Gene

KWMTBOMO07220

Pre Gene Modal

BGIBMGA010372

Annotation

PREDICTED:_WD_repeat_and_FYVE_domain-containing_protein_3_[Bombyx_mori]

Location

Bomo_Chr12(-):8461891-8510955      View in EpiBrowser

Full name

WD repeat and FYVE domain-containing protein 3      

Alternative Name

Beach domain, WD repeat and FYVE domain-containing protein 1
Autophagy-linked FYVE protein

Location in the cell

Nuclear   Reliability : 2.656

CDS

ATGAATTTGATGCGCAAATTGCGTGGGGCATCTTCCTCGGCGTCGTCCGAATCTGCCGAGGGCTCAGGTTCCTCATCTCACGTCCAACTTGGACTGATGCACCTGAAGAAGCTATTTGCAGAGTACACACATCCTCAACAACCACTAACAGACGCTGAAAAAGATGATAAACTTTACAATATGCTGCCTCTATTTTGTAAGGTGATTGGCACCAGTCCATCAAGTGAAATGAATGAAAAATTCTGGGATATATTGTCGTTTTGCCAGCAAGTTTCTAAGCTAATGGTGTCAGAAATTAGAAAGAGGGCCAGTAACCAAAGTACCGAGGCTGCTAGTTGTGCAATTGCAAAGTTCTTAGAGATTGAAAACTCGGAAGAGTCAAGTAATGGCTGGATGTTGTTATCAACACTAAATCTATTGGCAGCTGGAGATCAGTCTCTGATACAGGTCATGACCACTGCAGCTATACCATCAACACTAGTAAAATGTTTGTATCTGTTTTTTGATCTTCCTGAGATACCTGAATCAGAGGCTGATGTTCAGGATACTAATAGTGAATTTACACCCAGAGAGAGGAGGATCTTGTTGCAAAAAATATTTGTTCAGGTACTTGTAAGATTATGCAGCCATCCTTTCCCATGTGAAGAATTAGCGAGAAAGGATGATCTCACCCTCTTATTCTCCGCTATAACATCATGGTGTGCCCCTCATAATATAATGTGGAGAAAGTCAGCAGCTGAAGTGTTAATGACGCTTTCTCGACATGGTCTAACACAATCTGTTGTTCAGTACATTCATAATAAAGGTTGTGTTGCATTATGCATTGAAAATATGCAAAGGATACCAGAACTGACACCTCTAGAGGTTGTTGAAATGTTTGTGGCTGTATTTTGTTTCCTGAAAGACTCTAGTGAAGTTAGTCAATTACTGTTAGATGATTTTAGATCATGTCAAGGATATTTATTTCTCTCAGAATTCCTTTTAAAACATGAAACTCAAGATGTACCTGATTATTTAACTTCAGGGCTGGAAGAGGAACGCGTCAGCGGTTCAGAAGCTCGTGCTGCTTTACGAAATCTAGTATTGATGATATCGTCGCTATGCGCCTGCGGATTTTCAGAACTTCGACCGACCCGAGCAAATACTGAACTATTCCAATTACAAGGATTCGTTTTACCGCAGCCCTCTACACCCGGGCAGGCTGTAAGAAATGTGCAGGCTTTTCAGGTTTTGCAATCAGTTTTCATGAAGTCTAACTCTCCTGCATTGTGTTGCACTATATTGGATGCTATATCAAGTGTTTATCATGCTGACAATGCTAATTATTTTATATTGGAAAATCAAAACACCCTTAGTCAGTTTTCAGAAAGAATTTATACAAAAAATGCAGAAATCCAAGAGAAATTTTTCGAATTGTTAGAATTCATAGTGTTTCAACTAAACTTTGTTCCCTGTAAAGAACTTATATCACTCTCACTTTTGTTGAAAGCCAATAGATCAAGAAGTTGCAGTATTTTGTGTATAAAGACTCTTCTTAACATTTTAAAACATAATACAATCTTCAAAGATGTTTATCGTGAGGTGGGAATGTTAGAAGTATTTGTAACCTGTCTATCGCGATATGCAGCATATTTAAAAGATAAACAACTTGAAGAAGAAAGTAAAAAGAAAGATTCTGAAGCAATACAACAAGATAATGAATTGAATGAATCTCCTAAAGCTCCTGAAAGAAAGAAAAAAGCCACCAGAACGGACTCATTGATCCGAGATCCTAATATAGACAGTGAAGAGGAAGACTTAGGCTCATTATTAATGGAAGGCTTGACTGCATTATTGAATGCTAATTCTAGTAATTGTAACGTTTTTAGGGATTGTGGAGGTGCAAAATGTGTGCATGGTATGGTTGTCTATGAGTCTTGTCGTAGTAAAGCCTTAGGTGTCATTAGAGAATTAATAGTGAGTGGGTCCGGTGAGGAAGATATGTCTACGTTGCTTTGTGGCATGCATGCTGCACCTTCGGATGCTTTACATCTCAAACTCCACATCTTGAAGGCTTTGCTAGCTTGTCTAAGAGATTCTCATCGCACTAGGACTATATTTAGAAAGGTCAGTGGATTTGTTTATGTCACAAGTGTCCTGGTGTCGCTCGAAGGCAAGTTAAAAGGAAACGAGATCATGGATCAAGATATGCTTCAGTTGATTCATATAGTATTTTACACCATTTCTACTGCCATGAGATTCGAACCAGCCAATGCGAAATTTTTTCATCACGAGATTTGTATGACTACACTCAGCGAGACCATTCGTATGTTAGGCTGTTTTACTGAAGACGTAGAGTTACAATATGACACTGAACCCGGAGATCCGGACCTGTATGAAGTATTTCATGAATTGTTCACCGGAAACATATTAGAAATGACATTTCCCGCATCTGTGCCTGCAGTATTTTCGAATGCGTGCGTGGTTTTACGGTTACTTTACGATGTAGCGTTGGATTCATTCGACAAACCGACTTTCTGTGGATCTCTCAATGTTAAATCACCTAGTTTAACGCGACAGAGCTCTGCAATCAACGAAAATAAACCAACAGGACGCACGGCGCCCTTAAACTTTTCCACGGGTTCAAATAATGGGGAAGCGTGGATCATACATTCCGGTGTTGTAATAGTATTGGCCAAGCTTCTTCCCGCATTGCCGCGTCCCGCAGAACATGAAACTCATGCTAGGGCCATGAGGGACTATCTCGCGCATGTACTCAAAAGTCTCGTTAGGAGCGAGCGCAACCAGCAAGTGATGTGCGTGGCCGGGCTGGCGGGCACGGTGCTGCGGGTGTGCGGCGCCGCGCTGCGTTGCGAGCGACACGCGCTGCACTCGCCCGCCATGTACATGCTCGAACGACTCGCCGCGCATTCCTTACGACCTATTGAACTCAGAGAATTTTTAAGAATGGGTAATCCACTAAACTGTGTTGCCCCCGAGCAGGGACAAGTTTGCAAACCAGGTGGACCTGTTCCATTGACGAGAATAAAAACGTTGGTTTCCATGACAACACCGAGGGATTACCGGTCTCAAAATTCATGTACGCTGCCACCTTTCGTGGAGTTTGATATGTCGGCTGAGGGTTTCGGTTGTTTGTACATGCCCAGTATCGCGCCTCAGTCTGCTAATTTGAACGCTATCGGAACGCAAGATACGGCCACGCTGGGTGGTATAGGTTCAGGTGACAGAGTATTTCCCCCGCAAACGGGTTTGAGTTACTCAACGTGGATATGCGTCGAGAAATACTCCGACCCCCGCTCCGATCCGCACTGCGTTCGTTTGCTGACTTTAGTACGGAACATCAACAACACGCGCGACGAACACCTCGTGTGCCTCACCGTGGTACTGTCGGCCAGGGATAAGGCCATCATTGTATCCACGCAAGAGACCTTAGTGCCGCACAATGTAGGAGAATGGGAGCCGGAGGGTTCGGGTGAGTGCGGCGCCCGCGTGTGGTGCCCCGACCTGCAACACGAAGGACAGTGGCATCACCTCGCGCTCGTGCTTAATCGTGCTGTCCTCAAGAATTCCTCTTTTTCCCTTTACTTGGATGGTCAGCACATGCACTCCGGGAAGCTGCACTACGTGAGCGCGAACCCCGGGGGCGGCGCCGCCACGCTGTCGGGCGCGTCCAGCGTGTACTGCGTGCTCGGGACGCCCCCGCAGTGGCGGCGCTACTCGCGGCTGCTGTGGCGACAGGGCCCGGCGCTGCTGCTCGAAGACGTACTCACAGCACAGACAGTGTCGGTTATATACCAACTGGGTCCCCATTACGTGGGCACACTGCAAGCTCCACTGCCGCCGGGACAAAACCAAGAACCTCTGACGCCTCTAGTCGCAGAAGAAAAAGTTATTTTCGGAATTAATGCACGAGCGATGTCTCAATTGACCCTCGCGAAGATAAGGAAAGTGTACAGTAAAAACGACAACAAGGCCATCGCAAAGCAACTGGGCATGTCGTCGCACGAAAACGCAACCCCGATACGGATACTCCACAACTCCGCGGGACACCTGATGGGACCCGCCAGATGCTTGGGCGGCACCGTGGTGGGCTATTTGGGAGTCAGAGTATTCTGTTCGAAGCCAGCCGCGATTATGATTGACACGGTGGGCGGTTGTTCAGTGCTGTTGGGCTTGATCGCGATGGCACAAGACGTGGAATGTTTGTACGCCGGCGTTAAAGCGCTAGTGTGCGTCGTTCGATCGAACAAATCGGCTCAAGCCGAAATGGACCGGCGGAAGGGATACCAAACCTTAGCTATGTTATTGAAGAGGAAAAAGCAGCTATTGAATTCTCATATACTCCACCTTGTATTTGGACTGGTCGGAACTGTGGACAGCCAGAAGGAAACATCGTCTATTCCTAATTTGACAGCTTTTCAAGATCTCATCTGCGAGCTAGAGGTGTGGCTCGGCGCCCCCGGTGGCCTGATTAAATCGTTACTGGAGCATTTATTAGAACTGGCCACTGAAACGGCTCACAGAACGCACAATTTACGCACAATGAGAGAGCTCCAATTGGTTTCCAAACTTTTATACATAATTAATGACGTAAAAGTCGTCAGCACAAAGAACGTTCTAATACAATTGTTAGCTGCTTTATTAGGGGGGCAGCCCAGACCGAGCGATCTGTTATGCTTGGGACAATTCATGGCATACACTCTACCGCTACCCTCGCAGACTGAAAAGGGATTGAATCCAGTTGAAAGCGACTGCGAGAAAGACTCAGAGGGAGAACAAATTATTTTACGTAATAAATGCTTCAACGTGCTGCACGGCTTATTATTCACGGCGAGGAATCTAGTGAATACGATAGTTTGCGAGGAAATATCACGAGTCTTGGGCATGGATTGGTTGTTGAGTTTTATGCAGGAGAACGTTCATCCGACAACGGTGCTTTGGGCCCTCAGAATTTTAGTAATACTTTGTTCGGGACAAGGACACCAATCTGCAATTATGCAAAGGTTCCGCGAAGGAGTGGGTAATGGTGGCTGGTTGCGTCACACAGAGATGATAGCGAGCTCGCAGCAAGCAGGCGTGGTGCTCACGGCCGCCGTCCACTCGCAGTCTCATCTACACGCGTCCTTGCTCCACACCTCGGGATTCACTTTACTCGCATGGTTGATCCTGTCGCACCTGCACATACCGGAGCTGTACTACCTGCTGTTCGGGCTGACGCTGGGGCAGCCGATGCGCGCGGCGTGCTCGGAGCGCGCGGTGTCGGTGGAGCGCGTGTGGGCGGCGGCGTGGGGCGCGGTGGCGCCCGCCCGGCAGTCGTCGGCCGCGCTGGCCGCCCGCATCACGCTGTGCCCCGAGGCCATCGTCATCCTGCTGGGGGCGGTGCGCGCGCTCGTGCACGCCGACCAGCCCGCTCTGCCCGACTGGCTCGTCGACCATCCAGTGCCCATCCTGCAGGTGTTGTTTTCCCTCTATAACACATTGCCAGACTTCGTGCCTATAATGATGTCAGCTGAAGTCCTTACTGCATTGGCTTCAACGCTGTTCCCTCTTAACTCATCCGATGACATTCATATGCCGATATGCGAGAGCGGGGAAAGTTCGGGCGCATCGACCCCCGGCTCGGAGAAGGAGGTGGTGATAGCGGGCGCGTCGGCCGCGCTCACACAGCACGCGGTGCGACAGAGCGTCATGGACTTCCTGCGGGTCATAGTATTGGACTCTCTGTCGCTCAACGTCACGGGGAAGACGGCGCCGAACGCGGAAAGCGCTGACACAGTGCCCTCTTCAATGTTTTGTACGCCATGTAGCTCCGGCCCGGCGAGATCTTACTTTCATAGCGTTATTGACCTTGTCTTAGATGCGTCTCCACCGAATTCTACAAGTCAGCAACAAATTGAATATCAGACTGAAGTGTTGACTACTCTGATGGAAAACTTGTTGAATACCGAACTGTTTAGTTCAGAATCTAACATATCGAATGTTTGCTATTTGGCCGCCCGGCTCGTCGATAAGTTATGGCAGGGACAATTGTCGAGGGACCCTCACGAGGTATTCGATTTTATTGTGAAACTGGTAACGCAAGCAAAAAAGAAATCTTCTCTTGTATCACTGGAAGGGCTCCATCATTGTTTGAACAGAACAATACTTTTCTTACTGTCGCGTTCTACTGATTCTATAGCCGATCAGATGTCCGTATTGGAGGCTTTACATAAGCTAACGACGAACAGATTGTTAATATTTGGGGCGGGAAATCATGAGTTGGAGTTTATCGGTTGCCTGACGTATTGCCTGCTGCAGTTGAGTGCTAACATGAAGATCGCTTTAGATTCGCACATGCGCACCACTTGGCACGTTAACCCCAGCGGAGATCTAGAATCTAGGGATGATAAGTTGACAACTCATCAAGGACGTAATCTCATGGCGGGTGCGGCTCGTAGAGTGTGGGAGGAGTTATACGTGTGCAAGAAACCTGCTATAGAAGAAGTCTTCAAAATAACATTAGTGTTGCCAGTCGGTAACGCGCACGCTCCCGACCTCACCACGGTCAGGGAACAGCTCAATGAAAGCGCTCACAAGCTGTGGATCAACTACATCGACACCGAAAGAAAAGCCGTATACAGAGTACCGTGGGAATTGCACAATCAGATCCAGTCCAAGATACAAAAAGTGACCGGCGGTTTGACCCGGCTTGCGTCCCGTACGAAGGTCAAAAAGGAGGATTCAGCTAAACAACGTCCCACCCCGCCCAGAGACCACGCGCTCGCTTACATGCAGGACCATGTGCAGTTGGTCAGACAGGCGTGGTGCAAGGAGCGTGCGAGCGCGGCCAACACGCGCGCGCACACGACGCGCTACGTGCAGGCGGAGTGGGCGGGCGCGTGGCGGGAGCTCACCCGCGAGCGCGCGCTGTGGGGCCCGCCGCGACCCGCGCCGCTCGACAAGTGGGCGCTCGACTGCACCGAGGGACCCTGCCGCATGCGCAAGATGCTGCGCCGGAACCATCTCTTCTACGCGCACTACCCCTACAGGGCCGACCTCGACAACCCAGATAACAAACAATTAAAGTACAAAGTCGCCCAAAGCTTAGACAGCAAGGAATATTACCGCGTGTATCAGCAATGGCGGACGGCCGGCGCTATATTGGACGAGGACGACAGCGTCGAGACACCCGAAATTAACAACTTCGAAGAGCCCGTAGCCAACACGAGTCAAACAAACTCAGTGGATGTGGTGGCGAATGAGGACGGGTCGCCTTCCGATTTAGTCAGCAGCGGCGTTGTTAGTCGGGGCACGAACCAAGCCTCTGGAGAAGCAAACGAAGATGGCCTAGATAATGAAGACGAAGATGAACAACCAACACCTCCTCCGGATAATCAGACTCTTCTTAGGCTGTTGGAACACCACGAAAAGATTTCACATATGTTCCGCTGCGCAAGAATTCAAGGCTTAGACACGACTGAAGGACTTCTGCTGTTCGGACGTGAGCATTGTTACGTCATCGATGGGTTTACGTTGTTGAAAAATCGAGAAATACGCGACTTGGACAGCTGTCCCGACGATTACGAACCTATACTTCCCAGCCAAGGGATACAGCGGAGCAACCAACGACAGTGCTCTAAATTTTTATATGAAGACATTAGGGAAGTGCACAAAAGAAGATATTTATTACAACCGATAGCTCTAGAAGTTTTTTCCAGCGATGGAAGAAATTACTTATTGGCTTTCCCCAGGAAAGTTAGAAATAAGGTGTACAGCAGGTTCACGGCGCTGGCGACCGGCATGGCGGACAGCGCGGCGGGCTCGGTGGCGGGACAGAAGCGCGGCGTGCCCGTCGAGCAGCCCGCCGGCCTATTCGCCTCGCTCATCGGAGACACCTCCGTCACGCAACGGTGGCTGAGAGGAGAAATATCAAACTTCCAATATTTAATGCATCTAAATACTCTCGCTGGGAGATCGTACAATGATCTCATGCAATACCCTGTGTTTCCGTGGATTCTTGCCGACTATGATACCTTAGAGCTGGATCTCAACGACCCGGCGACGTTCCGAGATCTTACTAAACCAATGGGAGCACAAAATCCTGAACGATTGGAGCAATTCAGGAAGAGATATAAGGAATGGGACGATCCTCACGGCGAGACGCCTCCGTATCACTACGGCACGCACTACTCTTCCGCCATGATCGTGTGCTCGTACTTAGTGCGTATGGAACCGTTCACGCAACACTTCTTGAGACTTCAAGGCGGCCATTTTGATTTAGCTGACAGAATGTTTCATTCGATAAAGGAAGCGTGGAACTCAGCTTCTAAACACAATATGGCCGACGTGAAAGAATTGATTCCAGAATTCTTTTATTTACCAGAGTTTTTAGTCAATTCGAATAATTTTGATCTGGGTTGTAAGCAGTCCGGCGTGGCCTTGGGTGACGTGGTGTTGCCGCCGTGGGCTAAGGGTGATCCTCGCGAGTTCATACGTCTGCACCGCGCCGCGCTGGAGTCTGACTACGTTTCTCACAGACTCCACCACTGGATCGACTTAGTTTTCGGATACAAACAACAAGGACAACCGGCAGTTGACTCATCTAACGTATTCCATCATCTGTTTTACGAAGGAAACGTTGATATTTACAATATTGATGATCCCCTTAAAAAGAACGCCACCATTGGCTTCATAAATAACTTTGGACAGATCCCGAAACAGTTGTTCAAAAAGGCTCATCCCAGTAAAAAAATGTCGCAAAGGAGCTCCACGATATTAGATCCTAATAACATAATACCATCTCAAGGTATCACTCCACCTGAAAAATTGTTCTTCCATAATCTAGAAAACCTGAGGCCTTCTTTACAACCAGTAAAAGAAGTGAAAGGGCCCGTCGGTCAAATATTATATACAGATAAAGCGATCCTAGCAGTAGAACAGAACAAAGTGTTGATGCCTCCCTCGTACAACAAGTACGTGGCTTGGGGCTTCGCTGATCATTCGTTGAGGATTGGGAACTACGACAACGACAAGGCGGTGTTCGTGTGCGAATCTGTGGCGCAGTCCTGTGGGGAAATTGTGGCTTGTGTCTGCCCCTCGGCCAAGACTATCGTGACCGCCGGCACCAGTACCGTCGTAACGGTGTGGCAGTATTTGGCTCGCCGGCGTCGGCTGTCGGTCAAGGTGTGTCTTTACGGTCACGAGGAGGCCGTGACGTGTCTGGCGGCCAGCCCCGCCTACAACCTGGTGGTGAGCGGCAGCCGGGACGGGCAGGTCATCGTCTGGGACGTCGAACGCGGCTCCTTCATCCGGCAACTGGTGCCCGACAACACGCGCGGCCCGCACCCCCCCGTGTCCGCGCTCGCCATCGACGACTTAACCGGCGACATAGCCACGTGTCGCGGCAGCTGGTTGTATCTGTGGTCCATCAACGGCACGTTACTGGGCGGCGTGGACACGGCGGGAGGGCGTGAACGGTCGCATCAGATTCTGTGCGTCGCTTTCAGCCAGACCCGGGAGTGGGACCCGCTCAACGTCGTCATCACGGGCTCGTCGGACGGGGTCGTCCGGATGTGGTCCATAGACTACATAGCGGATACATCAGAGAGTCAAGCCGATGAAAGCTTAGACTGCGGCGATGTTAGTGTTGACCCTGCCTCGAGCTCTGCTGATGTAGACAAAGGGAAAGAAGAACAAAAATCATCGGAACTGGACACCGAGGAGTTGAGAACAGAGAGTGAGAGAACAATAGACGCTGATGTGAAGATTAATGATCCTCAGCCCATAGAAACTGAGGCAGCTATCAAAAGGGTTGAAGAATTGGTTAAACAGATGAGTCTATCACAAGAAACTGATGGTCGTTTAGTGAAATCAGCATCGGAAAGTTCTCTGTCCGATGCGTGTGAAACTAGTGCAAAGGAGTCCGCTCGCAGACACGACGAGAAAGACATTTGCAGTGACAACGATGAAAGATTTGAACAAAAGGACGAACATATTGTCGATTCTTGTGATGAAATCAAACAGGATTACGACAATGAGAAGGAAGTTGATGATGACAAAGAAAATCTGACACACCGATGTAAGCTTCAGAAGCAAGGAAACGTAATACTGAGGCGGAAGTCAAAGGCGAATCCGTTGTACAGGAAAAGTGGAGGGAGCATCGGCGAATCAAGCGAGTCCAGTTCGATGGAGGTGGCGGGCGCGTCTGGGGAGGGGCGGGAAGAAGGCGGCCTGCGCACCAGCAAGTCCGACACCAGCCTCACGGACTCCTTCGTAGTGCTCTCCGCGCCGCCCTCGCCCTCCCCCGCCCACAAGCCGGCCGCCAGACCAGCGCCCGATATCGAAGGCGAGTGCAACGTGAAGTGGGTCCGGCGCGTGGTGCTGCGCGGCAAGCTCACCATGCACACGGCGTACGAGCGCCGCGACAACGTGAGCCCCGCCGCCGTCACCGCCGCCGCCGCGCCGCGCTCCGGCCGCGGGCTCGCCGTGGGGGACGCGCGCGGACGGTGTAAACGAATGCCATACGATAAATAA

Protein

MNLMRKLRGASSSASSESAEGSGSSSHVQLGLMHLKKLFAEYTHPQQPLTDAEKDDKLYNMLPLFCKVIGTSPSSEMNEKFWDILSFCQQVSKLMVSEIRKRASNQSTEAASCAIAKFLEIENSEESSNGWMLLSTLNLLAAGDQSLIQVMTTAAIPSTLVKCLYLFFDLPEIPESEADVQDTNSEFTPRERRILLQKIFVQVLVRLCSHPFPCEELARKDDLTLLFSAITSWCAPHNIMWRKSAAEVLMTLSRHGLTQSVVQYIHNKGCVALCIENMQRIPELTPLEVVEMFVAVFCFLKDSSEVSQLLLDDFRSCQGYLFLSEFLLKHETQDVPDYLTSGLEEERVSGSEARAALRNLVLMISSLCACGFSELRPTRANTELFQLQGFVLPQPSTPGQAVRNVQAFQVLQSVFMKSNSPALCCTILDAISSVYHADNANYFILENQNTLSQFSERIYTKNAEIQEKFFELLEFIVFQLNFVPCKELISLSLLLKANRSRSCSILCIKTLLNILKHNTIFKDVYREVGMLEVFVTCLSRYAAYLKDKQLEEESKKKDSEAIQQDNELNESPKAPERKKKATRTDSLIRDPNIDSEEEDLGSLLMEGLTALLNANSSNCNVFRDCGGAKCVHGMVVYESCRSKALGVIRELIVSGSGEEDMSTLLCGMHAAPSDALHLKLHILKALLACLRDSHRTRTIFRKVSGFVYVTSVLVSLEGKLKGNEIMDQDMLQLIHIVFYTISTAMRFEPANAKFFHHEICMTTLSETIRMLGCFTEDVELQYDTEPGDPDLYEVFHELFTGNILEMTFPASVPAVFSNACVVLRLLYDVALDSFDKPTFCGSLNVKSPSLTRQSSAINENKPTGRTAPLNFSTGSNNGEAWIIHSGVVIVLAKLLPALPRPAEHETHARAMRDYLAHVLKSLVRSERNQQVMCVAGLAGTVLRVCGAALRCERHALHSPAMYMLERLAAHSLRPIELREFLRMGNPLNCVAPEQGQVCKPGGPVPLTRIKTLVSMTTPRDYRSQNSCTLPPFVEFDMSAEGFGCLYMPSIAPQSANLNAIGTQDTATLGGIGSGDRVFPPQTGLSYSTWICVEKYSDPRSDPHCVRLLTLVRNINNTRDEHLVCLTVVLSARDKAIIVSTQETLVPHNVGEWEPEGSGECGARVWCPDLQHEGQWHHLALVLNRAVLKNSSFSLYLDGQHMHSGKLHYVSANPGGGAATLSGASSVYCVLGTPPQWRRYSRLLWRQGPALLLEDVLTAQTVSVIYQLGPHYVGTLQAPLPPGQNQEPLTPLVAEEKVIFGINARAMSQLTLAKIRKVYSKNDNKAIAKQLGMSSHENATPIRILHNSAGHLMGPARCLGGTVVGYLGVRVFCSKPAAIMIDTVGGCSVLLGLIAMAQDVECLYAGVKALVCVVRSNKSAQAEMDRRKGYQTLAMLLKRKKQLLNSHILHLVFGLVGTVDSQKETSSIPNLTAFQDLICELEVWLGAPGGLIKSLLEHLLELATETAHRTHNLRTMRELQLVSKLLYIINDVKVVSTKNVLIQLLAALLGGQPRPSDLLCLGQFMAYTLPLPSQTEKGLNPVESDCEKDSEGEQIILRNKCFNVLHGLLFTARNLVNTIVCEEISRVLGMDWLLSFMQENVHPTTVLWALRILVILCSGQGHQSAIMQRFREGVGNGGWLRHTEMIASSQQAGVVLTAAVHSQSHLHASLLHTSGFTLLAWLILSHLHIPELYYLLFGLTLGQPMRAACSERAVSVERVWAAAWGAVAPARQSSAALAARITLCPEAIVILLGAVRALVHADQPALPDWLVDHPVPILQVLFSLYNTLPDFVPIMMSAEVLTALASTLFPLNSSDDIHMPICESGESSGASTPGSEKEVVIAGASAALTQHAVRQSVMDFLRVIVLDSLSLNVTGKTAPNAESADTVPSSMFCTPCSSGPARSYFHSVIDLVLDASPPNSTSQQQIEYQTEVLTTLMENLLNTELFSSESNISNVCYLAARLVDKLWQGQLSRDPHEVFDFIVKLVTQAKKKSSLVSLEGLHHCLNRTILFLLSRSTDSIADQMSVLEALHKLTTNRLLIFGAGNHELEFIGCLTYCLLQLSANMKIALDSHMRTTWHVNPSGDLESRDDKLTTHQGRNLMAGAARRVWEELYVCKKPAIEEVFKITLVLPVGNAHAPDLTTVREQLNESAHKLWINYIDTERKAVYRVPWELHNQIQSKIQKVTGGLTRLASRTKVKKEDSAKQRPTPPRDHALAYMQDHVQLVRQAWCKERASAANTRAHTTRYVQAEWAGAWRELTRERALWGPPRPAPLDKWALDCTEGPCRMRKMLRRNHLFYAHYPYRADLDNPDNKQLKYKVAQSLDSKEYYRVYQQWRTAGAILDEDDSVETPEINNFEEPVANTSQTNSVDVVANEDGSPSDLVSSGVVSRGTNQASGEANEDGLDNEDEDEQPTPPPDNQTLLRLLEHHEKISHMFRCARIQGLDTTEGLLLFGREHCYVIDGFTLLKNREIRDLDSCPDDYEPILPSQGIQRSNQRQCSKFLYEDIREVHKRRYLLQPIALEVFSSDGRNYLLAFPRKVRNKVYSRFTALATGMADSAAGSVAGQKRGVPVEQPAGLFASLIGDTSVTQRWLRGEISNFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDTLELDLNDPATFRDLTKPMGAQNPERLEQFRKRYKEWDDPHGETPPYHYGTHYSSAMIVCSYLVRMEPFTQHFLRLQGGHFDLADRMFHSIKEAWNSASKHNMADVKELIPEFFYLPEFLVNSNNFDLGCKQSGVALGDVVLPPWAKGDPREFIRLHRAALESDYVSHRLHHWIDLVFGYKQQGQPAVDSSNVFHHLFYEGNVDIYNIDDPLKKNATIGFINNFGQIPKQLFKKAHPSKKMSQRSSTILDPNNIIPSQGITPPEKLFFHNLENLRPSLQPVKEVKGPVGQILYTDKAILAVEQNKVLMPPSYNKYVAWGFADHSLRIGNYDNDKAVFVCESVAQSCGEIVACVCPSAKTIVTAGTSTVVTVWQYLARRRRLSVKVCLYGHEEAVTCLAASPAYNLVVSGSRDGQVIVWDVERGSFIRQLVPDNTRGPHPPVSALAIDDLTGDIATCRGSWLYLWSINGTLLGGVDTAGGRERSHQILCVAFSQTREWDPLNVVITGSSDGVVRMWSIDYIADTSESQADESLDCGDVSVDPASSSADVDKGKEEQKSSELDTEELRTESERTIDADVKINDPQPIETEAAIKRVEELVKQMSLSQETDGRLVKSASESSLSDACETSAKESARRHDEKDICSDNDERFEQKDEHIVDSCDEIKQDYDNEKEVDDDKENLTHRCKLQKQGNVILRRKSKANPLYRKSGGSIGESSESSSMEVAGASGEGREEGGLRTSKSDTSLTDSFVVLSAPPSPSPAHKPAARPAPDIEGECNVKWVRRVVLRGKLTMHTAYERRDNVSPAAVTAAAAPRSGRGLAVGDARGRCKRMPYDK

Description

Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development (PubMed:25198012, PubMed:27648578). Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (PubMed:27648578). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (By similarity). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (PubMed:27330028). After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (By similarity).
Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (By similarity). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (By similarity). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400).

Subunit

Directly interacts with ATG5 and associates with the ATG12-ATG5-ATG16L complex. Interacts with p62/SQSTM1. Directly interacts with GABARAP, GABARAPL1 and GABARAPL2; the interaction with GABARAP is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies. Weakly interacts with MAP1LC3C; this interaction is direct. Does not interact with MAP1LC3A, nor MAP1LC3B (By similarity). Interacts with TRAF6 (PubMed:27330028).
Directly interacts with ATG5 and associates with the ATG12-ATG5-ATG16L complex (PubMed:20417604). Interacts with p62/SQSTM1; this interaction is required to recruit WDFY3 to cytoplasmic bodies and to PML bodies (PubMed:20168092, PubMed:20971078). Directly interacts with GABARAP, GABARAPL1 and GABARAPL2; the interaction with GABARAP is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies. Weakly interacts with MAP1LC3C; this interaction is direct. Does not interact with MAP1LC3A, nor MAP1LC3B (PubMed:24668264). Interacts with TRAF6 (By similarity).

Keywords

Alternative splicing   Autophagy   Cell projection   Complete proteome   Cytoplasm   Developmental protein   Lipid-binding   Membrane   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   WD repeat   Zinc   Zinc-finger   3D-structure   Disease mutation   Polymorphism   Primary microcephaly  

Feature

chain  WD repeat and FYVE domain-containing protein 3
splice variant  In isoform 2.
sequence variant  In MCPH18; increased cellular DVL3 protein levels as compared to the wild-type protein and loss of attenuation of Wnt signaling; when expressed in Drosophila, causes brain anomalies.

Uniprot

A0A212FAA3   A0A2A4K9R0   A0A2A4K9C2   A0A232FHR1   A0A195FAJ8   A0A158NCD1   + More
A0A151ITL5   F4WWX0   E2BI71   A0A154PFY3   A0A151WS21   A0A151IG65   A0A0N0BJ67   D6W992   E2B1V8   A0A0L7RDL3   A0A026VX02   A0A310SI86   A0A1W4WP87   A0A1J1ITB5   A0A1I8MA83   A0A1I8NN20   A0A1I8NN24   E0VI72   A0A0A1WKN5   A0A0K8U4F1   B4KGE6   A0A1B0A860   A0A1B0GAW3   B4JBT3   B4LR57   A0A023F476   B4MV10   A0A1W4UNG4   T1IFV9   B5DH51   A0A0M4EP89   B3MMN7   A0A1S4FNM4   A0A1A9X279   J9JR46   A0A2S2NZU6   Q16US2   A0A1B6D049   L7M6E8   A0A131XDQ4   A0A224Z0G3   A0A131Z0L5   A0A2R2MKD1   A0A1B0DKX8   A0A0L8GF85   A0A2T7PYP4   V4A297   A0A0P6AK04   A0A0P5ZHG9   A0A0P5BFK8   A0A0P4ZID8   A0A0P5T7B4   A0A0N8AAG6   A0A0P6H601   C3Z5D7   A0A0P5Y374   A0A0P5Y731   A0A162CEK7   A0A0P5D9Z1   A0A0P4ZNG2   A0A0P5YUA4   A0A0P4Y6L9   A0A0P5GE98   A0A093HRK8   G1KLD4   A0A087R3Z2   A0A1D5RLV7   G1RDI6   A0A091J7P0   A0A0A0AXP7   A0A061IJ03   Q6VNB8   A0A1W4YV94   A0A1U7U0R5   A0A2K6CVM1   Q8IZQ1-2   A0A2R9CMS5   A0A2I3SME5   A0A3Q1LRL4   A0A2K5L9C8   A0A1W4YL74   A0A2R8P612   A0A1W4YV50   A0A2K5U432   A0A2K5K5N2   F7H6J6   G3UYW1   F7AYV0   A0A2I3LHH0   A0A2K5S7H0   A0A2K5DEX6  

Pubmed

22118469    28648823    21347285    21719571    20798317    18362917    + More
19820115    24508170    25315136    20566863    25830018    17994087    18057021    25474469    15632085    23185243    17510324    25576852    28049606    28797301    26830274    26383154    23254933    18563158    19144319    19468303    21183079    23929341    15342963    16141072    15292400    25198012    27648578    27330028    15815621    10231032    12168954    14702039    15489334    18669648    20168092    20971078    20417604    24128730    23186163    24275569    24668264    27008544    22722832    16136131    19393038    17431167    19892987   

EMBL

AGBW02009504    OWR50662.1    NWSH01000030    PCG80523.1    PCG80524.1    NNAY01000199    + More
OXU30060.1    KQ981727    KYN37069.1    ADTU01011817    ADTU01011818    KQ981004    KYN10390.1    GL888417    EGI61213.1    GL448457    EFN84602.1    KQ434896    KZC10773.1    KQ982796    KYQ50618.1    KQ977728    KYN00259.1    KQ435720    KOX78692.1    KQ971312    EEZ98466.1    GL444981    EFN60314.1    KQ414614    KOC68880.1    KK107648    EZA48323.1    KQ760869    OAD58793.1    CVRI01000058    CRL02820.1    DS235184    EEB13078.1    GBXI01014890    JAC99401.1    GDHF01030938    JAI21376.1    CH933807    EDW12142.1    CCAG010014940    CH916368    EDW03018.1    CH940649    EDW63521.1    KRF81153.1    GBBI01002898    JAC15814.1    CH963857    EDW76355.1    ACPB03021527    CH379058    EDY69626.1    KRT03346.1    CP012523    ALC38357.1    CH902620    EDV31928.1    ABLF02035893    ABLF02035903    ABLF02035906    GGMR01010124    MBY22743.1    CH477615    EAT38266.1    GEDC01021426    GEDC01018247    JAS15872.1    JAS19051.1    GACK01005429    JAA59605.1    GEFH01003218    JAP65363.1    GFPF01009255    MAA20401.1    GEDV01003740    JAP84817.1    AJVK01006530    AJVK01006531    AJVK01006532    KQ422081    KOF75519.1    PZQS01000001    PVD38517.1    KB202619    ESO89055.1    GDIP01033635    JAM70080.1    GDIP01043928    JAM59787.1    GDIP01185858    JAJ37544.1    GDIP01212158    JAJ11244.1    GDIP01131665    JAL72049.1    GDIP01166609    JAJ56793.1    GDIQ01024152    JAN70585.1    GG666583    EEN52050.1    GDIP01063627    JAM40088.1    GDIP01063626    JAM40089.1    LRGB01000944    KZS14862.1    GDIP01163259    JAJ60143.1    GDIP01212157    JAJ11245.1    GDIP01053328    JAM50387.1    GDIP01232056    JAI91345.1    GDIQ01247768    JAK03957.1    KL206412    KFV82140.1    KL226085    KFM08196.1    AC131915    AC158143    AC171108    AC171109    ADFV01030429    ADFV01030430    ADFV01030431    ADFV01030432    ADFV01030433    ADFV01030434    KK501660    KFP16954.1    KL873122    KGL97870.1    KE665104    ERE89091.1    AY336569    AK047077    AF538685    AC095046    AC104082    AB023210    AK055806    AK094910    BC013377    BC015214    BC065502    BC119633    AJFE02114833    AJFE02114834    AJFE02114835    AJFE02114836    AJFE02114837    AJFE02114838    AJFE02114839    AJFE02114840    AJFE02114841    AJFE02114842    AACZ04033808    AQIA01054556    AQIA01054557    AQIA01054558    JSUE03033394    JSUE03033395    JSUE03033396    AHZZ02026732   

Proteomes

UP000007151    UP000218220    UP000215335    UP000078541    UP000005205    UP000078492    + More
UP000007755    UP000008237    UP000076502    UP000075809    UP000078542    UP000053105    UP000007266    UP000000311    UP000053825    UP000053097    UP000192223    UP000183832    UP000095301    UP000095300    UP000009046    UP000009192    UP000092445    UP000092444    UP000001070    UP000008792    UP000007798    UP000192221    UP000015103    UP000001819    UP000092553    UP000007801    UP000091820    UP000007819    UP000008820    UP000085678    UP000092462    UP000053454    UP000245119    UP000030746    UP000001554    UP000076858    UP000053584    UP000001646    UP000053286    UP000000589    UP000001073    UP000053119    UP000053858    UP000030759    UP000192224    UP000189704    UP000233120    UP000005640    UP000240080    UP000002277    UP000009136    UP000233060    UP000008225    UP000233100    UP000233080    UP000006718    UP000002281    UP000028761    UP000233040    UP000233020   

PRIDE

L7M6E8    A0A1D5RLV7    Q6VNB8    Q8IZQ1    G3UYW1   

Pfam

PF01363   FYVE        + More
PF02138   Beach
PF14844   PH_BEACH
PF00400   WD40
PF05028   PARG_cat
PF15787   DUF4704

Interpro

IPR017986   WD40_repeat_dom        + More
IPR023362   PH-BEACH_dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR001680   WD40_repeat       
IPR017455   Znf_FYVE-rel       
IPR016024   ARM-type_fold       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011011   Znf_FYVE_PHD       
IPR036372   BEACH_dom_sf       
IPR019775   WD40_repeat_CS       
IPR000409   BEACH_dom       
IPR036322   WD40_repeat_dom_sf       
IPR000306   Znf_FYVE       
IPR013320   ConA-like_dom_sf       
IPR007724   Poly_GlycHdrlase       
IPR031570   DUF4704       
IPR011989   ARM-like       
IPR036915   Cyclin-like_sf       

SUPFAM

SSF81837   SSF81837        + More
SSF57903   SSF57903       
SSF48371   SSF48371       
SSF50978   SSF50978       
SSF49899   SSF49899       
SSF47954   SSF47954       

Gene 3D

1.10.1540.10     2.130.10.10     3.30.40.10     1.25.10.10    

CDD

cd01201  PH_BEACH
cd06071  Beach

ProteinModelPortal

A0A212FAA3   A0A2A4K9R0   A0A2A4K9C2   A0A232FHR1   A0A195FAJ8   A0A158NCD1   + More
A0A151ITL5   F4WWX0   E2BI71   A0A154PFY3   A0A151WS21   A0A151IG65   A0A0N0BJ67   D6W992   E2B1V8   A0A0L7RDL3   A0A026VX02   A0A310SI86   A0A1W4WP87   A0A1J1ITB5   A0A1I8MA83   A0A1I8NN20   A0A1I8NN24   E0VI72   A0A0A1WKN5   A0A0K8U4F1   B4KGE6   A0A1B0A860   A0A1B0GAW3   B4JBT3   B4LR57   A0A023F476   B4MV10   A0A1W4UNG4   T1IFV9   B5DH51   A0A0M4EP89   B3MMN7   A0A1S4FNM4   A0A1A9X279   J9JR46   A0A2S2NZU6   Q16US2   A0A1B6D049   L7M6E8   A0A131XDQ4   A0A224Z0G3   A0A131Z0L5   A0A2R2MKD1   A0A1B0DKX8   A0A0L8GF85   A0A2T7PYP4   V4A297   A0A0P6AK04   A0A0P5ZHG9   A0A0P5BFK8   A0A0P4ZID8   A0A0P5T7B4   A0A0N8AAG6   A0A0P6H601   C3Z5D7   A0A0P5Y374   A0A0P5Y731   A0A162CEK7   A0A0P5D9Z1   A0A0P4ZNG2   A0A0P5YUA4   A0A0P4Y6L9   A0A0P5GE98   A0A093HRK8   G1KLD4   A0A087R3Z2   A0A1D5RLV7   G1RDI6   A0A091J7P0   A0A0A0AXP7   A0A061IJ03   Q6VNB8   A0A1W4YV94   A0A1U7U0R5   A0A2K6CVM1   Q8IZQ1-2   A0A2R9CMS5   A0A2I3SME5   A0A3Q1LRL4   A0A2K5L9C8   A0A1W4YL74   A0A2R8P612   A0A1W4YV50   A0A2K5U432   A0A2K5K5N2   F7H6J6   G3UYW1   F7AYV0   A0A2I3LHH0   A0A2K5S7H0   A0A2K5DEX6  

PDB

1MI1     E-value=2.07628e-102,     Score=960

KEGG

101746532    K22262 WD repeat and FYVE domain-containing protein 3 | (RefSeq) WD repeat and FYVE domain-containin

GO

GO:0046872   GO:0004649   GO:0005975   GO:0016021   GO:0048786   GO:0046622   GO:0031594   GO:0050807   GO:0032418   GO:0007420   GO:0022416   GO:0001578   GO:0048749   GO:0005764   GO:0097156   GO:0031396   GO:0016301   GO:0097635   GO:0035973   GO:0003831   GO:0005829   GO:0016605   GO:0005730   GO:0005635   GO:0016234   GO:0005545   GO:0005886   GO:0034274   GO:0005776   GO:0005737   GO:0007275   GO:0019898   GO:0005634   GO:0030424   GO:0043204   GO:0031965   GO:0005488   GO:0005515   GO:0009055   GO:0051536   GO:0004854   GO:0004855   GO:0050660   GO:0003824   GO:0005506   GO:0051537  

Subcellular location

Nucleus   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Cytoplasm   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Cytosol   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
PML body   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Membrane   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Perikaryon   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Cell projection   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Axon   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures. This redistribution is dependent on p62/SQSTM1. When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (By similarity). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (PubMed:27648578).   With evidence from 3 publications.
Nucleus membrane   Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures (PubMed:15292400, PubMed:20168092, PubMed:20971078, PubMed:20417604). This redistribution is dependent on p62/SQSTM1 (PubMed:20168092). When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (PubMed:20168092). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (By similarity).   With evidence from 3 publications.

Length:

3503

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.45372

Exp number, first 60 AAs:

0.00014

Total prob of N-in:

0.00250

outside

1  -  3503

 

 

Pi

2.532744

Theta

16.765696

Tajima's D

-1.494758

CLR

0.96681

CSRT

0.0580470976451177

Interpretation

Uncertain