Gene

KWMTBOMO07250  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010361

Annotation

muscle_glycogen_phosphorylase_[Bombyx_mori]

Location

Bomo_Chr12(-):9109797-9118880      View in EpiBrowser

Full name

Alpha-1,4 glucan phosphorylase       + More
Multifunctional fusion protein      
Glycogen phosphorylase      

Location in the cell

Cytoplasmic   Reliability : 3.051

CDS

ATGAGCGTACAGACTGACGCGGAAAAGCGTAAACAGATATCTGTCAGAGGAATTGTTGCTGTCGAAAATGTGACTGAAGTAAAGAAGGCGTTCAATCGTCATGTCCATTACACTTTAGTGAAAGATCGAAATGTTGCGACCCCGCGGGATTACTATTTTGCTCTCGCACACACCGTGAAAGATCATCTTGTCTCCAGGTGGATTCGTACTCAACAATACTATTATGAAAATGATCCTAAGAGAGTCTACTATTTGTCCTTGGAGTACTATATGGGGCGTTCTCTTCAAAATACCATGATCAACCTTGGCATCCAAGGTACTGTTGACGAAGCATTATACCAACTTGGTCTGGATATTGAAGAATTAGAAGAACTTGAGGAAGATGCTGGTCTGGGAAATGGAGGTCTTGGACGCTTAGCAGCTTGTTTCCTAGACTCTATGGCGACATTAGGTCTTGCTGCGTATGGATATGGTATAAGGTACGAATATGGTATATTTGCTCAAAAAATTGAAAACGGAGAACAACAGGAAGAGCCTGATGATTGGTTACGTTTCGGAAACCCCTGGGAGAAGGCAAGACCTGAGTTCATGCTGCCAGTTAACTTCTATGGTAGTGTAGTTGACACACCCGATGGAAAAAAATGGATTGATACACAGGTGGTATTTGCAATGCCATACGATAACCCTATTCCTGGTTATAACAATAATGTTGTGAATACATTGCGACTGTGGTCGGCGAAGAGCCCCATTGATTTCAATCTTAAATTTTTCAATTCTGGTGATTATATTCAAGCTGTATTGGATCGCAACGTTGCCGAAAACATATCGCGTGTTTTGTATCCCAACGACAACTTCTTCGAAGGCAAAGAGTTGCGTTTGCGCCAAGAATACTTCATGTGTGCTGCCACGCTCCAGGATATTATCAGACGGTACAAAGCATCTAAGTTCGGATGCCGAGATGCCGTTAGAACTTCGTTTGAACATTTACCTGAAAAAGTAGCCATCCAATTAAATGACACTCATCCGGCTCTGGCTATACCTGAATTTTTGAGAATCTTAGTCGACATTGAAAAGGTTCCCTATGAACAAGCTTGGGACTTAGTTGTTAAATGTTGTGCATACACCAACCACACAGTCCTGCCTGAGGCTCTCGAAAGATGGCCATGCTCGATGCTGGAAAATGTTCTGCCGAGACATATGCAATTGATTTACCATATCAACTTTTTACATTTGCAAGAGGTGCAAAAGCGTTGGCCCGGCGACATGGATCGTTTGCGCAGAATGTCCTTGATTGAAGAAGAAGGTGAAAAACGCGTCAATATGGCTAATTTATCTATTGTCGGCTCTCACGCTGTCAATGGTGTAGCAGCCATTCACTCCGAAATCTTAAAAGCCACTATTTTCCGCGACTTTTTCGAAATGTGGCCTGATAAATTCCAAAATAAGACTAACGGCATCACTCCCCGGCGTTGGTTGCTCCTCTGCAACCCTGGCTTATCTGATCTCATCTGCGACAAGATCGGAGAAGATTGGATCGTCCATTTGGAGAAGTTGAAGGAGCTGAAGCGCTGGGCTAAGGACCCGGCTTTCCAGCGCGCCGTTATGAAAGTGAAGCAAGAGAATAAACTCAAGCTGGCGGCCCTTATTGAAAGGGATACCGGAGTTAAAATTAATCCCGCGTCGATGTTCGATGTCCAAGTGAAGCGCATCCACGAGTACAAACGTCAGTTACTGAATATTTTGCACGTGATCACGCTTTACAACCGCATCAAGCGCGACCCCAGCGCGTCTTTCACGCCGAGGACTGTTATGATCGGTGGCAAAGCCGCTCCTGGATACTTCATCGCCAAACAAATTATCGCTTTAGCCTGTGCAGTTGGAAATACTGTGAACAACGACCCAGACGTAGGTGACAAGTTGAAGCTGATATTCCTCGAGAACTATCGGGTGACCTTGGCAGAGCGTATCATCCCGGCATCGGATTTGAGCGAACAGATTTCAACAGCAGGAACTGAGGCATCCGGCACCGGCAATATGAAGTTTATGCTAAATGGAGCGTTAACTATTGGCACCATGGACGGAGCCAACGTTGAAATGGCCGAAGAAGCTGGTGAAGAGAACTTTTTCATTTTCGGAATGAGAGTTGACGATGTCGAAGCACTGAAACAGCGCGGGTACAACGCATACGAGTACTACGAGCGCAACCCGGAGCTGCGGCAGTGCGTGGAGCAGATCCGCAGCGGGTTCTTCTCGACGGGCGAGCCCGGCAAGTTCGCGCACGTCGCCGACGTGCTGCTGCACCACGACCGCTTCCTGCACCTCGCCGACTACGACGCTTACGTCGAGGCCCAGCAGAAAGTCGCCGACGTATACCAGGACCAGACAAAATGGGCGGAGATGGTGATCGAGAACATCGCGTCGTCTGGCAAGTTCTCGTCTGACCGCACCATCACGGAGTACGCCCGCGAAATCTGGGGCGTGGAGCCCACCTGGGACAAGCTGCCCGCCCCGCACGAGACCGCTTAG

Protein

MSVQTDAEKRKQISVRGIVAVENVTEVKKAFNRHVHYTLVKDRNVATPRDYYFALAHTVKDHLVSRWIRTQQYYYENDPKRVYYLSLEYYMGRSLQNTMINLGIQGTVDEALYQLGLDIEELEELEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFAQKIENGEQQEEPDDWLRFGNPWEKARPEFMLPVNFYGSVVDTPDGKKWIDTQVVFAMPYDNPIPGYNNNVVNTLRLWSAKSPIDFNLKFFNSGDYIQAVLDRNVAENISRVLYPNDNFFEGKELRLRQEYFMCAATLQDIIRRYKASKFGCRDAVRTSFEHLPEKVAIQLNDTHPALAIPEFLRILVDIEKVPYEQAWDLVVKCCAYTNHTVLPEALERWPCSMLENVLPRHMQLIYHINFLHLQEVQKRWPGDMDRLRRMSLIEEEGEKRVNMANLSIVGSHAVNGVAAIHSEILKATIFRDFFEMWPDKFQNKTNGITPRRWLLLCNPGLSDLICDKIGEDWIVHLEKLKELKRWAKDPAFQRAVMKVKQENKLKLAALIERDTGVKINPASMFDVQVKRIHEYKRQLLNILHVITLYNRIKRDPSASFTPRTVMIGGKAAPGYFIAKQIIALACAVGNTVNNDPDVGDKLKLIFLENYRVTLAERIIPASDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVDDVEALKQRGYNAYEYYERNPELRQCVEQIRSGFFSTGEPGKFAHVADVLLHHDRFLHLADYDAYVEAQQKVADVYQDQTKWAEMVIENIASSGKFSSDRTITEYAREIWGVEPTWDKLPAPHETA

Description

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). Required for glycogen breakdown in skeletal muscle.

Catalytic Activity

[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the glycogen phosphorylase family.

Keywords

Carbohydrate metabolism   Complete proteome   Glycogen metabolism   Glycosyltransferase   Phosphoprotein   Pyridoxal phosphate   Reference proteome   Transferase  

Feature

chain  Glycogen phosphorylase

Uniprot

B2CMB5   H9JLG0   A0A2H1VEE6   A0A2W1BUS8   A0A2A4JHR0   A0A194R5J6   + More
S4PAM0   C0LRA9   A0A194PIF2   A0A2S1TNQ4   I7CKW1   A0A182L220   A0A182F4K3   A0A0L0BUC4   A0A182W9P0   A0A182TUX3   A0A084VP10   A0A3Q8B932   A0A2M4A0E8   A0A2M3YY01   A0A2Y9D354   A0A2Y9D126   Q7Q3L6   A0A182WT70   A0A1Y9H2J4   A0A2A3E7B2   W5JD07   A0A182MV21   A0A2M4BDP3   A0A336K387   A0A087ZVF4   A0A182QG57   A0A182YGT4   A0A182RBK7   B4KI29   A0A182JPV9   U5EZ80   B3N9F7   A4UZZ4   A0A310SEB9   Q17NG8   Q9XTL9   A0A182HDR9   A0A182J4Q7   A0A023EVY7   B3MJC8   T1PGX7   A0A0J9QU28   A0A1W4UTM2   B4LTC6   A0A1I8NIE9   B4NW47   B4MVT1   A0A154PP88   D2A0P2   B0WCF2   A0A0M4EN07   B4JAB0   A0A1L8E1Y2   A0A1Q3FM82   A0A1I8PPB2   A0A0K8VMW2   A0A026VYY3   A0A0K8UVG6   A0A0L7QRZ2   A0A3B0K2R5   A0A0T6BFY4   A0A034WBQ5   K7IQK0   A0A232F127   L7X9Z5   W8ARZ5   Q29MI1   B4G970   A0A0A1X1Y6   A0A0A9Y0L7   A0A1A9UT61   A0A0A9XZ40   A0A1W5YLJ9   E2BWP7   A0A0M9AA77   A0A0C9RJQ2   A0A158NVR8   A0A195EC44   E1ZZF6   A0A1Y1M6I5   A0A195B8I0   A0A286SDL8   F4WNR3   A0A346A6L6   A0A1A9WUG4   E2S085   A0A224X783   A0A023F5H7   T1I3T6   A0A2P1JJ59   U4UTB8   A0A087U449   E9G2G6   J9WM54  

EC Number

2.4.1.1

Pubmed

19121390    28756777    26354079    23622113    20966253    26108605    + More
24438588    12364791    14747013    17210077    20920257    23761445    25244985    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17510324    10092506    10731138    24265594    26483478    24945155    22936249    25315136    17550304    18362917    19820115    24508170    30249741    25348373    20075255    28648823    24495485    15632085    25830018    25401762    20798317    21347285    28004739    21719571    29187976    25474469    23537049    21292972    22972362   

EMBL

EU527367    ACB41088.1    BABH01005840    BABH01005841    BABH01005842    ODYU01002089    + More
SOQ39156.1    KZ149911    PZC78121.1    NWSH01001519    PCG70970.1    KQ460883    KPJ11136.1    GAIX01004946    JAA87614.1    FJ754277    ACN78408.1    KQ459603    KPI92828.1    MG517442    AWI63366.1    JX113672    AFO54708.2    JRES01001454    KNC22809.1    ATLV01014966    KE524999    KFB39704.1    KU556838    AQT25653.1    GGFK01000908    MBW34229.1    GGFM01000365    MBW21116.1    APCN01002494    AB523399    AAAB01008964    BAI60046.1    EAA12902.3    KZ288345    PBC27637.1    ADMH02001514    ETN62232.1    AXCM01007187    AXCM01007188    GGFJ01002021    MBW51162.1    UFQS01000097    UFQT01000097    SSW99426.1    SSX19806.1    AXCN02000872    CH933807    EDW11311.1    GANO01001273    JAB58598.1    CH954177    EDV57414.1    AE014134    AAZ66442.1    KQ762207    OAD56035.1    CH477199    EAT48250.1    AF073177    AF073178    AF073179    AF160947    JXUM01034765    JXUM01034766    KQ561035    KXJ79955.1    JXUM01055500    JXUM01055501    JXUM01055502    GAPW01000210    KQ561870    JAC13388.1    KXJ77284.1    CH902620    EDV31338.1    KA647395    AFP62024.1    CM002910    KMY87582.1    CH940649    EDW63896.1    CM000157    EDW87327.1    CH963857    EDW75801.1    KQ435007    KZC13705.1    KQ971338    EFA02541.1    DS231887    EDS43476.1    CP012523    ALC37975.1    CH916368    EDW03781.1    GFDF01001366    JAV12718.1    GFDL01006427    JAV28618.1    GDHF01012404    JAI39910.1    KK107558    QOIP01000012    EZA48982.1    RLU15903.1    GDHF01021989    JAI30325.1    KQ414766    KOC61387.1    OUUW01000004    SPP79301.1    LJIG01000676    KRT86264.1    GAKP01006823    JAC52129.1    NNAY01001358    OXU24250.1    JX974433    AGC97435.1    GAMC01019202    JAB87353.1    CH379060    EAL33713.1    CH479180    EDW28900.1    GBXI01009609    JAD04683.1    GBHO01018423    JAG25181.1    GBHO01018420    JAG25184.1    KX147656    ARI45060.1    GL451165    EFN79902.1    KQ435701    KOX80377.1    GBYB01013502    JAG83269.1    ADTU01002901    ADTU01002902    KQ979074    KYN22795.1    GL435343    EFN73448.1    GEZM01039845    JAV81141.1    KQ976565    KYM80547.1    KX766454    ASZ80181.1    GL888237    EGI64256.1    MF908516    AXK92638.1    AB596876    BAJ23879.1    GFTR01008160    JAW08266.1    GBBI01002304    JAC16408.1    ACPB03003299    MF385058    AVN99053.1    KB632354    ERL93360.1    KK118066    KFM72138.1    GL732530    EFX86312.1    JX462658    AFS17314.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000075882    UP000069272    + More
UP000037069    UP000075920    UP000075902    UP000030765    UP000075903    UP000075840    UP000007062    UP000076407    UP000075884    UP000242457    UP000000673    UP000075883    UP000005203    UP000075886    UP000076408    UP000075900    UP000009192    UP000075881    UP000008711    UP000000803    UP000008820    UP000069940    UP000249989    UP000075880    UP000007801    UP000192221    UP000008792    UP000095301    UP000002282    UP000007798    UP000076502    UP000007266    UP000002320    UP000092553    UP000001070    UP000095300    UP000053097    UP000279307    UP000053825    UP000268350    UP000002358    UP000215335    UP000001819    UP000008744    UP000078200    UP000008237    UP000053105    UP000005205    UP000078492    UP000000311    UP000078540    UP000007755    UP000091820    UP000015103    UP000030742    UP000054359    UP000000305   

PRIDE

B2CMB5    H9JLG0    A4UZZ4    Q9XTL9   

Pfam

PF00343   Phosphorylase        + More
PF02453   Reticulon

Interpro

IPR000811   Glyco_trans_35        + More
IPR011833   Glycg_phsphrylas       
IPR035090   Pyridoxal_P_attach_site       
IPR003388   Reticulon       

CDD

cd04300  GT1_Glycogen_Phosphorylase

ProteinModelPortal

B2CMB5   H9JLG0   A0A2H1VEE6   A0A2W1BUS8   A0A2A4JHR0   A0A194R5J6   + More
S4PAM0   C0LRA9   A0A194PIF2   A0A2S1TNQ4   I7CKW1   A0A182L220   A0A182F4K3   A0A0L0BUC4   A0A182W9P0   A0A182TUX3   A0A084VP10   A0A3Q8B932   A0A2M4A0E8   A0A2M3YY01   A0A2Y9D354   A0A2Y9D126   Q7Q3L6   A0A182WT70   A0A1Y9H2J4   A0A2A3E7B2   W5JD07   A0A182MV21   A0A2M4BDP3   A0A336K387   A0A087ZVF4   A0A182QG57   A0A182YGT4   A0A182RBK7   B4KI29   A0A182JPV9   U5EZ80   B3N9F7   A4UZZ4   A0A310SEB9   Q17NG8   Q9XTL9   A0A182HDR9   A0A182J4Q7   A0A023EVY7   B3MJC8   T1PGX7   A0A0J9QU28   A0A1W4UTM2   B4LTC6   A0A1I8NIE9   B4NW47   B4MVT1   A0A154PP88   D2A0P2   B0WCF2   A0A0M4EN07   B4JAB0   A0A1L8E1Y2   A0A1Q3FM82   A0A1I8PPB2   A0A0K8VMW2   A0A026VYY3   A0A0K8UVG6   A0A0L7QRZ2   A0A3B0K2R5   A0A0T6BFY4   A0A034WBQ5   K7IQK0   A0A232F127   L7X9Z5   W8ARZ5   Q29MI1   B4G970   A0A0A1X1Y6   A0A0A9Y0L7   A0A1A9UT61   A0A0A9XZ40   A0A1W5YLJ9   E2BWP7   A0A0M9AA77   A0A0C9RJQ2   A0A158NVR8   A0A195EC44   E1ZZF6   A0A1Y1M6I5   A0A195B8I0   A0A286SDL8   F4WNR3   A0A346A6L6   A0A1A9WUG4   E2S085   A0A224X783   A0A023F5H7   T1I3T6   A0A2P1JJ59   U4UTB8   A0A087U449   E9G2G6   J9WM54  

PDB

1Z8D     E-value=0,     Score=3266

KEGG

100144545    K00688 glycogen phosphorylase [EC:2.4.1.1] | (RefSeq) Glyp; glycogen phosphorylase

PATHWAY

00500    Starch and sucrose metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0102499   GO:0030170   GO:0102250   GO:0008184   GO:0005975   GO:0005789   GO:0016021   GO:0004645   GO:0005737   GO:0005980   GO:0008340   GO:0042803   GO:0045819   GO:0032991   GO:0050829   GO:0045824   GO:0006520   GO:0006508   GO:0008237   GO:0043401   GO:0003707   GO:0051537  

PANTHER

PTHR11468  

Subcellular location

Endoplasmic reticulum membrane  

Length:

841

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.14493

Exp number, first 60 AAs:

0.00093

Total prob of N-in:

0.05197

outside

1  -  841

 

 

Pi

0.721463

Theta

4.294427

Tajima's D

-2.280168

CLR

590.076746

CSRT

0.00164991750412479

Interpretation

Possibly Positive selection