Gene
KWMTBOMO07269
Pre Gene Modal
BGIBMGA010599
Annotation
Cadherin-like_protein_[Operophtera_brumata]
Full name
Cadherin-related tumor suppressor
+ More
Protocadherin Fat 4
Protocadherin Fat 3
Cadherin-23
Protocadherin-16
Protocadherin Fat 1
Protocadherin-23
Protein dachsous
Protocadherin Fat 2
Fat-like cadherin-related tumor suppressor homolog
Protocadherin-like protein
Neural-cadherin
Protocadherin-like wing polarity protein stan
Cadherin EGF LAG seven-pass G-type receptor 2
Cadherin EGF LAG seven-pass G-type receptor 3
Cadherin EGF LAG seven-pass G-type receptor 1
Cadherin-87A
Cadherin-4
Cadherin-related hmr-1
Protocadherin-15
Protocadherin-11 Y-linked
Protocadherin-11 X-linked
Protocadherin-1
Cadherin-3
Cadherin-related family member 2
Protocadherin-9
Protocadherin gamma-A9
Protocadherin-20
Protocadherin-19
Putative neural-cadherin 2
Protocadherin beta-12
Protocadherin gamma-A12
Protocadherin gamma-A1
Protocadherin gamma-B7
Protocadherin gamma-B3
Protocadherin gamma-A5
Protocadherin gamma-B5
Protocadherin alpha-1
Protocadherin gamma-A10
Protocadherin-17
Protocadherin alpha-C2
Cadherin-99C
Protocadherin-12
Protocadherin gamma-B4
Protocadherin alpha-11
Protocadherin-7
Protocadherin gamma-B2
Protocadherin gamma-B1
Protocadherin beta-6
Protocadherin beta-11
Protocadherin-10
Protocadherin beta-9
Protocadherin gamma-C5
Protocadherin-3
Protocadherin gamma-A4
Protocadherin beta-10
Protocadherin alpha-3
Protocadherin alpha-8
Protocadherin gamma-B6
Protocadherin Fat 4
Protocadherin Fat 3
Cadherin-23
Protocadherin-16
Protocadherin Fat 1
Protocadherin-23
Protein dachsous
Protocadherin Fat 2
Fat-like cadherin-related tumor suppressor homolog
Protocadherin-like protein
Neural-cadherin
Protocadherin-like wing polarity protein stan
Cadherin EGF LAG seven-pass G-type receptor 2
Cadherin EGF LAG seven-pass G-type receptor 3
Cadherin EGF LAG seven-pass G-type receptor 1
Cadherin-87A
Cadherin-4
Cadherin-related hmr-1
Protocadherin-15
Protocadherin-11 Y-linked
Protocadherin-11 X-linked
Protocadherin-1
Cadherin-3
Cadherin-related family member 2
Protocadherin-9
Protocadherin gamma-A9
Protocadherin-20
Protocadherin-19
Putative neural-cadherin 2
Protocadherin beta-12
Protocadherin gamma-A12
Protocadherin gamma-A1
Protocadherin gamma-B7
Protocadherin gamma-B3
Protocadherin gamma-A5
Protocadherin gamma-B5
Protocadherin alpha-1
Protocadherin gamma-A10
Protocadherin-17
Protocadherin alpha-C2
Cadherin-99C
Protocadherin-12
Protocadherin gamma-B4
Protocadherin alpha-11
Protocadherin-7
Protocadherin gamma-B2
Protocadherin gamma-B1
Protocadherin beta-6
Protocadherin beta-11
Protocadherin-10
Protocadherin beta-9
Protocadherin gamma-C5
Protocadherin-3
Protocadherin gamma-A4
Protocadherin beta-10
Protocadherin alpha-3
Protocadherin alpha-8
Protocadherin gamma-B6
Alternative Name
Protein fat
Cadherin family member 14
FAT tumor suppressor homolog 4
Fat-like cadherin protein FAT-J
FAT tumor suppressor homolog 3
Otocadherin
Protein dachsous homolog 1
Cadherin family member 7
Cadherin-related tumor suppressor homolog
Protein fat homolog
Cadherin-19
Cadherin-25
Fibroblast cadherin-1
Protein Dchs1
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ
Cadherin family member 15
Adherin
Cadherin family member 8
Multiple epidermal growth factor-like domains protein 1
Protein kugelei
FAT tumor suppressor homolog 2
Cadherin-N
Protein flamingo
Protein starry night
Flamingo homolog
Cadherin family member 10
Epidermal growth factor-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Cadherin family member 11
Epidermal growth factor-like protein 1
Flamingo homolog 1
Multiple epidermal growth factor-like domains protein 2
Cadherin family member 9
Flamingo homolog 2
Protein Hammerhead
Protocadherin on the Y chromosome
Protocadherin prostate cancer
Protocadherin-22
Protocadherin on the X chromosome
Protocadherin-S
Cadherin-like protein 1
Protocadherin-42
Protocadherin-13
Cadherin-N2
Cadherin-21
Fibroblast cadherin-3
Protocadherin-68
Vascular cadherin-2
Vascular endothelial cadherin-2
Cadherin-20
Fibroblast cadherin-2
Brain-heart protocadherin
Protocadherin-3H
Cadherin family member 14
FAT tumor suppressor homolog 4
Fat-like cadherin protein FAT-J
FAT tumor suppressor homolog 3
Otocadherin
Protein dachsous homolog 1
Cadherin family member 7
Cadherin-related tumor suppressor homolog
Protein fat homolog
Cadherin-19
Cadherin-25
Fibroblast cadherin-1
Protein Dchs1
Cadherin-27
Cadherin-like protein CDHJ
Cadherin-like protein VR8
Protein dachsous homolog 2
Protocadherin PCDHJ
Cadherin family member 15
Adherin
Cadherin family member 8
Multiple epidermal growth factor-like domains protein 1
Protein kugelei
FAT tumor suppressor homolog 2
Cadherin-N
Protein flamingo
Protein starry night
Flamingo homolog
Cadherin family member 10
Epidermal growth factor-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Cadherin family member 11
Epidermal growth factor-like protein 1
Flamingo homolog 1
Multiple epidermal growth factor-like domains protein 2
Cadherin family member 9
Flamingo homolog 2
Protein Hammerhead
Protocadherin on the Y chromosome
Protocadherin prostate cancer
Protocadherin-22
Protocadherin on the X chromosome
Protocadherin-S
Cadherin-like protein 1
Protocadherin-42
Protocadherin-13
Cadherin-N2
Cadherin-21
Fibroblast cadherin-3
Protocadherin-68
Vascular cadherin-2
Vascular endothelial cadherin-2
Cadherin-20
Fibroblast cadherin-2
Brain-heart protocadherin
Protocadherin-3H
Location in the cell
Nuclear Reliability : 2.373
Sequence
CDS
ATGCAATCAAAAGAAATAGTTGAAGTTGTGATCCTGGATAAGAATGACAGCCCTCCCGAATTTGTGAATATTCCGGCTGCTTACATGGCTTCAGAAGACTTGGCACCGGGACAGAGGGTCGCTACTATAACCACAGAAGACCCTGACACCATCGGCACTATCACGTACACTATACAGAACGAGGAACCGACTCCTTTCACTCTGGATTCTAGTACTGGTGTCCTAACGCTAAAAGACCCATTAGATAGAGAGACAGTTCCGGAATATAAAGTTATCGTCAGAGCTGAAGATGGGATTCAATTTACCGATGTGACTATAACAGTTCAGGTAACGGACACCAACGACAACCCGCCCGTTTTCAAAGAAAGCGCATACTCTTTCGACATTCCCGAGAACGCAGCGAGAGGTTCTGTGGTGGGCACCGTGGCGGCCATTGACCCTGATTCCGGGCCAAACGCTCAATTGACGTACACTGTCATATCGGACTGGGCCAATGACGTCTTCTCGCTCAATCCTCAGACCGGAGTCTTCACGCTCACTGCTAGACTCGACTATGAAGAGATACAACACTATATACTAGTCGCGCAGGCACAGGACAGCGGTCACCCATCATTATCGGGGACTGTTACAGTATACGTGAATGTAATCGACCTCAATGATAACGCGCCTCTGTTTGATCCAATGAGCTTCTCTAACGAAATACTAGAAGACGTTACCATCGGATCTTCAGTGGTGACAGTCAGCGCAACGGATTCAGACTCAGGCTTAAATGGAAAAATTCGATACAGCATCACATCCGGAGATGAAAACAAAGATTTCGGGATTGCCGACAATGGCACTATTTACACAGAGAGATATTTAGACAGAGAAAAGCTACCAATTTACAACCTTGTTGTGACTGCAAGGGATTCAGCCAAGCCACCCGAACCTCAGTTGTCGTCTACTGTTCAAGTGACGATACAACTGAAGGATGTGAACGACATGGCTCCTGAATTTATAACACCGAATGTAACATCTATATCTGAAAACATTCCTCTTAATACAGTTGTCATGACCATTAAAGCGATTGATAAAGATGAAGGGAGAAATGGATACGTTGAATATTTCATGATGCCTAACCCAGAAATTAACGGATATTTCTCGTTGGGTAATGTAGATGGAATTATAAGAGCAACTGGAAAACTGGATAGAGAATTAAAATCAAATTACATAATTACCGTCACTGCAAAAGATAGAGGCGACCCTCCTAACGTTACTAAGATGGATATAAAAATTAGTATTATAGATGAAAACGACAATAGTCCAGTTTTTGATCCTAAGCAATACAGTGCATCAGTTCCGGAAAATGCTAGCATCGGAGCCAGCGTGCTTCAGGTCTCAGCTACTGATGTTGATGAAGATGCTAATGGCAGAGTTCGGTATTCAATAGCTTCTGGTGATGAAAATAGAGATTTTAGTATCAGTGAAGATACCGGAATTGTTAGAGTGGCAAAAAATCTCAATTTCGAAAGAAAATCACGGTATCTTCTGTCTATTAAAGCAGAGGACTGCGCAAAAGATGATGTTAGGTTCGATACTGCAGAAATTGCCATCTCTATTCAAGATATTAATGATAACCCACCAACGTTTTTGGATTCACCGTATTTGGCATACGTAATGGAAAATGTTATTCCACCTAATGGTGGTTTTATAATATCAATCCTTGCTTATGATGCTGATTCACCACCATTTAACAATCAAGTTCGTTATTTTATAAAAGAAGGAGATGCAGATGTTTTTAAAATTAATGCGTCTTCGGGACAAATATCACTTCTTAGGACCTTAGATCGCGAAGTACAAGATGAATATACCCTTGCACTGGTCGCCATGGATACTGGATCGCCACCTCTTACAGGATCTGGTACTGTAAAAATAATTGTACAAGATGTAAACGATAATAGTCCAGAGTTTGAAAGACAAAGTTACAAGACTAGTGTAAAAGAAAACTTACCTTCAGAAACAATGATTTTTCATGCAAAAGCTACCGATAAAGATACGGGGAACAATGCTAAGATAAGATACAGTGTACTTGGAGATAAATCAGAACGATTTAAAATAGACCCTAATACTGGTATGCTATATACTAATGAGACATTAGACCGGGAGGAATGGGATGTATATTACTTAATTTTAATGGCCCAGGATTCATCGACAACTGATCCTCGAACTGCAACTGCAAATTTGACGATTGTTGTTGAAGACGAAAATGACAATACACCGACGTTCCCACATCCCGTATATGAAACACAAATTTCTGAAAGGACTATGAAAGGAAATTTTGTCTTTGGAGTTAAAGCCACAGATAATGATATTGGATTGAGTAAAAAAATTGAATATGATTTAGAAGGAGAACACAAGCATTTGTTTACCATCAACAAAGAGACGGGTGTCATAAAAGCAAAAGAGAATCTTATTACTTATAAAGACAAAAGTATATCATCGTTCAATTTGGTAATCACTGCAAAAGATAGCGGAACACCACCAAAAGAAAGTTCAGCTGAATTGATACTTATTCTCAAATCCGTCAGAAACTTTCCAAAGTTCTCTGTGACTAACAAGCTTTCGTTTACATTTTCCGAAGATACTCCAGAAGGTGTATTAGTCACAAGGCTATCAGCTACATCTCCAAAATCCGGTCCTGCTGGGCTATTACAATATGGAATAGCGGGAGGAAATATTGGTGATGCACTACGTGTAGATCAAATGAGTGGAGAAGTTTTTTTAACTGGAAAAGGTTTGGATTACGAAACAATGCCATTATATGAAGTATGGCTTGAAGCAAAAGATTCTGATAACCCTCCTTTGAAATCTTTTATCGAAGTTGAAATAAAAGTCACAGATGCCAATGACAATGCTCCCATAATAGAAAATTCTTTGTACAATGCTACAGTGTTGGAAGAAGAATCCCCTCCTCAGTTGGTGGCAGTAATTCATGCTTTTGATTACGATTCTAATGAAAATGGACGAATATCTTATAAATTAGTAAATGATTACGATGAAACATTTAGTATAGATTCTGAAACAGGTGAAATATATACAAATATGGCACTTGACCGTGAGTCTATACCATATTATGAAATAATTGTTGAAGCTGAAGATCATGGCCTTCCACAGTTAAGCGGCACATCAACAGTAATAATAACAGTTTTGGATAAAAATGACAACCCTCCTAGATTCACAAGGCTGTTTAGTGTTAATGTAACTGAAAATGCAGAAATCGGTTCCTTTGTAATAAGAGTGACCAGTTCTGATTTGGATACTGGGTCAAATGCAAATGCTACGTATAGTTTTGTTGAAAATATTGGAAATAAATTTATTATTGATCCAATCTCTGGAAATGTTACTGTGGCAGGTTCCTTAGATAGAGAAATACAGGACGAATATATTTTGAAAGTCGCTGCTATCGACGGAGCATGGCGATCTGAAACAGCCCTTACCATAACTATACAAGATCAAAATGATAACGCACCTGAATTTGAGTACTCCTATTATAGTTTTAATTTTCCTGAAATGCAATTTAAGAACAGTTTTGTTGGACAAGTAATCGCTACGGACAGAGACAAACAAGGCCCAAATTCGATAATATCATATTCGTTACAACAACCATCAGATTTGTTCTCAATAGATCCAGCGACTGGAGAGATTTTAAGTAAATTCACCATGAATTATAAAAGAACGTCCACAAATTCATCTCCGGAAAACACATATTCTGTCGTTGTTGTAGCTACAGATAATGGGAAACCTCCAATGTCATCAGAGTGCTTAGTGATCATAAACGTTGTCGATGCAAACAATAATGCACCCAAATTCAGGGATCATGAGAAACTAATACCTATTCCTAAAGAAGCCACTATTGGTGAAAAAATAATAAAAATGAAAGCAGAAGACAACATGGACTTTGGAATAAATGCTGAAGTTGAATATTACGTGTCTGGTGGTAATGGTTCGTCGTACTTGACTATTGACCCAAATAGTGGGTGGATTATCGTAAACAAACAATTTTATTATTTAGGGCAATACTATGAACTGAAAATAAAAGCTACAGATCGCGGTGTGCCGCCACAATCAGACGAAACATCAATCGTTTTTGTTGTGACCGGTGAAAATATGTACAGCCCAAAATTCACGGCTTTAAGCTATCAAGTTATAGTGCCTGAAAATGAACCTGTAGGTTCGTCAATTTTGACTATACAGGCTAGTGATGAAGATAATGGACCTAATGGAATTATTCGTTATTCCATTTCGTCCGGAAATGAAGGAAACGAATTTCAAATACATTCTATATCTGGTGCAATTAGCATAATGCGACCGCTCGATTTTGATACAATACAGGAATATCGACTCAATATCACAGCCAATGATCTTGGCTTTAAGTCAAAGAAAGCAACAGCGACATTGACTATTATTTTGACAGACATTAATGATAATGCACCTTTTTTTAATCAAACAACCTACGTCGCATTTTTGCCTGAAAACTCACCTTTAAACACGTTTATTTATAGAGTGACCGCTGTAGATATCGATTCACCAAAAAATGCAATAATCAAGTATTATTTAAACTCTAATATGCTATCATTATTTTACATTGATGAGAACACCGGAGAAATATATTCGAAAGAAGTATTTGATTTTGAAGAAAAAAACCTGTATGATTTAACAGTGAGAGCTGAAAACCCCGATTCGTCAATGAAAAACACAACCAATATTATCATTCATATAACAGGCGTTAACGAATACTATCCAAAATTCAAACAACCAGTTTTTCATTTCGACGTATCAGAATCAGCCGAAGTTGGAACAAATGTTGGAGTTATACAAGCTACAGATCAGGATAGTGGTGATGATGGAATAATCTATTACTTATTTGTTGGTTCAAGTAATGATAAAGGTTTTGGAATCAATTCTCAAACTGGCGTTATTCGAGTGGCACGGTATTTGGACAGAGAAACTCAAAATAGAGTAGTATTAACAGTACTTGCAAAAAACTCTGGAGGTATTCGAGGTAACGACACTGATGAAGCACAAGTGATAATTTCAATCCAAGACGGTAATGATCCTCCAGAGTTTGTACGCCTTAATTATGAAGCTACAGTATCTGAGGGAGCTTATATTGGCCACGAAGTTATTCAGGTACAGGCTGTAGACAAAGATGTAAGGCCACAAAATAATCAATTCAGCTTCTCAATTATCGGCGGAAATATTGAACAAAGTTTCAAAATAGATCCACAGAATGGTAAAATAGAAGTAGCAAGGAAGTTAGATAGAGAGAAACTACCTGCATACTCATTAATAGTTGGTGCAATAGATACCGGCTCACCACCCCAAACAGGAACAGCGACAGTCAAAATAATGTTGACTGATATAAATGACAACGGTCCTATTTTCGACATCAATTCTTTTGAAGGATCAGTGTACGAGAATGAGCCACCTAACACCAGCATAACAACATTATCAGCGACAGATCCAGATTTGCCACCAAATGGTGCACCTTTTACGTACTCCATTATAGGTGGGAAACATGAGAGCTTTATAAATGTAAATAAGCATACAGGCGTATTATCCACAGCCAGGAAAATCGACAGGGAAGCTACACCGATACTCGAAATAAGTATACAAATTGAAGATAGTGGAACACCTGTAATGCGATCTAAATATGATATATTAATAAAAGTTCTCGACCGAAATGATAATCCGCCGACTCCTCGATCGGTTCATGTTGTTGTATATGCATTTAATAACAAAGTGCCAAATGGAAAAATTGCTGACGTTAAACCTAATGATCCTGATATTATTGGTGACTATAAATGTAAGATTATTCGAGATTCTACTTCAGATAGAACACTTTCACTATTGAATATCAGATCTGGATGTGACCTCTACACTAATACTATAAAACCTGGTCAAGGTTATTCTTTTTCAGTGCTGGGTAATGACGGTATTCACAAAGACGTCATATCCTCAATTTTAGAAGACACAAAAATTATAGATAGTTCAGCTATTATCTTATCTTCACCTTTCGTTAAACATGATTACGAATGTCATTGTGCTGAAGGATTTATGGGAAAGAATTGCGAAAAACGTCAAGATCCTTGTTCACCTAATCCTTGCCGCTATGGAGGACATTGTCGAAAACAAGGACATGATTTCTTATGTACTTGCCCTGTTCGCCGTGATGGGAAAACTTGCGAATTAGAAAAAAATGACGTGTGCAGTAGCAGTCCTTGTAAAAATGGAGGTTCTTGTAAAGAAAGTGCAGATGGTAGTTCATTCTTCTGTCTTTGTCGGCCCGGATATCGGGGTAATCATTGTGAAGCTCTGGTAGATTCATGTCGACCAAATCCATGCTTATATGGTGGAATATGTGTCAGCTTAAAACCTGGCTATAAATGTAGTTGTTCGGATGGACGTTACGGAACCCATTGTGAAAGCACAACATTTGGATTCGACGAACTATCATATATGCAGTTCCCGGCACTGGATGCATCGACCAATGACATCACGATAATTTTTGCAACAACGAAACCGGATGCATTACTTTTATACAACTTCGGCGCGCAAACTGGAGGCAGATCTGACTTCATAGCTATTGAACTACTTAATGGAAAACCTATTTTTTCTTTCGGGGGTGCAAGAACTTCAATAACATCTGTAGCCATATCGAATCCAAATAAAAATTTAGCGGACGGCAACTGGCATAAACTCACTGCAACAAGAAATGGAAGGGTCATATCTTTGAGCACAACATCTTGCACTGATCACGGAGATATTTGTATGGAATGCGAACCTGGAGACGACTCCTGTTACAATGATGACACCGGACAAGCCGGAACTTTGAACTTCAACAACGAACCACTTTTGATTGGAGGAATTCACAAAGCTGATCCTCTGTTAGAACGCCCAGGGCAAGTCCACTCTGATGACTTCGTAGGATGTATGCATAGCATAACCATAAATGGTCGTTTGCTAAATCTTTCAAATCCTTTAAATTCCCGAGGTGTTGAAGCAAATTGTGGTCGATCCGAAAAAGGAACATGTTATAAAAAAGCTATGTGTGGATTGGGAGAATGCATCGACCGGTGGAAATCCAATTTGTGTAAATGTGATGGTACTTTTATTGCACCTGATTGTTCAGCCGCCTTACAATCTATTTCAGTCGGAGAAACAGGGCTTATATCATTTTCTATATCAGAAAAACATCGGAGAATGCAGTTATTGGATACATTTTACAGCGGAAATACCATGTGGGAAAAACACGCTAATAAAGTTCTTAGTAAAATTAATACACGTACAAATAGTCCAGCCAAAATGTTGTCATTTCTTTTTCGGACTCACAGAAAAGATGGAATACTGTTTTACGCAGCCACTGAAAAGTATTTTACATTAATTGAATTACACGAAGGAAAAGTAAGTTATACTTCAAAACAGAATTCCGTGGTGAATATGACACAAAATGAACAGAATGATGTGTCTGATGGTACCTGGCATAATATAACCTTATTGTCTTTTGGAAGGAGTATTCGATTGTTAGTAGACAATAATGATGTTGGGGAAGAGCTGGATGCTGCTGGTGTACACGATTTCTTAGATCCGTATCTCACTGTAATGTCCCTAGGAGGAGTAAAAGCTGAATTATTAATGACTTCGAGCCAAAACAAATTTGAAGGTTGCTTAGCCAACTTTTCTATTAATAATGAAATACAGCCGTTTGCTGGGAATGGAAGTATTTTTAAGGAAACCATTTTAAAAGGGAAAATTCTAAATGGTTGCCACAGTGCATTTGGTATTGGGGCAGCACAAAATCCAGATCCCCTGCGTATTGGTATTACACTTGTCATTGTGTTTTTCGTAATTTTACTTGTTGCTATTTCCGTGTCCATTATATTCTATCGTTTACGAAAGCAAAAAAAGGAAAAAGTTGGTGGCTCCACAGGGAAAATGAATGCCGTTCATTCGAAGCAAAATGGTGGAACATCCATGTCTAATGCACCAAACCTAATAGCTGGAACCAATGAAAGTTTGATGAATCGTGGCTTACACAACAATGACACTAGCCTAAACAGTTATATTTCTGAAAGCGTTGATATAACACGTAATGTCGGACATATTGTTGGTCCTGAACTTTTATCAAAAAAATATAAAGACAGAGAAATAATGAATATAGACCCACTCAGGCCGCAACGTCCCGACATCATTGAACGAGAAGTTGTTGGGAAAAGCCCAGCTTTAAGAGAAGATCATCATCCGCCTCCACCTCTTTCGACCAACACTTCACATCACCATGATCATCCAAGTGGAATGGACCTAAATTCAGAAATACCAGAACATTACGATTTAGAAAATGCAAGTTCAATAGCACCTTCTGATATAGATATTGTTTACCACTACAAAGGTTTTCGAGAAGCGGCTAATGTCCGAAAATATAAAGCAACTCCACCACCTTTAACCGGTTATCATCATAAACATCAAACACCTCAACATCGTCACTCTCCTCATCACCCAGGCGGATACCCGTCCAGAGTACTACAGCAGGCTTCTCAGCCCCCACCCCAACCACGCCAACATCAAACAACGCCACTTGCACGACTATCACCAAGTAGTGAATTAAGCCAGCAGCCTCGTATATTGACCCTGCACGATATATCAGGAAAACCTTTGCAAAGCGCTCTACTTGCTACAACGTCCAGTTCTGGAGGTGTGGGCAAAGATGCTTTACATAGTAATAGTGAACGTAGCCTAAACAGCCCTGTGATGTCTCAGTTAAGTGGACAAAGTTCATCAGCTGGAAGAAAGACACCCAGTGCTACACCCCAAGTACCTCAAGTAGTGTCCGTAGGATCAGGGGCTGTCGGCTTAACTGCAGAAGAAATAGAAAGAATGAATGCGAGACAAAGAACGTCGAGCTTAGTGTCAACATTAGATGCAGTTTCTAGCTCCAGTGAAGCACAACGAGGTACAGGAGTAGGACATCACATGTCACATAGACATCATTCCCCTCAAGACGACAATAGAAGTTCAACAGGGTCCGATGATGAAAGCGGTAATGACAGTTTTACTTGCTCCGAAATCGAATACGATAACAACAGTATTAATGCTGAAAAACTTGACGACGTTAGGAGACCAAATGTGAGCAACGCAAATAACACAAAGAAATCAATTTTACCGCCACCATATGAAAGTTTTGACTCTTCATTTCGAGGCTCTTTAAGCACTCTAGTAGCTTCGGATGATGATCTTGTGCCGCATGTCAGTTCAGCTTTATATCGACAAGCGAATGGTTCACCAGCCTCAGCCGCTCTCGGTTGGGATCATCTCTTTAACTGGAGACCCAATTTCGAAAGTATGATCGGGGTTTTTAAAGACATTGCTGAATTACCAGACGCTGTCAACGGGCGTATGTCATCTTCGTTGAGACTTCAGAACGGCACGCCGAAACCTTCTGAAGAATATGTTTAA
Protein
MQSKEIVEVVILDKNDSPPEFVNIPAAYMASEDLAPGQRVATITTEDPDTIGTITYTIQNEEPTPFTLDSSTGVLTLKDPLDRETVPEYKVIVRAEDGIQFTDVTITVQVTDTNDNPPVFKESAYSFDIPENAARGSVVGTVAAIDPDSGPNAQLTYTVISDWANDVFSLNPQTGVFTLTARLDYEEIQHYILVAQAQDSGHPSLSGTVTVYVNVIDLNDNAPLFDPMSFSNEILEDVTIGSSVVTVSATDSDSGLNGKIRYSITSGDENKDFGIADNGTIYTERYLDREKLPIYNLVVTARDSAKPPEPQLSSTVQVTIQLKDVNDMAPEFITPNVTSISENIPLNTVVMTIKAIDKDEGRNGYVEYFMMPNPEINGYFSLGNVDGIIRATGKLDRELKSNYIITVTAKDRGDPPNVTKMDIKISIIDENDNSPVFDPKQYSASVPENASIGASVLQVSATDVDEDANGRVRYSIASGDENRDFSISEDTGIVRVAKNLNFERKSRYLLSIKAEDCAKDDVRFDTAEIAISIQDINDNPPTFLDSPYLAYVMENVIPPNGGFIISILAYDADSPPFNNQVRYFIKEGDADVFKINASSGQISLLRTLDREVQDEYTLALVAMDTGSPPLTGSGTVKIIVQDVNDNSPEFERQSYKTSVKENLPSETMIFHAKATDKDTGNNAKIRYSVLGDKSERFKIDPNTGMLYTNETLDREEWDVYYLILMAQDSSTTDPRTATANLTIVVEDENDNTPTFPHPVYETQISERTMKGNFVFGVKATDNDIGLSKKIEYDLEGEHKHLFTINKETGVIKAKENLITYKDKSISSFNLVITAKDSGTPPKESSAELILILKSVRNFPKFSVTNKLSFTFSEDTPEGVLVTRLSATSPKSGPAGLLQYGIAGGNIGDALRVDQMSGEVFLTGKGLDYETMPLYEVWLEAKDSDNPPLKSFIEVEIKVTDANDNAPIIENSLYNATVLEEESPPQLVAVIHAFDYDSNENGRISYKLVNDYDETFSIDSETGEIYTNMALDRESIPYYEIIVEAEDHGLPQLSGTSTVIITVLDKNDNPPRFTRLFSVNVTENAEIGSFVIRVTSSDLDTGSNANATYSFVENIGNKFIIDPISGNVTVAGSLDREIQDEYILKVAAIDGAWRSETALTITIQDQNDNAPEFEYSYYSFNFPEMQFKNSFVGQVIATDRDKQGPNSIISYSLQQPSDLFSIDPATGEILSKFTMNYKRTSTNSSPENTYSVVVVATDNGKPPMSSECLVIINVVDANNNAPKFRDHEKLIPIPKEATIGEKIIKMKAEDNMDFGINAEVEYYVSGGNGSSYLTIDPNSGWIIVNKQFYYLGQYYELKIKATDRGVPPQSDETSIVFVVTGENMYSPKFTALSYQVIVPENEPVGSSILTIQASDEDNGPNGIIRYSISSGNEGNEFQIHSISGAISIMRPLDFDTIQEYRLNITANDLGFKSKKATATLTIILTDINDNAPFFNQTTYVAFLPENSPLNTFIYRVTAVDIDSPKNAIIKYYLNSNMLSLFYIDENTGEIYSKEVFDFEEKNLYDLTVRAENPDSSMKNTTNIIIHITGVNEYYPKFKQPVFHFDVSESAEVGTNVGVIQATDQDSGDDGIIYYLFVGSSNDKGFGINSQTGVIRVARYLDRETQNRVVLTVLAKNSGGIRGNDTDEAQVIISIQDGNDPPEFVRLNYEATVSEGAYIGHEVIQVQAVDKDVRPQNNQFSFSIIGGNIEQSFKIDPQNGKIEVARKLDREKLPAYSLIVGAIDTGSPPQTGTATVKIMLTDINDNGPIFDINSFEGSVYENEPPNTSITTLSATDPDLPPNGAPFTYSIIGGKHESFINVNKHTGVLSTARKIDREATPILEISIQIEDSGTPVMRSKYDILIKVLDRNDNPPTPRSVHVVVYAFNNKVPNGKIADVKPNDPDIIGDYKCKIIRDSTSDRTLSLLNIRSGCDLYTNTIKPGQGYSFSVLGNDGIHKDVISSILEDTKIIDSSAIILSSPFVKHDYECHCAEGFMGKNCEKRQDPCSPNPCRYGGHCRKQGHDFLCTCPVRRDGKTCELEKNDVCSSSPCKNGGSCKESADGSSFFCLCRPGYRGNHCEALVDSCRPNPCLYGGICVSLKPGYKCSCSDGRYGTHCESTTFGFDELSYMQFPALDASTNDITIIFATTKPDALLLYNFGAQTGGRSDFIAIELLNGKPIFSFGGARTSITSVAISNPNKNLADGNWHKLTATRNGRVISLSTTSCTDHGDICMECEPGDDSCYNDDTGQAGTLNFNNEPLLIGGIHKADPLLERPGQVHSDDFVGCMHSITINGRLLNLSNPLNSRGVEANCGRSEKGTCYKKAMCGLGECIDRWKSNLCKCDGTFIAPDCSAALQSISVGETGLISFSISEKHRRMQLLDTFYSGNTMWEKHANKVLSKINTRTNSPAKMLSFLFRTHRKDGILFYAATEKYFTLIELHEGKVSYTSKQNSVVNMTQNEQNDVSDGTWHNITLLSFGRSIRLLVDNNDVGEELDAAGVHDFLDPYLTVMSLGGVKAELLMTSSQNKFEGCLANFSINNEIQPFAGNGSIFKETILKGKILNGCHSAFGIGAAQNPDPLRIGITLVIVFFVILLVAISVSIIFYRLRKQKKEKVGGSTGKMNAVHSKQNGGTSMSNAPNLIAGTNESLMNRGLHNNDTSLNSYISESVDITRNVGHIVGPELLSKKYKDREIMNIDPLRPQRPDIIEREVVGKSPALREDHHPPPPLSTNTSHHHDHPSGMDLNSEIPEHYDLENASSIAPSDIDIVYHYKGFREAANVRKYKATPPPLTGYHHKHQTPQHRHSPHHPGGYPSRVLQQASQPPPQPRQHQTTPLARLSPSSELSQQPRILTLHDISGKPLQSALLATTSSSGGVGKDALHSNSERSLNSPVMSQLSGQSSSAGRKTPSATPQVPQVVSVGSGAVGLTAEEIERMNARQRTSSLVSTLDAVSSSSEAQRGTGVGHHMSHRHHSPQDDNRSSTGSDDESGNDSFTCSEIEYDNNSINAEKLDDVRRPNVSNANNTKKSILPPPYESFDSSFRGSLSTLVASDDDLVPHVSSALYRQANGSPASAALGWDHLFNWRPNFESMIGVFKDIAELPDAVNGRMSSSLRLQNGTPKPSEEYV
Summary
Description
Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells (PubMed:11893338). This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor (PubMed:15548581). Also required for planar cell polarity of wing hairs (PubMed:12540853, PubMed:15240556). Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface (PubMed:15240556). Involved in regulation of eye imaginal disk size (PubMed:23667559). Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex (PubMed:16996265). Probably acts as a cell surface receptor for ds (PubMed:20434335).
Ft-mito: Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
May play a role in the interactions between neurites derived from specific subsets of neurons during development.
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation (By similarity).
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).
Calcium-dependent cell-adhesion protein.
Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:7601355, PubMed:26073018). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018).
Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells (PubMed:19906848, PubMed:23369713). Required for proper egg chamber shape and elongation of the egg chamber during oogenesis (PubMed:19906848, PubMed:23369713). Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation (PubMed:23369713).
Involved in the regulation of cell migration (PubMed:29053796). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (PubMed:12213440).
Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord.
Cadherins are calcium-dependent cell adhesion proteins (PubMed:25938815, PubMed:25850673). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:25938815, PubMed:25850673). Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (PubMed:26412237).
Isoform a is required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567, PubMed:12847081). Required for proper localization of other junctional components, such as hmp-1, hmp-2, jac-1 and pac-1 (PubMed:9531567, PubMed:25938815). Recruitment of pac-1 is required to establish cell polarity, independent of its role in cell adhesion (PubMed:25938815). Required for primodial germ cell ingression and adherence to endodermal cells during gastrulation (PubMed:20515680, PubMed:22675206).
Isoform b is involved in axonal guidance in a subset of motor neurons.
Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity).
Potential calcium-dependent cell-adhesion protein.
Cell adhesion protein involved in the control of epithelial morphogenesis (PubMed:9012534). Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development (PubMed:15960981).
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.
Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794). Essential for female fertility (PubMed:16260500, PubMed:16507588). Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597). Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597). Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597). Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992). May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992). Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992). In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523).
Ft-mito: Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
May play a role in the interactions between neurites derived from specific subsets of neurons during development.
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation (By similarity).
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).
Calcium-dependent cell-adhesion protein.
Required for normal morphogenesis of adult structures derived from imaginal disks (PubMed:7601355, PubMed:26073018). Plays a role in planar cell polarity and in determining body left-right asymmetry. Expression in segment H1 of the imaginal ring and interaction with Myo31DF are required to induce changes of cell shape and orientation in segment H2, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:26073018).
Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells (PubMed:19906848, PubMed:23369713). Required for proper egg chamber shape and elongation of the egg chamber during oogenesis (PubMed:19906848, PubMed:23369713). Required for the correct planar polarization of Rab10 within the basal follicle cell epithelium and is therefore indirectly involved in the Rab10-dependent remodeling of the basal membrane during egg chamber elongation (PubMed:23369713).
Involved in the regulation of cell migration (PubMed:29053796). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (PubMed:12213440).
Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity).
Involved in the fz signaling pathway that controls wing tissue polarity. Also mediates homophilic cell adhesion. May play a role in initiating prehair morphogenesis. May play a critical role in tissue polarity and in formation of normal dendrite fields.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).
Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord.
Cadherins are calcium-dependent cell adhesion proteins (PubMed:25938815, PubMed:25850673). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:25938815, PubMed:25850673). Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (PubMed:26412237).
Isoform a is required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567, PubMed:12847081). Required for proper localization of other junctional components, such as hmp-1, hmp-2, jac-1 and pac-1 (PubMed:9531567, PubMed:25938815). Recruitment of pac-1 is required to establish cell polarity, independent of its role in cell adhesion (PubMed:25938815). Required for primodial germ cell ingression and adherence to endodermal cells during gastrulation (PubMed:20515680, PubMed:22675206).
Isoform b is involved in axonal guidance in a subset of motor neurons.
Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity).
Potential calcium-dependent cell-adhesion protein.
Cell adhesion protein involved in the control of epithelial morphogenesis (PubMed:9012534). Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development (PubMed:15960981).
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.
Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794). Essential for female fertility (PubMed:16260500, PubMed:16507588). Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597). Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597). Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597). Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992). May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992). Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992). In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).
Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523).
Subunit
Interacts with Fbxl7 (PubMed:25107277). Ft-mito interacts with NADH dehydrogenase subunit ND-24 and with ATP synthase subunit ATPsynC (PubMed:25215488).
Heterophilic interaction with DCHS1; this interaction affects their respective protein levels. Interacts (via cytoplasmic domain) with MPDZ. Forms a complex with MPP5 and MPDZ.
antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (PubMed:19297620, PubMed:21436032).
Interacts with USH1C and USH1G (By similarity). antiparallel heterodimer with PCDH15. Isoform C1: Interacts with CAMSAP3; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180).
antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (By similarity).
Heterophilic interaction with FAT4; this interaction affects their respective protein levels.
Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH (By similarity). Interacts (via cytoplasmic domain) with CTNNB1 (By similarity).
Interacts (via cytoplasmic region) with Myo31DF.
Homodimer.
Monomer in solution (PubMed:20689042). Isoform a is a component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:20689042, PubMed:25850673). Isoform a interacts with hmp-2; the interaction is direct (PubMed:10952315, PubMed:20689042, PubMed:25850673, PubMed:26412237). Isoform a interacts (via intracellular domain) with jac-1 (PubMed:12847081, PubMed:25938815).
Antiparallel heterodimer with CDH23. Found in a complex with TMIE and LHFPL5. Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles. Interacts with MYO7A. Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane. Interacts with TOMT. Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus).
Antiparallel heterodimer with CDH23 (PubMed:23135401, PubMed:17805295). Found in a complex with TMIE and LHFPL5 (PubMed:25467981). Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with MYO7A (PubMed:16481439). Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with TOMT (PubMed:28504928). Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus) (PubMed:25114259).
Interacts with CTNNB1.
Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with MAST2 (By similarity). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (Probable).
Interacts (via the cytoplasmic domain) with ck (PubMed:25236597, PubMed:27331610). Interacts (via the cytoplasmic domain) with Cul1 and Ubr3 (PubMed:27331610).
Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins.
Heterophilic interaction with DCHS1; this interaction affects their respective protein levels. Interacts (via cytoplasmic domain) with MPDZ. Forms a complex with MPP5 and MPDZ.
antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (PubMed:19297620, PubMed:21436032).
Interacts with USH1C and USH1G (By similarity). antiparallel heterodimer with PCDH15. Isoform C1: Interacts with CAMSAP3; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180).
antiparallel heterodimer with PCDH15 (By similarity). Interacts with USH1C and USH1G (By similarity).
Heterophilic interaction with FAT4; this interaction affects their respective protein levels.
Interacts (via the C-terminus 4300-4400 AA) with ATN1. Interacts with RERE. Interacts (via EVH1 domains) with ENAH (By similarity). Interacts (via cytoplasmic domain) with CTNNB1 (By similarity).
Interacts (via cytoplasmic region) with Myo31DF.
Homodimer.
Monomer in solution (PubMed:20689042). Isoform a is a component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:20689042, PubMed:25850673). Isoform a interacts with hmp-2; the interaction is direct (PubMed:10952315, PubMed:20689042, PubMed:25850673, PubMed:26412237). Isoform a interacts (via intracellular domain) with jac-1 (PubMed:12847081, PubMed:25938815).
Antiparallel heterodimer with CDH23. Found in a complex with TMIE and LHFPL5. Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles. Interacts with MYO7A. Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane. Interacts with TOMT. Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus).
Antiparallel heterodimer with CDH23 (PubMed:23135401, PubMed:17805295). Found in a complex with TMIE and LHFPL5 (PubMed:25467981). Interacts with LHFPL5/TMHS; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with MYO7A (PubMed:16481439). Interacts with USH1G; this interaction may recruit USH1G to the plasma membrane (PubMed:21436032). Interacts with TOMT (PubMed:28504928). Isoforms CD1 and CD3 interact with TMC1 (via N-terminus) and TMC2 (via N-terminus) (PubMed:25114259).
Interacts with CTNNB1.
Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts with MAST2 (By similarity). Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR2 to microvilli tips and its function in brush border differentiation (Probable).
Interacts (via the cytoplasmic domain) with ck (PubMed:25236597, PubMed:27331610). Interacts (via the cytoplasmic domain) with Cul1 and Ubr3 (PubMed:27331610).
Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins.
Miscellaneous
The name 'fat' originates from weak mutant alleles that exhibit a broadening of the abdomen.
Overexpression in segment H1 of the imaginal ring causes aberrant gut looping in about 40% of the cases, but no phenotype is observed when both Myo31DF and ds are overexpressed.
Overexpression in segment H1 of the imaginal ring causes aberrant gut looping in about 40% of the cases, but no phenotype is observed when both Myo31DF and ds are overexpressed.
Similarity
Belongs to the G-protein coupled receptor 2 family.
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Keywords
Calcium
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Mitochondrion
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Alternative splicing
Deafness
Disease mutation
Mental retardation
Polymorphism
Developmental protein
Methylation
3D-structure
Hearing
Metal-binding
Non-syndromic deafness
Retinitis pigmentosa
Sensory transduction
Usher syndrome
Vision
Cytoplasm
Nucleus
Cell junction
Golgi apparatus
Neurodegeneration
Spinocerebellar ataxia
Direct protein sequencing
G-protein coupled receptor
Laminin EGF-like domain
Transducer
Hydroxylation
Differentiation
Neurogenesis
Ubl conjugation
Secreted
Chromosomal rearrangement
Cell projection
Epilepsy
Endosome
Immunity
Primary microcephaly
Feature
chain Cadherin-related tumor suppressor
splice variant In isoform 2.
sequence variant In dbSNP:rs6847454.
splice variant In isoform 2.
sequence variant In dbSNP:rs6847454.
Uniprot
P33450.3
Q6V0I7.2
Q2PZL6.2
Q8BNA6.2
Q9H251.2
Q8R508.1
+ More
Q99PF4.2 P58365.1 D4ACX8.2 Q14517.2 Q96JQ0.1 E9PVD3.1 Q6V1P9.1 Q8TDW7.3 Q24292.3 Q9NYQ8.2 Q9VW71.3 O88277.1 Q5F226.1 B8V7Q1.1 O15943.2 Q9V5N8.4 Q9R0M0.3 Q9HCU4.1 Q91ZI0.2 Q9NYQ7.2 O88278.1 O35161.3 Q9VGG5.4 Q9NYQ6.1 Q19319.3 Q967F4.1 Q96QU1.2 Q99PJ1.3 Q0ZM14.1 Q9BZA8.1 Q6WYY1.1 Q71M42.1 Q6WXV7.1 Q9BZA7.1 Q6X862.1 Q08174.2 Q6KEQ9.1 P34616.1 E9Q7P9.1 Q9HC56.2 Q5DRB1.1 Q9Y5G4.1 Q8BIZ0.3 Q8N6Y1.2 Q80TF3.3 Q9VJB6.3 Q9Y5F1.1 Q5DRB9.1 Q9Y5H4.1 Q9Y5F8.1 Q9Y5G1.4 O60330.1 Q9Y5G8.1 Q5DRA5.1 Q5DRC2.1 Q5DRB5.1 Q9Y5G0.1 Q9Y5I3.1 Q5DRD7.1 Q8TAB3.3 Q9Y5H3.1 O14917.2 Q5DRC1.1 Q9Y5I4.1 Q5DRF5.1 Q5DRA7.1 Q5DRE1.1 Q9VAF5.2 Q9NPG4.1 Q9UN71.1 Q5DRA8.1 Q5DRF3.1 Q9Y5I1.1 O60245.2 Q5DRA9.1 Q9Y5G2.1 Q5DRB0.1 Q91XZ4.1 Q9Y5G3.1 Q5DRD8.1 Q9P2E7.2 Q9Y5E1.2 Q9Y5F6.1 Q5DRA2.1 Q63418.1 Q5DRB6.1 Q5DRD9.1 Q9Y5H8.1 Q9Y5F2.1 Q9Y5H6.1 Q9Y5F9.1 Q5DRC4.1 Q9Y5G9.2 Q5DRE9.1
Q99PF4.2 P58365.1 D4ACX8.2 Q14517.2 Q96JQ0.1 E9PVD3.1 Q6V1P9.1 Q8TDW7.3 Q24292.3 Q9NYQ8.2 Q9VW71.3 O88277.1 Q5F226.1 B8V7Q1.1 O15943.2 Q9V5N8.4 Q9R0M0.3 Q9HCU4.1 Q91ZI0.2 Q9NYQ7.2 O88278.1 O35161.3 Q9VGG5.4 Q9NYQ6.1 Q19319.3 Q967F4.1 Q96QU1.2 Q99PJ1.3 Q0ZM14.1 Q9BZA8.1 Q6WYY1.1 Q71M42.1 Q6WXV7.1 Q9BZA7.1 Q6X862.1 Q08174.2 Q6KEQ9.1 P34616.1 E9Q7P9.1 Q9HC56.2 Q5DRB1.1 Q9Y5G4.1 Q8BIZ0.3 Q8N6Y1.2 Q80TF3.3 Q9VJB6.3 Q9Y5F1.1 Q5DRB9.1 Q9Y5H4.1 Q9Y5F8.1 Q9Y5G1.4 O60330.1 Q9Y5G8.1 Q5DRA5.1 Q5DRC2.1 Q5DRB5.1 Q9Y5G0.1 Q9Y5I3.1 Q5DRD7.1 Q8TAB3.3 Q9Y5H3.1 O14917.2 Q5DRC1.1 Q9Y5I4.1 Q5DRF5.1 Q5DRA7.1 Q5DRE1.1 Q9VAF5.2 Q9NPG4.1 Q9UN71.1 Q5DRA8.1 Q5DRF3.1 Q9Y5I1.1 O60245.2 Q5DRA9.1 Q9Y5G2.1 Q5DRB0.1 Q91XZ4.1 Q9Y5G3.1 Q5DRD8.1 Q9P2E7.2 Q9Y5E1.2 Q9Y5F6.1 Q5DRA2.1 Q63418.1 Q5DRB6.1 Q5DRD9.1 Q9Y5H8.1 Q9Y5F2.1 Q9Y5H6.1 Q9Y5F9.1 Q5DRC4.1 Q9Y5G9.2 Q5DRE9.1
Pubmed
1959133
10731132
12537572
11893338
12540853
15240556
+ More
15548581 16687445 16996265 18327897 18635802 19574458 20434335 23667559 25215488 25107277 15003449 15815621 12880961 14702039 17974005 16865240 24056717 24913602 19468303 16141072 15489334 15345747 16059920 18604206 19506035 21183079 21303848 17131403 24129315 11138009 12975309 15882574 15164054 11347906 11090341 11597768 21436032 19297620 12075507 12522556 15660226 15537665 15829536 16679490 17850630 18429043 22899989 24767429 24916380 28413019 28887846 11811999 11138008 11386759 11750125 17805295 27349180 20399731 20498078 23135401 15057822 8586420 15922730 18220336 19131340 19159218 19349973 21269460 26566883 29053796 9199196 26258302 16959974 16554811 7601355 26073018 10716726 9693030 15372022 16335952 17900869 18534823 12537569 19906848 23369713 12213440 15368895 22490231 23765379 9247265 9635189 10556066 10490098 10790539 11850187 10907856 16710414 9039502 18669648 11677057 16641997 16641100 9858697 9339365 17893096 10591208 22095531 9851916 12754521 17761667 17213328 9531567 11790304 10952315 12847081 15888633 20515680 20689042 22675206 25938815 26412237 25850673 11487575 11398101 14570705 18719945 16369489 22815625 28281779 11138007 16799054 16807332 11429292 16481439 17242355 23217710 25467981 25114259 28504928 15592404 11003707 12420223 12815422 14727141 17357069 16331680 10644456 15772651 10718198 8508762 21406692 24275569 15112107 7906398 9012534 15960981 26812017 15057823 16136131 15744052 10380929 12693553 11322959 9628581 18469813 11549318 20830798 19214208 19752159 20713952 21480887 21053371 21519002 22050978 22267240 25818041 26993267 27864847 17978184 15708564 16260500 16507588 24718992 25236597 25639794 27331610 11063261 21402705 27164683 28804758 9615233 19413330 20068231 23186163 11230163 27161523 8575755
15548581 16687445 16996265 18327897 18635802 19574458 20434335 23667559 25215488 25107277 15003449 15815621 12880961 14702039 17974005 16865240 24056717 24913602 19468303 16141072 15489334 15345747 16059920 18604206 19506035 21183079 21303848 17131403 24129315 11138009 12975309 15882574 15164054 11347906 11090341 11597768 21436032 19297620 12075507 12522556 15660226 15537665 15829536 16679490 17850630 18429043 22899989 24767429 24916380 28413019 28887846 11811999 11138008 11386759 11750125 17805295 27349180 20399731 20498078 23135401 15057822 8586420 15922730 18220336 19131340 19159218 19349973 21269460 26566883 29053796 9199196 26258302 16959974 16554811 7601355 26073018 10716726 9693030 15372022 16335952 17900869 18534823 12537569 19906848 23369713 12213440 15368895 22490231 23765379 9247265 9635189 10556066 10490098 10790539 11850187 10907856 16710414 9039502 18669648 11677057 16641997 16641100 9858697 9339365 17893096 10591208 22095531 9851916 12754521 17761667 17213328 9531567 11790304 10952315 12847081 15888633 20515680 20689042 22675206 25938815 26412237 25850673 11487575 11398101 14570705 18719945 16369489 22815625 28281779 11138007 16799054 16807332 11429292 16481439 17242355 23217710 25467981 25114259 28504928 15592404 11003707 12420223 12815422 14727141 17357069 16331680 10644456 15772651 10718198 8508762 21406692 24275569 15112107 7906398 9012534 15960981 26812017 15057823 16136131 15744052 10380929 12693553 11322959 9628581 18469813 11549318 20830798 19214208 19752159 20713952 21480887 21053371 21519002 22050978 22267240 25818041 26993267 27864847 17978184 15708564 16260500 16507588 24718992 25236597 25639794 27331610 11063261 21402705 27164683 28804758 9615233 19413330 20068231 23186163 11230163 27161523 8575755
EMBL
M80537
AE014134
AY356402
AC079835
AC092629
AC098865
+ More
AB075518 AK026709 AK291461 AL713715 DQ286572 AC122841 AC161228 AK031348 AK034552 BC079887 AC154406 AC154741 AC161370 AC161421 AC162903 BC117744 AK084245 AF312024 AY358617 AY563161 AY563162 AY563165 AY563166 AC012469 AL359183 AL731541 AL772287 BC011570 BC136976 BC136977 AB058715 AY010111 AB053445 AB076401 AF308939 AY026062 AY563159 AY563160 AY563163 AY563164 AK016365 AC079082 AC079818 AC079819 AC153517 AB053447 AABR06007653 X87241 AC107050 AC110761 AB053446 AB000895 AC121823 AY354497 AK000054 AK127704 AC079298 AC110608 AC110775 BC140919 AP000722 AP000805 AP002514 AP003171 AP003718 BC016722 AB076400 L08811 AAF51468.3 AF231022 AB011535 AL157443 AC011337 AC011374 AC034205 AE014296 AY060955 AY118666 AAL28503.1 AB011527 AL713870 CH466575 AK173031 AK132523 JT011093 AB002397 AF172329 AB028498 AE013599 AB028499 AF031573 AL671899 AL672200 CH466607 BC005499 AF234887 AB065955 AL390252 D87469 AF427498 AC168054 AF188752 AF231023 AC121252 AB011536 AB011528 AF031572 AC116764 AC139513 AE014297 AY128505 AF231024 AL021392 AL031588 AL031597 BC000059 Z35599 Z34802 Z35662 AF016854 AJ307058 Z82064 AL032638 Z82093 AY029205 AY029237 AY388963 EU718480 EU718481 EU718482 AL834134 AC013737 AC016817 AC024073 AC027671 AL353784 AL356114 AL360214 AL365496 AF281899 AY949849 DQ354396 DQ354397 DQ354398 DQ354399 DQ354400 DQ354401 DQ354402 DQ354403 DQ354404 DQ354405 DQ354406 DQ354407 DQ354408 DQ354409 DQ354410 DQ354411 DQ354412 DQ354413 DQ354414 DQ354415 DQ354416 DQ354417 DQ354418 AK139154 AK141024 AC108392 AC119894 AC121142 AC121602 AC121832 AC123032 AC123809 AC144802 AC147721 AC153858 AC158800 AC159477 AC186813 AC188091 CAAA01110489 HQ404375 HQ420254 DQ354419 DQ354420 DQ354421 DQ354422 DQ354423 DQ354424 DQ354425 DQ354426 DQ354427 DQ354428 DQ354429 AADN03005146 AADN02035256 AADN02035257 AADN02035258 AJ276803 AF277053 AF332216 AF332217 AJ564958 AJ564959 AJ564960 AJ564961 AJ564962 AJ564963 AJ564966 AJ564969 AY264487 AY264485 AY264486 AY264492 AY264489 AY264491 AY264490 AY264488 AF461067 AF461065 AF461066 AF461072 AF461069 AF461071 AF461070 AF461068 AY264879 AY264877 AY264878 AY264884 AY264881 AY264883 AY264882 AY264880 AB026187 AJ276804 AF332218 AF332219 AF206516 AF217288 AY861432 AY861433 AY861434 AY861435 AC004388 AL121869 AL133274 AL133321 AJ564931 AJ564932 AJ564933 AJ564934 AJ564935 AJ564936 AJ564942 AJ564945 AJ564946 AJ564947 AB037747 AY249903 AY249901 AY249902 AY249908 AY249904 AY249905 AY249906 AY249907 AC094107 CH471062 BC035812 L11369 L11370 AJ564972 AJ564973 AJ564974 AJ564975 FO080308 AK144400 AC162526 BC141301 BC145624 AF169692 AL834258 BX537422 AL603863 AL136999 AL355173 AL138814 BC136626 BC136627 AF152329 AF152516 BC132769 AK049965 AK083114 AC164553 AF169693 AK289924 AL833830 AL592490 CH471124 BC027907 AL713863 AK046726 AK122492 BT132666 AF152491 AF217746 AK293336 AK316160 AC005752 BC045637 AF152318 AF152507 BC112082 BC112084 AF152336 AF152523 BC051788 AF152332 AF152519 AC005366 AC005618 AC008781 BC150172 AF152321 AF152506 AB011160 AY358946 AB000897 AF152325 AF152512 BC104926 BC113460 AF152334 AF152521 BC093877 BC093879 AF152305 AF152479 AF169695 AC005609 EF676096 AL355593 CR749278 AB037734 AF152319 AF152503 AF029343 AK289980 AL445216 AL445288 BC028165 AF152304 AF152474 BC104776 BC105111 AY853687 AY853686 BT016059 AAV36944.1 AAX12107.1 AF231025 AF240635 AB026893 AK023785 AK024140 AK027282 AY358428 AF152333 AF152520 BC112088 BC113607 AB000896 AF152307 AF152476 AJ007609 BC136706 AB006755 AB006756 AB006757 AC097716 AC098595 AC107394 AC110766 AC112239 AF152331 AF152518 BC101805 AY013788 AC020974 AF152330 AF152517 BC103926 BC103927 AY013874 AB037821 AK314377 AC105383 CH471056 AF152502 AF217749 BC100672 BC105636 BC105640 AF282973 AF152339 AF152526 L43592 AF152311 AF152481 AF152490 AF217747 AK299719 BC112132 BC113611 AF152316 AF152486 BC136750 AF152335 AF152522 KC877131 AF152324 AF152511
AB075518 AK026709 AK291461 AL713715 DQ286572 AC122841 AC161228 AK031348 AK034552 BC079887 AC154406 AC154741 AC161370 AC161421 AC162903 BC117744 AK084245 AF312024 AY358617 AY563161 AY563162 AY563165 AY563166 AC012469 AL359183 AL731541 AL772287 BC011570 BC136976 BC136977 AB058715 AY010111 AB053445 AB076401 AF308939 AY026062 AY563159 AY563160 AY563163 AY563164 AK016365 AC079082 AC079818 AC079819 AC153517 AB053447 AABR06007653 X87241 AC107050 AC110761 AB053446 AB000895 AC121823 AY354497 AK000054 AK127704 AC079298 AC110608 AC110775 BC140919 AP000722 AP000805 AP002514 AP003171 AP003718 BC016722 AB076400 L08811 AAF51468.3 AF231022 AB011535 AL157443 AC011337 AC011374 AC034205 AE014296 AY060955 AY118666 AAL28503.1 AB011527 AL713870 CH466575 AK173031 AK132523 JT011093 AB002397 AF172329 AB028498 AE013599 AB028499 AF031573 AL671899 AL672200 CH466607 BC005499 AF234887 AB065955 AL390252 D87469 AF427498 AC168054 AF188752 AF231023 AC121252 AB011536 AB011528 AF031572 AC116764 AC139513 AE014297 AY128505 AF231024 AL021392 AL031588 AL031597 BC000059 Z35599 Z34802 Z35662 AF016854 AJ307058 Z82064 AL032638 Z82093 AY029205 AY029237 AY388963 EU718480 EU718481 EU718482 AL834134 AC013737 AC016817 AC024073 AC027671 AL353784 AL356114 AL360214 AL365496 AF281899 AY949849 DQ354396 DQ354397 DQ354398 DQ354399 DQ354400 DQ354401 DQ354402 DQ354403 DQ354404 DQ354405 DQ354406 DQ354407 DQ354408 DQ354409 DQ354410 DQ354411 DQ354412 DQ354413 DQ354414 DQ354415 DQ354416 DQ354417 DQ354418 AK139154 AK141024 AC108392 AC119894 AC121142 AC121602 AC121832 AC123032 AC123809 AC144802 AC147721 AC153858 AC158800 AC159477 AC186813 AC188091 CAAA01110489 HQ404375 HQ420254 DQ354419 DQ354420 DQ354421 DQ354422 DQ354423 DQ354424 DQ354425 DQ354426 DQ354427 DQ354428 DQ354429 AADN03005146 AADN02035256 AADN02035257 AADN02035258 AJ276803 AF277053 AF332216 AF332217 AJ564958 AJ564959 AJ564960 AJ564961 AJ564962 AJ564963 AJ564966 AJ564969 AY264487 AY264485 AY264486 AY264492 AY264489 AY264491 AY264490 AY264488 AF461067 AF461065 AF461066 AF461072 AF461069 AF461071 AF461070 AF461068 AY264879 AY264877 AY264878 AY264884 AY264881 AY264883 AY264882 AY264880 AB026187 AJ276804 AF332218 AF332219 AF206516 AF217288 AY861432 AY861433 AY861434 AY861435 AC004388 AL121869 AL133274 AL133321 AJ564931 AJ564932 AJ564933 AJ564934 AJ564935 AJ564936 AJ564942 AJ564945 AJ564946 AJ564947 AB037747 AY249903 AY249901 AY249902 AY249908 AY249904 AY249905 AY249906 AY249907 AC094107 CH471062 BC035812 L11369 L11370 AJ564972 AJ564973 AJ564974 AJ564975 FO080308 AK144400 AC162526 BC141301 BC145624 AF169692 AL834258 BX537422 AL603863 AL136999 AL355173 AL138814 BC136626 BC136627 AF152329 AF152516 BC132769 AK049965 AK083114 AC164553 AF169693 AK289924 AL833830 AL592490 CH471124 BC027907 AL713863 AK046726 AK122492 BT132666 AF152491 AF217746 AK293336 AK316160 AC005752 BC045637 AF152318 AF152507 BC112082 BC112084 AF152336 AF152523 BC051788 AF152332 AF152519 AC005366 AC005618 AC008781 BC150172 AF152321 AF152506 AB011160 AY358946 AB000897 AF152325 AF152512 BC104926 BC113460 AF152334 AF152521 BC093877 BC093879 AF152305 AF152479 AF169695 AC005609 EF676096 AL355593 CR749278 AB037734 AF152319 AF152503 AF029343 AK289980 AL445216 AL445288 BC028165 AF152304 AF152474 BC104776 BC105111 AY853687 AY853686 BT016059 AAV36944.1 AAX12107.1 AF231025 AF240635 AB026893 AK023785 AK024140 AK027282 AY358428 AF152333 AF152520 BC112088 BC113607 AB000896 AF152307 AF152476 AJ007609 BC136706 AB006755 AB006756 AB006757 AC097716 AC098595 AC107394 AC110766 AC112239 AF152331 AF152518 BC101805 AY013788 AC020974 AF152330 AF152517 BC103926 BC103927 AY013874 AB037821 AK314377 AC105383 CH471056 AF152502 AF217749 BC100672 BC105636 BC105640 AF282973 AF152339 AF152526 L43592 AF152311 AF152481 AF152490 AF217747 AK299719 BC112132 BC113611 AF152316 AF152486 BC136750 AF152335 AF152522 KC877131 AF152324 AF152511
Proteomes
PRIDE
P33450
Q6V0I7
Q2PZL6
Q8BNA6
Q9H251
Q8R508
+ More
Q99PF4 P58365 D4ACX8 Q14517 Q96JQ0 E9PVD3 Q6V1P9 Q8TDW7 Q24292 Q9NYQ8 Q9VW71 O88277 Q5F226 O15943 Q9V5N8 Q9R0M0 Q9HCU4 Q91ZI0 Q9NYQ7 O88278 O35161 Q9VGG5 Q9NYQ6 Q19319 Q967F4 Q96QU1 Q99PJ1 Q0ZM14 Q9BZA8 Q6WYY1 Q71M42 Q9BZA7 Q6X862 Q08174 Q6KEQ9 P34616 E9Q7P9 Q9HC56 Q5DRB1 Q9Y5G4 Q8BIZ0 Q8N6Y1 Q80TF3 Q9VJB6 Q9Y5F1 Q5DRB9 Q9Y5H4 Q9Y5F8 Q9Y5G1 O60330 Q9Y5G8 Q5DRA5 Q5DRC2 Q5DRB5 Q9Y5G0 Q9Y5I3 Q5DRD7 Q8TAB3 Q9Y5H3 O14917 Q5DRC1 Q9Y5I4 Q5DRA7 Q5DRE1 Q9VAF5 Q9NPG4 Q9UN71 Q5DRA8 Q9Y5I1 O60245 Q5DRA9 Q9Y5G2 Q5DRB0 Q91XZ4 Q9Y5G3 Q9P2E7 Q9Y5E1 Q9Y5F6 Q5DRA2 Q63418 Q5DRB6 Q9Y5H8 Q9Y5F2 Q9Y5H6 Q9Y5F9 Q5DRC4 Q9Y5G9
Q99PF4 P58365 D4ACX8 Q14517 Q96JQ0 E9PVD3 Q6V1P9 Q8TDW7 Q24292 Q9NYQ8 Q9VW71 O88277 Q5F226 O15943 Q9V5N8 Q9R0M0 Q9HCU4 Q91ZI0 Q9NYQ7 O88278 O35161 Q9VGG5 Q9NYQ6 Q19319 Q967F4 Q96QU1 Q99PJ1 Q0ZM14 Q9BZA8 Q6WYY1 Q71M42 Q9BZA7 Q6X862 Q08174 Q6KEQ9 P34616 E9Q7P9 Q9HC56 Q5DRB1 Q9Y5G4 Q8BIZ0 Q8N6Y1 Q80TF3 Q9VJB6 Q9Y5F1 Q5DRB9 Q9Y5H4 Q9Y5F8 Q9Y5G1 O60330 Q9Y5G8 Q5DRA5 Q5DRC2 Q5DRB5 Q9Y5G0 Q9Y5I3 Q5DRD7 Q8TAB3 Q9Y5H3 O14917 Q5DRC1 Q9Y5I4 Q5DRA7 Q5DRE1 Q9VAF5 Q9NPG4 Q9UN71 Q5DRA8 Q9Y5I1 O60245 Q5DRA9 Q9Y5G2 Q5DRB0 Q91XZ4 Q9Y5G3 Q9P2E7 Q9Y5E1 Q9Y5F6 Q5DRA2 Q63418 Q5DRB6 Q9Y5H8 Q9Y5F2 Q9Y5H6 Q9Y5F9 Q5DRC4 Q9Y5G9
Pfam
Interpro
IPR001881
EGF-like_Ca-bd_dom
+ More
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR002126 Cadherin-like_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR009030 Growth_fac_rcpt_cys_sf
IPR018097 EGF_Ca-bd_CS
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR033030 CDH23
IPR000233 Cadherin_cytoplasmic-dom
IPR039808 Cadherin
IPR027397 Catenin_binding_dom_sf
IPR032471 GAIN_dom_N
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001879 GPCR_2_extracellular_dom
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR038765 Papain-like_cys_pep_sf
IPR018247 EF_Hand_1_Ca_BS
IPR041149 EC_dom
IPR030718 Protocadherin-15
IPR013164 Cadherin_N
IPR013585 Protocadherin
IPR030276 CDHR2
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR030716 Protocadherin-19
IPR030736 PCDHGA1
IPR030740 PCDHA1
IPR030709 Protocadherin-17
IPR030726 PCDHAC2
IPR030720 Protocadherin-12
IPR030734 PCDHB11
IPR030712 Protocadherin-10
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR002126 Cadherin-like_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR009030 Growth_fac_rcpt_cys_sf
IPR018097 EGF_Ca-bd_CS
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR033030 CDH23
IPR000233 Cadherin_cytoplasmic-dom
IPR039808 Cadherin
IPR027397 Catenin_binding_dom_sf
IPR032471 GAIN_dom_N
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001879 GPCR_2_extracellular_dom
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR038765 Papain-like_cys_pep_sf
IPR018247 EF_Hand_1_Ca_BS
IPR041149 EC_dom
IPR030718 Protocadherin-15
IPR013164 Cadherin_N
IPR013585 Protocadherin
IPR030276 CDHR2
IPR032455 Cadherin_C
IPR031904 Cadherin_CBD
IPR030716 Protocadherin-19
IPR030736 PCDHGA1
IPR030740 PCDHA1
IPR030709 Protocadherin-17
IPR030726 PCDHAC2
IPR030720 Protocadherin-12
IPR030734 PCDHB11
IPR030712 Protocadherin-10
SUPFAM
Gene 3D
ProteinModelPortal
P33450.3
Q6V0I7.2
Q2PZL6.2
Q8BNA6.2
Q9H251.2
Q8R508.1
+ More
Q99PF4.2 P58365.1 D4ACX8.2 Q14517.2 Q96JQ0.1 E9PVD3.1 Q6V1P9.1 Q8TDW7.3 Q24292.3 Q9NYQ8.2 Q9VW71.3 O88277.1 Q5F226.1 B8V7Q1.1 O15943.2 Q9V5N8.4 Q9R0M0.3 Q9HCU4.1 Q91ZI0.2 Q9NYQ7.2 O88278.1 O35161.3 Q9VGG5.4 Q9NYQ6.1 Q19319.3 Q967F4.1 Q96QU1.2 Q99PJ1.3 Q0ZM14.1 Q9BZA8.1 Q6WYY1.1 Q71M42.1 Q6WXV7.1 Q9BZA7.1 Q6X862.1 Q08174.2 Q6KEQ9.1 P34616.1 E9Q7P9.1 Q9HC56.2 Q5DRB1.1 Q9Y5G4.1 Q8BIZ0.3 Q8N6Y1.2 Q80TF3.3 Q9VJB6.3 Q9Y5F1.1 Q5DRB9.1 Q9Y5H4.1 Q9Y5F8.1 Q9Y5G1.4 O60330.1 Q9Y5G8.1 Q5DRA5.1 Q5DRC2.1 Q5DRB5.1 Q9Y5G0.1 Q9Y5I3.1 Q5DRD7.1 Q8TAB3.3 Q9Y5H3.1 O14917.2 Q5DRC1.1 Q9Y5I4.1 Q5DRF5.1 Q5DRA7.1 Q5DRE1.1 Q9VAF5.2 Q9NPG4.1 Q9UN71.1 Q5DRA8.1 Q5DRF3.1 Q9Y5I1.1 O60245.2 Q5DRA9.1 Q9Y5G2.1 Q5DRB0.1 Q91XZ4.1 Q9Y5G3.1 Q5DRD8.1 Q9P2E7.2 Q9Y5E1.2 Q9Y5F6.1 Q5DRA2.1 Q63418.1 Q5DRB6.1 Q5DRD9.1 Q9Y5H8.1 Q9Y5F2.1 Q9Y5H6.1 Q9Y5F9.1 Q5DRC4.1 Q9Y5G9.2 Q5DRE9.1
Q99PF4.2 P58365.1 D4ACX8.2 Q14517.2 Q96JQ0.1 E9PVD3.1 Q6V1P9.1 Q8TDW7.3 Q24292.3 Q9NYQ8.2 Q9VW71.3 O88277.1 Q5F226.1 B8V7Q1.1 O15943.2 Q9V5N8.4 Q9R0M0.3 Q9HCU4.1 Q91ZI0.2 Q9NYQ7.2 O88278.1 O35161.3 Q9VGG5.4 Q9NYQ6.1 Q19319.3 Q967F4.1 Q96QU1.2 Q99PJ1.3 Q0ZM14.1 Q9BZA8.1 Q6WYY1.1 Q71M42.1 Q6WXV7.1 Q9BZA7.1 Q6X862.1 Q08174.2 Q6KEQ9.1 P34616.1 E9Q7P9.1 Q9HC56.2 Q5DRB1.1 Q9Y5G4.1 Q8BIZ0.3 Q8N6Y1.2 Q80TF3.3 Q9VJB6.3 Q9Y5F1.1 Q5DRB9.1 Q9Y5H4.1 Q9Y5F8.1 Q9Y5G1.4 O60330.1 Q9Y5G8.1 Q5DRA5.1 Q5DRC2.1 Q5DRB5.1 Q9Y5G0.1 Q9Y5I3.1 Q5DRD7.1 Q8TAB3.3 Q9Y5H3.1 O14917.2 Q5DRC1.1 Q9Y5I4.1 Q5DRF5.1 Q5DRA7.1 Q5DRE1.1 Q9VAF5.2 Q9NPG4.1 Q9UN71.1 Q5DRA8.1 Q5DRF3.1 Q9Y5I1.1 O60245.2 Q5DRA9.1 Q9Y5G2.1 Q5DRB0.1 Q91XZ4.1 Q9Y5G3.1 Q5DRD8.1 Q9P2E7.2 Q9Y5E1.2 Q9Y5F6.1 Q5DRA2.1 Q63418.1 Q5DRB6.1 Q5DRD9.1 Q9Y5H8.1 Q9Y5F2.1 Q9Y5H6.1 Q9Y5F9.1 Q5DRC4.1 Q9Y5G9.2 Q5DRE9.1
PDB
6E6B
E-value=6.95453e-56,
Score=558
Ontologies
PATHWAY
GO
GO:0005739
GO:0044331
GO:0018149
GO:0098609
GO:0045296
GO:0045570
GO:0035209
GO:0090251
GO:0016339
GO:0007164
GO:0035332
GO:0048105
GO:0045198
GO:0001736
GO:0016324
GO:0045317
GO:0046621
GO:0016021
GO:0040008
GO:0045571
GO:0007156
GO:0005886
GO:0090176
GO:0060071
GO:0001737
GO:0007157
GO:0005509
GO:0016327
GO:0032880
GO:0045926
GO:0009888
GO:0016336
GO:0000904
GO:0010629
GO:0005887
GO:0008285
GO:0007446
GO:0043065
GO:0035220
GO:0007476
GO:0042067
GO:0035159
GO:0007447
GO:0008283
GO:0003007
GO:0060122
GO:0008543
GO:0072307
GO:0043931
GO:0035329
GO:0007009
GO:0022008
GO:0045177
GO:0072137
GO:0001658
GO:0021987
GO:0048565
GO:0070062
GO:0007219
GO:0072006
GO:0001822
GO:0030425
GO:2000171
GO:0001764
GO:0010842
GO:0050953
GO:0051480
GO:0050957
GO:0007626
GO:0045494
GO:0006816
GO:0032420
GO:0007601
GO:0050896
GO:0016020
GO:0007605
GO:0007275
GO:0005813
GO:0045202
GO:0048563
GO:0042491
GO:0042472
GO:0032426
GO:0048839
GO:0047485
GO:0060091
GO:0098684
GO:0060088
GO:0098683
GO:0007155
GO:0001917
GO:0005911
GO:0003192
GO:0072659
GO:0090102
GO:0007389
GO:0003273
GO:0021915
GO:0036342
GO:0007267
GO:0030027
GO:0048593
GO:0048471
GO:0045197
GO:0016477
GO:0007015
GO:0030175
GO:0009653
GO:0003382
GO:0007163
GO:0005925
GO:0005634
GO:0003183
GO:0030054
GO:0035331
GO:0005794
GO:0031589
GO:0010631
GO:0005913
GO:0050829
GO:1902463
GO:0060269
GO:0007431
GO:0031254
GO:0007442
GO:0045089
GO:0007424
GO:0042247
GO:0009925
GO:0050839
GO:0044877
GO:0098858
GO:0048477
GO:0051491
GO:0007295
GO:0007440
GO:0030950
GO:0007412
GO:0042803
GO:0045467
GO:0007413
GO:0007411
GO:0048841
GO:0030424
GO:0031290
GO:0048814
GO:0048846
GO:0050774
GO:0016318
GO:0048675
GO:0008013
GO:0045463
GO:0048813
GO:0004888
GO:0050770
GO:0016319
GO:0051963
GO:0016358
GO:0001738
GO:1902669
GO:0070593
GO:0007409
GO:0090175
GO:0007464
GO:0004930
GO:0045773
GO:0007367
GO:0048057
GO:0003341
GO:0021591
GO:0021999
GO:0060271
GO:0033326
GO:0006355
GO:0016055
GO:0022407
GO:0005737
GO:0007186
GO:0001932
GO:0036514
GO:0036515
GO:1904938
GO:0007266
GO:0060488
GO:0001942
GO:0001843
GO:0042060
GO:0001702
GO:0046983
GO:0009952
GO:0007165
GO:0060490
GO:0090179
GO:0046928
GO:0042249
GO:0060489
GO:0045176
GO:0032956
GO:0005654
GO:0007417
GO:0097402
GO:0007399
GO:0007369
GO:0007016
GO:0042074
GO:0003384
GO:0044214
GO:0030866
GO:0000132
GO:0016342
GO:0009792
GO:0070097
GO:0005615
GO:0001750
GO:0005576
GO:0001964
GO:0007628
GO:0032421
GO:0050910
GO:0051017
GO:0060013
GO:1905515
GO:0035264
GO:0051592
GO:0050973
GO:0002009
GO:0098981
GO:0098793
GO:0061827
GO:0030177
GO:0097225
GO:0007283
GO:0010923
GO:0043231
GO:0005730
GO:0045138
GO:0016331
GO:0005604
GO:0034769
GO:0005198
GO:0016323
GO:0005903
GO:0031528
GO:0030855
GO:0031526
GO:0090675
GO:0060243
GO:0032532
GO:0030426
GO:0044291
GO:0003723
GO:0007420
GO:0005783
GO:0099560
GO:0050805
GO:1904071
GO:2000807
GO:0099055
GO:0099056
GO:0098982
GO:0098978
GO:0030534
GO:0032529
GO:0032533
GO:2000370
GO:0002385
GO:0007304
GO:0019722
GO:0035239
GO:0010008
GO:0005902
GO:0017022
GO:0007305
GO:0060711
GO:0008038
GO:0005977
GO:0002576
GO:0031092
GO:0042802
GO:0009988
GO:0007416
GO:0007268
GO:0050808
GO:0005515
GO:0008237
GO:0043401
GO:0003707
GO:0051537
PANTHER
Topology
Subcellular location
Cell membrane
Apical cell membrane
Mitochondrion
Membrane In the kidney, localizes to primary cilia. With evidence from 1 publications.
Nucleus
Cytoplasm
Perinuclear region
Cell junction Colocalizes with Myo32DF at cell contact sites. With evidence from 5 publications.
Golgi apparatus Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. With evidence from 9 publications.
trans-Golgi network Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. With evidence from 9 publications.
Adherens junction The basal to apical translocation from the cell membrane to adherens junctions is determined by the coupled sumoylation and desumoylation state of hmr-1. With evidence from 17 publications.
Secreted
Basolateral cell membrane
Cell projection
Microvillus membrane
Endosome membrane Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil. With evidence from 10 publications.
Apical cell membrane
Mitochondrion
Membrane In the kidney, localizes to primary cilia. With evidence from 1 publications.
Nucleus
Cytoplasm
Perinuclear region
Cell junction Colocalizes with Myo32DF at cell contact sites. With evidence from 5 publications.
Golgi apparatus Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. With evidence from 9 publications.
trans-Golgi network Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. With evidence from 9 publications.
Adherens junction The basal to apical translocation from the cell membrane to adherens junctions is determined by the coupled sumoylation and desumoylation state of hmr-1. With evidence from 17 publications.
Secreted
Basolateral cell membrane
Cell projection
Microvillus membrane
Endosome membrane Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil. With evidence from 10 publications.
Length:
3163
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
22.9434099999999
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00002
outside
1 - 2618
TMhelix
2619 - 2641
inside
2642 - 3163
Population Genetic Test Statistics
Pi
24.773933
Theta
23.304711
Tajima's D
0.125106
CLR
0.644465
CSRT
0.4034798260087
Interpretation
Uncertain
