Silkworm Genome Informatics Database

Gene

KWMTBOMO07263 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010595

Annotation

PREDICTED:_hsc70-interacting_protein-like_[Papilio_machaon]

Location

Bomo_Chr12(+):9490452-9496736 View in EpiBrowser

Full name

Hsc70-interacting protein

Alternative Name

Protein FAM10A1
Protein ST13 homolog

Location in the cell

Nuclear Reliability : 2.573

CDS

ATGAGTTGCCCGTACAACGCTGAGCAATTAGACCAGTTGAAATCCTTTGTGGAAATATGTAAAACACAGCCGCAACTATTACACCATCCACAATTGGCGTTTTTTAAGGATTATCTGATATCTCTTGGTGTATCATTGCCGACCGCTACTTTTGGTGCCAAAGATTTTACGGCTGCTGGTGATAAAAAATCTAGCAATGAAGAAAAAGTGGAATCGTCATCTGACGAGGAACAGGAGCCTGAATCAGATGTAGAATTAGATATGGAAGGTGTCATAGCTCCTGATCAAACAGACGAATCTCAAGACATGGGTGATCCAAACAAGGAGGTCACTGAAGAAGAAAGAGATGAGTCAGATGAAAAGCGCTCTGAAGCAATGAGAGCATTCTCGGAACAAAAATACGACGAAGCTATTAATCTATATACTGCAGCCATACAATTAAATCCACAGAGTGCTTTGTTGTTTGCTAAACGGGGACAGGTGTATCTAAAACTAAACAAACCAAATGCATGTATTAAAGACTGCACACATGCCTTAGAGTTGAACTGTGACAGCGCAGCTGCCTACAAATTCCGAGGGCGAGCATATAGGCTCTTGGGTAAATTTGAAGAATCTTCCCACGATCTTTGTGAATCTTTAAAGATTGACTATGATGATCAAACAAATGAGTGGCTTAATGAAGTTAAACCAAATGCTGAAAAATTACGTCAACACAAATTAAGTGCCCAACGTAAAAAAGAGGAGAAAGAGCATAGAGAGAAATTACGCAGAGCCCGTAAAGCACAGGAAGCAAGAGCACGTGCTGCTCAGGCCCAAGCCAATGCTGCAGCTGGTGCAACACCCGGGGATTTCCCTGGCTTCCCTGGAGGCATGCCTAATGTCCCTGGTGGTATGCCTGCTGGTGTAAATCTGGATGACTTCAATGACATGTTCCTGGATCCAGAAATTATGGCAGCATTCCAGGATCCTGAAATATCTGCAGCATTCAAAGATGTTACAAGTAATCCAGCAAATTTCATTAAATATCAGAACAATCCTAAAATTGCTGCTGTTATAGCTAAATTACAAGCGAAACTTGGTAGACGTTCTGGTGGACCTGCGGGCGGCTTTCCAGGTTTTGGTGGACCCAAACCTGGCGCTGGACCACGGTCGTCCGCCGATGATGACGTCGGACTTGATTAA

Protein

MSCPYNAEQLDQLKSFVEICKTQPQLLHHPQLAFFKDYLISLGVSLPTATFGAKDFTAAGDKKSSNEEKVESSSDEEQEPESDVELDMEGVIAPDQTDESQDMGDPNKEVTEEERDESDEKRSEAMRAFSEQKYDEAINLYTAAIQLNPQSALLFAKRGQVYLKLNKPNACIKDCTHALELNCDSAAAYKFRGRAYRLLGKFEESSHDLCESLKIDYDDQTNEWLNEVKPNAEKLRQHKLSAQRKKEEKEHREKLRRARKAQEARARAAQAQANAAAGATPGDFPGFPGGMPNVPGGMPAGVNLDDFNDMFLDPEIMAAFQDPEISAAFKDVTSNPANFIKYQNNPKIAAVIAKLQAKLGRRSGGPAGGFPGFGGPKPGAGPRSSADDDVGLD

Description

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).

Subunit

Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity).

Similarity

Belongs to the FAM10 family.

Keywords

Chaperone Complete proteome Cytoplasm Reference proteome Repeat TPR repeat

Feature

chain Hsc70-interacting protein

Uniprot

A0A194PIG3 Q16NR0 A0A154PE57 A9CPG8 A0A158NUQ5 A0A195B8D6 + More
B4L1W2 F1NH21 Q5ZLF0 A0A1J1I1I4 B0W1J5

Pubmed

26354079 17510324 19940440 22293439 21347285 17994087 + More
15592404 15642098

EMBL

KQ459603 KPI92838.1 CH477811 EAT36000.1 KQ434886 KZC10107.1 + More
AB306287 AKHW03002956 BAF94150.1 KYO36270.1 ADTU01002860 ADTU01002861 ADTU01002862 KQ976565 KYM80505.1 CH933810 EDW07683.1 AADN05000523 AJ719784 CVRI01000037 CRK93618.1 DS231822 EDS25793.1

Proteomes

UP000053268 UP000008820 UP000076502 UP000050525 UP000005205 UP000078540 + More
UP000009192 UP000000539 UP000183832 UP000002320

PRIDE

Q5ZLF0

Pfam

PF18253   HipN        + More
PF17830   STI1
PF13181   TPR_8
PF13881   Rad60-SLD_2
PF00515   TPR_1

Interpro

IPR006636   STI1_HS-bd        + More
IPR013026   TPR-contain_dom
IPR011990   TPR-like_helical_dom_sf
IPR019734   TPR_repeat
IPR041243   STI1
IPR034649   Hip_N
IPR039540   UBL3-like_ubiquitin_dom
IPR000626   Ubiquitin_dom
IPR029071   Ubiquitin-like_domsf
IPR001440   TPR_1

SUPFAM

SSF48452 SSF48452 + More
SSF54236 SSF54236

Gene 3D

1.25.40.10

CDD

cd14438 Hip_N

ProteinModelPortal

A0A194PIG3 Q16NR0 A0A154PE57 A9CPG8 A0A158NUQ5 A0A195B8D6 + More
B4L1W2 F1NH21 Q5ZLF0 A0A1J1I1I4 B0W1J5

PDB

4J8F E-value=5.14243e-32, Score=344

KEGG

101742938 K09560 suppressor of tumorigenicity protein 13 | (RefSeq) hsc70-interacting protein-like

GO

GO:0046983 GO:0009617 GO:0005829 GO:0005737 GO:0051085 GO:0005515 GO:0016020 GO:0051056 GO:0030170 GO:0006520 GO:0006508 GO:0008237 GO:0043401 GO:0003707 GO:0051537

Subcellular location

Cytoplasm

Length:

393

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0376300000000001

Exp number, first 60 AAs:

0.03218

Total prob of N-in:

0.00844

outside

1 - 393

Pi

18.277033

Theta

17.386021

Tajima's D

0.534253

CLR

0.662928

CSRT

0.532623368831558

Interpretation

Uncertain

Source	Sequence	Identity	Evalue
28556443	INILQTFHLYDK	100.00	6e-08
28556443	SGGPAGGFPGFGGPK	100.00	2e-05
28556443	SGGPAGGFPGFGGPKPGAGPR	100.00	0.008

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics