Gene

KWMTBOMO07383  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010330

Annotation

PREDICTED:_multidrug_resistance-associated_protein_1_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr12(-):11622974-11656359      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.492

CDS

ATGTCTTACAACTCCACGCTTGACAGCTTTTGCGGGACACCGTTTTGGAACAGTACTGCCACCTGGTACACGGATAATCCTGAACTAACACCATGTTTCCAGCAGACTGTCCTCATTTGGACACCCTGTCTCTATCTCTGGGTGTTTGCATTCCTTGACTTATATTACATATTCAATAGTAAGGAACGAAATATACCATGGAACATACTGAACATCACGAAATTGCTAGTAACATGTCTTTTAATAGTTTTGAAATTTGTGGACTTGGGTGTAGCAGTCCATTTATCTTCAAACGGAGAAAAGGAAGTCTACAATGCGAATTATTACAGTCCTGTAATAAAAATATTAACATTCGGCTTATCAGCAACATTGCTATTCTATAACAGAAAGTATGGTATGAGAGCATCTGGAGTGCTCTTTTTCTTCTGGTTACTGCTCGTCGTAGCTGGAATACCCCAGCTAAGATCCGAAATTATCGATCACAAGAATTTAGATGACGACGAAAACGTCAAATACAATTTTATTAGTTACATGGTCTACTATCCTTTGATAGTTCTCATGTTCATACTTAATTGTTTTGCCGATTTGCCACCTAAGGACACGCCTTATAAGTATCAAAAGAATCAATGTCCGGAGAATGCAGCGGGATTCCCGAGCCGCCTCACGTTTAGCTGGTTCGATCCGCTCGCCCTGACTGGATTCCGCAGGAGTCTTGTTGAGAACGATCTGTGGGCCCTGAACCCACCGGACTCTTCGAAAGAATGCGTTCCGAAATTCGATAAATTTTGGGAAAGATCTCTGAAGAAACGCGAACTATCGAACGGTACTAAGGCGACATACCGAAAAACTTCAGCCAGTGTCAACTTCAAGCCAGAAAATGAAAAGAAGCCAGCCTCGATATTACCAGCACTGTGTCTCGCATTTGGAGGACAGTTTCTTTTTGGTTCTATCTTGAAGTTAATCAACGATATTCTCATGTTTATATCTCCACAGCTCCTCAAATTATTAATAAGTTTCGTTAAGAACGATGAACCGGACTGGAAAGGTTACGCATACGCCGTCGCGCTGCTGCTGTGTGCCATTACTCAAACAATGCTATTGGCGCACTACTTCACTAGGATGTATCTAGTGGGTATGAGGATCAGAACAGCGTTGACGAGCGCCATCTACAGAAAATCCCTACGTTTGTCGAACTCGGCTAGAAAGGAGTCAACCGTTGGAGAAATTGTCAATTTGATGTCTGTCGATGCTCAGAGATTCGTTGAGTTAACGGCATATTTGAACATGATATGGTCGGCGCCTCTGCAGATCGCCCTCGCCCTATATTTCTTGTGGGCTATCTTAGGTCCGTCAGTTCTCGCTGGTTTGGCGGTAATGATCATTCTTATACCGGTGAACGGTCTAATAGCGAACAGGGTCAAGACATTGCAAATAAAACAGATGAAGTACAAGGATGAGAGAGTTAAACTTATGAACGAAGTGCTCAATGGAATTAAGGTTCTGAAAATGTACGCTTGGGAGCCTAGCTTCGAAGATCAGATCCTGCAAATAAGGAACAAGGAAATGCACGTACTGAAACAAACGGCGTATCTAAATTCTGCGACCTCTTTCATTTGGTCATGTGCTCCGTTTTTGGTTTCACTGATGTCGTTCGGATGCTTTGTATTGGTGAACGATAAGGAAACTCTGGACTCTGAGAAGGCTTTCGTTGCATTATCACTTTTCAACATACTGCGTTTTCCACTGTCAATGCTGCCTAACGTTATATCGAATGTAGTACAAACGTCGGTAGGCATAAAGAGATTGAACAAATTCATGAACTGCGATGAGCTCGACATTAGTTCCGTCGATCACGACAAGAAAGAGCCCAGTCCAATTGTTATCGAAAACGGGAATTTCACGTGGGGCGAAAAAGATGCCGATCCTGTATTGAAGAACATTAATTTGAATGTACCGCGTGGCTCTTTGGTGGCCATAGTCGGAGCTGTAGGTTCCGGGAAGAGTTCATTGCTCGCTGCAATGCTTGGCGAGATGAACAAGATATCAGGCAGAGTGAATACACACGGCAGCATAGCGTACGTCCCGCAACAGGCCTGGATCCAAAATGCCACGCTACAAGATAATATACTCTTTGGGAAGCCTCTGCAGCAGCAGTCTTATAATAACGTTATTAATGTGTGCGCCCTCAAACCCGACTTTGACGTGTTACCTGGAGGAGATCAGACCGAAATCGGAGAGAAAGGTATAAACTTATCGGGCGGTCAGAAGCAGCGCGTGTCGCTGGCGCGCGCCGTGTACCACGAGGCGGACAACTACCTGCTGGACGACCCGCTGAGCGCCGTGGACTCGCACGTCGGCAAGCACATCTTCGACAAGGTCATCGGGCCCGCCGGCCTGCTCAAGGACAGGACGCGCGTCTGGGTCACGCACAACGTGTCCTACCTCGCGCAGACCGACCTGGTCGTCGTGCTGCGCGACGGACAGGTCTCCGAGGCCGGCTCCTACCAGCACCTGCTCGAGAAGAAGGGCGCCTTCGCTGACTTCCTGCTTCATCATCTGAGCGACATCGAGAAAACTTCGCCTGACGAGTTAGATGTTCTCAAGCAAGACCTGGAAACAAAACTCGGTACAGAATTCCAGAACAAACTGCAAAGGGCTCGCTCGCTCTCCGAAAGTACTTCAGAGTCGGAACAAACTCCCGCAGGTGATAGAGCTGGCAGCGTGAAACAAAAGACTCCTGACGCCCTCACTCAAAGCAATCTCAAAGAAAAGAACAAACTGATTGAAGCCGAGAAAGCGGAAACAGGAAGTGTGAAATGGAGTATATATAAGCACTACTTGATGAGCGTCGGTGTTTTCGCGTCCGTCGTGACGATTCTGATGAATCTGATCCTGCAAGTGTTCCAAGTCGGCTCCAACTACTGGCTGGCGGAGTGGTCCAGTGATTCGAAAATCATTGTTAACGGAACAGTGGACAGAGCAAAAAGGGACATGTACCTCGGTGTGTATGGAGCGCTCGGAGCAGGACAGGTGCTGTCGGTGTCGGTGTCGTCGCTGGCGCTATACCTGGGCACGCTGGCGGCGGCGCGCGCCCTCCACGCGACTCTGCTGGCCGGCGTGCTGCGGGCGCCGTCCATCGGCTTCTTCGACTGCACGCCCGTCGGCCGCGTGCTCAACCGCTTCAGCAAGGACGTTGACGTGCTCGACAACACGCTGCCCATGACGCTGCGGGGCTGGACGTCCTGCTTCTTCTCGGTACTGGGAACGCTGTTCGTGATAAGCGTGTCGACGCCCTTATTCTTAGTGATCGTGGTCCCGGTGGGTCTGATCTACTACGTGATCCAGAGGTTCTACGTGGCGACGTCCCGGCAACTCAAACGGCTGGAGTCGATATCGCGATCGCCCATCTATTCGCATTTCGGCGAGAGTATCACCGGGGCGTCCACAATACGAGCCTACGGTGTAACTGATAGATTTATTGAAGAAAGCGAAAGTCGAGTGGATCACAATCAGTCGTGCTATTACCCGAGCTGCATCGCGAATCGGTGGCTGGCCATCCGTCTGGAAATGATTGGAAACTTCATTATATTCAGCGCGGCTGTGTTCGCGGTGCTCGGTAGAAACTCTATCTATCCGGGTATTGTAGGACTCTCGATCAGCTATGCGCTACAGATCACTCAAACACTCAATTGGTTGGTCAGAATGACCTCTGAAGTTGAAACGAATATTGTCGCCGTCGAAAGGATAAAAGAGTACGCGGAAACCGAACAGGAGGCCGCGTGGAACTTGGAGAAAGGGCCCGGCGCAACGTGGCCCGAGACGGGAGCGCTACAGCTGGAGCAGCTGACGCTGGAGTACCGCCCCGGCGAGCCGGCGCTGCGTGACGTCACGTGCACGGTGGCGCCGCGCGACAAGCTCGGCATCGTGGGACGCACCGGCGCCGGCAAGTCTACTCTCACGCTCGGGCTCTTCAGGATCGTGGAGGCAGCCGCCGGACGCATCCTGATCGACGGCGTCGACATCGCGACCCTCGGGCTACACCAGCTGCGGTCGCGCATCACCATCATCCCGCAGGAGCCGATCCTGTTCTCGGGCACGCTGCGCTCCAACCTGGACCCGTTCGAGGCGTACAGCGACGAGGAGATCTGGCGCGCGCTGGAACACGCCCACCTCCGTGCCTTCGTGCAGGGGCTGCCGGCCGGGCTGCGGCACGAGGTGGCGGAGGGCGGCGAGAACCTGTCGGTGGGACAGCGCCAGCTCGTGTGCCTGGCGCGCGCGCTGCTACGCAAGACGCCGCTGCTGGTGCTGGACGAGGCCACCGCGGCCGTCGACCTCGAGACTGACGACCTCATCCAGAAGACGATCCGCTCGGAGTTCGCGTCGTGCACGGTGCTCACTATCGCGCACCGCCTCAACACCATCATGGACTCCACCAAAGTGATGGTGCTCGACCGCGGGCAGCTCGTAGAATATGCGGCCCCTCAACAACTACTTAACGATAAAAACTCCATTTTCTACTCCATGGCTAAAGATGCCGGAATAGTTAACTAA

Protein

MSYNSTLDSFCGTPFWNSTATWYTDNPELTPCFQQTVLIWTPCLYLWVFAFLDLYYIFNSKERNIPWNILNITKLLVTCLLIVLKFVDLGVAVHLSSNGEKEVYNANYYSPVIKILTFGLSATLLFYNRKYGMRASGVLFFFWLLLVVAGIPQLRSEIIDHKNLDDDENVKYNFISYMVYYPLIVLMFILNCFADLPPKDTPYKYQKNQCPENAAGFPSRLTFSWFDPLALTGFRRSLVENDLWALNPPDSSKECVPKFDKFWERSLKKRELSNGTKATYRKTSASVNFKPENEKKPASILPALCLAFGGQFLFGSILKLINDILMFISPQLLKLLISFVKNDEPDWKGYAYAVALLLCAITQTMLLAHYFTRMYLVGMRIRTALTSAIYRKSLRLSNSARKESTVGEIVNLMSVDAQRFVELTAYLNMIWSAPLQIALALYFLWAILGPSVLAGLAVMIILIPVNGLIANRVKTLQIKQMKYKDERVKLMNEVLNGIKVLKMYAWEPSFEDQILQIRNKEMHVLKQTAYLNSATSFIWSCAPFLVSLMSFGCFVLVNDKETLDSEKAFVALSLFNILRFPLSMLPNVISNVVQTSVGIKRLNKFMNCDELDISSVDHDKKEPSPIVIENGNFTWGEKDADPVLKNINLNVPRGSLVAIVGAVGSGKSSLLAAMLGEMNKISGRVNTHGSIAYVPQQAWIQNATLQDNILFGKPLQQQSYNNVINVCALKPDFDVLPGGDQTEIGEKGINLSGGQKQRVSLARAVYHEADNYLLDDPLSAVDSHVGKHIFDKVIGPAGLLKDRTRVWVTHNVSYLAQTDLVVVLRDGQVSEAGSYQHLLEKKGAFADFLLHHLSDIEKTSPDELDVLKQDLETKLGTEFQNKLQRARSLSESTSESEQTPAGDRAGSVKQKTPDALTQSNLKEKNKLIEAEKAETGSVKWSIYKHYLMSVGVFASVVTILMNLILQVFQVGSNYWLAEWSSDSKIIVNGTVDRAKRDMYLGVYGALGAGQVLSVSVSSLALYLGTLAAARALHATLLAGVLRAPSIGFFDCTPVGRVLNRFSKDVDVLDNTLPMTLRGWTSCFFSVLGTLFVISVSTPLFLVIVVPVGLIYYVIQRFYVATSRQLKRLESISRSPIYSHFGESITGASTIRAYGVTDRFIEESESRVDHNQSCYYPSCIANRWLAIRLEMIGNFIIFSAAVFAVLGRNSIYPGIVGLSISYALQITQTLNWLVRMTSEVETNIVAVERIKEYAETEQEAAWNLEKGPGATWPETGALQLEQLTLEYRPGEPALRDVTCTVAPRDKLGIVGRTGAGKSTLTLGLFRIVEAAAGRILIDGVDIATLGLHQLRSRITIIPQEPILFSGTLRSNLDPFEAYSDEEIWRALEHAHLRAFVQGLPAGLRHEVAEGGENLSVGQRQLVCLARALLRKTPLLVLDEATAAVDLETDDLIQKTIRSEFASCTVLTIAHRLNTIMDSTKVMVLDRGQLVEYAAPQQLLNDKNSIFYSMAKDAGIVN

Uniprot

A0A2H4KAX1   A0A0F6PP97   A0A220A455   D2Y5V6   A0A0F6PQJ9   A0A3S2NW63   + More
K7J1C7   A0A026W727   A0A139WC08   A0A1W4XSV3   A0A1Y1N5M9   A0A1Y1N973   A0A1W4XTX1   A0A1L8DUP5   A0A1W4XTS4   A0A182H2B8   A0A1W4XIR5   A0A1B6EGY9   A0A1B6E1F3   A0A1Q3FWR2   A0A1S4F8S7   A0A0M8ZP27   A0A1J1IJS3   A0A161ANL7   A0A023F4D8   A0A069DZT4   A0A2A3EBU1   A0A2S2QJQ0   A0A154PCK7   A0A146M0N2   X1WW89   A0A125RM75   A0A1I8PGD2   A0A1I8M696   A0A1I8PGK1   A0A1I8M6A3   A0A1I8PGC3   A0A1I8PGJ1   A0A1I8M6A1   A0A1I8M699   A0A0Q9XGP2   A0A1I8M694   A0A1I8M691   A0A1I8M687   A0A1I8M6A2   A0A1I8PGK7   A0A1I8PGL6   T1PG89   A0A034V5U5   A0A1I8PGB6   T1PED2   A0A1I8PGJ8   A0A1I8PGC8   A0A1I8M698   A0A1I8PGB1   A0A1I8PGB4   A0A1I8PGJ2   A0A1I8M6A6   A0A034V2K4   A0A1I8M6B5   A0A1I8M692   A0A336KSQ1   A0A034V6X7   A0A0Q9X3T7   A0A0Q9XDD3   A0A0Q9XEN4   A0A0Q9WL68   A0A1B0F930   A0A1I8PGK2   A0A1I8PGB9   A0A0Q9X475   N6UIL0   A0A0Q9WLL0   E2B8D1   A0A0Q9X3Q7   A0A0Q9XGA4   A0A336MD69   A0A1I8PGL1   A0A1I8M6A8   A0A1I8M6A4   A0A1I8M6B3   A0A0Q9WXE7   A0A0Q9WYS7   A0A1I8M6B0   A0A0Q9WWH8   A0A0Q9WLR3   A0A1I8PGC2   A0A0Q9WMZ8   A0A336KWU5   A0A1I8PGK6   A0A1I8M6B1   A0A1I8PGJ6   A0A0Q9X4D4   A0A1I8PGK3   B4KIM7   A0A1I8M6A9   A0A1Q3FWN9   A0A336MEP5   A0A0R3P0Y9  

Pubmed

25662100    20075255    24508170    18362917    19820115    28004739    + More
26483478    17510324    25474469    26334808    26823975    25315136    17994087    25348373    23537049    20798317    18057021    15632085   

EMBL

KY484778    ASS36020.1    KM453742    KP335687    AKC34057.1    AKC34899.1    + More
KY796050    ARE31046.1    GU357490    ADB45217.1    KP335686    KM244042    AKC42335.1    RSAL01000139    RVE46159.1    KK107390    EZA51426.1    KQ971371    KYB25508.1    GEZM01012123    JAV93174.1    GEZM01012122    JAV93175.1    GFDF01003928    JAV10156.1    JXUM01023791    JXUM01023792    JXUM01023793    KQ560671    KXJ81341.1    GEDC01001842    GEDC01000137    JAS35456.1    JAS37161.1    GEDC01025119    GEDC01005564    GEDC01003693    JAS12179.1    JAS31734.1    JAS33605.1    GFDL01003050    JAV31995.1    KQ435944    KOX68195.1    CVRI01000054    CRL00440.1    KF828785    AIN44102.1    GBBI01002685    JAC16027.1    GBGD01000085    JAC88804.1    KZ288292    PBC29188.1    GGMS01008735    MBY77938.1    KQ434864    KZC08998.1    GDHC01006312    JAQ12317.1    ABLF02016184    ABLF02016186    KT428603    AMD40296.1    CH933807    KRG02659.1    KA647155    AFP61784.1    GAKP01021440    JAC37512.1    KA647049    AFP61678.1    GAKP01021441    JAC37511.1    UFQS01000890    UFQT01000890    SSX07519.1    SSX27859.1    GAKP01021442    JAC37510.1    KRG02667.1    KRG02658.1    KRG02657.1    CH940661    KRF85612.1    KRG02669.1    APGK01023890    KB740523    ENN80486.1    KRF85625.1    GL446310    EFN88051.1    KRG02662.1    KRG02664.1    SSX07520.1    SSX27860.1    KRF85613.1    KRF85627.1    KRF85631.1    KRF85621.1    KRF85615.1    KRF85619.1    KRF85622.1    UFQS01000910    UFQT01000910    SSX07613.1    SSX27951.1    KRG02661.1    EDW11370.2    GFDL01003048    JAV31997.1    SSX27861.1    CH379061    KRT04598.1   

Proteomes

UP000283053    UP000002358    UP000053097    UP000007266    UP000192223    UP000069940    + More
UP000249989    UP000053105    UP000183832    UP000242457    UP000076502    UP000007819    UP000095300    UP000095301    UP000009192    UP000008792    UP000092443    UP000019118    UP000008237    UP000001819   

Pfam

PF00005   ABC_tran        + More
PF16185   MTABC_N
PF00664   ABC_membrane
PF08190   PIH1
PF18201   PIH1_CS

Interpro

IPR003593   AAA+_ATPase        + More
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR036640   ABC1_TM_sf       
IPR032410   MTABC_N       
IPR003439   ABC_transporter-like       
IPR005292   Multidrug-R_assoc       
IPR017871   ABC_transporter_CS       
IPR041442   PIH1D1/2/3_CS-like       
IPR012981   PIH1_N       

SUPFAM

SSF90123   SSF90123        + More
SSF52540   SSF52540       

Gene 3D

1.20.1560.10    

ProteinModelPortal

A0A2H4KAX1   A0A0F6PP97   A0A220A455   D2Y5V6   A0A0F6PQJ9   A0A3S2NW63   + More
K7J1C7   A0A026W727   A0A139WC08   A0A1W4XSV3   A0A1Y1N5M9   A0A1Y1N973   A0A1W4XTX1   A0A1L8DUP5   A0A1W4XTS4   A0A182H2B8   A0A1W4XIR5   A0A1B6EGY9   A0A1B6E1F3   A0A1Q3FWR2   A0A1S4F8S7   A0A0M8ZP27   A0A1J1IJS3   A0A161ANL7   A0A023F4D8   A0A069DZT4   A0A2A3EBU1   A0A2S2QJQ0   A0A154PCK7   A0A146M0N2   X1WW89   A0A125RM75   A0A1I8PGD2   A0A1I8M696   A0A1I8PGK1   A0A1I8M6A3   A0A1I8PGC3   A0A1I8PGJ1   A0A1I8M6A1   A0A1I8M699   A0A0Q9XGP2   A0A1I8M694   A0A1I8M691   A0A1I8M687   A0A1I8M6A2   A0A1I8PGK7   A0A1I8PGL6   T1PG89   A0A034V5U5   A0A1I8PGB6   T1PED2   A0A1I8PGJ8   A0A1I8PGC8   A0A1I8M698   A0A1I8PGB1   A0A1I8PGB4   A0A1I8PGJ2   A0A1I8M6A6   A0A034V2K4   A0A1I8M6B5   A0A1I8M692   A0A336KSQ1   A0A034V6X7   A0A0Q9X3T7   A0A0Q9XDD3   A0A0Q9XEN4   A0A0Q9WL68   A0A1B0F930   A0A1I8PGK2   A0A1I8PGB9   A0A0Q9X475   N6UIL0   A0A0Q9WLL0   E2B8D1   A0A0Q9X3Q7   A0A0Q9XGA4   A0A336MD69   A0A1I8PGL1   A0A1I8M6A8   A0A1I8M6A4   A0A1I8M6B3   A0A0Q9WXE7   A0A0Q9WYS7   A0A1I8M6B0   A0A0Q9WWH8   A0A0Q9WLR3   A0A1I8PGC2   A0A0Q9WMZ8   A0A336KWU5   A0A1I8PGK6   A0A1I8M6B1   A0A1I8PGJ6   A0A0Q9X4D4   A0A1I8PGK3   B4KIM7   A0A1I8M6A9   A0A1Q3FWN9   A0A336MEP5   A0A0R3P0Y9  

PDB

6BHU     E-value=0,     Score=3678

KEGG

101746706    K05665 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 [EC:7.6.2.3] | (RefSeq) multidrug resi

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0008514   GO:0005887   GO:0005524   GO:0042626   GO:0016021   GO:0005774   GO:0016020   GO:0055085   GO:0009636   GO:0097254   GO:0016887   GO:0006810   GO:0005215   GO:0043022   GO:0005488   GO:0003707   GO:0051537   GO:0022857  

Length:

1516

Number of predicted TMHs:

16

Exp number of AAs in TMHs:

353.09155

Exp number, first 60 AAs:

22.73936

Total prob of N-in:

0.00168

POSSIBLE N-term signal

sequence

outside

1  -  35

TMhelix

36  -  58

inside

59  -  70

TMhelix

71  -  93

outside

94  -  107

TMhelix

108  -  128

inside

129  -  134

TMhelix

135  -  154

outside

155  -  173

TMhelix

174  -  196

inside

197  -  298

TMhelix

299  -  321

outside

322  -  348

TMhelix

349  -  371

inside

372  -  424

TMhelix

425  -  447

outside

448  -  450

TMhelix

451  -  473

inside

474  -  535

TMhelix

536  -  558

outside

559  -  567

TMhelix

568  -  590

inside

591  -  945

TMhelix

946  -  968

outside

969  -  1000

TMhelix

1001  -  1023

inside

1024  -  1035

TMhelix

1036  -  1058

outside

1059  -  1091

TMhelix

1092  -  1114

inside

1115  -  1182

TMhelix

1183  -  1205

outside

1206  -  1516

 

 

Pi

17.608545

Theta

16.445644

Tajima's D

-1.675673

CLR

0.802215

CSRT

0.0378481075946203

Interpretation

Uncertain