SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07456
Pre Gene Modal
BGIBMGA005186
Annotation
dpy-30-like_protein_[Danaus_plexippus]
Full name
Protein dpy-30 homolog      
Alternative Name
Dpy-30-like protein
Protein rAIP1
Location in the cell
Nuclear   Reliability : 2.57
 

Sequence

CDS
ATGTCAGAAAGTTCAACACAGATAAATCACAACAAGGAAGAACAATCCACGACGAAAATACCAGATTCGGTAAAGAAAATTATATTAATGGAAAAAGACAATGAAGCCAATGCTAACAGAAAATCCAGAATTGACCTCAATGCTCTACCGACTCGACAGTATTTGGACCAGACAGTAGTACCCATACTGCTGCAAGGTCTATCAGCATTAGCTAAAGAACGTCCTCCGGACCCGATAAATTATTTAGCAGCTTACTTACTTAAAAACAAAACTACTTTCGAACTTGCCAACTCAGGCAATAACAATAATCAACCAACAAACCCACAAACATAA
Protein
MSESSTQINHNKEEQSTTKIPDSVKKIILMEKDNEANANRKSRIDLNALPTRQYLDQTVVPILLQGLSALAKERPPDPINYLAAYLLKNKTTFELANSGNNNNQPTNPQT

Summary

Description
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport.
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity).
Subunit
Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ASH2L. The interaction with ASH2L is direct (By similarity). Interacts with ARFGEF1 (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity).
Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct. Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.
Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct (By similarity). Interacts with ARFGEF1 (By similarity). Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity).
Homodimer. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity). Interacts with ASH2L; the interaction is direct (By similarity). Interacts with ARFGEF1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (By similarity).
Similarity
Belongs to the dpy-30 family.
Keywords
Acetylation   Chromatin regulator   Complete proteome   Golgi apparatus   Isopeptide bond   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation   Ubl conjugation   3D-structure  
Feature
chain  Protein dpy-30 homolog
EMBL
BABH01038151    AGBW02008864    OWR52341.1    KQ460636    KPJ13385.1    NWSH01006480    + More
PCG63402.1    RSAL01000020    RVE52627.1    GDQN01001603    JAT89451.1    ODYU01008350    SOQ51862.1    KQ459592    KPI96823.1    GAIX01011433    JAA81127.1    JTDY01000493    KOB76932.1    GFTR01002050    JAW14376.1    GEBQ01012455    JAT27522.1    GECZ01027055    JAS42714.1    GECU01011734    JAS95972.1    KC632406    AGM32220.1    NEDP02005067    OWF43548.1    NNAY01000798    OXU26448.1    AC139392    CH473947    EDM02841.1    AK003688    AK011643    AK013073    AK077902    BC002240    AAMC01001126    AAMC01001127    BC082731    CR760705    AAH82731.1    CAJ81411.1    KB030580    ELK14110.1    AAQR03049743    AAQR03049744    AAQR03049745    AY297538    AAP85259.1    JH000321    RAZU01000247    EGW02708.1    RLQ62637.1    JH880854    ELR58340.1    AGTP01024915    AGTP01024916    KB016924    EPY82419.1    GFFW01004761    JAV40027.1    KN121053    KFO37183.1    AAGW02005810    AAPE02028502    AQIA01018625    CABD030013583    ADFV01011574    ADFV01011575    AEMK02000021    DQIR01115934    DQIR01268845    HDA71410.1    AJFE02095359    AJFE02095360    AJFE02095361    AJFE02095362    AJFE02095363    AHZZ02005142    AHZZ02005143    KE164790    EPQ20131.1    ABGA01121802    ABGA01121803    ABGA01121804    ABGA01121805    ABGA01191737    NDHI03003415    PNJ59073.1    PNJ59074.1    JSUE03010519    JSUE03010520    JSUE03010521    JSUE03010522    JU320223    JU473496    JV048468    AFE63979.1    AFH30300.1    AFI38539.1    AACZ04002030    GABC01007852    GABF01010123    GABD01009796    GABE01011611    NBAG03000318    JAA03486.1    JAA12022.1    JAA23304.1    JAA33128.1    PNI41261.1    PNI41262.1    GAMS01009741    GAMR01005581    GAMQ01005389    JAB13395.1    JAB28351.1    JAB36462.1    AF226998    CH471053    BC015970    BC111634    AY129401    GAMP01010843    JAB41912.1    ACTA01129117    ACTA01137117    AAEX03010834    AANG04003404    CYRY02006524    VCW70890.1    AEYP01092831    AEYP01092832    GAMT01007770    JAB04091.1    MKHE01000011    OWK10668.1    CM004474    OCT79968.1    AAKN02023527    GEBF01005773    JAN97859.1    BC072739    CM004475    AAH72739.1    OCT77933.1    KL218009    KFP00973.1   
Pfam
PF05186   Dpy-30
Interpro
IPR007858   Dpy-30_motif        + More
IPR037856   Sdc1/DPY30       
PDB
6E2H     E-value=1.71744e-17,     Score=212

Ontologies

Topology

Subcellular location
Nucleus  
Golgi apparatus  
trans-Golgi network  
Length:
110
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0034
Exp number, first 60 AAs:
0.00139
Total prob of N-in:
0.32422
outside
1  -  110
 
 

Population Genetic Test Statistics

Pi
7.89279
Theta
15.840237
Tajima's D
-1.51159
CLR
8.299891
CSRT
0.0585470726463677
Interpretation
Uncertain
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