Gene

KWMTBOMO07442

Pre Gene Modal

BGIBMGA005230

Annotation

PREDICTED:_dnaJ_homolog_subfamily_C_member_10_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr12(-):13446074-13461872      View in EpiBrowser

Full name

DnaJ homolog subfamily C member 10      

Location in the cell

PlasmaMembrane   Reliability : 2.147

CDS

ATGCAACCAATAATGTTAAAACTAGTATTTATCGTGATAGTCCTTATCGAAGCGGTTAACCTCACAGACGTATCATATTATGAAATTCTAGGGATAACTAAACAGGCATCGACTCAGGAAATAAAACAGGCGTATAAAAAATTAGTCGTAAAGTTTCACCCTGATAAAAATCCTAATGAAGCCAAACAAGAAAAATTTCTTAAAATAACTGAAGCCTATGAAACCTTGAAGGATCCAGAGAAAAGGCGCAATTATGATTTGTATGGATCATACACAACTTATTCAAGAAAATATGATTATAAATCTCAGTCGGAATATGATAATTTGTACTATAAAGGACTGTACCATAATGATCCATTTGTTGACACTTTATCTGGATCAAGTTTCTACAATTACCTGAATGAAGGATTTCACTTTATAAATTTTTACTCACCATTTTGTCCCCCCTGTCAAAATATTGCAGATCATTGGAAGAAGTTAGCAGAAATATATAAGGGCATTGTGAAAGTCGGTGCTGTTAACTGCAAATACCATAACTCATTTTGTTATAACTCAATGCGAATTGGCAGCTATCCAACTCTATTATTTTACCCTAATGGTAAAAGTGGAAACTATTTATATTACCGAGGCGACAGGACTTTCGAGGCTCTAGATGATTTTGTAATGACATACCTAAACAGTCATGTGCATGTGCCTACCGTCTCTCAACTGCGAAATACCGACAGGCCAATCGCCTACGTTCTCGGTGCTAATAGAATAGACAGGAGTGCCTTAACAAGGATTGCATATCGATTGAACGGCCTTGTAGCAATCGCTATCGTAGAAGACGAGAGCTTGAGAGATAAATTATCCGAAAGTGACTACACAACGATCGTGTTCAAATACAAAGGTTTTATTAAAGACATAGAGAGTACAAATGAGGAAGATGTTCTAAAAGATATAGTGGCTGCCTTGCCGAAGATCGAGCTAATTGATCCAGAAAAGTTGAAGAACATACGTAATAAGTTACGTAGAGGAGAACAAACGCCTTGGGTCCTGTATTTCTCCACCAAGGGAAGTGACAGACTCGTTCTACATCAAATGAGAATGTCGTTCCCTAATTTAAATTTTGGCGAGATCGATTGCGACGTATGGGCGGAGCTGTGCTCGTCGCTGCACGTGGAGGCGGCGCCGGCGTGGGCGGTCCTGAAGCGCGGCGGCGCCTACCAGCGGGCGTACGCGCCGGCGGACGCACGCACCTTCGTCCGCACCGCCGCCGCCGCCCTCAGCCTGCACACGCTCTCCGCTTCCGACCTCAACAAGATCTTGGAAGGGGATGTCGGCGTGTGGGTGCTGCTGGTAGTTCCGCACGGATCGCCGTGGGACAGCATGGCCGGACCCTTCACTCAGACCAGCATGCATTTCAACAACGACGAAAACGTCAGTTTCGGCATAATGATATGCACGGCAAGCACCGACCAGCACTGCCGACGAGTGGCGCCGGAGAAGCCCGTCGTGCTTCTGCAGAACTTCACCAGGCGGCACACGTACCGCGGCGAGCTTAACGAGAGGGAGCTTTTGGAGTACATCAATATGCTGAGAGACAGTGAAGATCTTGAGTTGACGGAGAATCAAGTTTTAGAGATATCGGATCCGAGCCGCGAGCACGCGTGGCTGGTGGCGTACCTGCCCGCGCACTGCGGCGCCTTCTGCGACGACCTCGCCCACCACTGGATGATCGTTGCCAGCAAGCTGCGACCTCTGACTTTTGTTCGAGTTGGAATGTTGCAATGTGCAAAAATAAAGAGCGGTTTCTGTACAAACATTCGATCAGCCACGGCAAGACTCTATCCTATAGCGTCTGGACAACATTATAGCGTCAGTCTACAGCATTTATCGCAAGCTCCGTACATACTGGAATGGGCGTTACAGTTCATAGACGATTCGGTTGTGAAACTCAACTGGAAACTGTTCGCTAAGACCGTTATTGCCGAGGAACTGAACCCGACGAGCGGCAACAAACCTTGGCTGGTCTATTTCCACTCTCCCAGATGTTACCGCTGCTACGAGATGTACGCTGACTTTGCTATAGCCGGTATTCTACTGAACAACGCGGTGCAGCTCGGCAAAGTCAATTGCCTGAACGAGCGCGGCCTCTGCCAACACGAGCACATCACAAGCTATCCGTCGCTCAAGCTGTACCTCGGCAGGAACAGCCGCCAGCGCTTCAGCAGCGTCGTGACACTGCAGGTCAGAGACCACAAGAGCATTCTAGAAGAAATCGAACCTCATTTAAGGAGATACGACGCCAGTCTGCTGGCCACCCGCGACGGTGCTGCCAGTAATAGCATCAGACACGACGAATTTTAA

Protein

MQPIMLKLVFIVIVLIEAVNLTDVSYYEILGITKQASTQEIKQAYKKLVVKFHPDKNPNEAKQEKFLKITEAYETLKDPEKRRNYDLYGSYTTYSRKYDYKSQSEYDNLYYKGLYHNDPFVDTLSGSSFYNYLNEGFHFINFYSPFCPPCQNIADHWKKLAEIYKGIVKVGAVNCKYHNSFCYNSMRIGSYPTLLFYPNGKSGNYLYYRGDRTFEALDDFVMTYLNSHVHVPTVSQLRNTDRPIAYVLGANRIDRSALTRIAYRLNGLVAIAIVEDESLRDKLSESDYTTIVFKYKGFIKDIESTNEEDVLKDIVAALPKIELIDPEKLKNIRNKLRRGEQTPWVLYFSTKGSDRLVLHQMRMSFPNLNFGEIDCDVWAELCSSLHVEAAPAWAVLKRGGAYQRAYAPADARTFVRTAAAALSLHTLSASDLNKILEGDVGVWVLLVVPHGSPWDSMAGPFTQTSMHFNNDENVSFGIMICTASTDQHCRRVAPEKPVVLLQNFTRRHTYRGELNERELLEYINMLRDSEDLELTENQVLEISDPSREHAWLVAYLPAHCGAFCDDLAHHWMIVASKLRPLTFVRVGMLQCAKIKSGFCTNIRSATARLYPIASGQHYSVSLQHLSQAPYILEWALQFIDDSVVKLNWKLFAKTVIAEELNPTSGNKPWLVYFHSPRCYRCYEMYADFAIAGILLNNAVQLGKVNCLNERGLCQHEHITSYPSLKLYLGRNSRQRFSSVVTLQVRDHKSILEEIEPHLRRYDASLLATRDGAASNSIRHDEF

Description

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins (By similarity).
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.

Keywords

Disulfide bond   Endoplasmic reticulum   Glycoprotein   Oxidoreductase   Redox-active center   Repeat   Signal  

Feature

chain  DnaJ homolog subfamily C member 10

Uniprot

A0A2A4JY20   A0A3S2P550   A0A194PU39   A0A2H1VKE8   A0A0N1I782   A0A212FFB3   + More
A0A1W4XRD8   N6U1H5   D6WB87   K7IUJ8   A0A067R8R7   A0A0T6AXX5   A0A232EVB6   A0A1B6K1C2   E9HSV1   A0A0C9RUD2   L7M9R9   A0A224YLI3   A0A131YX50   A0A1S3ICH4   A0A131XCL6   V4CLN4   A0A1B6D3Y5   A0A0A9WTW6   A0A0P6JMH9   A0A195CP40   K1R407   A0A164XM53   E2C8F2   A0A0P5E587   T1ICK1   A7RXE0   A0A210QKP4   A0A0P5W9U5   U4UEY1   A0A0P4VZ11   A0A091J2M0   A0A158NIB7   A0A091G042   Q6NRT6   A0A1L8EPM5   A0A195EFX2   R0LS95   A0A091PT94   U3J188   A0A218UPK8   A0A091HR19   F4WGA6   A0A093D0G1   A0A091HEW0   A0A224X7Y8   A0A2T7Q1M0   G1N9Z6   A0A091NRI4   A0A093NIJ9   A0A093QSW7   A0A093EV94   A0A091PMM1   U3JLW4   A0A093IVM4   A0A0A0AL06   T1IPH3   A0A0P5XH85   A0A091QP43   A0A087QGY3   T1ED98   A0A2I0UPW3   A0A091VNZ0   H0ZH31   A0A0P4YVH1   E1BRA6   A0A099ZAI7   A0A0P5UBM5   A0A1L8EWF7   A0A091KIA8   A0A091M795   A0A093GH98   A0A091EPS8   A0A1V4L0K1   A0A3B1J415   A0A091UV72   A0A2I0LXI9   A0A3L8SEP1   F7FJY1   A0A0B8RZ19   A0A093HHB7   B7PNU9   A0A151LZP1   A0A3B4BQ05   G3VP55   K7F258   W5UIN2   R7TG96   A0A2D0R3S8   A0A2D0R5C2   F7E9S8  

EC Number

1.8.4.-

Pubmed

26354079    22118469    23537049    18362917    19820115    20075255    + More
24845553    28648823    21292972    25576852    28797301    26830274    28049606    23254933    25401762    22992520    20798317    17615350    28812685    21347285    27762356    23749191    21719571    20838655    20360741    15592404    25329095    23371554    30282656    18464734    25476704    22293439    21709235    17381049    23127152    17495919   

EMBL

NWSH01000443    PCG76393.1    RSAL01000020    RVE52633.1    KQ459592    KPI96832.1    + More
ODYU01003032    SOQ41295.1    KQ460636    KPJ13373.1    AGBW02008839    OWR52419.1    APGK01043268    APGK01043269    APGK01043270    KB741014    ENN75400.1    KQ971312    EEZ97922.2    AAZX01002625    KK852809    KDR15988.1    LJIG01022541    KRT80031.1    NNAY01002021    OXU22293.1    GECU01002447    JAT05260.1    GL732758    EFX65186.1    GBYB01012425    JAG82192.1    GACK01005175    JAA59859.1    GFPF01007351    MAA18497.1    GEDV01004794    JAP83763.1    GEFH01004716    JAP63865.1    KB200084    ESP03215.1    GEDC01016920    GEDC01004515    JAS20378.1    JAS32783.1    GBHO01032738    JAG10866.1    GDIQ01002824    JAN91913.1    KQ977481    KYN02410.1    JH817910    EKC28571.1    LRGB01000966    KZS14374.1    GL453666    EFN75787.1    GDIP01151373    JAJ72029.1    ACPB03013479    DS469550    EDO43758.1    NEDP02003178    OWF49324.1    GDIP01102381    JAM01334.1    KB632328    ERL92534.1    GDRN01101528    JAI58356.1    KK501437    KFP14852.1    ADTU01016302    ADTU01016303    KL447622    KFO75293.1    BC070632    CM004483    OCT61219.1    KQ978957    KYN27061.1    KB742873    EOB03273.1    KK678051    KFQ10551.1    ADON01053152    ADON01053153    MUZQ01000205    OWK55350.1    KL217737    KFO98336.1    GL888128    EGI66873.1    KL474897    KFV20258.1    KL535944    KFO94411.1    GFTR01007960    JAW08466.1    PZQS01000001    PVD39550.1    KL393317    KFP92393.1    KL224607    KFW61830.1    KL431002    KFW91621.1    KK382500    KFV49217.1    KK661632    KFQ08586.1    AGTO01000451    KK563429    KFW02829.1    KL872189    KGL94721.1    JH431262    GDIP01073902    JAM29813.1    KK702751    KFQ28376.1    KL225576    KFM00487.1    AMQM01006708    KB097502    ESN95836.1    KZ505661    PKU48075.1    KK734218    KFR05152.1    ABQF01010254    GDIP01223064    JAJ00338.1    AADN05000350    KL890656    KGL77983.1    GDIP01115385    JAL88329.1    CM004482    OCT63684.1    KK746325    KFP40339.1    KK524674    KFP67673.1    KL215731    KFV66297.1    KK718916    KFO59913.1    LSYS01000429    OPJ90162.1    KL410237    KFQ94854.1    AKCR02000066    PKK22148.1    QUSF01000024    RLW00998.1    GBSH01000882    JAG68143.1    KL206406    KFV82033.1    ABJB010074310    DS754779    EEC08271.1    AKHW03006853    KYO17745.1    AEFK01112961    AEFK01112962    AGCU01076169    AGCU01076170    AGCU01076171    JT415868    AHH41846.1    AMQN01002771    KB310004    ELT92793.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    UP000192223    + More
UP000019118    UP000007266    UP000002358    UP000027135    UP000215335    UP000000305    UP000085678    UP000030746    UP000078542    UP000005408    UP000076858    UP000008237    UP000015103    UP000001593    UP000242188    UP000030742    UP000053119    UP000005205    UP000053760    UP000186698    UP000078492    UP000016666    UP000197619    UP000054308    UP000007755    UP000245119    UP000001645    UP000054081    UP000016665    UP000053858    UP000053286    UP000015101    UP000053605    UP000007754    UP000000539    UP000053641    UP000053875    UP000052976    UP000190648    UP000018467    UP000053283    UP000053872    UP000276834    UP000002279    UP000053584    UP000001555    UP000050525    UP000261440    UP000007648    UP000007267    UP000014760    UP000221080    UP000002280   

PRIDE

L7M9R9    B7PNU9   

Pfam

PF00226   DnaJ        + More
PF00085   Thioredoxin
PF07690   MFS_1
PF16187   Peptidase_M16_M
PF05193   Peptidase_M16_C
PF00675   Peptidase_M16

Interpro

IPR001623   DnaJ_domain        + More
IPR017937   Thioredoxin_CS       
IPR013766   Thioredoxin_domain       
IPR036869   J_dom_sf       
IPR036249   Thioredoxin-like_sf       
IPR018253   DnaJ_domain_CS       
IPR011701   MFS       
IPR036259   MFS_trans_sf       
IPR020846   MFS_dom       
IPR005829   Sugar_transporter_CS       
IPR001431   Pept_M16_Zn_BS       
IPR011765   Pept_M16_N       
IPR007863   Peptidase_M16_C       
IPR032632   Peptidase_M16_M       
IPR011249   Metalloenz_LuxS/M16       
IPR035674   ERdj5_TRX_C       
IPR021170   ERdj5       
IPR035673   ERdj5_TRX_N       

SUPFAM

SSF46565   SSF46565        + More
SSF52833   SSF52833       
SSF103473   SSF103473       
SSF63411   SSF63411       

Gene 3D

1.10.287.110    

CDD

cd06257  DnaJ
cd06174  MFS
cd03004  PDI_a_ERdj5_C
cd03003  PDI_a_ERdj5_N

ProteinModelPortal

A0A2A4JY20   A0A3S2P550   A0A194PU39   A0A2H1VKE8   A0A0N1I782   A0A212FFB3   + More
A0A1W4XRD8   N6U1H5   D6WB87   K7IUJ8   A0A067R8R7   A0A0T6AXX5   A0A232EVB6   A0A1B6K1C2   E9HSV1   A0A0C9RUD2   L7M9R9   A0A224YLI3   A0A131YX50   A0A1S3ICH4   A0A131XCL6   V4CLN4   A0A1B6D3Y5   A0A0A9WTW6   A0A0P6JMH9   A0A195CP40   K1R407   A0A164XM53   E2C8F2   A0A0P5E587   T1ICK1   A7RXE0   A0A210QKP4   A0A0P5W9U5   U4UEY1   A0A0P4VZ11   A0A091J2M0   A0A158NIB7   A0A091G042   Q6NRT6   A0A1L8EPM5   A0A195EFX2   R0LS95   A0A091PT94   U3J188   A0A218UPK8   A0A091HR19   F4WGA6   A0A093D0G1   A0A091HEW0   A0A224X7Y8   A0A2T7Q1M0   G1N9Z6   A0A091NRI4   A0A093NIJ9   A0A093QSW7   A0A093EV94   A0A091PMM1   U3JLW4   A0A093IVM4   A0A0A0AL06   T1IPH3   A0A0P5XH85   A0A091QP43   A0A087QGY3   T1ED98   A0A2I0UPW3   A0A091VNZ0   H0ZH31   A0A0P4YVH1   E1BRA6   A0A099ZAI7   A0A0P5UBM5   A0A1L8EWF7   A0A091KIA8   A0A091M795   A0A093GH98   A0A091EPS8   A0A1V4L0K1   A0A3B1J415   A0A091UV72   A0A2I0LXI9   A0A3L8SEP1   F7FJY1   A0A0B8RZ19   A0A093HHB7   B7PNU9   A0A151LZP1   A0A3B4BQ05   G3VP55   K7F258   W5UIN2   R7TG96   A0A2D0R3S8   A0A2D0R5C2   F7E9S8  

PDB

5AYL     E-value=9.5118e-51,     Score=509

KEGG

101737299    K09530 DnaJ homolog subfamily C member 10 | (RefSeq) DnaJ-27; dnaJ homolog subfamily C member 10

PATHWAY

04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0005623   GO:0045454   GO:0005215   GO:0055085   GO:0016021   GO:0005739   GO:0046872   GO:0051603   GO:0004222   GO:0005783   GO:0015036   GO:0034975   GO:0016671   GO:0030433   GO:0005788   GO:0015035   GO:0001933   GO:0034663   GO:0051787   GO:0051087   GO:0051117   GO:0070059   GO:0030544   GO:0001671   GO:0016853   GO:0003756   GO:0046982   GO:0006412   GO:0005737   GO:0006520   GO:0006508   GO:0008237   GO:0016020   GO:0003707   GO:0051537  

Subcellular location

Endoplasmic reticulum lumen  

SignalP

Position:   1 - 18,         Likelihood:  0.867973

 

 

Length:

782

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.8456

Exp number, first 60 AAs:

1.82253

Total prob of N-in:

0.08387

outside

1  -  782

 

 

Pi

23.899893

Theta

24.516473

Tajima's D

0.363733

CLR

0.864348

CSRT

0.47967601619919

Interpretation

Uncertain