAELTTQGNGEMTHATTLIN

Description

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic Activity

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Keywords

Alternative splicing   Complete proteome   Hydrolase   Lipid degradation   Lipid metabolism   Reference proteome   Transducer  

Feature

chain  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
splice variant  In isoform G.

Uniprot

D2XZ01   A0A3S2TQT2   A0A0N1I804   A0A3F2YUQ1   A0A3F2YSM6   A0A3F2Z0E3   + More
A0A3F2Z0D3   A0A3F2YSL3   A0A3F2YUR1   A0A2J7Q899   A0A1S4H047   A0A3F2YY95   A0A1B6CHB2   A0A2M4CQY9   A0A2M4AKN9   A0A0Q9WME2   B4LUP2   A0A139WIL1   A0A0Q9W9U6   A0A0Q9WKU7   A0A2P8YIN0   P25455-5   P25455-4   P25455-1   P25455-2   A0A1W4V296   A0A1W4V2A1   A0A1W4V3S2   A0A1W4UPU2   A0A0J9TCG8   P25455   A0A0J9QU17   B4Q625   A0A0J9QTB1   A0A0Q9X7Z7   B4KL19   A0A0Q9XI68   A0A0Q9XCQ0   A0A0A1XM90   A0A0M4EEF0   A0A0Q5WFP2   A0A0A1WZX4   A0A0R1DII7   A0A0Q5WKB5   B3N7P0   A0A0Q5W8P3   B4P2C8   W8AH00   A0A0R1DIL4   A0A0R1DIT6   A0A034V484   A0A0Q9X0K2   A0A0Q9X212   A0A0Q9WRM6   B4MTQ4   A0A0K8TX62   B4ICV5   A0A0K8VX29   A0A0K8TZ67   A0A0K8W468   A0A1Y1L7W1   A0A1Y1L7V7   Q29N33   A0A087ZZ32   V9I905   V9IBA6   B4JDA1   A0A1J1I203   A0A2A3EDU3   A0A310SIG3   A0A336LK31   A0A336ML84   A0A154PD39   A0A336MIR0   A0A336MTI4   A0A336LB40   A0A2R7WKJ7   A0A1I8MB41   A0A1I8MB42   A0A1I8MB39   A0A336LBM4   A0A1I8MB48   A0A336MTU1   A0A1I8NX92   A0A1I8NX64   A0A1I8NX66   A0A1I8NX61   A0A084VG80   Q7PW25   E2BMN6   J9HZD6   A0A232F2V6   K7IWF5   A0A026WZA0   A0A3L8DPC3   A0A195F2M4   E2AT88   F4X6N0   A0A023F3E7   A0A0L0CID1  

EC Number

3.1.4.11

Pubmed

26354079    20966253    12364791    17994087    18362917    19820115    + More
18057021    29403074    2061323    10731132    12537572    12537569    22936249    25830018    17550304    24495485    25348373    28004739    15632085    25315136    24438588    20798317    17510324    28648823    20075255    24508170    30249741    21719571    25474469    26108605   

EMBL

GU266210    ADB25313.1    RSAL01000020    RVE52618.1    KQ460479    KPJ14367.1    + More
APCN01003744    APCN01003745    NEVH01016966    PNF24811.1    AAAB01008984    GEDC01024506    GEDC01011531    GEDC01011062    GEDC01002558    JAS12792.1    JAS25767.1    JAS26236.1    JAS34740.1    GGFL01003130    MBW67308.1    GGFK01008029    MBW41350.1    CH940649    KRF81520.1    EDW64228.2    KQ971338    KYB27786.1    KRF81517.1    KRF81518.1    PYGN01000568    PSN44092.1    M60452    M60453    AE014134    AY051657    CM002910    KMY87295.1    KMY87294.1    CM000361    EDX03209.1    KMY87292.1    KMY87296.1    CH933807    KRG03417.1    EDW12769.2    KRG03419.1    KRG03416.1    KRG03418.1    GBXI01001858    JAD12434.1    CP012523    ALC38505.1    CH954177    KQS69925.1    GBXI01010349    JAD03943.1    CM000157    KRJ97035.1    KQS69922.1    EDV57216.1    KQS69923.1    EDW87124.1    GAMC01021628    JAB84927.1    KRJ97034.1    KRJ97032.1    GAKP01021638    JAC37314.1    CH963852    KRF98251.1    KRF98252.1    KRF98253.1    EDW75493.1    GDHF01033267    JAI19047.1    CH480829    EDW45381.1    GDHF01008878    JAI43436.1    GDHF01032582    JAI19732.1    GDHF01006457    JAI45857.1    GEZM01062372    JAV69783.1    GEZM01062373    JAV69782.1    CH379060    EAL33510.3    JR037088    AEY57573.1    JR037089    AEY57574.1    CH916368    EDW03274.1    CVRI01000037    CRK93620.1    KZ288269    PBC29897.1    KQ759870    OAD62421.1    UFQS01002466    UFQT01002466    SSX14112.1    SSX33528.1    UFQS01001383    UFQT01001383    SSX10628.1    SSX30311.1    KQ434875    KZC09772.1    SSX10629.1    SSX30312.1    SSX14110.1    SSX33526.1    SSX14111.1    SSX33527.1    KK854992    PTY20163.1    SSX14113.1    SSX33529.1    SSX14114.1    SSX33530.1    ATLV01012696    ATLV01012697    ATLV01012698    KE524808    KFB36974.1    EAA14708.4    GL449275    EFN83054.1    CH477639    EJY57850.1    NNAY01001186    OXU24820.1    KK107063    EZA61123.1    QOIP01000005    RLU22284.1    KQ981864    KYN34344.1    GL442545    EFN63333.1    GL888818    EGI57812.1    GBBI01002884    JAC15828.1    JRES01000438    KNC31249.1   

Proteomes

UP000283053    UP000053240    UP000075882    UP000075840    UP000075903    UP000235965    + More
UP000008792    UP000007266    UP000245037    UP000000803    UP000192221    UP000000304    UP000009192    UP000092553    UP000008711    UP000002282    UP000007798    UP000001292    UP000001819    UP000005203    UP000001070    UP000183832    UP000242457    UP000076502    UP000095301    UP000095300    UP000030765    UP000007062    UP000008237    UP000008820    UP000215335    UP000002358    UP000053097    UP000279307    UP000078541    UP000000311    UP000007755    UP000037069   

PRIDE

D2XZ01    P25455   

Pfam

PF00388   PI-PLC-X        + More
PF17787   PH_14
PF08703   PLC-beta_C
PF00387   PI-PLC-Y
PF09279   EF-hand_like

Interpro

IPR000008   C2_dom        + More
IPR011992   EF-hand-dom_pair       
IPR001192   PI-PLC_fam       
IPR014815   PLC-beta_C       
IPR001711   PLipase_C_Pinositol-sp_Y       
IPR016280   PLC-beta       
IPR035892   C2_domain_sf       
IPR017946   PLC-like_Pdiesterase_TIM-brl       
IPR015359   PLC_EF-hand-like       
IPR000909   PLipase_C_PInositol-sp_X_dom       
IPR037862   PLC-beta_PH       

SUPFAM

SSF47473   SSF47473        + More
SSF51695   SSF51695       

Gene 3D

2.60.40.150     3.20.20.190    

CDD

cd13361  PH_PLC_beta

ProteinModelPortal

D2XZ01   A0A3S2TQT2   A0A0N1I804   A0A3F2YUQ1   A0A3F2YSM6   A0A3F2Z0E3   + More
A0A3F2Z0D3   A0A3F2YSL3   A0A3F2YUR1   A0A2J7Q899   A0A1S4H047   A0A3F2YY95   A0A1B6CHB2   A0A2M4CQY9   A0A2M4AKN9   A0A0Q9WME2   B4LUP2   A0A139WIL1   A0A0Q9W9U6   A0A0Q9WKU7   A0A2P8YIN0   P25455-5   P25455-4   P25455-1   P25455-2   A0A1W4V296   A0A1W4V2A1   A0A1W4V3S2   A0A1W4UPU2   A0A0J9TCG8   P25455   A0A0J9QU17   B4Q625   A0A0J9QTB1   A0A0Q9X7Z7   B4KL19   A0A0Q9XI68   A0A0Q9XCQ0   A0A0A1XM90   A0A0M4EEF0   A0A0Q5WFP2   A0A0A1WZX4   A0A0R1DII7   A0A0Q5WKB5   B3N7P0   A0A0Q5W8P3   B4P2C8   W8AH00   A0A0R1DIL4   A0A0R1DIT6   A0A034V484   A0A0Q9X0K2   A0A0Q9X212   A0A0Q9WRM6   B4MTQ4   A0A0K8TX62   B4ICV5   A0A0K8VX29   A0A0K8TZ67   A0A0K8W468   A0A1Y1L7W1   A0A1Y1L7V7   Q29N33   A0A087ZZ32   V9I905   V9IBA6   B4JDA1   A0A1J1I203   A0A2A3EDU3   A0A310SIG3   A0A336LK31   A0A336ML84   A0A154PD39   A0A336MIR0   A0A336MTI4   A0A336LB40   A0A2R7WKJ7   A0A1I8MB41   A0A1I8MB42   A0A1I8MB39   A0A336LBM4   A0A1I8MB48   A0A336MTU1   A0A1I8NX92   A0A1I8NX64   A0A1I8NX66   A0A1I8NX61   A0A084VG80   Q7PW25   E2BMN6   J9HZD6   A0A232F2V6   K7IWF5   A0A026WZA0   A0A3L8DPC3   A0A195F2M4   E2AT88   F4X6N0   A0A023F3E7   A0A0L0CID1  

PDB

4QJ5     E-value=3.39917e-121,     Score=1114

KEGG

100329153    K05858 phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] | (RefSeq) PLCb1; phospholipase C be

GO

GO:0005509   GO:0016042   GO:0004435   GO:0035556   GO:0007165   GO:0051209   GO:0005623   GO:0048015   GO:0032959   GO:0043153   GO:1900073   GO:0070050   GO:0007629   GO:0006629   GO:0008081   GO:0003723   GO:0005634   GO:0006396   GO:0030529   GO:0008237   GO:0016020   GO:0003707   GO:0051537  

PANTHER

PTHR10336  

Length:

505

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.000690000000000001

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.00716

outside

1  -  505

 

 

Pi

23.269612

Theta

22.601258

Tajima's D

-1.032668

CLR

0.573617

CSRT

0.127893605319734

Interpretation

Uncertain