Gene

KWMTBOMO07333

Annotation

PREDICTED:_WASH_complex_subunit_7-like_[Plutella_xylostella]

Location

Bomo_Chr12(-):10732034-10736567      View in EpiBrowser

Full name

WASH complex subunit 4      

Alternative Name

Strumpellin and WASH-interacting protein
WASH complex subunit SWIP

Location in the cell

Nuclear   Reliability : 2.012 PlasmaMembrane   Reliability : 1.831

CDS

ATGAAAAGTGATTTCGAGAAAGAAAGTACAAGCAATATTTTAAAAAAATATGGCATATTTTTCAAGATGCAGTATCAGGTTTTGGCATTCAATTGCAATAATGAAATACTAGATGATAATAAAACATTTTTGCCGATTCAATTACTCATGAGTCCACACGAGCTCGTACCAATTACTGAGTTAGTAGTATCGGATAACACATTTATGACTAAAGTTTTGAGTGTGTTTACTTCCTTATGTGTTGAAGTAAATAACTTGAAAGAGGAAGCCTTTGAAAAGTATTTTATCTACTTGGCTGCTTATGAAAAATATGAAACAGAAGATGTGAGTTCCCAGATGGAAATGATATGCTTACTCTGCGCATTTATCATTCGATGTGATGAAACTTTAAGAAACATGTGCAACCAAGTTTTTGCTTTGTTTTCCGATGGAACTGTTAATCTCAATTGCATTCAACTACACTATATCATCAACCACATTGGAGAGATATTTACTATTCTTGTCTTACTTGAAATACTGATAGCCAATACTTCAATGCCCACAAATTGGAATAAATTTTGCAAAACATTAAAAACATACCATAACAAGAACTCGGCAGCTTTAGATATTACTGAAGAGAAATTTAATGCAATGATGGGGGCTATTAATAACATCACAGTCAAAATAATGAATGATGATATTGTACAAAAATCATTACAAAGTGTATCACTATTGAGAAAGAACTTGATTGACAAGAATTGTTCTATGATAGCAACAGAGTTTTCACACTACCTTAAACAGGGAATTATAAATTTGGACAAACTTGTACAGGAACAACCCAATGTTCGAAATATGTACAAATGTATTAAAATTAATAGTTTATTTGTATTGTCTTCACAATTGTTTGGTAATGTAGACAAGAAGATATTTAAGTCATTAGTGGAATTGAACACAAAGGCACACAGTGTTCATGTGATTGGAACAACTATGTGGTATCCTGAGCAATTTCTACAGAAACATGCCCCTGCACTTTGTGCAAAACAGGAAAAATTATCACAAACTATGTTGAAAACACGGCAATCGTATATCAATATGAAAAAAACTAGCCTATCTCGTGATATAATTAATCTTCAAATAGTATGTGGTCAATGGGTGTTAAATATTGAAGATTTCTTTTCTGCTGATCATCATAGGCTTAGTGCTGCTGAAATGAATTTACATTCCAGAACTCTTTTAAATGGCTTGGACCTAGCATCCAGAATCAATCATGAAGTTTTGACATTGATAAATTTACATCTTTCCCTTGGGATACCTCTTCCAAAGAGTATGTTAATGTTGGTATTTGAGATAATCAATATTTTAAAATCAATGCTGAATGCAATATCACGGCATAGAAGCCAAATAATTTTATCTATCAATATGGTCATTCAACATTTTGTATTCCAAGCAACATCAACAATATTAGAAGTAAAGAAATTATTAGTTTCAGACAAGAATTTCGCAAATAAAAGATTGGATGAACTTACATGCATCGTTATTGCAGAAAAAGCACTTCGTGGCGTAGCTACAATTGAACGAAATGTAGTAGCTAACACAGCACTGAGCTTTATACCTGAAAGTACTTATTTAGAAGACAGCTATGTAAAGCTTGGTTTGTTGTTAGAGAATGTTCAAACATTGACAAACTTGATGAAATCAATGGAAAGTTTTTGCAATTGCTCTTGGCTGTTCTGGCATCAGAACATATTTCCAATTTACTTTGATCAAAACTTTTCTATGCAATTGAGTACTTTAAAATTAAAATACTTCTTAATGGCCTTAGAAGACTGTACGGTGCTATTACATAAAACAGATAAATTATTTGATAGTAATATAAAAGAAGATTTTATGGAAACAGTTAAAAAGTACATGGAACAAAAATTTATCAAAGGTGCAAGTCAGAATATTGAAACAAATTTACGATTGCATATACATTCACATCTTCAACTTGATGTAATCAATCCATTTACTTTTGAAATGGTAAAAAAATTGCTTCTAGCAATTAATACTTTTAGAGTTCAGTACATTTACATGTGTGTTGTGCCATCAGTTGAACACTATCTTTCAACAATGTTCTACAACCTAACTACCGTTGTATTATCAGATTGGAAAACTTATGGTGAAATGAGACAAATGGCGAGACTAAAATTCAATTTAAAAACGGTTCAAGATAATCTCCCAACTCAGACTCTGGAGCAGGGCCTAGATATACTAGAGATTATGCGCAACATTCATATATTCGTTTCGAAGTATCTTTACAATCTAAACAATCAAATATTTATTGAAAGAAGCAGCAACAATAAACACTTGAGCTCAATTAACATTCGACATGTCGCCAATTCTATACGGACTCATGGTACTGGGATAATGAACACAACAGTGAATTTTACATACCAGTTTTTAAAAAAGAAGTTCTTTACATTTTCTCAGTTCATGTATGATGAACATATAAAATCCAGGTTAATTAAAGATCTTAGAATCTTCAAAGAAACCACTGATGGAAACTACAGCTACATGTATCCATTTAAAAATGCAGAAAGATTTAACAAGGGTATAAAGGTGTTGGGACTTTCAGAGGATGGACAGAGTTACTTAGATCTGTTTCGAGATCTTATTAGTCAAATTGGAAACGCCATGGGATATGTTAGGATGATTAGGTCAGGCGGCCGACATTGCTGTTCGGATGCGACTGTTTTCCTGCCAAATCTGGAAGATGTTGTTAATTTCAAAGAACTATGCCAAAAAGAGGCTCTTGGGCCCCAGACTGTTCAATCAGCGGAAATTCTAGATCAGAACACAAACGACCTTATTTCCAACTTTATTCAAGGAACTGAATATTTCAAGCTGCTGGTAGACGTGTTCTCACCCGTTTTCCGAAATCCTAAGAATGTTCATTTGAAGAATTTTTATATTATTGTTCCTCCATTGACACTTAATTTTGTGGAACATCTAATCTTGTCGAAAGATAAAATGTCGAAAAAGAATAAAATAGGAGCTGCTTTTACTGATGATGGTTTTGCTATGGGAATTGCTTACATACTGAAATTACTAGATCAGGATTCTAATTTTGAATCTCTACACTGGTTTGAATCAGTATGGAAACACATTGATGACGAAAGAAAGTTACTAGAAGAACAGAAAAACAAAGGAACCATTCAATTACAACAAGCCTTAGCATTGACCGAGAAGAAAATAAAAACATTAGAAGAAGAGTACAAACTCCTCTATTACAGTCTTACAAGTGCCAGAATATTTTTTCGTTAA

Protein

MKSDFEKESTSNILKKYGIFFKMQYQVLAFNCNNEILDDNKTFLPIQLLMSPHELVPITELVVSDNTFMTKVLSVFTSLCVEVNNLKEEAFEKYFIYLAAYEKYETEDVSSQMEMICLLCAFIIRCDETLRNMCNQVFALFSDGTVNLNCIQLHYIINHIGEIFTILVLLEILIANTSMPTNWNKFCKTLKTYHNKNSAALDITEEKFNAMMGAINNITVKIMNDDIVQKSLQSVSLLRKNLIDKNCSMIATEFSHYLKQGIINLDKLVQEQPNVRNMYKCIKINSLFVLSSQLFGNVDKKIFKSLVELNTKAHSVHVIGTTMWYPEQFLQKHAPALCAKQEKLSQTMLKTRQSYINMKKTSLSRDIINLQIVCGQWVLNIEDFFSADHHRLSAAEMNLHSRTLLNGLDLASRINHEVLTLINLHLSLGIPLPKSMLMLVFEIINILKSMLNAISRHRSQIILSINMVIQHFVFQATSTILEVKKLLVSDKNFANKRLDELTCIVIAEKALRGVATIERNVVANTALSFIPESTYLEDSYVKLGLLLENVQTLTNLMKSMESFCNCSWLFWHQNIFPIYFDQNFSMQLSTLKLKYFLMALEDCTVLLHKTDKLFDSNIKEDFMETVKKYMEQKFIKGASQNIETNLRLHIHSHLQLDVINPFTFEMVKKLLLAINTFRVQYIYMCVVPSVEHYLSTMFYNLTTVVLSDWKTYGEMRQMARLKFNLKTVQDNLPTQTLEQGLDILEIMRNIHIFVSKYLYNLNNQIFIERSSNNKHLSSINIRHVANSIRTHGTGIMNTTVNFTYQFLKKKFFTFSQFMYDEHIKSRLIKDLRIFKETTDGNYSYMYPFKNAERFNKGIKVLGLSEDGQSYLDLFRDLISQIGNAMGYVRMIRSGGRHCCSDATVFLPNLEDVVNFKELCQKEALGPQTVQSAEILDQNTNDLISNFIQGTEYFKLLVDVFSPVFRNPKNVHLKNFYIIVPPLTLNFVEHLILSKDKMSKKNKIGAAFTDDGFAMGIAYILKLLDQDSNFESLHWFESVWKHIDDERKLLEEQKNKGTIQLQQALALTEKKIKTLEEEYKLLYYSLTSARIFFR

Description

Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093).

Subunit

Component of the WASH core complex also described as WASH regulatory complex (SHRC) composed of WASH (WASHC1, WASH2P or WASH3P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. The WASH core complex associates via WASHC2 with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB) in a transient or substoichiometric manner which was initially described as WASH complex.

Similarity

Belongs to the SWIP family.

Keywords

Acetylation   Alternative splicing   Coiled coil   Complete proteome   Disease mutation   Endosome   Mental retardation   Phosphoprotein   Polymorphism   Protein transport   Reference proteome   Transport  

Feature

chain  WASH complex subunit 4
splice variant  In isoform 2.
sequence variant  In dbSNP:rs34434425.

Uniprot

A0A2H1VDY1   A0A2A4JWE3   A0A1E1W053   A0A3S2LFI3   A0A194PIW6   A0A194R2Z4   + More
A0A212ETZ5   A0A0L7KRI2   A0A1E1WK11   A0A067QYP0   A0A2J7PXZ5   A0A210QJ49   A0A2J7PXZ8   T1J3X6   A0A1S3JFP0   H0ZLG1   L5KF43   M3VK14   A0A3Q2IAN7   G5E600   L8IEP9   I3LLV0   H0WQT5   A0A2C9JNT2   R4GHH2   A0A1V4K7W3   A0A093RRJ7   W5Q6S3   M3VWP4   G1P956   A0A341AB65   A0A2U3ZZ47   A0A2Y9QKE1   A0A224YRZ8   A0A091Q5C7   A0A091P062   U3EJC9   A0A131Z8M7   R7UQC0   U3KG72   F7HA23   A0A3Q7WYU4   A0A091GNN6   D2H1T9   A0A1S3ACV0   A0A2U3WXU5   A0A383YSH6   A0A091UID3   A0A2K5F184   A0A2K6UPC6   G1NJT1   A0A3Q7PT10   A0A2K5RWX0   A0A2Y9H0S5   A0A3Q7Q7T4   A0A091EW44   A0A094LF41   J9P227   A0A2Y9T2K3   A0A2Y9IU07   A0A2C9JNS4   A0A2C9JNS6   A0A091G738   G3W5X6   A0A3Q7TN06   H2R755   A0A131Y0E5   C3YUG4   G5C464   A0A2R9CAM4   A0A2J8XM21   A0A2Y9IRC4   M3YL02   A0A3L8SCM6   H0V7S3   G7N5B6   H9EPA4   L7M974   A0A094K1P4   A0A384DAB7   A0A2U3ZUV1   Q2M389   A0A093D5J2   A0A1W7RGE6   A0A091QTV7   A0A2K5N2C0   A0A2Y9DFV9   B7PRX4   A0A091S5I5   I3MMP7   A0A2K6BLP5   G7PJE1   A0A2K5VNY9   A0A0D9S2H4   A0A096MN14   A0A2K5N1T9   A0A091I6Q2   A0A2Y9IY17   A0A2J8MZR6   A0A131XDK8  

Pubmed

26354079    22118469    26227816    24845553    28812685    20360741    + More
23258410    19892987    19393038    22751099    15562597    15592404    20809919    17975172    21993624    28797301    25243066    26830274    23254933    20010809    20838655    16341006    21709235    16136131    18563158    21993625    22722832    30282656    22002653    25319552    25576852    10470851    14702039    16541075    15489334    19922875    20498093    20068231    21498477    21406692    23186163    23676666    21269460    26358130    28049606   

EMBL

ODYU01002048    SOQ39070.1    NWSH01000510    PCG75954.1    GDQN01010696    JAT80358.1    + More
RSAL01000020    RVE52649.1    KQ459603    KPI92659.1    KQ460845    KPJ12062.1    AGBW02012510    OWR44958.1    JTDY01006866    KOB65634.1    GDQN01003722    JAT87332.1    KK852819    KDR15615.1    NEVH01020852    PNF21205.1    NEDP02003393    OWF48767.1    PNF21207.1    JH431832    ABQF01016176    ABQF01016177    ABQF01016178    ABQF01016179    KB030754    ELK10309.1    GACC01000440    JAA74144.1    JH881492    ELR54014.1    AEMK02000037    AAQR03016528    AAQR03016529    AAQR03016530    AC145942    LSYS01004200    OPJ80451.1    KL225530    KFW73469.1    AMGL01082029    AMGL01082030    AANG04003655    AAPE02025061    AAPE02025062    GFPF01005446    MAA16592.1    KK686367    KFQ14733.1    KK649298    KFQ00844.1    GAMT01007944    GAMT01007943    GAMS01001101    GAMS01001100    GAMR01004756    GAMQ01003256    GAMQ01003255    GAMP01005983    GAMP01005982    JAB03917.1    JAB22035.1    JAB29176.1    JAB38595.1    JAB46772.1    GEDV01002006    JAP86551.1    AMQN01006786    KB299138    ELU08313.1    AGTO01000072    KL505791    KFO84794.1    GL192434    EFB13462.1    KK432927    KFQ89455.1    KK719069    KFO61211.1    KL289504    KFZ69370.1    AAEX03007381    KL447761    KFO76969.1    AEFK01192082    AEFK01192083    AEFK01192084    AACZ04070390    GABC01004182    GABD01004389    GABE01000614    NBAG03000240    JAA07156.1    JAA28711.1    JAA44125.1    PNI65014.1    GEFM01003926    JAP71870.1    GG666553    EEN56084.1    JH173279    EHB16325.1    AJFE02117077    AJFE02117078    AJFE02117079    AJFE02117080    NDHI03003364    PNJ83062.1    AEYP01012424    QUSF01000028    RLW00070.1    AAKN02055453    CM001263    EHH21135.1    JU320457    JU471911    AFE64213.1    AFH28715.1    GACK01005336    JAA59698.1    KL335586    KFZ49614.1    AB028956    AK001657    BC031358    AC016257    BC040936    BC104992    BC104994    BC110850    KL475304    KFV20369.1    GDAY02001210    JAV50217.1    KK707071    KFQ31010.1    ABJB010196317    DS775456    EEC09346.1    KK941274    KFQ50881.1    AGTP01024622    CM001286    EHH66661.1    AQIA01012545    AQIA01012546    AQIB01024467    AQIB01024468    AHZZ02002901    AHZZ02002902    KL217466    KFO95425.1    PNI65016.1    GEFH01004346    JAP64235.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000027135    UP000235965    UP000242188    UP000085678    UP000007754    UP000010552    UP000002281    UP000009136    UP000008227    UP000005225    UP000076420    UP000000539    UP000190648    UP000054081    UP000002356    UP000011712    UP000001074    UP000252040    UP000245320    UP000248483    UP000014760    UP000016665    UP000008225    UP000286642    UP000079721    UP000245340    UP000261681    UP000233020    UP000233220    UP000001645    UP000286641    UP000233040    UP000248481    UP000052976    UP000002254    UP000248484    UP000248482    UP000053760    UP000007648    UP000286640    UP000002277    UP000001554    UP000006813    UP000240080    UP000000715    UP000276834    UP000005447    UP000261680    UP000005640    UP000233060    UP000248480    UP000001555    UP000005215    UP000233120    UP000009130    UP000233100    UP000029965    UP000028761    UP000054308   

PRIDE

M3VK14    I3LLV0    Q2M389    B7PRX4   

Pfam

PF14744   WASH-7_mid        + More
PF14746   WASH-7_C
PF14745   WASH-7_N

Interpro

IPR028283   WASH-7_C        + More
IPR028191   WASH-7_N       
IPR027307   WASH7       
IPR028282   WASH-7_central       

ProteinModelPortal

A0A2H1VDY1   A0A2A4JWE3   A0A1E1W053   A0A3S2LFI3   A0A194PIW6   A0A194R2Z4   + More
A0A212ETZ5   A0A0L7KRI2   A0A1E1WK11   A0A067QYP0   A0A2J7PXZ5   A0A210QJ49   A0A2J7PXZ8   T1J3X6   A0A1S3JFP0   H0ZLG1   L5KF43   M3VK14   A0A3Q2IAN7   G5E600   L8IEP9   I3LLV0   H0WQT5   A0A2C9JNT2   R4GHH2   A0A1V4K7W3   A0A093RRJ7   W5Q6S3   M3VWP4   G1P956   A0A341AB65   A0A2U3ZZ47   A0A2Y9QKE1   A0A224YRZ8   A0A091Q5C7   A0A091P062   U3EJC9   A0A131Z8M7   R7UQC0   U3KG72   F7HA23   A0A3Q7WYU4   A0A091GNN6   D2H1T9   A0A1S3ACV0   A0A2U3WXU5   A0A383YSH6   A0A091UID3   A0A2K5F184   A0A2K6UPC6   G1NJT1   A0A3Q7PT10   A0A2K5RWX0   A0A2Y9H0S5   A0A3Q7Q7T4   A0A091EW44   A0A094LF41   J9P227   A0A2Y9T2K3   A0A2Y9IU07   A0A2C9JNS4   A0A2C9JNS6   A0A091G738   G3W5X6   A0A3Q7TN06   H2R755   A0A131Y0E5   C3YUG4   G5C464   A0A2R9CAM4   A0A2J8XM21   A0A2Y9IRC4   M3YL02   A0A3L8SCM6   H0V7S3   G7N5B6   H9EPA4   L7M974   A0A094K1P4   A0A384DAB7   A0A2U3ZUV1   Q2M389   A0A093D5J2   A0A1W7RGE6   A0A091QTV7   A0A2K5N2C0   A0A2Y9DFV9   B7PRX4   A0A091S5I5   I3MMP7   A0A2K6BLP5   G7PJE1   A0A2K5VNY9   A0A0D9S2H4   A0A096MN14   A0A2K5N1T9   A0A091I6Q2   A0A2Y9IY17   A0A2J8MZR6   A0A131XDK8  

KEGG

101744291    K18465 WASH complex subunit 7 | (RefSeq) WASH complex subunit 7

PATHWAY

04144    Endocytosis - Bombyx mori (domestic silkworm)

GO

GO:0071203   GO:0016197   GO:0005654   GO:0005768   GO:0007032   GO:0005769   GO:0015031  

PANTHER

PTHR31409  

Subcellular location

Early endosome  

Length:

1093

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.70244999999999

Exp number, first 60 AAs:

0.00965

Total prob of N-in:

0.17568

outside

1  -  1093

 

 

Pi

1.659944

Theta

5.953028

Tajima's D

-2.094619

CLR

127.863098

CSRT

0.00789960501974901

Interpretation

Uncertain