Gene

KWMTBOMO07327  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010621

Annotation

PREDICTED:_ribonucleoside-diphosphate_reductase_large_subunit_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr12(-):10666951-10672141      View in EpiBrowser

Full name

Ribonucleoside-diphosphate reductase       + More
Ribonucleoside-diphosphate reductase large subunit      

Alternative Name

Ribonucleoside-diphosphate reductase subunit M1
Ribonucleotide reductase large subunit

Location in the cell

Cytoplasmic   Reliability : 2.709

CDS

ATGGTTGGTAAAATGAATAAATTGTACGTTTTAAAGAGAGGCGGAAGAATGGAGGAGGTGCATATAGACAAGATAACATCAAGAATTAAAAAACTATGTTATGGATTAAATATGGATTTTGTTGATCCGGTGTGTATAACACTAAAAGTTATCAATGGAATCTACTCGGGAGTGACAACTGTGGAACTGGATAATCTTGCTGCAGAGACAGCTGCTACAATGACTACCGATCATCCAGATTATGCTGTTCTTGCAGCCAGGCTTGCAATATCAAACTTACATAAAGAAACAAAAAAACACTTTTCAGATGTTATGAAAGATTTGTTTGACATTGTTAATCCACACACTAAGAAGAGGGCACCAATGATATCTGAATTTCATTATAATATAGTTATGAACCATAAAGAAAGATTAGATTCTGCTATTGTGTATGACAGAGACTTCAAATATAATCATTTTGGGTTTAAAACTTTAGAGCGCTCATATTTATTGAAAATAAACAATAAGGTTGCTGAACGACCTCAACATATGCTGATGCGAGTGTCAATTGGAATTCATGGTGAAGATATTGATGCAGCCATAAATACATACAACTTACTTTCTGAGAAATATTTCACTCATGCCAGCCCAACCTTATTCTCAGCTGCAACTCCACGCCCCCAACTATCATCATGTTTTCTAGTGGCAATGAAAGATGACAGCATTGAAGGAATTTACGATACCTTAAAGCAGTGTGCTTTGATATCTAAATCTGCAGGTGGAATTGGTGTCCATGTCCACTGTATAAGGGCTAAAGGTACTTATATAGCAGGAACAAATGGTGTATCAAATGGTCTTGTACCAATGTTACGAGTTTACAATAATACAGCTAGATATGTTGATCAAGGAGGTAATAAGCGCCCTGGAGCTTTTGCAGTCTATTTGGAACCGTGGCATGCCGATATATTTGAATTCTTAGATTTAAAGAAAAACACTGGAAAAGAAGAAGTACGTGCCAGGGAACTTTTTTATGCATTGTGGATACCTGATCTTTTCATGAAAAGAGTTGAAAATGATGGCGTATGGACCCTTATGTGTCCTCATGATTGCCCAGGGTTAGCTGACTGTTGGGGAAAAGAATTTGAATCCTTATATGAAACATATGAAAAAGAAAATAGATTTGTAAAACAAGTAAGGGCACAAGTTCTTTGGAAAGCAATAATAGAAGCTCAAGTAGAGACTGGTACTCCATACATGTTATTTAAAGATTCATGTAATAGAAAAAGTAATCAGAAAAATTTAGGTACCATAAAATGTAGTAACCTGTGCACTGAAATAGTTGAATATACATCTGATGATGAAGTGGCAGTATGCAACTTAGCCTCTATAGCGCTAAATATGTTTGTTGATGATAACAAAACATATAACTTTAAGAAATTAAAAGAAGTTACTAAAACTATAACAGAAAATTTGAATAAAATCATTGATGTAAATTATTACCCTGTTCCGGAAGCAAAAAAATCTAATCTTAGACATAGACCTATTGGAATAGGTGTTCAAGGTCTTGCTGATGCTTTTATTTTAATGCGTTTACCTTACGAAAGTCCAGAAGCTATTAAATTAAATCAACAAATATTTGAAACTATTTACTATGGAGCACTAGAGGCAAGTTGTGAACTAGCAGAAAAGTATGGAGTGTATGAAACATACGAAGGATGCCCTGCAAGTCGAGGCATATTACAGTACGAAATGTGGAATAAAAATCCAACAGATTTATGGGACTGGACTGCTTTAAAAGAAAACATTGCCAAGCATGGTCTTCGTAATTCTCTTTTGGTAGCCCCAATGCCCACTGCCTCAACAGCTCAGATTTTAGGAAATAATGAATCTTTTGAGCCCTTCACTTCTAATATTTATCAAAGACGTGTTTTATCTGGAGAATTTCAAGTTGTAAATCATCATTTACTTCGTGATTTGACAGAAGCAGATTTATGGGATGAGGAAATGAAAAATCTCATTATACACAATAATGGATCTATACAAAATATCGAAAGTATACCTACAGAAATAAGGGACTTATATAAGACAGTTTGGGAAATTTCAGTCAAAACAACAATACAAATGGCTGCTGATCGTGGAGCTTTTATTGATCAAAGTCAATCTTTTAATATACACGTTGCTGAACCGAACTACGGAAAATTAACTTCTATTCATTTCTATTCATGGAAAATGGGTTTAAAAACAGGGATGTATTATTTGCGAACAAAACCGGCAGCCAATGCCATACAATTTACTGTGGATAAATCCAAAGTTAAAACTAAAATGAATAATAGTAAATCTGAAATAGATGAGGCAAACATGGCAGCAATAACTTGTTCGTTACGGAATAAAGATGAATGTTTAAGTTGTGGATCGTAA

Protein

MVGKMNKLYVLKRGGRMEEVHIDKITSRIKKLCYGLNMDFVDPVCITLKVINGIYSGVTTVELDNLAAETAATMTTDHPDYAVLAARLAISNLHKETKKHFSDVMKDLFDIVNPHTKKRAPMISEFHYNIVMNHKERLDSAIVYDRDFKYNHFGFKTLERSYLLKINNKVAERPQHMLMRVSIGIHGEDIDAAINTYNLLSEKYFTHASPTLFSAATPRPQLSSCFLVAMKDDSIEGIYDTLKQCALISKSAGGIGVHVHCIRAKGTYIAGTNGVSNGLVPMLRVYNNTARYVDQGGNKRPGAFAVYLEPWHADIFEFLDLKKNTGKEEVRARELFYALWIPDLFMKRVENDGVWTLMCPHDCPGLADCWGKEFESLYETYEKENRFVKQVRAQVLWKAIIEAQVETGTPYMLFKDSCNRKSNQKNLGTIKCSNLCTEIVEYTSDDEVAVCNLASIALNMFVDDNKTYNFKKLKEVTKTITENLNKIIDVNYYPVPEAKKSNLRHRPIGIGVQGLADAFILMRLPYESPEAIKLNQQIFETIYYGALEASCELAEKYGVYETYEGCPASRGILQYEMWNKNPTDLWDWTALKENIAKHGLRNSLLVAPMPTASTAQILGNNESFEPFTSNIYQRRVLSGEFQVVNHHLLRDLTEADLWDEEMKNLIIHNNGSIQNIESIPTEIRDLYKTVWEISVKTTIQMAADRGAFIDQSQSFNIHVAEPNYGKLTSIHFYSWKMGLKTGMYYLRTKPAANAIQFTVDKSKVKTKMNNSKSEIDEANMAAITCSLRNKDECLSCGS

Description

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic Activity

[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate

Subunit

Heterodimer of a large and a small subunit.

Similarity

Belongs to the ribonucleoside diphosphate reductase large chain family.

Keywords

Allosteric enzyme   ATP-binding   Complete proteome   Disulfide bond   DNA replication   Nucleotide-binding   Oxidoreductase   Phosphoprotein   Reference proteome  

Feature

chain  Ribonucleoside-diphosphate reductase large subunit

Uniprot

H9JM68   A0A2A4IZ66   A0A3S2NDU8   A0A194R877   A0A194PHX7   S4NVM0   + More
A0A212EU05   Q5TNU6   A0A182GUD5   A0A182H8R8   Q8WRS8   A0A1S4FQW9   A0A182MJ42   A0A1Y9HDS2   A0A182P8B4   A0A1Q3EVF9   A0A1S4H479   A0A182KD02   A0A336M8P8   A0A182KJQ7   A0A182I0P1   A0A1Q3EVE8   A0A182V737   A0A084W615   A0A182XB46   A0A182IJ99   A0A182VT04   A0A1S4JFW6   A0A182Q4F3   B4G7A7   A0A182QBJ5   A0A182YHA5   A0A182TDT3   B4HWK9   A0A1J1HFW3   B0WF21   A0A2H1WX45   A0A182N8K0   B4Q8U0   B3N974   B4NZ99   A0A182FMT1   B4MGW0   B4JPM7   A0A2M4CG12   A0A0A1XB28   P48591   B3MPR4   A0A1W4UT49   W8C3W0   B4KJJ8   A0A034WBX7   E0VP30   A0A0L7LIQ0   W5JHJ2   A0A3B0JMQ6   A0A0K8VYS2   T1PBH3   A0A0L0C6V7   A0A3R7NNT8   A0A1I8PUT0   A0A3Q3BFR2   A0A0A9WSE4   A0A0A9WPF2   A0A2J7PKH7   A0A067RQQ2   A0A3B3YLV0   M3ZQ49   A0A3Q0S419   A0A224XEY7   F1R2K9   A0A087XVR3   A0A3B3UTD9   A0A3P9MUF2   A0A2I4CE75   I3J6Z8   A0A1A8BAR6   A0A0P5ESK7   A0A1A8GEQ6   A0A0P5ZGZ5   A0A1A8L9R2   A0A1A8RUI6   A0A1A8KN63   A0A1A8V1J7   C3ZNF9   A0A3B4FCX7   A0A0F8AR43   A0A3Q3BIK7   E1C4Q0   A0A3P9HAD2   A0A3P8Q276   A0A3P9CK29   A0A0A9WSE8   A0A3Q1IMZ6   G3WDV0   A0A1A8QBW5   Q5ZM69   A0A3P9LPM7   H2LQV4   A0A3B5M008  

EC Number

1.17.4.1

Pubmed

19121390    26354079    23622113    22118469    12364791    26483478    + More
12213240    17510324    20966253    24438588    17994087    25244985    22936249    17550304    25830018    10731132    12537572    10731138    8050359    18327897    24495485    25348373    20566863    26227816    20920257    23761445    25315136    26108605    25401762    24845553    23542700    23594743    25186727    18563158    25835551    15592404    17554307    21709235    15642098   

EMBL

BABH01033434    NWSH01004441    PCG65115.1    RSAL01000182    RVE44913.1    KQ460845    + More
KPJ12066.1    KQ459603    KPI92653.1    GAIX01011486    JAA81074.1    AGBW02012509    OWR44968.1    AAAB01008980    EAL39294.3    JXUM01018474    KQ560514    KXJ82039.1    JXUM01119134    KQ566258    KXJ70271.1    AF411296    CH477677    AAL58843.1    EAT37356.1    AXCM01000009    GFDL01015750    JAV19295.1    UFQS01000558    UFQS01000942    UFQT01000558    UFQT01000942    SSX04917.1    SSX07903.1    SSX25279.1    APCN01005228    GFDL01015754    JAV19291.1    ATLV01020717    KE525305    KFB45659.1    AXCN02001835    AXCN02001836    CH479180    EDW28361.1    AXCN02001837    CH480818    EDW52404.1    CVRI01000002    CRK86888.1    DS231913    EDS25929.1    ODYU01011731    SOQ57645.1    CM000361    CM002910    EDX04505.1    KMY89490.1    CH954177    EDV58509.1    CM000157    EDW88794.1    CH940725    EDW57333.1    CH916372    EDV98857.1    GGFL01000109    MBW64287.1    GBXI01006131    JAD08161.1    AE014134    AF132143    AY119149    U09369    CH902620    EDV32312.1    GAMC01009941    JAB96614.1    CH933807    EDW13578.2    GAKP01007317    JAC51635.1    DS235354    EEB15136.1    JTDY01000955    KOB75290.1    ADMH02001174    ETN63837.1    OUUW01000006    SPP81602.1    GDHF01008313    JAI44001.1    KA646107    AFP60736.1    JRES01000835    KNC27971.1    QCYY01003560    ROT62696.1    GBHO01033258    GBHO01033255    GBHO01033254    GBRD01009418    GBRD01009417    JAG10346.1    JAG10349.1    JAG10350.1    JAG56406.1    GBHO01033257    JAG10347.1    NEVH01024540    PNF16836.1    KK852479    KDR22970.1    GFTR01008078    JAW08348.1    BX511168    AYCK01003502    AERX01035242    HADZ01000711    HAEA01014950    SBP64652.1    GDIQ01265320    LRGB01002244    JAJ86404.1    KZS08302.1    HAEB01018758    HAEC01002158    SBQ70235.1    GDIP01044147    JAM59568.1    HAEF01003861    SBR41243.1    HAEI01000677    HAEH01019252    SBS08944.1    HAED01003344    HAEE01013820    SBR33870.1    HADY01021416    HAEJ01014102    SBS54559.1    GG666651    EEN45912.1    KQ041068    KKF30837.1    AADN05001070    GBHO01033253    JAG10351.1    AEFK01120230    AEFK01120231    HAEG01011918    SBR90996.1    AJ719515    CAG31174.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000007062    UP000069940    UP000249989    UP000008820    UP000075883    UP000075900    UP000075885    UP000075881    UP000075882    UP000075840    UP000075903    UP000030765    UP000076407    UP000075880    UP000075920    UP000075886    UP000008744    UP000076408    UP000075902    UP000001292    UP000183832    UP000002320    UP000075884    UP000000304    UP000008711    UP000002282    UP000069272    UP000008792    UP000001070    UP000000803    UP000007801    UP000192221    UP000009192    UP000009046    UP000037510    UP000000673    UP000268350    UP000095301    UP000037069    UP000283509    UP000095300    UP000264800    UP000235965    UP000027135    UP000261480    UP000002852    UP000261340    UP000000437    UP000028760    UP000261500    UP000242638    UP000192220    UP000005207    UP000076858    UP000001554    UP000261460    UP000264840    UP000000539    UP000265200    UP000265100    UP000265160    UP000265040    UP000007648    UP000265180    UP000001038    UP000261380   

PRIDE

H9JM68    P48591    F1R2K9   

Pfam

PF02867   Ribonuc_red_lgC        + More
PF03477   ATP-cone
PF00317   Ribonuc_red_lgN

Interpro

IPR013346   NrdE_NrdA        + More
IPR039718   Rrm1       
IPR008926   RNR_R1-su_N       
IPR000788   RNR_lg_C       
IPR013509   RNR_lsu_N       
IPR005144   ATP-cone_dom       

SUPFAM

SSF48168   SSF48168       

ProteinModelPortal

H9JM68   A0A2A4IZ66   A0A3S2NDU8   A0A194R877   A0A194PHX7   S4NVM0   + More
A0A212EU05   Q5TNU6   A0A182GUD5   A0A182H8R8   Q8WRS8   A0A1S4FQW9   A0A182MJ42   A0A1Y9HDS2   A0A182P8B4   A0A1Q3EVF9   A0A1S4H479   A0A182KD02   A0A336M8P8   A0A182KJQ7   A0A182I0P1   A0A1Q3EVE8   A0A182V737   A0A084W615   A0A182XB46   A0A182IJ99   A0A182VT04   A0A1S4JFW6   A0A182Q4F3   B4G7A7   A0A182QBJ5   A0A182YHA5   A0A182TDT3   B4HWK9   A0A1J1HFW3   B0WF21   A0A2H1WX45   A0A182N8K0   B4Q8U0   B3N974   B4NZ99   A0A182FMT1   B4MGW0   B4JPM7   A0A2M4CG12   A0A0A1XB28   P48591   B3MPR4   A0A1W4UT49   W8C3W0   B4KJJ8   A0A034WBX7   E0VP30   A0A0L7LIQ0   W5JHJ2   A0A3B0JMQ6   A0A0K8VYS2   T1PBH3   A0A0L0C6V7   A0A3R7NNT8   A0A1I8PUT0   A0A3Q3BFR2   A0A0A9WSE4   A0A0A9WPF2   A0A2J7PKH7   A0A067RQQ2   A0A3B3YLV0   M3ZQ49   A0A3Q0S419   A0A224XEY7   F1R2K9   A0A087XVR3   A0A3B3UTD9   A0A3P9MUF2   A0A2I4CE75   I3J6Z8   A0A1A8BAR6   A0A0P5ESK7   A0A1A8GEQ6   A0A0P5ZGZ5   A0A1A8L9R2   A0A1A8RUI6   A0A1A8KN63   A0A1A8V1J7   C3ZNF9   A0A3B4FCX7   A0A0F8AR43   A0A3Q3BIK7   E1C4Q0   A0A3P9HAD2   A0A3P8Q276   A0A3P9CK29   A0A0A9WSE8   A0A3Q1IMZ6   G3WDV0   A0A1A8QBW5   Q5ZM69   A0A3P9LPM7   H2LQV4   A0A3B5M008  

PDB

6AUI     E-value=0,     Score=3274

KEGG

101741714    K10807 ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] | (RefSeq) ribonucleoside-dipho

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004748   GO:0006260   GO:0009263   GO:0005971   GO:0016021   GO:0006919   GO:0042246   GO:0051290   GO:0042802   GO:0097718   GO:0006487   GO:0006488   GO:0007156   GO:0008237   GO:0043401   GO:0003707   GO:0051537   GO:0055114  

PANTHER

PTHR11573  

Length:

798

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06044

Exp number, first 60 AAs:

0.05578

Total prob of N-in:

0.00273

outside

1  -  798

 

 

Pi

0.957946

Theta

2.550402

Tajima's D

-1.552723

CLR

1114.018725

CSRT

0.0458477076146193

Interpretation

Uncertain