Gene

KWMTBOMO07402

Pre Gene Modal

BGIBMGA010343

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_tyrosine-protein_kinase_transmembrane_receptor_Ror-like_[Bombyx_mori]

Location

Bomo_Chr12(+):12090675-12094354      View in EpiBrowser

Full name

Tyrosine-protein kinase receptor      

Location in the cell

Nuclear   Reliability : 2.567

CDS

ATGAAATGTATTACAGTGTTAGTTATGTGCCTGTGTTTACATGACATTCATTCATCAAGTGAAGAGAAAACAGAATCTATCTCTCCTCTAAGACTTAATAGTACATCAGAATGGAACATCAAACTGGATATATTCTTTTCTAAATCTTTACCTCAGCATGTAACGAGATCTCCTGGTAGTGATGTTCGTTTTAAATGTGAAGCTTACATAAACTTTACGAAAGTTGAAAAGTACACTAAAAATGAACAAGGTATAGAAACTTTACATGCTGAGCTACCCCCGCAGCATATACAGCAAAGACTGTTGAACAATGTAAAAGTATATTGGCTCAAAAACAATAAAAGTATTGAAATTTCAAACAAAGTTAATGTTACAACTAAAATCAATAATATAACGATTTCCACAAATTTAAAGATCAGAAACATAAGTAATGGTGATGCAGGTAACTACACATGTGTTTACAAACAAATGTATGAAAAAAAGCAAACTTCCTTACTCAAAGTTGAAGATAGTGTTGACATACCTACCCATGCACCATATTTCCCAAATTCAAATTTTGTAAATGAATTAAGAATTACAACCCCGGATGTGGTGTCAGAAAATATTAAAACTATGAATATAAACGTTACTGATTCTCCTAATATACCTCTTCAAAAACTTGAACCAATTTGTCAAGAATATGTTGGGAAAGTTTGTGCATTTCACTTAAGAGGCCAATCTGTTTATATCCCATATGATACCACACAGATTGAATTGGAAGAGAAGTTAAGAAAAGCAATACAAGTTACAAGATTTTCTAATGAAATAAGTTCACACTGTGAAAGATATGCATTACCTAGTTTGTGCTACTCCACTTTTCCCATATGTAGAAATCCTGTAGCTACAAATGCTAATTTCTTTAAAGATGCAAGACAGGTATTTCTCATATCAAATAGAACCAACACTGCAGATTTTCCTGAAGTTGTATTTGAAAATATGCCTAATGGAAATGTACCTAATACTTTTTACTTGAAACCAAACAATATATCAAATGAAATGTTTAACTATCGTCATAATACAACAATACTGAGGAGAGTATGTAAGAAAGAGTGTGAAATTTTAGAAACAGAATTATGTCAGAAAGAATATGCCATAGCGAAAAGGCATCCCCATATTGGTCAGCAATTAACTTTAGAAGAATGTCAAGATTTACCTGAAAATGATCCAGACTGTCTTAAAATTGAAATTGGAGCTTTAATGATTTCAGATGATGAGTGTTATTGGGAAAACGGCAGTAGTTATTTGGGCAAAGTTAATGTTGCCAGTAATGGGTTGGCTTGTATTGAATGGTCAAAGCAAATGTATGTTACATTATCAAATTACCCTGTACTTGCTGGTAGACACAGCTACTGCCGTAACCCAGGAGGAGTCAATGAACAGCCTTGGTGTGTGGTAGATAAAGATGGTAAACTATATAAACAATTTTGTAACATTCCCAAATGTGCTCACAAACTTTGGATATACATAGTTGTTATCTTGGCAGTATCGTTCATAGTTATTGTGGGATTTGTTGTTTGTCTCATTTGCAGACATAAAAAAAAGAGTAATGCTGCTGCAATTAGAGACATTAACTTACCTAATGCTGATAAGAATATCTATGGAAATTCTAGATTGAATTCTCCAATAGAAATGACAGACTTACTGCCAAACCATAGTAATCAGCCCCATTTGACCAGGAGTACTCGTGGAAATGGTGTACTCAGAATACCTCAATATTCACTGTCGCAGATCAAATTCCTGGAAGAGTTAGGGGAGGGAGCTTTTGGAAAAGTTTACAAAGGAGCACTGAAAAAGAGTGGAGATACACAGTTTATAGCAGTCAAAGCACTCAAAGAAAATGCTTCAGCTAAGACCAAGGCTGATTTCAGAAGAGAAATTGATTTGATTTCTGAACTTAACCATGACAATATTGTGTGTATTGTTGGTGTTGCTTTAAGTGAAGAACCACTTTGCATGTTATTTGAGTTCATGGCTCGAGGAGACTTGCATGAATTTTTAATGGGAAGAGCACCTCCATCAGGAAAGGGTTTACCTCCCATGAGACTGCTGAACATTGCACATAATATTGCATCAGGCATGCAGTATTTGGCCTCACACCATTATGTACATAGAGATTTAGCTGCAAGAAATTGTTTGGTTTCCGATGATTTTGTTGTGAAGATATCTGATTTTGGCCTCTCTAGAGATATATATAGTTCAGATTATTACAGAGTACAATCAAAAAGTTTATTGCCCGTTAGATGGATGCCACCAGAATCTATACTTTATGGAAAATTCACTACTGAAAGTGATATATGGTCATATGGGGTTGTCCTGTGGGAAATTTACAGTTATGGCCTCCAGCCTTATTATGGTTATAGTAATCAAGAAGTCATATCGATGGTGCGGAGTGGTGAGTTTTTAGCAGCACCATCAGCATGTCCATTGCCCATGTATGAACTCATGAGGGACTGTTGGAAACACACACCACATCGAAGGCCATCATTTGAAGATATAGTTAACAGAATTCAAGAGTGGATCCAGATGGGGGGATGTTCAGATGTTGGACCATCAGAATCTAGCAGCAATATAAGCGCGTACAGAACGACTAGTACTAGCAGGGATCTTCAGGAAAGAGTTCCACTGTTGCCCCCTCATTGCTCTTCATCTAATGGCTCTCTTGCCACCGGGAGCTTAAAGAAATTTAGTGTAGCTGGTTCAAGTTCGAAGGTAACTGATGATAATTGCTCTACATGTAGTGAAGTACCCCCATTAGCTCCAAAATCTAAAAAACACAGTGCAGCATCGCTGATAGACTCAGACAAAATAGGCAACATGAGTACAAGGGAGACAATCATTAGAATACCTAATGCACAGCACGGTAATGAAATTTAG

Protein

MKCITVLVMCLCLHDIHSSSEEKTESISPLRLNSTSEWNIKLDIFFSKSLPQHVTRSPGSDVRFKCEAYINFTKVEKYTKNEQGIETLHAELPPQHIQQRLLNNVKVYWLKNNKSIEISNKVNVTTKINNITISTNLKIRNISNGDAGNYTCVYKQMYEKKQTSLLKVEDSVDIPTHAPYFPNSNFVNELRITTPDVVSENIKTMNINVTDSPNIPLQKLEPICQEYVGKVCAFHLRGQSVYIPYDTTQIELEEKLRKAIQVTRFSNEISSHCERYALPSLCYSTFPICRNPVATNANFFKDARQVFLISNRTNTADFPEVVFENMPNGNVPNTFYLKPNNISNEMFNYRHNTTILRRVCKKECEILETELCQKEYAIAKRHPHIGQQLTLEECQDLPENDPDCLKIEIGALMISDDECYWENGSSYLGKVNVASNGLACIEWSKQMYVTLSNYPVLAGRHSYCRNPGGVNEQPWCVVDKDGKLYKQFCNIPKCAHKLWIYIVVILAVSFIVIVGFVVCLICRHKKKSNAAAIRDINLPNADKNIYGNSRLNSPIEMTDLLPNHSNQPHLTRSTRGNGVLRIPQYSLSQIKFLEELGEGAFGKVYKGALKKSGDTQFIAVKALKENASAKTKADFRREIDLISELNHDNIVCIVGVALSEEPLCMLFEFMARGDLHEFLMGRAPPSGKGLPPMRLLNIAHNIASGMQYLASHHYVHRDLAARNCLVSDDFVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPPESILYGKFTTESDIWSYGVVLWEIYSYGLQPYYGYSNQEVISMVRSGEFLAAPSACPLPMYELMRDCWKHTPHRRPSFEDIVNRIQEWIQMGGCSDVGPSESSSNISAYRTTSTSRDLQERVPLLPPHCSSSNGSLATGSLKKFSVAGSSSKVTDDNCSTCSEVPPLAPKSKKHSAASLIDSDKIGNMSTRETIIRIPNAQHGNEI

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Belongs to the protein kinase superfamily. Tyr protein kinase family.

Feature

chain  Tyrosine-protein kinase receptor

Uniprot

A0A2A4K4D3   A0A3S2THF9   A0A194R429   A0A194PUX8   A0A0L7L2X6   A0A1S4FQ29   + More
W8C503   A0A336MEA8   A0A336LGT4   A0A3L8DZ56   A0A195EY13   A0A151WKE8   A0A195CE65   A0A195BQD8   A0A154P7U0   A0A0J7KNY4   E9IQD9   E2C8Q0   F4W9T8   A0A0M9A8C4   A0A158NYX7   A0A088A947   D2A6A0   E2A5T3   A0A0L7R2I1   A0A2A3E0N0   A0A232FIZ5   K7J9R8   A0A026W8W6   A0A151JB73   A0A1Y1M7L8   A0A1Y1M0D5   A0A1Y1M7M7   A0A1Y1M5Z5   A0A3B0K6J9   A0A0C9R3F9   A0A336K6V3   T1HCV4   A0A146M6A3   A0A0A9Z5Y9   A0A0U3K0U7   A0A1B6J519   T1IJ71   A0A1B6LIV8  

EC Number

2.7.10.1

Pubmed

26354079    26227816    17510324    24495485    30249741    21282665    + More
20798317    21719571    21347285    18362917    19820115    28648823    20075255    24508170    28004739    26823975    25401762   

EMBL

NWSH01000173    PCG78768.1    RSAL01000139    RVE46142.1    KQ460845    KPJ12000.1    + More
KQ459592    KPI96793.1    JTDY01003386    KOB69634.1    GAMC01009286    JAB97269.1    UFQT01001062    SSX28694.1    UFQS01000002    UFQT01000002    SSW96699.1    SSX17086.1    QOIP01000002    RLU25724.1    KQ981909    KYN33175.1    KQ983012    KYQ48342.1    KQ977876    KYM99097.1    KQ976423    KYM88786.1    KQ434839    KZC07989.1    LBMM01004843    KMQ92042.1    GL764736    EFZ17209.1    GL453671    EFN75674.1    GL888033    EGI69074.1    KQ435721    KOX78546.1    ADTU01000806    KQ971346    EFA05483.2    GL437059    EFN71205.1    KQ414666    KOC65085.1    KZ288477    PBC25280.1    NNAY01000158    OXU30449.1    AAZX01001946    KK107329    EZA52500.1    KQ979229    KYN22205.1    GEZM01043121    JAV79307.1    GEZM01043124    JAV79302.1    GEZM01043117    GEZM01043113    JAV79317.1    GEZM01043116    GEZM01043114    JAV79326.1    OUUW01000006    SPP81639.1    GBYB01007322    JAG77089.1    SSW96700.1    SSX17087.1    ACPB03000222    ACPB03000223    GDHC01003328    JAQ15301.1    GBHO01004304    GBHO01004303    JAG39300.1    JAG39301.1    KT355588    ALV82507.1    GECU01013434    JAS94272.1    JH430232    GEBQ01016378    JAT23599.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000053268    UP000037510    UP000279307    + More
UP000078541    UP000075809    UP000078542    UP000078540    UP000076502    UP000036403    UP000008237    UP000007755    UP000053105    UP000005205    UP000005203    UP000007266    UP000000311    UP000053825    UP000242457    UP000215335    UP000002358    UP000053097    UP000078492    UP000268350    UP000015103   

Pfam

PF07679   I-set        + More
PF00051   Kringle
PF07714   Pkinase_Tyr
PF00047   ig
PF01392   Fz

Interpro

IPR000719   Prot_kinase_dom        + More
IPR036179   Ig-like_dom_sf       
IPR008266   Tyr_kinase_AS       
IPR002011   Tyr_kinase_rcpt_2_CS       
IPR020635   Tyr_kinase_cat_dom       
IPR013783   Ig-like_fold       
IPR017441   Protein_kinase_ATP_BS       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR018056   Kringle_CS       
IPR020067   Frizzled_dom       
IPR041775   Ror-like_CRD       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR013098   Ig_I-set       
IPR011009   Kinase-like_dom_sf       
IPR038178   Kringle_sf       
IPR000001   Kringle       
IPR013806   Kringle-like       
IPR036790   Frizzled_dom_sf       
IPR003598   Ig_sub2       
IPR013151   Immunoglobulin       

SUPFAM

SSF57440   SSF57440        + More
SSF56112   SSF56112       
SSF48726   SSF48726       

Gene 3D

2.40.20.10     2.60.40.10     1.10.2000.10    

CDD

cd00108  KR
cd07459  CRD_TK_ROR_like

ProteinModelPortal

A0A2A4K4D3   A0A3S2THF9   A0A194R429   A0A194PUX8   A0A0L7L2X6   A0A1S4FQ29   + More
W8C503   A0A336MEA8   A0A336LGT4   A0A3L8DZ56   A0A195EY13   A0A151WKE8   A0A195CE65   A0A195BQD8   A0A154P7U0   A0A0J7KNY4   E9IQD9   E2C8Q0   F4W9T8   A0A0M9A8C4   A0A158NYX7   A0A088A947   D2A6A0   E2A5T3   A0A0L7R2I1   A0A2A3E0N0   A0A232FIZ5   K7J9R8   A0A026W8W6   A0A151JB73   A0A1Y1M7L8   A0A1Y1M0D5   A0A1Y1M7M7   A0A1Y1M5Z5   A0A3B0K6J9   A0A0C9R3F9   A0A336K6V3   T1HCV4   A0A146M6A3   A0A0A9Z5Y9   A0A0U3K0U7   A0A1B6J519   T1IJ71   A0A1B6LIV8  

KEGG

101744465    K05122 receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1] | (RefSeq) tyrosine-protein kin

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0016021   GO:0004714   GO:0007169   GO:0017147   GO:0043235   GO:0048856   GO:0030424   GO:0005887   GO:0005515   GO:0004713   GO:0006468   GO:0004672   GO:0016020   GO:0003707   GO:0051537  

SignalP

Position:   1 - 18,         Likelihood:  0.992222

 

 

Length:

970

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

27.92171

Exp number, first 60 AAs:

0.00016

Total prob of N-in:

0.05399

outside

1  -  497

TMhelix

498  -  520

inside

521  -  970

 

 

Pi

17.735233

Theta

14.965264

Tajima's D

0.668771

CLR

0.478898

CSRT

0.568921553922304

Interpretation

Uncertain