SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07216  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA010377
Annotation
xanthine_dehydrogenase_[Bombyx_mori]
Full name
Xanthine dehydrogenase      
Alternative Name
Protein rosy locus
Location in the cell
PlasmaMembrane   Reliability : 2.347
 

Sequence

CDS
ATGGATGCGATAAATGAAGTTGTGCCCCGAAACGCTGAAACGGCTTTAGTGTTTTTTGTTAATGGAAAAAAAGTCCTGGAATCTAATCCTGATCCGGAATGGACGTTACTCTTCTATTTAAGGAAAAAATTAAAGTTGACCGGCACTAAATATGGATGTGGAGAAGGCGGCTGCGGCGCTTGTACCGTCATGGTTTCGAAATACTTAAAAAATGAAGATCGGATAAATCACATCGCGGTTAATGCGTGCCTGATATCTGTATGTGCAATGCATGGGTTAGCAGTCACAACCGTAGAAGGTATCGGTTCCACACAAGATCGATTACATCCTGTCCAAGAGAGAATTGCAAAATCTCACGGATCACAATGCGGCTTTTGCACACCCGGAATAGTCATGTCTATGTATGCTTTGCTCAGAAACAACAACAAAATAGCATATGAAGATATTGAGGGTGCTTTACAAGGCAATTTATGTAGATGCACGGGATATAGGCCTATTATAGAAGGATTCAAAACATTTATGGAGGGTTGGGAAAACGTTTACAGTACGGGGGGAAATATGTGTAAGATGGGAGAGAATTGTTGTCGAATTAAAAAGGAAACCGAACATGATATTTTATTTGATCCTTCGGCTTTTCGGCCGTATGATCCAACACAAGAACCAATATTCCCGCCCGAACTAAAATTGGAGAATGAATATAGTACATCATATCTTGTATTTAGAGGTGAAAATGTGATTTGGCTAAGACCACGAAATTTAAAAGAATTGGTTTTAGTAAAATCAAGGATTCCTGATAGTAAAGTAGTTGTGGGCAATACAGAAATAGGTGTGGAAATGAAATTTAAAAAGAAATTCTATCCTGTATTGATCTCGCCTACTATTATTGGAGAAGTGAATTATTGTAGTATTGAAAATGATGGTATTTTAGTTGGTGCTGCCGTGACATTAACAGAGCTACAAATATTTTTGAAATCTTTCATTGTTGAACATCCTTCAAAAAGTAAAATATTTAAAGCTGTTAATGCTATGTTACACTGGTTCGCCGGCAGTCAAGTAAGGAATGTAGCCTCACTCACAGGAAACATTGTAACGGCAAGCCCTATTTCTGACTTGAACCCAATATTAATGGCTTGTAGTGCAGTACTTAATGTTTATAGCACTACGAATGGGAGCAGGCAAATAACAATCGATGAAAATTTCTTTAAAGGCTACCGAAAGACAATATTAGAAGATGATGAAGTTGTTATTTCCATTAAGTTACCATTTTCAACTAACGATCAATATTTTAAATCCTATAAACAGGCTCGGAGAAGGGATGATGACATATCCATTGTTACTGCTGCATTTAATGTACAATTCGAAGGTAATAAAGTTATAAAATCTAAATTGTGTTATGGTGGTATGGGACCAACCACACTTTTGGCTTCGAAATCTTCAAAGATGCTCCTGGGTAAACATTGGAATCATGAAACCCTATCGACCGTTTTTCACTCTTTATGTGAAGAATTTAACTTGGAATTTTCAGTTCCTGGAGGAATGGCTGAGTATAGAAAGTCATTGTGTCTGAGTTTATTCTTTAAGTTCTATTTAAACGTCAAAGATAAATTAGATATATCAAACGGAGAAAGCTCAACAAGGCCACCTAAATTAAGTTGTGGCGATGAAACTAGAGGAGAGCCGAGTAGCTCTCAATATTTTGAGATACGTAATAGCGGTGAAGTTGATGCACTTGGGAAGCCATTGCCACATGCATCTGCTATGAAACACGCTACTGGAGAAGCTATTTATTGTGATGATTTACCGCGCATCGATGGAGAACTATTTTTAACTCTGGTTTTAAGTTCTGAGTCACATGCTAAAATAAAATCTATTGATACTACTGCTGCTCTGTCGATACCTGGTGTTGTAGCATTCTTTTGTGCTAAAGATTTAGAAGTTGATCGCAACATATGGGGTTCTATAATCAAAGATGAGGAAATATTTTGTAGCACATACGTGACGAGTCGATCTTGTATTGTTGGTGCTATAGTTGCAACCTCTGAAATAGTTGCGAAAAAGGCTAGAGATTTAGTTTCAATAACATACGAACGTCTTCAACCAGTAATAGTCACACTAGAAGATGCAATTGAACACAATTCGTATTTTGAAAACTACCCTCAAACTTTAAGCCAAGGTAACGTTGATGAAGTGTTTTCAAAAACGAAATTCACAGTTGAAGGAAAACAGAGAAGTGGCGCACAAGAACACTTTTATCTAGAGACCATTTCAGCGTACGCCATTAGAAAAGAAGACGAACTGGAGATCATATGTAGTTCACAAAGTCCAAGCGAAATAGCTTCATTCGTGTCGCATACACTCGGTATACCTCAGCACAAAGTTATAGCAAAAGTCAAAAGGATTGGAGGTGGCTTTGGCGGAAAAGAAACCAGATCATCTAGCCTTGCATTACCTGTTGCTATCGCTGCATATATACTCAAGAAGCCAGTTAGATCTGTTCTAGATCGAGATGAAGATATTCAAATGTCAGGATACCGACATCCATTTTTGACAAAATACAAAGTAGCTTTTGACGAGAATGGTAAAATTTCCGGTGCTGTTTTTGATGTATTTGCGAACGGAGGGTTTTCAATGGATTTATCTTGTGCTTTGATAGAAAGATCGACATTCCATGTAGATAATTGCTATTCTATACCAAACATTAAAATCAACGCATATGTCTGTAAGACTAATTTACCATCCAATACAGCCTTTAGAGGATTTGGAGCTCCACAAGTGATGCTGGCAGCAGAGTCTATGATAAGACAAATAGCTTCGACGTTAGGAAAAAGTTATGAAGAAATCGTTGAAGTGAACATTTACAAAGAAGGATCTGTGACATATTATAATCAACTTCTTACTTATTGCACTTTGTCTAGATGTTGGAATCAATGTATTGACTCTTCGAGATATATAGCCAGGAAAAAAGCCGTTAATGATTTTAACAGATCTAACAGATGGAAAAAGAAAGGTATTGCTTTGGTCCCAACAAAATATGGGATATCTTTCCAAACAGACGTCTTAATGCAAGCCGGTGCGTTACTTCTAGTGTATAATGATGGTGCAGTTTTGCTTTCCATCGGGGGCATAGAAATGGGACAAGGTCTCTTCACTAAGATGATACAGATTGCATCTAAAGCATTAGAAATAGAACAGAGCCGAATTCACATTAGTGAAGCTGCTACCGACAAAATACCAAACAGTACAGCCACTGCAGCGAGTATGAGCTCTGACCTATACGGAATGGCGGTTCTAAATGCGTGCAATACTTTGAATCAAAGATTAAAGCCATACAAAACTAAGGACCCCAATGGTAAATGGGAAGACTGGGTTTCTGAAGCGTATGTAGATCGAGTGTGTTTATTTGCAACTGGTTTTTACTCTGCTCCAAAAATAGAATATAACAGAAATACGAACAGCGGTAGATTATTTGAGTATTTCACATATGGAGTGGCGTGCTCTGAGGTGATAATAGATTGTTTGACCGGAGATCACGAGGTACTAAGAACCGATATCGTTATGGACGTGGGCGAGAGTATAAACCCTGCAATCGACATTGGACAAATTGAAGGGGCGTTTATGCAAGGATATGGCTTTCTTACTATGGAAGAAGTTGTTTTTTCGGCAAACGGAGAAACACTTTCTCGTGGCCCTGGTACTTATAAGATACCTACTTTGTCCGATATACCGAAAGAATTCAATGTTTCGCTGCTGAAAGGTGCTCCAAACCCACGTGCAGTATATTCTTCTAAGGCCATCGGGGAGCCACCACTGTTCTTAGCTGCTTCAGTATTCTTCGCCATCAAAGAAGCAATAATGGCCGCTCGCTCGGACAGTGGGGTGCCCGTGGAATTCGAACTGGATGCACCTGCGACTTGTGAACGTATTCGAATGTCATGTGAAGACGACATCACTCTGCAGGTTAAGCCAACTGTAAAACGTATTGGAGTTCCGTGGAATGTAATTGCCTAG
Protein
MDAINEVVPRNAETALVFFVNGKKVLESNPDPEWTLLFYLRKKLKLTGTKYGCGEGGCGACTVMVSKYLKNEDRINHIAVNACLISVCAMHGLAVTTVEGIGSTQDRLHPVQERIAKSHGSQCGFCTPGIVMSMYALLRNNNKIAYEDIEGALQGNLCRCTGYRPIIEGFKTFMEGWENVYSTGGNMCKMGENCCRIKKETEHDILFDPSAFRPYDPTQEPIFPPELKLENEYSTSYLVFRGENVIWLRPRNLKELVLVKSRIPDSKVVVGNTEIGVEMKFKKKFYPVLISPTIIGEVNYCSIENDGILVGAAVTLTELQIFLKSFIVEHPSKSKIFKAVNAMLHWFAGSQVRNVASLTGNIVTASPISDLNPILMACSAVLNVYSTTNGSRQITIDENFFKGYRKTILEDDEVVISIKLPFSTNDQYFKSYKQARRRDDDISIVTAAFNVQFEGNKVIKSKLCYGGMGPTTLLASKSSKMLLGKHWNHETLSTVFHSLCEEFNLEFSVPGGMAEYRKSLCLSLFFKFYLNVKDKLDISNGESSTRPPKLSCGDETRGEPSSSQYFEIRNSGEVDALGKPLPHASAMKHATGEAIYCDDLPRIDGELFLTLVLSSESHAKIKSIDTTAALSIPGVVAFFCAKDLEVDRNIWGSIIKDEEIFCSTYVTSRSCIVGAIVATSEIVAKKARDLVSITYERLQPVIVTLEDAIEHNSYFENYPQTLSQGNVDEVFSKTKFTVEGKQRSGAQEHFYLETISAYAIRKEDELEIICSSQSPSEIASFVSHTLGIPQHKVIAKVKRIGGGFGGKETRSSSLALPVAIAAYILKKPVRSVLDRDEDIQMSGYRHPFLTKYKVAFDENGKISGAVFDVFANGGFSMDLSCALIERSTFHVDNCYSIPNIKINAYVCKTNLPSNTAFRGFGAPQVMLAAESMIRQIASTLGKSYEEIVEVNIYKEGSVTYYNQLLTYCTLSRCWNQCIDSSRYIARKKAVNDFNRSNRWKKKGIALVPTKYGISFQTDVLMQAGALLLVYNDGAVLLSIGGIEMGQGLFTKMIQIASKALEIEQSRIHISEAATDKIPNSTATAASMSSDLYGMAVLNACNTLNQRLKPYKTKDPNGKWEDWVSEAYVDRVCLFATGFYSAPKIEYNRNTNSGRLFEYFTYGVACSEVIIDCLTGDHEVLRTDIVMDVGESINPAIDIGQIEGAFMQGYGFLTMEEVVFSANGETLSRGPGTYKIPTLSDIPKEFNVSLLKGAPNPRAVYSSKAIGEPPLFLAASVFFAIKEAIMAARSDSGVPVEFELDAPATCERIRMSCEDDITLQVKPTVKRIGVPWNVIA

Summary

Description
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).
Catalytic Activity
H2O + NAD(+) + xanthine = H(+) + NADH + urate
H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine
Cofactor
FAD
Mo-molybdopterin
[2Fe-2S] cluster
Subunit
Homodimer.
Similarity
Belongs to the xanthine dehydrogenase family.
Keywords
2Fe-2S   FAD   Flavoprotein   Iron   Iron-sulfur   Metal-binding   Molybdenum   NAD   Oxidoreductase   Peroxisome   Complete proteome   Reference proteome  
Feature
chain  Xanthine dehydrogenase
EC Number
1.17.1.4
EMBL
AB060286    BAB47183.1    D43965    BAA24290.1    BABH01005768    BABH01005769    + More
BABH01005770    AB005911    BAA21639.1    ODYU01000219    SOQ34621.1    NWSH01000030    PCG80530.1    KQ459603    KPI92786.1    AGBW02009504    OWR50667.1    KQ460883    KPJ11175.1    SOQ34622.1    PCG80531.1    OWR50668.1    BAA21640.1    RSAL01000003    RVE54763.1    D38159    BAA07348.1    KPI92785.1    JTDY01005560    KOB66882.1    KQ435830    KOX71781.1    KK855492    PTY22814.1    GEDC01024291    JAS13007.1    NNAY01000242    OXU29769.1    QOIP01000012    RLU15975.1    GFTR01008778    JAW07648.1    GECL01003376    JAP02748.1    GBGD01000107    JAC88782.1    GEZM01042838    JAV79553.1    KQ979074    KYN22790.1    KK852674    KDR18732.1    ADTU01002895    AM887864    CAP08999.1    CH477249    EAT46105.1    GEDC01002348    JAS34950.1    GGFK01001120    MBW34441.1    GGFK01001110    MBW34431.1    JXUM01065174    JXUM01065175    KQ562333    KXJ76128.1    KQ981215    KYN44509.1    KQ414668    KOC64646.1    KQ434804    KZC06074.1    KZ288336    PBC27858.1    KQ982316    KYQ57848.1    KQ976565    KYM80544.1    GFDF01002809    JAV11275.1    GANO01001536    JAB58335.1    GBYB01010764    JAG80531.1    OUUW01000013    SPP87937.1    Y08237    GL888237    EGI64250.1    KX384737    AOE46690.1    KQ976892    KYN07230.1    GGFK01001318    MBW34639.1    CH480815    EDW42369.1    CH933806    EDW14382.1    JRES01000321    KNC32318.1    Y00308    AE014297    BT015293    AY094689    CH902617    EDV42625.1    UFQT01001227    SSX29566.1    GGFJ01000577    MBW49718.1    UFQS01000746    UFQT01000746    SSX06562.1    SSX26909.1    CM000160    EDW97183.1    ADMH02001962    ETN60170.1    CH940652    EDW59307.1    GGFM01001519    MBW22270.1    GGFJ01000576    MBW49717.1    KX384734    AOE46687.1    CH478315    EAT33242.1    CH954181    EDV49282.1    AY014961    GAMC01016290    AAG47345.1    JAB90265.1    DS235286    EEB14413.1    KA646889    AFP61518.1    CH479179    EDW24874.1    GEDC01029337    JAS07961.1    M33977    CM000070    AY754605    JXUM01065178    JXUM01065179    AY279336    AAQ17526.1    X07229    X07323    X07324    X07325    M18423    GFDL01008163    JAV26882.1    AY279338    AAQ17528.1    AY279342    AAQ17532.1    AY279337    AAQ17527.1    CH964232    EDW81741.1    DS231880    EDS42575.1    CH916369    EDV93247.1    AY279339    AAQ17529.1    ACPB03003258    CP012526    ALC47458.1    AY279341    AAQ17531.1    GAMC01016289    JAB90266.1    GDHF01031091    JAI21223.1   
Pfam
PF01799   Fer2_2        + More
PF00941   FAD_binding_5
PF02738   Ald_Xan_dh_C2
PF00111   Fer2
PF03450   CO_deh_flav_C
PF01315   Ald_Xan_dh_C
PF00664   ABC_membrane
PF00005   ABC_tran
Interpro
IPR036010   2Fe-2S_ferredoxin-like_sf        + More
IPR001041   2Fe-2S_ferredoxin-type       
IPR036683   CO_DH_flav_C_dom_sf       
IPR012675   Beta-grasp_dom_sf       
IPR006058   2Fe2S_fd_BS       
IPR002346   Mopterin_DH_FAD-bd       
IPR037165   AldOxase/xan_DH_Mopterin-bd_sf       
IPR016166   FAD-bd_PCMH       
IPR036856   Ald_Oxase/Xan_DH_a/b_sf       
IPR002888   2Fe-2S-bd       
IPR014307   Xanthine_DH_ssu       
IPR016208   Ald_Oxase/xanthine_DH       
IPR000674   Ald_Oxase/Xan_DH_a/b       
IPR016169   FAD-bd_PCMH_sub2       
IPR036318   FAD-bd_PCMH-like_sf       
IPR005107   CO_DH_flav_C       
IPR008274   AldOxase/xan_DH_Mopterin-bd       
IPR036884   2Fe-2S-bd_dom_sf       
IPR016167   FAD-bd_PCMH_sub1       
IPR022407   OxRdtase_Mopterin_BS       
IPR014309   Xanthine_DH_Mopterin-bd_su       
IPR001497   MethylDNA_cys_MeTrfase_AS       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR003593   AAA+_ATPase       
SUPFAM
SSF47741   SSF47741        + More
SSF55447   SSF55447       
SSF56176   SSF56176       
SSF56003   SSF56003       
SSF54292   SSF54292       
SSF54665   SSF54665       
SSF90123   SSF90123       
SSF52540   SSF52540       
PDB
2CKJ     E-value=0,     Score=3409

Ontologies

Topology

Subcellular location
Peroxisome  
Length:
1335
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
4.29609999999999
Exp number, first 60 AAs:
0.01757
Total prob of N-in:
0.18366
outside
1  -  1335
 
 

Population Genetic Test Statistics

Pi
20.457481
Theta
18.940985
Tajima's D
0.119943
CLR
0.414406
CSRT
0.405729713514324
Interpretation
Uncertain
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