Gene

KWMTBOMO07334  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010619

Annotation

TBP_SPOFR_RecName:_Full%3DTATA-box-binding_protein;_short=TBP;_altname:_full=TATA_sequence-binding_protein,TATA-binding_factor,TATA-box_factor,Transcription_initiation_factor_TFIID_TBP_subunit

Location

Bomo_Chr12(-):10744549-10747877      View in EpiBrowser

Full name

TATA-box-binding protein      

Alternative Name

TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit

Location in the cell

Nuclear   Reliability : 4.515

CDS

ATGGATCATATGCTGCCAAGTCCGTATAACATACCTGGAATAGGTACACCATTGCATCAACCTGAAGAAGACCAGCAAATCTTGCCTAATGCAATGCAACAGCAACAGCTTCAACAGCAACAGTCCCAGGCACAACCGTCACTTGCCGCTCTGGGTTCGTCGCCAATTGTAGGATTTGGCGCAATCATGGGGACTCCACAGAGGTCTATGCACACATATGCACCAACAGCCAGCTATGCAACTCCGCAACAGATGATGCAGCCTCAAACTCCACAAAATATGATGTCTCCGATGATAGCTGCAGGAAATCTATCAAGTCAACAAATGCTAAGCCAAGCTAGTCCTGCCCCAATGACTCCTCTGACACCACTCTCTGCAGACCCTGGAATTTTACCACAGTTACAAAACATAGTCTCTACTGTAAATCTTGACTGCAAATTAGATTTGAAGAAGATTGCATTACATGCTCGTAATGCTGAGTATAATCCCAAACGTTTTGCCGCTGTAATTATGAGAATAAGGGAACCGAGAACAACAGCTTTAATTTTCTCATCTGGTAAAATGGTCTGTACTGGTGCCAAAAGTGAGGAAGACTCCCGTTTAGCGGCAAGAAAATATGCTAGAATAATCCAGAAATTAGGCTTCACAGCAAAATTTTTAGATTTCAAAATACAGAACATGGTTGGTAGTTGCGATGTGAAGTTCCCCATAAGGCTTGAAGGCTTAGTACTAACACACGGACAGTTCAGTTCTTATGAGCCTGAATTATTCCCTGGCCTTATTTACAGAATGGTCAAACCTAGGATAGTTCTTTTGATCTTTGTTTCAGGAAAAGTTGTATTGACTGGGGCCAAAGTAAGGGAAGAAATATATGAAGCCTTTGACAATATATATCCAATACTTAAAAGTTTCAAAAAACAATAG

Protein

MDHMLPSPYNIPGIGTPLHQPEEDQQILPNAMQQQQLQQQQSQAQPSLAALGSSPIVGFGAIMGTPQRSMHTYAPTASYATPQQMMQPQTPQNMMSPMIAAGNLSSQQMLSQASPAPMTPLTPLSADPGILPQLQNIVSTVNLDCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEDSRLAARKYARIIQKLGFTAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHGQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVREEIYEAFDNIYPILKSFKKQ

Description

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Subunit

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.

Similarity

Belongs to the TBP family.

Keywords

Complete proteome   DNA-binding   Nucleus   Reference proteome   Repeat   Transcription  

Feature

chain  TATA-box-binding protein

Uniprot

O45211   A0A2H1VE61   P53361   A0A2A4JVA4   A0A1E1VXH2   A0A212EU04   + More
A0A194R872   A0A0B5KXM8   S4NNE0   A0A346S727   A0A195FBT4   A0A195DG97   A0A195BNE5   A0A158NKN4   A0A026WTY6   E2BLK6   A0A195CJU5   A0A0M8ZQ35   E2AA44   A0A151WRQ1   A0A0J7KZN6   A0A154PDU4   E9IBP8   A0A088A767   F4WWH0   A0A232EY05   A0A0L7R7A5   A0A1B6F5H1   A0A1B6KFC2   A0A1B6IES1   A0A2A3E6E6   A0A1B6D291   A0A1W4X1I1   A0A1B0DB59   A0A0C4URQ1   A0A0N7Z9I8   A0A069DSD7   A0A1L8DHH8   A0A1Y1LLB7   A0A0V0GCU1   A0A2D1QW06   A0A1B0GJJ2   J3JVZ2   R4FQ61   A0A023F9G2   D2A1K8   E0VZG8   J9JN27   A0A084WQZ5   A0A2S2R7J5   A0A3G4R987   A0A2S2PBH2   A0A182PRM9   A0A182J2W0   A0A182WFV2   A0A182MN25   A0A0P5XSH4   A0A182WUM7   Q7PFI3   A0A2L0NG83   A0A182NA35   A0A0A9Y1B1   A0A182R2X3   A0A182YKP0   Q16ME4   A0A182R167   A0A2M4ATB7   A0A182H1Z0   W5JVY7   A0A0K8S6M9   A0A182V540   A0A182KKD5   A0A182HVU8   E9G7V1   A0A182K194   A0A1Q3F0B6   B0WM49   E4W6N7   F8S866   C1C292  

Pubmed

9795220    7520800    22118469    26354079    23622113    30151374    + More
21347285    24508170    30249741    20798317    21282665    21719571    28648823    25692689    27129103    26334808    28004739    22516182    23537049    25474469    18362917    19820115    20566863    24438588    12364791    14747013    17210077    25401762    26823975    25244985    17510324    26483478    20920257    23761445    20966253    21292972    21507980   

EMBL

AJ222806    ODYU01002048    SOQ39071.1    L22538    NWSH01000510    PCG75955.1    + More
GDQN01011662    JAT79392.1    AGBW02012510    OWR44959.1    KQ460845    KPJ12061.1    KM923792    AJG43851.1    GAIX01012294    JAA80266.1    MG657270    AXT16315.1    KQ981693    KYN37846.1    KQ980886    KYN11866.1    KQ976439    KYM86738.1    ADTU01018927    KK107105    QOIP01000011    EZA59433.1    RLU16452.1    GL449036    EFN83340.1    KQ977649    KYN00717.1    KQ435916    KOX68795.1    GL438029    EFN69682.1    KQ982805    KYQ50530.1    LBMM01001609    KMQ96022.1    KQ434869    KZC09350.1    GL762137    EFZ21981.1    GL888406    EGI61512.1    NNAY01001637    OXU23356.1    KQ414642    KOC66755.1    GECZ01024418    JAS45351.1    GEBQ01029831    JAT10146.1    GECU01022268    JAS85438.1    KZ288353    PBC27317.1    GEDC01017532    GEDC01014326    JAS19766.1    JAS22972.1    AJVK01004621    AJVK01004622    KJ534562    AIY54303.1    GDKW01000427    JAI56168.1    GBGD01002312    JAC86577.1    GFDF01008274    JAV05810.1    GEZM01052503    JAV74474.1    GECL01000432    JAP05692.1    KY027055    ATP16741.1    AJWK01021848    BT127410    KB632168    AEE62372.1    ERL89361.1    GAHY01000579    JAA76931.1    GBBI01000692    JAC18020.1    KQ971338    EFA02682.1    DS235852    EEB18774.1    ABLF02011554    ATLV01025856    KE525401    KFB52639.1    GGMS01016786    MBY85989.1    MH000610    AYU58907.1    GGMR01014113    MBY26732.1    AXCM01000462    GDIP01068360    LRGB01002076    JAM35355.1    KZS09299.1    AAAB01008823    EAA45305.2    KY654102    AUY55085.1    GBHO01032818    GBHO01032815    GBHO01016762    GBHO01016475    GDHC01005276    JAG10786.1    JAG10789.1    JAG26842.1    JAG27129.1    JAQ13353.1    CH477863    EAT35515.1    AXCN02002378    GGFK01010702    MBW44023.1    JXUM01023411    JXUM01031600    KQ560927    KQ560661    KXJ80314.1    KXJ81384.1    ADMH02000135    ETN67643.1    GBRD01017437    JAG48390.1    APCN01001422    GL732534    EFX84545.1    GFDL01014054    JAV20991.1    DS232990    DS231994    EDS27228.1    EDS30877.1    FJ870977    ACZ56425.1    HQ599317    ADU15470.1    BT080971    ACO15395.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000078541    UP000078492    + More
UP000078540    UP000005205    UP000053097    UP000279307    UP000008237    UP000078542    UP000053105    UP000000311    UP000075809    UP000036403    UP000076502    UP000005203    UP000007755    UP000215335    UP000053825    UP000242457    UP000192223    UP000092462    UP000092461    UP000030742    UP000007266    UP000009046    UP000007819    UP000030765    UP000075885    UP000075880    UP000075920    UP000075883    UP000076858    UP000076407    UP000007062    UP000075884    UP000075900    UP000076408    UP000008820    UP000075886    UP000069940    UP000249989    UP000000673    UP000075903    UP000075882    UP000075840    UP000000305    UP000075881    UP000002320   

PRIDE

O45211    P53361   

Pfam

PF00352   TBP

Interpro

IPR000814   TBP        + More
IPR030491   TBP_CS       
IPR033710   TBP_eukaryotic       
IPR012295   TBP_dom_sf       

Gene 3D

3.30.310.10    

CDD

cd04516  TBP_eukaryotes

ProteinModelPortal

O45211   A0A2H1VE61   P53361   A0A2A4JVA4   A0A1E1VXH2   A0A212EU04   + More
A0A194R872   A0A0B5KXM8   S4NNE0   A0A346S727   A0A195FBT4   A0A195DG97   A0A195BNE5   A0A158NKN4   A0A026WTY6   E2BLK6   A0A195CJU5   A0A0M8ZQ35   E2AA44   A0A151WRQ1   A0A0J7KZN6   A0A154PDU4   E9IBP8   A0A088A767   F4WWH0   A0A232EY05   A0A0L7R7A5   A0A1B6F5H1   A0A1B6KFC2   A0A1B6IES1   A0A2A3E6E6   A0A1B6D291   A0A1W4X1I1   A0A1B0DB59   A0A0C4URQ1   A0A0N7Z9I8   A0A069DSD7   A0A1L8DHH8   A0A1Y1LLB7   A0A0V0GCU1   A0A2D1QW06   A0A1B0GJJ2   J3JVZ2   R4FQ61   A0A023F9G2   D2A1K8   E0VZG8   J9JN27   A0A084WQZ5   A0A2S2R7J5   A0A3G4R987   A0A2S2PBH2   A0A182PRM9   A0A182J2W0   A0A182WFV2   A0A182MN25   A0A0P5XSH4   A0A182WUM7   Q7PFI3   A0A2L0NG83   A0A182NA35   A0A0A9Y1B1   A0A182R2X3   A0A182YKP0   Q16ME4   A0A182R167   A0A2M4ATB7   A0A182H1Z0   W5JVY7   A0A0K8S6M9   A0A182V540   A0A182KKD5   A0A182HVU8   E9G7V1   A0A182K194   A0A1Q3F0B6   B0WM49   E4W6N7   F8S866   C1C292  

PDB

1CDW     E-value=1.77431e-90,     Score=847

KEGG

692612    K03120 transcription initiation factor TFIID TATA-box-binding protein | (RefSeq) Tbp; TATA-box-bindi

PATHWAY

03022    Basal transcription factors - Bombyx mori (domestic silkworm)

GO

GO:0003677   GO:0006366   GO:0005634   GO:0000995   GO:0005669   GO:0006383   GO:0006352   GO:0000978   GO:0001016   GO:0000126   GO:0005667   GO:0003700   GO:0070898   GO:0000979   GO:0008134   GO:0032440   GO:0015095   GO:0015693   GO:0006488   GO:0007156   GO:0008237   GO:0043401   GO:0003707   GO:0051537  

PANTHER

PTHR10126  

Subcellular location

Nucleus  

Length:

307

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.79958

Exp number, first 60 AAs:

0.24756

Total prob of N-in:

0.02407

outside

1  -  307

 

 

Pi

8.147113

Theta

11.457364

Tajima's D

-0.461355

CLR

1.145916

CSRT

0.252937353132343

Interpretation

Uncertain