Gene

KWMTBOMO07378  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004955

Annotation

serine_protease_inhibitor_13_precursor_[Bombyx_mori]

Location

Bomo_Chr12(-):11546196-11556519      View in EpiBrowser

Full name

Plasminogen activator inhibitor 1      

Alternative Name

Endothelial plasminogen activator inhibitor
Serpin E1

Location in the cell

Extracellular   Reliability : 1.772

CDS

ATGCGACGAAAAATCCAATTCTTTCTGTGCTGTAAACTTATCATCGGAACATGGTGTAACACTATGGACGGAGTAACAACAAAAGCAAATTCCTCAGAGGCTCAATTTCAACCAAATTATTTGGCAGACTCAGTCAACAATTTTGGGTACAAATTACTTTTAAAAATGATGGAGCAAAACAAGAATGAAAACATCGCATTGTCTCCGACCGGTATTGCTGGATTACTGGCAATGACACTTCTCGGTAGTGTGGGAAGTACATACGACGAGCTCGCCACAAGCCTCGGTTTTTCTCAAGACATATTGGCCAATCGAAACCACCACGAGCAGTTCGGTGAGCTGCTTCAACAATTGAACGATAATGAAACGAACTCCAAAACATTGTATGCAGATGCCATGTTTGTTGATTCACAAACCCGGATCCGGTCCGTTTTTAAAGATTATTTGACGACCGTGTACCACGGGGAAGCCCGCGGTGTCAACTTCACACAAAAGAATGAAGTCAAACAAATGATAAATGAGTGGGTCAAAGCGCAAACGCAGGCAAAGATTGAAGATTTTTTAAAACAATCACTACCAGAGGCAACAAAGGTGGTATTGCTAAGCGCTCTCTACTTCAGCGGACAATGGGCATCACCCTTTATTCCGGAATACACATTTAAGATGCCGTTTAAGAAACCTGAGGGCGAAGTAATGGCCGACCTTATGCTTAATTTAGGAGACTTCGATTACATTTTCTCTGAAAAAGACGGTTTGCATATGATCGCACTACCGTACAACGACTCTACAACCGTTATGTACGCTCTCAAACCTAGATTACCAATGAAACTAAGCCTTTTTGATCTGATGAAAAAACTAGACTACAATAAGATTGACGAACTAATTAATAAAATGAACGAAAGAAAGGCTGTTGTGCGATTCCCTAAAATGGACTTGGAGAGCAACGTTAATCTAGACAAAGCACTGAAAGCTGTCGGAATCAAGTCTATGTTCAGTCCCGACGAAGCTAATTTTGCTTTGATGATAGATTCGTCTGATGATAAAAAAGAAAACGAGGTAGTTATTAGATCGAGATTCGGTCACGAGCAGTCAAGAATGTTAAAAGACGCATTGAACAGTTTACCCAATCCGGGAGTGTACGTCGACTCCGTTTTACATAACGTCAAGATTACTGTTAACGAATTCGGAACGGAAGCTGTGGCGGCGACGGCCGGGATATTGGCGCGATCAGCTGAACAGTTCTACGCGGACTCCCCGTTCTACATATTCATTCGGAACGAGAAGACCAAACTAGTGACCTTTAGTGCCGTCGTATACGATCCTACGATATAG

Protein

MRRKIQFFLCCKLIIGTWCNTMDGVTTKANSSEAQFQPNYLADSVNNFGYKLLLKMMEQNKNENIALSPTGIAGLLAMTLLGSVGSTYDELATSLGFSQDILANRNHHEQFGELLQQLNDNETNSKTLYADAMFVDSQTRIRSVFKDYLTTVYHGEARGVNFTQKNEVKQMINEWVKAQTQAKIEDFLKQSLPEATKVVLLSALYFSGQWASPFIPEYTFKMPFKKPEGEVMADLMLNLGDFDYIFSEKDGLHMIALPYNDSTTVMYALKPRLPMKLSLFDLMKKLDYNKIDELINKMNERKAVVRFPKMDLESNVNLDKALKAVGIKSMFSPDEANFALMIDSSDDKKENEVVIRSRFGHEQSRMLKDALNSLPNPGVYVDSVLHNVKITVNEFGTEAVAATAGILARSAEQFYADSPFYIFIRNEKTKLVTFSAVVYDPTI

Description

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Subunit

Forms a heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Interacts with PPP1CB.

Similarity

Belongs to the serpin family.

Keywords

Complete proteome   Glycoprotein   Protease inhibitor   Reference proteome   Secreted   Serine protease inhibitor   Signal  

Feature

chain  Plasminogen activator inhibitor 1

Uniprot

C0J8G2   A0A3G1VCH2   A0A2A4J5M2   A0A212F3H3   A0A194PVI0   A0A194R3B9   + More
J7HLS7   S4NYK9   A0A2H1VQ07   X2J109   A0A1W4X1P5   A0A195F1F1   A0A2J7RSS5   A0A067R8V4   D2A2J9   A0A151XC37   J3JUV5   N6UPE2   U4UQY2   A0A1B6GCU3   A0A195CH67   A0A1B6JCM9   A0A026WZD2   A0A1V1FIT8   T1DGH8   T1DGG7   A0A084WQL3   Q16S06   P79335   B4MVS2   A0A1Q3FIJ5   U6CX60   G9KN61   A0A1S4JWS5   B0WX63   A0A023ESX4   A0A182J1Y2   P50449   A0A023ESG3   A0A2Y9E5Y9   A0A182H582   B3MJQ6   G3T7G7   B4KGA6   A0A023EV90   A0A182GK96   A0A2K6FA88   B4QBV3   I3LQQ6   A0A2Y9PNI9   A0A1W4V0X4   B4HNC1   H0UTC2   A0A3B0JGQ0   A0A286XDM0   C1JFL8   A0A0M3QT24   A0A1S2ZE36   A0A1B6DSP6   A0A0D9S037   S7Q4B4   A0A2M3ZZQ8   A0A2D0PLI2   A0A1Z4NK21   A0A252DWU7   A0A252DGG5   A0A1L8H381   A0A2M3ZZT6   A0A3L7HLU5   A0A1U7R3V0   K7FMQ9   A0A2K6TSH2   Q0IHE4   B4NWB7   G5E899   G5B5Z9   A0A2M4CUF6   B4JAP4   A0A2M3ZE19   A0A2M4BUU6   A0A1W4VWE9   G1NYA4   A0A182F4A5   A0A2M4BM55   A5D8P7   B4G7D2   A0A2M4AK75   A0A2M3ZFW7   Q29LV3  

Pubmed

19150649    28987647    22118469    26354079    23622113    24845553    + More
18362917    19820115    22516182    23537049    24508170    28410430    24330624    24438588    17510324    9157595    17994087    23236062    24945155    7557448    26483478    22936249    21993624    19223926    27762356    29704459    17381049    17550304    12040188    19468303    21993625    15632085   

EMBL

EU935614    ACG61176.1    MG732911    AYK02793.1    NWSH01003223    PCG66730.1    + More
AGBW02010564    OWR48286.1    KQ459592    KPI96769.1    KQ460845    KPJ12024.1    JN400446    AFQ01145.1    GAIX01008519    JAA84041.1    ODYU01003476    SOQ42314.1    KJ127528    AHN49718.1    KQ981864    KYN34293.1    NEVH01000250    PNF43885.1    KK852808    KDR16030.1    KQ971338    EFA02869.2    KQ982314    KYQ57956.1    BT127020    AEE61982.1    APGK01023288    APGK01023289    APGK01023290    KB740481    ENN80572.1    KB632431    ERL95517.1    GECZ01009507    JAS60262.1    KQ977754    KYN00081.1    GECU01027274    GECU01010869    JAS80432.1    JAS96837.1    KK107063    EZA61168.1    FX985318    BAX07331.1    GALA01001651    JAA93201.1    GALA01001666    JAA93186.1    ATLV01025637    KE525396    KFB52507.1    CH477692    EAT37202.1    Y11347    CH963857    EDW75792.2    GFDL01007624    JAV27421.1    HAAF01002611    CCP74437.1    AEYP01053153    JP017742    AES06340.1    DS232158    EDS36324.1    GAPW01001200    JAC12398.1    X58541    GAPW01001393    JAC12205.1    JXUM01026061    KQ560742    KXJ81047.1    CH902620    EDV31395.2    CH933807    EDW11093.1    GAPW01001199    JAC12399.1    JXUM01069686    JXUM01069687    JXUM01069688    JXUM01069689    KQ562564    KXJ75606.1    CM000362    CM002911    EDX07613.1    KMY94760.1    AEMK02000015    CH480816    EDW48403.1    AAKN02032075    OUUW01000004    SPP79442.1    FJ608558    ACO24971.1    CP012523    ALC38139.1    GEDC01008592    JAS28706.1    AQIB01127710    KE164168    EPQ15712.1    GGFK01000735    MBW34056.1    AP018254    BAZ06050.1    MTAW01000089    OUL32095.1    MTAX01000054    OUL26509.1    CM004470    OCT90552.1    GGFK01000742    MBW34063.1    RAZU01000172    RLQ66934.1    AGCU01051555    BC123188    AAI23189.1    CM000157    EDW88434.1    AC147986    CH466529    EDL19287.1    JH168609    EHB04710.1    GGFL01004633    MBW68811.1    CH916368    EDW03852.1    GGFM01006066    MBW26817.1    GGFJ01007696    MBW56837.1    AAPE02003478    GGFJ01005029    MBW54170.1    BC141762    AAI41763.1    CH479180    EDW29265.1    GGFK01007811    MBW41132.1    GGFM01006579    MBW27330.1    CH379060    EAL33942.2   

Proteomes

UP000218220    UP000007151    UP000053268    UP000053240    UP000192223    UP000078541    + More
UP000235965    UP000027135    UP000007266    UP000075809    UP000019118    UP000030742    UP000078542    UP000053097    UP000030765    UP000008820    UP000008227    UP000007798    UP000000715    UP000002320    UP000075880    UP000248480    UP000069940    UP000249989    UP000007801    UP000007646    UP000009192    UP000233160    UP000000304    UP000248483    UP000192221    UP000001292    UP000005447    UP000268350    UP000092553    UP000079721    UP000029965    UP000221080    UP000218621    UP000195197    UP000195154    UP000186698    UP000273346    UP000189706    UP000007267    UP000233220    UP000002282    UP000000589    UP000006813    UP000001070    UP000001074    UP000069272    UP000008744    UP000001819   

PRIDE

C0J8G2    P79335    I3LQQ6   

Pfam

PF00079   Serpin        + More
PF08445   FR47

Interpro

IPR036186   Serpin_sf        + More
IPR000215   Serpin_fam       
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR023796   Serpin_dom       
IPR023795   Serpin_CS       
IPR013653   FR47       
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF56574   SSF56574        + More
SSF55729   SSF55729       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C0J8G2   A0A3G1VCH2   A0A2A4J5M2   A0A212F3H3   A0A194PVI0   A0A194R3B9   + More
J7HLS7   S4NYK9   A0A2H1VQ07   X2J109   A0A1W4X1P5   A0A195F1F1   A0A2J7RSS5   A0A067R8V4   D2A2J9   A0A151XC37   J3JUV5   N6UPE2   U4UQY2   A0A1B6GCU3   A0A195CH67   A0A1B6JCM9   A0A026WZD2   A0A1V1FIT8   T1DGH8   T1DGG7   A0A084WQL3   Q16S06   P79335   B4MVS2   A0A1Q3FIJ5   U6CX60   G9KN61   A0A1S4JWS5   B0WX63   A0A023ESX4   A0A182J1Y2   P50449   A0A023ESG3   A0A2Y9E5Y9   A0A182H582   B3MJQ6   G3T7G7   B4KGA6   A0A023EV90   A0A182GK96   A0A2K6FA88   B4QBV3   I3LQQ6   A0A2Y9PNI9   A0A1W4V0X4   B4HNC1   H0UTC2   A0A3B0JGQ0   A0A286XDM0   C1JFL8   A0A0M3QT24   A0A1S2ZE36   A0A1B6DSP6   A0A0D9S037   S7Q4B4   A0A2M3ZZQ8   A0A2D0PLI2   A0A1Z4NK21   A0A252DWU7   A0A252DGG5   A0A1L8H381   A0A2M3ZZT6   A0A3L7HLU5   A0A1U7R3V0   K7FMQ9   A0A2K6TSH2   Q0IHE4   B4NWB7   G5E899   G5B5Z9   A0A2M4CUF6   B4JAP4   A0A2M3ZE19   A0A2M4BUU6   A0A1W4VWE9   G1NYA4   A0A182F4A5   A0A2M4BM55   A5D8P7   B4G7D2   A0A2M4AK75   A0A2M3ZFW7   Q29LV3  

PDB

5CDZ     E-value=7.8097e-38,     Score=395

KEGG

100272177    no KO assigned | (RefSeq) serpin-13; serine protease inhibitor 13

GO

GO:0005615   GO:0008233   GO:0010951   GO:0004867   GO:0090399   GO:0009611   GO:0035009   GO:0016747   GO:0045861   GO:0071222   GO:0050829   GO:0001525   GO:1901331   GO:2000352   GO:0045766   GO:0010757   GO:0048260   GO:0002020   GO:0062023   GO:2000098   GO:0070062   GO:0061044   GO:0035491   GO:0090026   GO:0014912   GO:0001300   GO:0097187   GO:0032757   GO:0005102   GO:1902042   GO:0033629   GO:0051918   GO:0010469   GO:0090136   GO:0005829   GO:0032940   GO:0061108   GO:0060384   GO:0031091   GO:0051966   GO:0060291   GO:0007596   GO:0045879   GO:0014067   GO:0042177   GO:0048711   GO:0008201   GO:0010766   GO:0021683   GO:0042628   GO:0090331   GO:0048505   GO:0031232   GO:0008285   GO:0031594   GO:0030308   GO:0050974   GO:0033363  

PANTHER

PTHR11461  

Subcellular location

Secreted  

SignalP

Position:   1 - 19,         Likelihood:  0.893808

 

 

Length:

443

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

14.9506

Exp number, first 60 AAs:

0.13609

Total prob of N-in:

0.66108

inside

1  -  64

TMhelix

65  -  87

outside

88  -  443

 

 

Pi

25.570577

Theta

21.930892

Tajima's D

0.774006

CLR

0.449003

CSRT

0.610069496525174

Interpretation

Uncertain