Gene

KWMTBOMO07389  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010337

Annotation

PREDICTED:_RNA_polymerase_II_transcriptional_coactivator_[Papilio_machaon]

Location

Bomo_Chr12(+):11903835-11906018      View in EpiBrowser

Full name

RNA polymerase II transcriptional coactivator      

Alternative Name

p11

Transcription factor

PC4

Location in the cell

Nuclear   Reliability : 3.501

CDS

ATGCCTAAACAAAAGAGAGAAGAAAAACCTAAGAACAAGAAAAACGATAGTTCTAGTAGTGACAGTGATGACGGCCCTGAAGATAGGAACCCTCCTGCTGAAAAAAAGGCAAAAATGGCAGACAGGACTAATGATAAAGAGCCAACATGGGTGTTACAGGGCAAGAAATTACTGAAAGTCCGAGAATTCAAAGGAAAAGTATATGTAGACATAAGAGAATTTTATGAAAAGAATGGTGAACTTTTACCAGGTAAAAAAGGGATAAGTCTCACTCCAGAACAATGGAGAAAATTGTTATCAGTAGGTGAAGAGGTTAATGAGACTGTTAGTTCCATGTGTTAA

Protein

MPKQKREEKPKNKKNDSSSSDSDDGPEDRNPPAEKKAKMADRTNDKEPTWVLQGKKLLKVREFKGKVYVDIREFYEKNGELLPGKKGISLTPEQWRKLLSVGEEVNETVSSMC

Description

General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity). Binds specifically to the NssBF element, a short nucleotide sequence of the 1731 retrotransposon, to repress promoter activity.

Similarity

Belongs to the transcriptional coactivator PC4 family.
Belongs to the DEAD box helicase family.

Keywords

Activator   Complete proteome   DNA-binding   Nucleus   Reference proteome   Repressor   Transcription   Transcription regulation  

Feature

chain  RNA polymerase II transcriptional coactivator

Uniprot

A0A2H1V6G4   A0A194R2T6   A0A2A4K4C6   A0A3S2LWX8   A0A194PTP0   I4DL99   + More
A0A212F3J1   A0A1E1WSB6   A9CTQ5   S4P875   A0A0L7L4S2   A0A067QUX2   A0A0L0C5L1   A0A2P8XGM8   R4WJP6   A0A2S2QF21   A0A1B0D2B4   B4NWF3   A0A1W4UV16   A8D8C5   B3N720   U5EXJ9   A0A2J7R3R7   A0A0M5IW01   A0A1Q3F3I1   A0A023ECV9   A0A2R7WFZ5   B0WYK9   A0A1B0CJZ2   W8AVU4   A0A2M3ZDM0   A0A1A9UY98   A0A1I8PWB1   A0A1A9Z9F3   A0A023EET7   J9JYF1   A0A1A9Y509   A0A1B0AWX8   Q16XW9   A0A2M3ZKB7   A0A0K8UB16   A0A164S6X0   A0A1B2AJ64   Q9VLR5   A0A0P5FD41   A0A2M4C4A8   B4JB34   N6STT5   A0A0P4XBI1   A0A2M4ATI4   A0A023ECU3   A0A2M4C494   B4HYG4   B4Q6B6   W5JGS1   A0A1I8M2C4   B4MVX6   A0A1B0FHM8   A0A2S2NVE8   A0A182FT97   A0A2H8TVV2   B3MPH5   A0A1W4WUX3   A0A226EW24   A0A1D2MXD6   A0A1L8EBS8   B4LUB6   A0A1L8EC48   A0A1S3DHG8   B4KGW9   A0A1B6IMP3   A0A1B6KUG9   A0A0P4VT06   T1H8G2   A0A293M4Q4   D6WW15   A0A1A9VZR5   A0A034WI66   A0A1Y1LXT4   A0A195B259   A0A1B6F020   A0A195E6D3   A0A0P4WKV7   G3MRI6   A0A182Q9D1   A0A023GDN4   Q29ML7   B4G919  

Pubmed

26354079    22651552    22118469    23622113    26227816    24845553    + More
26108605    29403074    23691247    17994087    17550304    24945155    24495485    17510324    8559667    10731132    12537572    23537049    22936249    20920257    23761445    25315136    27289101    27129103    18362917    19820115    25348373    28004739    22216098    15632085   

EMBL

ODYU01000923    SOQ36421.1    KQ460845    KPJ12012.1    NWSH01000173    PCG78764.1    + More
RSAL01000139    RVE46127.1    KQ459592    KPI96781.1    AK402067    BAM18689.1    AGBW02010564    OWR48308.1    GDQN01001115    JAT89939.1    AB371909    BAF95583.1    GAIX01006066    JAA86494.1    JTDY01003002    KOB70331.1    KK852921    KDR13791.1    JRES01000864    KNC27683.1    PYGN01002208    PSN31161.1    AK417800    BAN21015.1    GGMS01006917    MBY76120.1    AJVK01022719    CM000157    EDW88470.1    EU142272    ABV60408.1    CH954177    EDV59316.1    GANO01000917    JAB58954.1    NEVH01007818    PNF35476.1    CP012523    ALC38206.1    GFDL01012935    JAV22110.1    GAPW01006391    JAC07207.1    KK854773    PTY18587.1    DS232191    EDS37086.1    AJWK01015541    GAMC01021654    JAB84901.1    GGFM01005854    MBW26605.1    GAPW01006389    GAPW01006388    JAC07209.1    ABLF02015899    JXJN01004961    CH477530    EAT39475.1    EJY57774.1    GGFM01008149    MBW28900.1    GDHF01028551    JAI23763.1    LRGB01002076    KZS09316.1    KX531387    ANY27197.1    U18971    AE014134    BT023261    GDIQ01256790    JAJ94934.1    GGFJ01010993    MBW60134.1    CH916368    EDW03926.1    APGK01056555    KB741277    ENN71074.1    GDIP01243430    JAI79971.1    GGFK01010794    MBW44115.1    GAPW01006390    JAC07208.1    GGFJ01010992    MBW60133.1    CH480818    EDW52094.1    CM000361    CM002910    EDX04192.1    KMY88978.1    ADMH02001578    ETN61999.1    CH963857    EDW75846.1    CCAG010020379    GGMR01008403    MBY21022.1    GFXV01006235    MBW18040.1    CH902620    EDV31271.2    LNIX01000001    OXA61719.1    LJIJ01000418    ODM97703.1    GFDG01002599    JAV16200.1    CH940649    EDW64102.2    GFDG01002607    JAV16192.1    CH933807    EDW11169.1    GECU01019527    JAS88179.1    GEBQ01025083    JAT14894.1    GDKW01000265    JAI56330.1    ACPB03015821    GFWV01010342    MAA35071.1    KQ971361    EFA08648.1    GAKP01003716    JAC55236.1    GEZM01045908    GEZM01045907    JAV77628.1    KQ976662    KYM78377.1    GECZ01026221    JAS43548.1    KQ979568    KYN20733.1    GDRN01013365    JAI67861.1    JO844487    AEO36104.1    AXCN02001663    GBBM01003132    JAC32286.1    CH379060    EAL33676.2    CH479180    EDW28849.1   

Proteomes

UP000053240    UP000218220    UP000283053    UP000053268    UP000007151    UP000037510    + More
UP000027135    UP000037069    UP000245037    UP000092462    UP000002282    UP000192221    UP000008711    UP000235965    UP000092553    UP000002320    UP000092461    UP000078200    UP000095300    UP000092445    UP000007819    UP000092443    UP000092460    UP000008820    UP000076858    UP000000803    UP000001070    UP000019118    UP000001292    UP000000304    UP000000673    UP000095301    UP000007798    UP000092444    UP000069272    UP000007801    UP000192223    UP000198287    UP000094527    UP000008792    UP000079169    UP000009192    UP000015103    UP000007266    UP000091820    UP000078540    UP000078492    UP000075886    UP000001819    UP000008744   

PRIDE

Q9VLR5   

Pfam

PF02229   PC4        + More
PF00271   Helicase_C
PF00270   DEAD

Interpro

IPR009044   ssDNA-bd_transcriptional_reg        + More
IPR003173   PC4       
IPR017415   KELP       
IPR027417   P-loop_NTPase       
IPR001650   Helicase_C       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR014014   RNA_helicase_DEAD_Q_motif       

SUPFAM

SSF54447   SSF54447        + More
SSF52540   SSF52540       

Gene 3D

2.30.31.10    

CDD

cd00079  HELICc

ProteinModelPortal

A0A2H1V6G4   A0A194R2T6   A0A2A4K4C6   A0A3S2LWX8   A0A194PTP0   I4DL99   + More
A0A212F3J1   A0A1E1WSB6   A9CTQ5   S4P875   A0A0L7L4S2   A0A067QUX2   A0A0L0C5L1   A0A2P8XGM8   R4WJP6   A0A2S2QF21   A0A1B0D2B4   B4NWF3   A0A1W4UV16   A8D8C5   B3N720   U5EXJ9   A0A2J7R3R7   A0A0M5IW01   A0A1Q3F3I1   A0A023ECV9   A0A2R7WFZ5   B0WYK9   A0A1B0CJZ2   W8AVU4   A0A2M3ZDM0   A0A1A9UY98   A0A1I8PWB1   A0A1A9Z9F3   A0A023EET7   J9JYF1   A0A1A9Y509   A0A1B0AWX8   Q16XW9   A0A2M3ZKB7   A0A0K8UB16   A0A164S6X0   A0A1B2AJ64   Q9VLR5   A0A0P5FD41   A0A2M4C4A8   B4JB34   N6STT5   A0A0P4XBI1   A0A2M4ATI4   A0A023ECU3   A0A2M4C494   B4HYG4   B4Q6B6   W5JGS1   A0A1I8M2C4   B4MVX6   A0A1B0FHM8   A0A2S2NVE8   A0A182FT97   A0A2H8TVV2   B3MPH5   A0A1W4WUX3   A0A226EW24   A0A1D2MXD6   A0A1L8EBS8   B4LUB6   A0A1L8EC48   A0A1S3DHG8   B4KGW9   A0A1B6IMP3   A0A1B6KUG9   A0A0P4VT06   T1H8G2   A0A293M4Q4   D6WW15   A0A1A9VZR5   A0A034WI66   A0A1Y1LXT4   A0A195B259   A0A1B6F020   A0A195E6D3   A0A0P4WKV7   G3MRI6   A0A182Q9D1   A0A023GDN4   Q29ML7   B4G919  

PDB

4USG     E-value=3.16643e-08,     Score=132

KEGG

101743454    no KO assigned | (RefSeq) RNA polymerase II transcriptional coactivator

GO

GO:0006355   GO:0003677   GO:0003697   GO:0045892   GO:0005634   GO:0005524   GO:0004004   GO:0003743   GO:0005667   GO:0060261   GO:0003713   GO:0000398   GO:0003723   GO:0005215   GO:0043022   GO:0005488   GO:0003707   GO:0051537  

Subcellular location

Nucleus  

Length:

113

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.45975

outside

1  -  113

 

 

Pi

6.845674

Theta

13.111557

Tajima's D

-1.174509

CLR

5.124936

CSRT

0.104494775261237

Interpretation

Uncertain