Gene

KWMTBOMO07318

Annotation

glycoprotein_hormone_alpha_2_precursor_[Bombyx_mori]

Location

Bomo_Chr12(-):10582320-10584341      View in EpiBrowser

Full name

Thyrostimulin alpha-2 subunit      

Location in the cell

Extracellular   Reliability : 2.214 PlasmaMembrane   Reliability : 1.841

CDS

ATGCTTCTTAGATTTATTGTTACCCTCATGTTTTTATGCCAAATTTTTGCCGCTGAATCGTGGAGAAAACCAGGCTGTCATAGAATTGGTCACACAAGAAATATAAGCATCCCAGATTGCGTAGAATTTAAAATAACAACGAATGCATGCCGCGGGTATTGTGAGTCCTGGTCCCTTCCCAGTATTATGCTTGGGTTTAAGAGACATCCCGTAACTTCATTAGGACAATGCTGTAACATAATGGAAGCTGAAGATGTACCTGTCAAAGTCCTGTGCTTGGATGGAGAAAGAAATTTAATATTTAAATCTGCGGTTTCATGCGCATGTTACCATTGCCAAAAAGAATGA

Protein

MLLRFIVTLMFLCQIFAAESWRKPGCHRIGHTRNISIPDCVEFKITTNACRGYCESWSLPSIMLGFKRHPVTSLGQCCNIMEAEDVPVKVLCLDGERNLIFKSAVSCACYHCQKE

Subunit

Heterodimer with GPHB5; non-covalently-linked.

Similarity

Belongs to the glycoprotein hormones subunit alpha family.

Keywords

Direct protein sequencing   Disulfide bond   Hormone   Secreted   Signal   Toxin  

Feature

chain  Thyrostimulin alpha-2 subunit

Uniprot

B3XYE1   A0A0L7LPR3   A0A194R3H7   A0A194PIV1   M4QC45   A0A0S1U1N8   + More
A0A2A4J493   A0A385H8V5   A0A212F3K0   A0A2H1V2K4   A0A067QSH1   A0A2J7QXV2   C6SUP2   T1HSS2   W5J3I6   U3U7C9   A0A224XWZ9   A0A0H3YEI7   A0A182GQ02   A0A182PAU6   A0A2S2QRP7   A0A1Y9HEH9   A0A182JTH5   A0A2C9GS92   A0A182VEV2   A0A182TT19   A0A182L0T8   Q7PJ83   A0A182F505   A0A182Y3E8   B0X0Y3   A0A1E1G7S7   A0A182NU68   A0A182QNT0   D6X356   A0A182MUL9   A0A084VXY8   A0A2R7W268   C6SUP0   J9LHE2   A0A2U8JAF2   A0A1Q3FRB0   A0A1Q3FQ52   A0A1I8QBB4   A0A2S2NY71   A0A1Q3FQA2   A0A1I8M647   A0A0K8UIA1   W8CB56   A0A0L0C2Q8   A0A0P8XKI1   A0A1B0DQU1   A0A0A1X2W0   B4KFF3   B5DK43   A0A1W4UXI7   A0A2P8YSC7   A0A3B0JTX5   B4JQ28   B4MUL4   T1JQM9   Q58L88   A0A1S3CUF9   A0A0Q5VKA1   A0A0R1E961   A0A0P6BIF0   B2Z9X2   A0A1B0FQT8   A0A1A9VF46   A0A1A9W5J4   E9GLP7   A0A1D2NDK3   A0A1J1IT51   A0A182W6N4   A0A0P5QCG0   C6SUN9   A0A2T7NXA4   A0A0F7Z3J2   A0A1S6JQ29   A0A0P6IC84   A0A346CIW0   A0A346CJI7   A0A182J389   A0A087TXD7   A0A1Y3ANS8   C6SUP1   A0A1X9ZNE1   A0A0P5NNQ3   A0A2C9K1U4   A0A346GAT9   A0A336MA94   B4LQP5   A0A1X9ZND6   C6SUN8   O46182   K1QSB9   V3ZQ40   A0A1A9ZFC5  

Pubmed

19264871    26227816    26354079    30171635    22118469    24845553    + More
20920257    23761445    23932938    26036749    26483478    20966253    12364791    14747013    17210077    25244985    18362917    19820115    24438588    20566863    27924858    25315136    24495485    26108605    17994087    25830018    15632085    29403074    10731132    12537568    12537572    12537573    12537574    15890769    16110336    17569856    17569867    26109357    26109356    17550304    21292972    27289101    24505301    26301480    28082215    30060147    28502716    15562597    9364772    22992520    23254933   

EMBL

AB365128    BN001243    BAG55000.1    CAR94699.1    JTDY01000386    KOB77427.1    + More
KQ460845    KPJ12074.1    KQ459603    KPI92644.1    KC340925    AGH25557.1    KT005971    RSAL01000022    ALM30322.1    RVE52390.1    NWSH01003090    PCG66967.1    MH028086    AXY04255.1    AGBW02010564    OWR48317.1    ODYU01000383    SOQ35077.1    KK853336    KDR08333.1    NEVH01009372    PNF33409.1    BN001241    CAR94697.1    ACPB03004813    ADMH02002110    ETN58907.1    AB817258    BAO00955.1    GFTR01002008    JAW14418.1    KP895540    AKN21239.1    JXUM01079391    KQ563124    KXJ74437.1    GGMS01011198    MBY80401.1    APCN01000797    AAAB01008964    EAA43859.4    BN001242    DS232248    CAR94698.1    EDS38375.1    LC146505    BAV78809.1    AXCN02000773    KQ971372    EFA10706.1    AXCM01004580    ATLV01018225    KE525226    KFB42832.1    KK854234    PTY13518.1    BN001239    DS235354    CAR94695.1    EEB15080.1    ABLF02034426    ABLF02034428    MH210978    AWK57521.1    GFDL01005013    JAV30032.1    GFDL01005381    JAV29664.1    GGMR01009403    MBY22022.1    GFDL01005254    JAV29791.1    GDHF01025882    JAI26432.1    GAMC01000759    JAC05797.1    JRES01000973    KNC26638.1    CH902628    KPU75323.1    AJVK01008750    GBXI01008628    JAD05664.1    CH933807    EDW12053.1    CH379061    EDY70669.1    PYGN01000390    PSN47146.1    OUUW01000010    SPP85555.1    CH916372    EDV99008.1    CH963857    EDW76209.1    CAEY01000437    AY940435    CP007081    AAX38184.1    EDP27970.2    CH954179    KQS61761.1    CH898078    KRK05705.1    GDIP01014090    GDIQ01079018    LRGB01000626    JAM89625.1    JAN15719.1    KZS17589.1    EU620226    ACC99601.1    CCAG010000954    GL732551    EFX79541.1    LJIJ01000077    ODN03327.1    CVRI01000058    CRL02756.1    GDIQ01137497    JAL14229.1    BN001238    CAR94694.2    PZQS01000008    PVD25804.1    GAIH01000105    KY287983    AQS80514.1    GDIQ01006694    JAN88043.1    MH360460    AXL95509.1    MH360687    AXL95736.1    KK117181    KFM69776.1    MUJZ01067344    OTF70089.1    BN001240    CAR94696.1    MF033101    ARS73219.1    GDIQ01139840    JAL11886.1    MH045224    AXN93492.1    UFQS01000558    UFQS01000675    UFQT01000558    UFQT01000675    SSX04925.1    SSX06070.1    SSX25287.1    CH940649    EDW63429.2    MF033099    ARS73217.1    FJ195453    BN001237    ACN32202.1    CAR94693.2    U73802    AAB92391.1    JH817298    EKC24491.1    KB201891    ESO93503.1   

Proteomes

UP000037510    UP000053240    UP000053268    UP000283053    UP000218220    UP000007151    + More
UP000027135    UP000235965    UP000015103    UP000000673    UP000069940    UP000249989    UP000075885    UP000075900    UP000075881    UP000075840    UP000075903    UP000075902    UP000075882    UP000007062    UP000069272    UP000076408    UP000002320    UP000075884    UP000075886    UP000007266    UP000075883    UP000030765    UP000009046    UP000007819    UP000095300    UP000095301    UP000037069    UP000007801    UP000092462    UP000009192    UP000001819    UP000192221    UP000245037    UP000268350    UP000001070    UP000007798    UP000015104    UP000000803    UP000079169    UP000008711    UP000002282    UP000076858    UP000092444    UP000078200    UP000091820    UP000000305    UP000094527    UP000183832    UP000075920    UP000245119    UP000075880    UP000054359    UP000076420    UP000008792    UP000005408    UP000030746    UP000092445   

PRIDE

B3XYE1    Q58L88   

Pfam

PF00007   Cys_knot        + More
PF03045   DAN
PF04055   Radical_SAM
PF00583   Acetyltransf_1
PF16199   Radical_SAM_C

Interpro

IPR029034   Cystine-knot_cytokine        + More
IPR006208   Glyco_hormone_CN       
IPR004133   DAN       
IPR040045   DYNC2LI1       
IPR007197   rSAM       
IPR039661   ELP3       
IPR023404   rSAM_horseshoe       
IPR034687   ELP3-like       
IPR016181   Acyl_CoA_acyltransferase       
IPR000182   GNAT_dom       
IPR032432   Radical_SAM_C       
IPR006638   Elp3/MiaB/NifB       

SUPFAM

SSF55729   SSF55729        + More
SSF57501   SSF57501       

Gene 3D

2.10.90.10     3.80.30.20    

ProteinModelPortal

B3XYE1   A0A0L7LPR3   A0A194R3H7   A0A194PIV1   M4QC45   A0A0S1U1N8   + More
A0A2A4J493   A0A385H8V5   A0A212F3K0   A0A2H1V2K4   A0A067QSH1   A0A2J7QXV2   C6SUP2   T1HSS2   W5J3I6   U3U7C9   A0A224XWZ9   A0A0H3YEI7   A0A182GQ02   A0A182PAU6   A0A2S2QRP7   A0A1Y9HEH9   A0A182JTH5   A0A2C9GS92   A0A182VEV2   A0A182TT19   A0A182L0T8   Q7PJ83   A0A182F505   A0A182Y3E8   B0X0Y3   A0A1E1G7S7   A0A182NU68   A0A182QNT0   D6X356   A0A182MUL9   A0A084VXY8   A0A2R7W268   C6SUP0   J9LHE2   A0A2U8JAF2   A0A1Q3FRB0   A0A1Q3FQ52   A0A1I8QBB4   A0A2S2NY71   A0A1Q3FQA2   A0A1I8M647   A0A0K8UIA1   W8CB56   A0A0L0C2Q8   A0A0P8XKI1   A0A1B0DQU1   A0A0A1X2W0   B4KFF3   B5DK43   A0A1W4UXI7   A0A2P8YSC7   A0A3B0JTX5   B4JQ28   B4MUL4   T1JQM9   Q58L88   A0A1S3CUF9   A0A0Q5VKA1   A0A0R1E961   A0A0P6BIF0   B2Z9X2   A0A1B0FQT8   A0A1A9VF46   A0A1A9W5J4   E9GLP7   A0A1D2NDK3   A0A1J1IT51   A0A182W6N4   A0A0P5QCG0   C6SUN9   A0A2T7NXA4   A0A0F7Z3J2   A0A1S6JQ29   A0A0P6IC84   A0A346CIW0   A0A346CJI7   A0A182J389   A0A087TXD7   A0A1Y3ANS8   C6SUP1   A0A1X9ZNE1   A0A0P5NNQ3   A0A2C9K1U4   A0A346GAT9   A0A336MA94   B4LQP5   A0A1X9ZND6   C6SUN8   O46182   K1QSB9   V3ZQ40   A0A1A9ZFC5  

KEGG

100174849    no KO assigned | (RefSeq) GPA2, Gpa; glycoprotein hormone alpha 2

GO

GO:0005576   GO:0005868   GO:0005929   GO:0035735   GO:0035721   GO:0007166   GO:0005615   GO:0051427   GO:0016021   GO:0016740   GO:0009755   GO:0046982   GO:0010469   GO:0003824   GO:0051536   GO:0005179   GO:0090729  

PANTHER

PTHR13236   PTHR11135   PTHR11135:SF0  

Subcellular location

Secreted  

SignalP

Position:   1 - 20,         Likelihood:  0.998057

 

 

Length:

115

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.19954

Exp number, first 60 AAs:

0.19949

Total prob of N-in:

0.06665

outside

1  -  115

 

 

Pi

6.317983

Theta

15.246379

Tajima's D

-1.0525

CLR

0.570526

CSRT

0.127743612819359

Interpretation

Uncertain