Gene

KWMTBOMO07268

Pre Gene Modal

BGIBMGA010597

Annotation

PREDICTED:_cadherin-related_tumor_suppressor-like?_partial_[Bombyx_mori]

Location

Bomo_Chr12(+):9554612-9556086      View in EpiBrowser

Full name

Cadherin-related tumor suppressor      

Alternative Name

Protein fat

Location in the cell

Extracellular   Reliability : 0.978

CDS

ATGACGAGGATGTGGCGATGGCACGTGGCGCTGGCGGTGCTGGCGCTGCTGGGTGGCGCAGGCGTGACCGCCGTCGCCGAGCAGATGCAGTCGCGCGCCGCCGACACCGGTGTCGATCTTCGAGTCCCCGAGGATCAACCGATCGGTACTCTTGTCGGTAGGATTCCAATTAAGCCTGGCTTCACGTACCGTTTTAATGAGCCTCCCAAAGAATTTGTTCTCGACCCTGTATCTGGCGAGATAAGGACGAATGTAGTGCTGGACCGGGAAACTGTTGATCGCTATGCGTTCGTGGTGCTCTCAAGTCAGCCCACGTATCCTATAGAAGTGCGATTAAGGGTAACGGATGTAAACGATAATTACCCAGAGTTCCCGGAACCTAGTATCGGTGTGACGTTATCGGAAAGTACAGCTGCGGGAACTAAGCTTCTTCTCGATGCAGCGACTGATAAGGATTTAGGTGAGAATGGTATCACTAATGACTACAGAATAATAGACGGCGACACTGAAGGGAAATTTAGACTGAACGTTACCGTTAATCCGAGCGGTCAGACTTCTTATTTGCATTTAGAAACTACAGGAAAACTAGACAGAGAAACAACAGATTTTTACGTGTTAAACATCTCTGCCCGCGATGGCGGTAATCCTCCGAAATTTGGATACCTTCAAGTGAATGTTAGCATATTGGATGTAAACGACAACCCGCCTATATTCGACCAAAGTGATTTCTCTGTGTCGTTGAATGAGAGCGTGCCTCCTGGAACCACTGTCTTAAAAGTAACAGCCACTGATAATGATTTAGGAGACAATAGTAAAATTACGTACGAGGTCATGGACACAGAAAAACAGTTCGCCGTAGATCCTGAATCGGGCGTGATAACAACTAGTAGAATATTAAACTGTCCTAAATATTGTAGTAATGCTACATGTAACATGACATGTGTATTGACAGTCATAGCTAAAGATCACGGTGTACCACGACAAGATGCCCGGACTTATTCGATGAAAATGCCAAGAATGGGTCACTTGTTGCCGCCATCACTGTTACTGATTTGGATGCCGGCTTGA

Protein

MTRMWRWHVALAVLALLGGAGVTAVAEQMQSRAADTGVDLRVPEDQPIGTLVGRIPIKPGFTYRFNEPPKEFVLDPVSGEIRTNVVLDRETVDRYAFVVLSSQPTYPIEVRLRVTDVNDNYPEFPEPSIGVTLSESTAAGTKLLLDAATDKDLGENGITNDYRIIDGDTEGKFRLNVTVNPSGQTSYLHLETTGKLDRETTDFYVLNISARDGGNPPKFGYLQVNVSILDVNDNPPIFDQSDFSVSLNESVPPGTTVLKVTATDNDLGDNSKITYEVMDTEKQFAVDPESGVITTSRILNCPKYCSNATCNMTCVLTVIAKDHGVPRQDARTYSMKMPRMGHLLPPSLLLIWMPA

Description

Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells (PubMed:11893338). This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor (PubMed:15548581). Also required for planar cell polarity of wing hairs (PubMed:12540853, PubMed:15240556). Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface (PubMed:15240556). Involved in regulation of eye imaginal disk size (PubMed:23667559). Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex (PubMed:16996265). Probably acts as a cell surface receptor for ds (PubMed:20434335).
Ft-mito: Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.

Subunit

Interacts with Fbxl7 (PubMed:25107277). Ft-mito interacts with NADH dehydrogenase subunit ND-24 and with ATP synthase subunit ATPsynC (PubMed:25215488).

Miscellaneous

The name 'fat' originates from weak mutant alleles that exhibit a broadening of the abdomen.

Keywords

Calcium   Cell adhesion   Cell membrane   Complete proteome   Disulfide bond   EGF-like domain   Glycoprotein   Membrane   Mitochondrion   Phosphoprotein   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Cadherin-related tumor suppressor

Uniprot

H9JM45   A0A2A4JGB0   A0A194R096   A0A0L7LEK0   A0A212EWJ7   A0A194PIG7   + More
A0A1B0BXS9   A0A139WIU3   A0A1W4WS50   A0A2P8XK47   U4UMJ9   A0A0K8WIK8   A0A0K8WGR0   A0A1J1ILU1   A0A1B0D4J3   W8BM12   A0A182GBS5   W8BXI0   A0A0L0C4R4   B0W5P9   A0A1A9W0F1   A0A1A9XH88   A0A067RK74   A0A1A9UMV7   A0A1B0BXS8   A0A1A9ZJ37   B4N0N1   A0A182JZ92   A0A182PJ70   N6UFF5   A0A1B0FNU6   A0A182MKD8   A0A182F4L6   A0A182UAH5   A0A0M4E2E8   A0A182W7V5   A0A182VN95   A0A182WT87   B4I369   A0A182HV80   A0A182RBM1   A0A182SG56   W5J9S7   A0A182Q423   P33450   A0A0J9QVG6   A0A182YGU6   B3N3P8   A0A182IV90   A0A2R7WSJ6   A0A1W4UQG6   A0A1S4GXD7   A0A3B0JEL3   Q7Q3K5   B3MLP3   B4NYI2   Q29NP3   T1I617   A0A1I8MY28   A0A1I8P2A4   B4MDC5   A0A0M8ZZC1   E9IY59   B4JD41   A0A2A3ENR6   A0A2A3EQA1   A0A195D170   A0A0L7RBN5   E1ZWJ5   A0A088A7Z0   A0A195ERJ8   E2C5B8   E9HFS0   A0A0J7NXR0   A0A3L8DKB9   F4WQR0   A0A195BRJ0   A0A0P5CCQ8   A0A158NRY6   A0A0N8D072   A0A0P6J127   A0A0P5ZTU5   A0A0P4YMD5   A0A0P5B7A8   A0A0P5B1P8   A0A0P4YB10   A0A0P4XXI2   A0A0P5U2L5   A0A0P4ZCX0   A0A0N7ZFF4   A0A0P4YSZ5   A0A195D885   A0A151X3F5   E0VP03   K7ILV2   A0A3Q0JFL9   Q0IF47   A0A182L245   B7P9Y6   A0A1D2MXS1  

Pubmed

19121390    26354079    26227816    22118469    18362917    19820115    + More
29403074    23537049    24495485    26483478    26108605    24845553    17994087    20920257    23761445    1959133    10731132    12537572    11893338    12540853    15240556    15548581    16687445    16996265    18327897    18635802    19574458    20434335    23667559    25215488    25107277    22936249    25244985    12364791    17550304    15632085    23185243    25315136    21282665    20798317    21292972    30249741    21719571    21347285    20566863    20075255    17510324    20966253    27289101   

EMBL

BABH01039937    BABH01039938    NWSH01001485    PCG71107.1    KQ460883    KPJ11122.1    + More
JTDY01001533    KOB73626.1    AGBW02011969    OWR45849.1    KQ459603    KPI92843.1    JXJN01022342    KQ971338    KYB27849.1    PYGN01001873    PSN32381.1    KB632278    ERL91250.1    GDHF01001397    JAI50917.1    GDHF01002047    JAI50267.1    CVRI01000054    CRL00722.1    AJVK01003260    GAMC01008527    JAB98028.1    JXUM01052978    KQ561757    KXJ77618.1    GAMC01008529    JAB98026.1    JRES01000986    KNC26429.1    DS231844    EDS35702.1    KK852424    KDR24197.1    CH963920    EDW77644.1    APGK01029087    APGK01029088    APGK01029089    APGK01029090    APGK01029091    APGK01029092    APGK01029093    APGK01029094    APGK01029095    APGK01029096    KB740724    ENN79361.1    CCAG010009664    AXCM01006694    CP012523    ALC39766.1    CH480820    EDW54214.1    APCN01002500    ADMH02001962    ETN60163.1    AXCN02000871    M80537    AE014134    CM002910    KMY88033.1    CH954177    EDV57707.2    KK855429    PTY22532.1    AAAB01008964    OUUW01000004    SPP79093.1    EAA12848.4    CH902620    EDV30764.2    CM000157    EDW87615.2    CH379059    EAL34175.3    KRT03716.1    ACPB03003610    CH940661    EDW71186.2    KQ435793    KOX74190.1    GL766908    EFZ14511.1    CH916368    EDW04285.1    KZ288203    PBC33405.1    PBC33406.1    KQ977041    KYN06149.1    KQ414617    KOC68171.1    GL434853    EFN74432.1    KQ981993    KYN30880.1    GL452770    EFN76851.1    GL732637    EFX69368.1    LBMM01000928    KMQ97200.1    QOIP01000007    RLU20895.1    GL888275    EGI63423.1    KQ976424    KYM88569.1    GDIP01188458    JAJ34944.1    ADTU01024312    ADTU01024313    ADTU01024314    ADTU01024315    ADTU01024316    ADTU01024317    ADTU01024318    ADTU01024319    ADTU01024320    ADTU01024321    GDIP01081671    JAM22044.1    GDIQ01001375    JAN93362.1    GDIP01039529    JAM64186.1    GDIP01225206    JAI98195.1    GDIP01188459    JAJ34943.1    GDIP01191058    JAJ32344.1    GDIP01231006    JAI92395.1    GDIP01236656    JAI86745.1    GDIP01120565    JAL83149.1    GDIP01227607    JAI95794.1    GDIP01250705    JAI72696.1    GDIP01227606    JAI95795.1    KQ981153    KYN09067.1    KQ982562    KYQ54945.1    DS235354    EEB15109.1    CH477394    EAT41892.1    ABJB010022594    ABJB010731548    ABJB010823282    ABJB010823901    ABJB010839736    DS668046    EEC03408.1    LJIJ01000407    ODM97827.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000037510    UP000007151    UP000053268    + More
UP000092460    UP000007266    UP000192223    UP000245037    UP000030742    UP000183832    UP000092462    UP000069940    UP000249989    UP000037069    UP000002320    UP000091820    UP000092443    UP000027135    UP000078200    UP000092445    UP000007798    UP000075881    UP000075885    UP000019118    UP000092444    UP000075883    UP000069272    UP000075902    UP000092553    UP000075920    UP000075903    UP000076407    UP000001292    UP000075840    UP000075900    UP000075901    UP000000673    UP000075886    UP000000803    UP000076408    UP000008711    UP000075880    UP000192221    UP000268350    UP000007062    UP000007801    UP000002282    UP000001819    UP000015103    UP000095301    UP000095300    UP000008792    UP000053105    UP000001070    UP000242457    UP000078542    UP000053825    UP000000311    UP000005203    UP000078541    UP000008237    UP000000305    UP000036403    UP000279307    UP000007755    UP000078540    UP000005205    UP000078492    UP000075809    UP000009046    UP000002358    UP000079169    UP000008820    UP000075882    UP000001555    UP000094527   

PRIDE

H9JM45    P33450   

Pfam

PF00028   Cadherin        + More
PF00054   Laminin_G_1
PF00008   EGF
PF02210   Laminin_G_2

Interpro

IPR002126   Cadherin-like_dom        + More
IPR020894   Cadherin_CS       
IPR015919   Cadherin-like_sf       
IPR013320   ConA-like_dom_sf       
IPR013032   EGF-like_CS       
IPR001791   Laminin_G       
IPR000742   EGF-like_dom       
IPR001881   EGF-like_Ca-bd_dom       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       

SUPFAM

SSF49313   SSF49313        + More
SSF49899   SSF49899       

ProteinModelPortal

H9JM45   A0A2A4JGB0   A0A194R096   A0A0L7LEK0   A0A212EWJ7   A0A194PIG7   + More
A0A1B0BXS9   A0A139WIU3   A0A1W4WS50   A0A2P8XK47   U4UMJ9   A0A0K8WIK8   A0A0K8WGR0   A0A1J1ILU1   A0A1B0D4J3   W8BM12   A0A182GBS5   W8BXI0   A0A0L0C4R4   B0W5P9   A0A1A9W0F1   A0A1A9XH88   A0A067RK74   A0A1A9UMV7   A0A1B0BXS8   A0A1A9ZJ37   B4N0N1   A0A182JZ92   A0A182PJ70   N6UFF5   A0A1B0FNU6   A0A182MKD8   A0A182F4L6   A0A182UAH5   A0A0M4E2E8   A0A182W7V5   A0A182VN95   A0A182WT87   B4I369   A0A182HV80   A0A182RBM1   A0A182SG56   W5J9S7   A0A182Q423   P33450   A0A0J9QVG6   A0A182YGU6   B3N3P8   A0A182IV90   A0A2R7WSJ6   A0A1W4UQG6   A0A1S4GXD7   A0A3B0JEL3   Q7Q3K5   B3MLP3   B4NYI2   Q29NP3   T1I617   A0A1I8MY28   A0A1I8P2A4   B4MDC5   A0A0M8ZZC1   E9IY59   B4JD41   A0A2A3ENR6   A0A2A3EQA1   A0A195D170   A0A0L7RBN5   E1ZWJ5   A0A088A7Z0   A0A195ERJ8   E2C5B8   E9HFS0   A0A0J7NXR0   A0A3L8DKB9   F4WQR0   A0A195BRJ0   A0A0P5CCQ8   A0A158NRY6   A0A0N8D072   A0A0P6J127   A0A0P5ZTU5   A0A0P4YMD5   A0A0P5B7A8   A0A0P5B1P8   A0A0P4YB10   A0A0P4XXI2   A0A0P5U2L5   A0A0P4ZCX0   A0A0N7ZFF4   A0A0P4YSZ5   A0A195D885   A0A151X3F5   E0VP03   K7ILV2   A0A3Q0JFL9   Q0IF47   A0A182L245   B7P9Y6   A0A1D2MXS1  

PDB

5T9T     E-value=4.98016e-29,     Score=318

KEGG

101743456    K16669 protocadherin Fat 4 | (RefSeq) cadherin-related tumor suppressor-like

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)
04392    Hippo signaling pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0007156   GO:0005886   GO:0005509   GO:0016021   GO:0098609   GO:0005911   GO:0045198   GO:0048105   GO:0045317   GO:0035209   GO:0016339   GO:0090251   GO:0035332   GO:0044331   GO:0018149   GO:0045296   GO:0007447   GO:0035159   GO:0008283   GO:0005887   GO:0010629   GO:0008285   GO:0043065   GO:0007446   GO:0016327   GO:0016336   GO:0032880   GO:0000904   GO:0090176   GO:0045571   GO:0001737   GO:0007157   GO:0045570   GO:0005739   GO:0001736   GO:0046621   GO:0016324   GO:0007164   GO:0045926   GO:0009888   GO:0060071   GO:0040008   GO:0042067   GO:0007476   GO:0035220   GO:0008353   GO:0004693   GO:0004022   GO:0007155   GO:0016020   GO:0006508   GO:0008237   GO:0043401   GO:0003707   GO:0051537  

Subcellular location

Cell membrane  
Apical cell membrane  
Mitochondrion  

SignalP

Position:   1 - 24,         Likelihood:  0.988360

 

 

Length:

355

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.08842

Exp number, first 60 AAs:

20.07774

Total prob of N-in:

0.97145

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  355

 

 

Pi

8.310385

Theta

6.956201

Tajima's D

0.868534

CLR

0.221918

CSRT

0.644067796610169

Interpretation

Uncertain