SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO07215  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA010377
Annotation
xanthine_dehydrogenase_1_[Bombyx_mori]
Full name
Xanthine dehydrogenase      
Alternative Name
Protein rosy locus
Location in the cell
Cytoplasmic   Reliability : 1.447
 

Sequence

CDS
ATGGGATTATTGAATGCCGAGGAAGATCCGAATAAAATATGCACCGAACTTGTTTTCTACGTAAATGGTAAAAAGGTTATAGAATCTAGTCCTGATCCAGAATGGACATTATTATGGTATTTGCGAAAGAAACTTCGACTGACGGGCACAAAATTAGGTTGTGCGGAAGGTGGATGTGGTGCTTGCACTGTTATGGTCTCCAAATATAACCGACAAGAAAATAAAATTATTCATCTGGCAGTAAATGCTTGTCTCGCACCATTATGTGCTATGCACGGTTTGGCTGTGACCACAGTTGAAGGTATCGGATCAACCAAAACTAAGCTGCATCCAGTTCAAGAAAGAATAGCCAAAGCCCACGGATCACAGTGCGGTTTCTGTACGCCTGGAATCGTAATGTCCATGTATACTTTACTGAGAAGCTGTAAAAATATTCAATATTCTGATTTGGAGGTCGCGTTTCAAGGTAATTTATGTAGGTGTACAGGTTATCGCGCCATAATAGAGGGCTACAAAACGTTTATCGAAGATTGGGAGACTCAACGAATTGTCAAGAATGGACCACAGAACGGAACTTGTGCGATGGGGAAAGACTGTTGCAAAAATAAATCGGATAGCTGTGAAGAAGCAGATAGTGAATCACAATATATTTTTGACAAGTCGTCGTTCTTACCGTACGATTCCAGTCAAGAACCAATTTTTCCACCGGAATTGAAATTATCTTCAATATACGATAGTCAGTACGTAATATATCGTGGAAAACAAACAACGTGGTATCGGCCAACTAACATAGAAACAGTTTTATCGTTGAAAGATAAGTTCCCGAATGCAAAAGTGGTAGTGGGAAATAGTGAAGTTGGTGTTGAAGTTAAATTCAAACGTTGTGTTTATCCAATAATAATAATGCCTAATTGCGTTCCCGAATTGAATACTATTACTGAAAATGAGCATGGTTTAACGGTTGGAGCTTCAGTAACACTCAATGACATCGAAAAAACTTTTAGAGAGTATATAAAGAAACTACCACCATACAAAACTAGAGTCTTAACTGCTATAGTAGAAATGTTGAATTGGTTTGCTGGAAAACAAATCAGAAATGTTGCTGCCATTGGCGGGAATGTAATGACGGGCAGTCCAATATCTGATTTGAATCCGATTTTAATGTCTCTCAAGGTGAAACTTAATCTTCTCAGTCAAGAAAACGGCCATCGTACCGTGCTAATGGATGAAACTTTTTTCACTGGGTATAGAAAGAATGTCGTCAAATCAAATGAAATATTACTTTCAATAGAGATACCGTTTTCAACCAAATTTCAATACCTGAAGGCTATTAAGCAAGCGAAAAGAAGAGAGGACGATATATCCATAGTAACTTCAGCTGTTAATGTTGAATTCGAAGAGAACACAAATGTTATAAAATATATAAATTTGGCATTCGGGGGAATGGCTCCCGTAACAAAGATTGCAACAAACACTGGAAATGTGTTAAAAGGGCTTAAATGGAATGAAAACATGTTAGAAAAAGCGTATTCGTTACTGATAGATGAACTGCCATTAGATCCATCGGCACCAGGTGGAAATATACAATTTCGGCGTGCATTGACTATGAGTTTGTTTTTAAAGTCGTATTTGGCTATTGGAAAAGCAATGTCAACTGATTATTTTTACGGAGATCTTATTGAATCGTACTACGGTAGCGGTGCAGATAGTTTTCACGGAAATGTGCCGAAAAGTTCTCAATACTTTGAATTGGTCGGAGAAAAACAGCTTAAAAGTGATGCTGTTGGAAGGCCGATACAGCATATGTCAGCATACAAGCAAGCTACAGGCGAAGCAATATATTGCGATGATATGCCCATTGCAGAAGGTGAGCTATATTTAGCATTTGTTTTGAGTTCAAAAGCTCATGCAAAATTAATATCAGTAGATGCAAAAAAAGCGCTAGCCGAACCTGGTGTTATAGCATTTTATTCAGCAAAAGACTTAACAAAAGAACAAAATAGCATTGGCCCCATATTTCACGATGAAGAATTGTTTGCAAGAGATAAAGTGTTGAGTCAAGGTCAAACTATTGGCGTTATAGTAGCTGTGGATCAAGCGACTGCACAAGCTGCTGCAAGAATGGTTAAAGTTGAATACGAGGAGATACAGCCAATTATCGTTACTATAGAAGACGCTATAAAATATAACTCATTTTATCCACAATTCCCTAAAACAATAAAACGGGGAAATGTAAAAGCCGTGTTTGACGATAAAAATAATATTATAATAGAAGGACAGTGTCGTATGGGAGGTCAAGAACATTTTTATTTGGAGACTCATGCTGCGTTTGCTATTCCAAAGAAAGAAGACGACGAGCTAGAAATATTTTGTTCCAGCCAACATCCCTCAGAGATCGCAAAACTGGTTAGTCACATCCTGCACGTACCGATGAATAGAATAGTGGCGAGAGTGAAACGTATGGGTGGTGGTTTTGGTGGAAAAGAGTCACGGGGTATGTTAGTGGCATTACCGGTTGCATTAGCTGCTCATAAACTCAACAGGCCCGTGCGGTGCATGCTCGATAGAGACGAAGATATGCAGATGACGGGCACTAGACATCCATTCCTGATAAAGTATAAAGCAGCGGCAACTAAAGAAGGAAAAATTGTTGGAGCTGTTGTCAATATTTATAACAACGGAGGCTATTCCACTGATCTGTCAGGTCCAGTTGTCGAACGAGCAATGTTCCATTTTGAAAATGCTTATTACATCCCAAATTGTGAAGTGACCGGATATGTCTGTAGAACTAATTTACCCTCAAATACGGCTTTTCGAGGCTTCGGAGGTCCCCAAGGAATGTTTGGTGCCGAAAATATGGTTAGAGAGATAGCTCATCGACTGGGAAAATCTCCCGAGGAAATAAGCAGACTAAACTTGTATCGAGAAAATAATACTACACATTATGGACAAGTTCTGACATATTGTACGTTACAAAGATGTTGGGACGAATGTGTACAAAACTGTAATTTAGCAGAAAGAAAATTAAAAATTAAAGAATTCAACAAACAACATAGATGGAGAAAACGTGGTATTTCGATAATACCAACAAAATTCGGTATCGCTTTTACGGAGAAACTTTTAAACCAAGCTGGTGCATTGGTATTAGTTTATGTTGATGGTTCAGTACTTCTATCACACGGTGGTACTGAGATGGGACAGGGCTTACATACAAAGATGATACAAGTAGCTACTCGGGCTCTTGGTATAGACGTTTCTAAAATTCACATCAGCGAAACAAGTACAGATAAAGTCCCTAATACTTCGGCAACAGCGGCTAGTGCCGGCTCAGATTTGAACGGTATGGCAGTACTAGAGGCTTGCGAGAAAATAATGAAGCGCCTAAAACCGTATATAGATAAGAATCCGGACGGGAAATGGGAAAATTGGGTATCAGCTGCCTATGTCGACCGTGTTAGCTTATCCGCTACCGGCTTCCACGCTACACCGGATATAGGATTCGATTTCAAGACCACTTCGGGAAAACCGTTTAACTATTTCACATACGGTGTTGCTTGCACGGAAGTAGAAATTGATTGTCTTAGCGGTGACCACCAAGTCCTTAGAACGGATATTGTAATGGACCTCGGTGAGAGTATCAATCCAGCGATAGATATTGGCCAGATTGAAGGCGGTTTCATACAAGGCTACGGTTTGTTTACCATAGAAGAATTAATTTATTCACCCACCGGAACTTTATATTCGCGAGGGCCGGGTGCTTACAAAATTCCTGGATTTGGCGATATTCCTCTAGAATTCAACGTTTCATTGTTAAAGGGTGCACCTAACCCTCGAGCAGTATATTCTTCTAAGGCCGTAGGAGAACCTCCGCTGTTCTTGGCTTCTTCAGCTTATTTTGCGATACATGAAGCCATTAAAGCTGCAAGAGCAGATGCCGGAGTACCGCTCGAGTTCGACATGGAGGCACCAGCAACATCTGCTCGAATTCGAATGGCATGTGAGGACCATATAACGAAGAAACTTGATAAACCAGATCCAAATAGCTTTGTGCCGTGGAATGTTGTCCCTTAA
Protein
MGLLNAEEDPNKICTELVFYVNGKKVIESSPDPEWTLLWYLRKKLRLTGTKLGCAEGGCGACTVMVSKYNRQENKIIHLAVNACLAPLCAMHGLAVTTVEGIGSTKTKLHPVQERIAKAHGSQCGFCTPGIVMSMYTLLRSCKNIQYSDLEVAFQGNLCRCTGYRAIIEGYKTFIEDWETQRIVKNGPQNGTCAMGKDCCKNKSDSCEEADSESQYIFDKSSFLPYDSSQEPIFPPELKLSSIYDSQYVIYRGKQTTWYRPTNIETVLSLKDKFPNAKVVVGNSEVGVEVKFKRCVYPIIIMPNCVPELNTITENEHGLTVGASVTLNDIEKTFREYIKKLPPYKTRVLTAIVEMLNWFAGKQIRNVAAIGGNVMTGSPISDLNPILMSLKVKLNLLSQENGHRTVLMDETFFTGYRKNVVKSNEILLSIEIPFSTKFQYLKAIKQAKRREDDISIVTSAVNVEFEENTNVIKYINLAFGGMAPVTKIATNTGNVLKGLKWNENMLEKAYSLLIDELPLDPSAPGGNIQFRRALTMSLFLKSYLAIGKAMSTDYFYGDLIESYYGSGADSFHGNVPKSSQYFELVGEKQLKSDAVGRPIQHMSAYKQATGEAIYCDDMPIAEGELYLAFVLSSKAHAKLISVDAKKALAEPGVIAFYSAKDLTKEQNSIGPIFHDEELFARDKVLSQGQTIGVIVAVDQATAQAAARMVKVEYEEIQPIIVTIEDAIKYNSFYPQFPKTIKRGNVKAVFDDKNNIIIEGQCRMGGQEHFYLETHAAFAIPKKEDDELEIFCSSQHPSEIAKLVSHILHVPMNRIVARVKRMGGGFGGKESRGMLVALPVALAAHKLNRPVRCMLDRDEDMQMTGTRHPFLIKYKAAATKEGKIVGAVVNIYNNGGYSTDLSGPVVERAMFHFENAYYIPNCEVTGYVCRTNLPSNTAFRGFGGPQGMFGAENMVREIAHRLGKSPEEISRLNLYRENNTTHYGQVLTYCTLQRCWDECVQNCNLAERKLKIKEFNKQHRWRKRGISIIPTKFGIAFTEKLLNQAGALVLVYVDGSVLLSHGGTEMGQGLHTKMIQVATRALGIDVSKIHISETSTDKVPNTSATAASAGSDLNGMAVLEACEKIMKRLKPYIDKNPDGKWENWVSAAYVDRVSLSATGFHATPDIGFDFKTTSGKPFNYFTYGVACTEVEIDCLSGDHQVLRTDIVMDLGESINPAIDIGQIEGGFIQGYGLFTIEELIYSPTGTLYSRGPGAYKIPGFGDIPLEFNVSLLKGAPNPRAVYSSKAVGEPPLFLASSAYFAIHEAIKAARADAGVPLEFDMEAPATSARIRMACEDHITKKLDKPDPNSFVPWNVVP

Summary

Description
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).
Catalytic Activity
H2O + NAD(+) + xanthine = H(+) + NADH + urate
H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine
Cofactor
FAD
Mo-molybdopterin
[2Fe-2S] cluster
Subunit
Homodimer.
Similarity
Belongs to the xanthine dehydrogenase family.
Belongs to the UDP-glycosyltransferase family.
Keywords
2Fe-2S   Complete proteome   FAD   Flavoprotein   Iron   Iron-sulfur   Metal-binding   Molybdenum   NAD   Oxidoreductase   Peroxisome   Reference proteome  
Feature
chain  Xanthine dehydrogenase
EC Number
1.17.1.4
EMBL
AB005911    BAA21640.1    D38159    BAA07348.1    BABH01005768    BABH01005769    + More
BABH01005770    ODYU01000219    SOQ34622.1    RSAL01000003    RVE54763.1    NWSH01000030    PCG80531.1    AGBW02009504    OWR50668.1    KQ460883    KPJ11175.1    JTDY01005560    KOB66882.1    KQ459603    KPI92785.1    GEZM01042838    JAV79553.1    GECL01003376    JAP02748.1    GBHO01039856    GBRD01002792    JAG03748.1    JAG63029.1    KQ976892    KYN07230.1    GBGD01000107    JAC88782.1    ADTU01002895    KQ979074    KYN22790.1    GEDC01024291    JAS13007.1    GFTR01008778    JAW07648.1    QOIP01000012    RLU15975.1    KK852674    KDR18732.1    KQ981215    KYN44509.1    KQ976565    KYM80544.1    KQ982316    KYQ57848.1    NNAY01000242    OXU29769.1    GL888237    EGI64250.1    AM887864    CAP08999.1    JXUM01065174    JXUM01065175    KQ562333    KXJ76128.1    GGFK01001120    MBW34441.1    KQ435830    KOX71781.1    GGFK01001110    MBW34431.1    CH477249    EAT46105.1    GBYB01010764    JAG80531.1    GEDC01002348    JAS34950.1    ACPB03003258    GGFK01001318    MBW34639.1    GGFM01001519    MBW22270.1    GGFJ01000577    MBW49718.1    GFDF01002809    JAV11275.1    ADMH02001962    ETN60170.1    GGFJ01000576    MBW49717.1    GL451165    EFN79891.1    KK855492    PTY22814.1    KQ434804    KZC06074.1    GEDC01029337    JAS07961.1    GFDL01008163    JAV26882.1    UFQS01000746    UFQT01000746    SSX06562.1    SSX26909.1    KZ288336    PBC27858.1    UFQT01001227    SSX29566.1    AAAB01008964    DS231880    EDS42575.1    Y00308    AE014297    BT015293    AY094689    CM000160    EDW97183.1    CH954181    EDV49282.1    X07229    X07323    X07324    X07325    M18423    KX384737    AOE46690.1    CH480815    EDW42369.1    CH902617    EDV42625.1    KQ414668    KOC64646.1    CH933806    EDW14382.1    CH479179    EDW24874.1    JRES01000321    KNC32318.1    M33977    CM000070    AY754605    CH964232    EDW81741.1    AY279337    AAQ17527.1    AY279338    AAQ17528.1    AY279341    AAQ17531.1    GANO01001536    JAB58335.1    CH916369    EDV93247.1    OUUW01000013    SPP87937.1    Y08237    AY279336    AAQ17526.1    M30316    AAA27880.1    CP012526    ALC47458.1    AY279339    AAQ17529.1    EAA12866.3    DS235286    EEB14413.1    AY279342    AAQ17532.1    CH940652    EDW59307.1    AY279340    AAQ17530.1    AY014961    GAMC01016290    AAG47345.1    JAB90265.1    AY279343    AAQ17533.1    KX384734    AOE46687.1    GDHF01031091    JAI21223.1    GAMC01016289    JAB90266.1    KA646889    AFP61518.1    CVRI01000001    CRK86175.1    SOQ34621.1   
Pfam
PF00941   FAD_binding_5        + More
PF01799   Fer2_2
PF02738   Ald_Xan_dh_C2
PF01315   Ald_Xan_dh_C
PF03450   CO_deh_flav_C
PF00111   Fer2
PF00664   ABC_membrane
PF00005   ABC_tran
PF12597   DUF3767
PF00003   7tm_3
PF00201   UDPGT
Interpro
IPR001041   2Fe-2S_ferredoxin-type        + More
IPR036010   2Fe-2S_ferredoxin-like_sf       
IPR036683   CO_DH_flav_C_dom_sf       
IPR006058   2Fe2S_fd_BS       
IPR016166   FAD-bd_PCMH       
IPR002346   Mopterin_DH_FAD-bd       
IPR037165   AldOxase/xan_DH_Mopterin-bd_sf       
IPR036856   Ald_Oxase/Xan_DH_a/b_sf       
IPR002888   2Fe-2S-bd       
IPR022407   OxRdtase_Mopterin_BS       
IPR014307   Xanthine_DH_ssu       
IPR016208   Ald_Oxase/xanthine_DH       
IPR000674   Ald_Oxase/Xan_DH_a/b       
IPR036318   FAD-bd_PCMH-like_sf       
IPR036884   2Fe-2S-bd_dom_sf       
IPR005107   CO_DH_flav_C       
IPR008274   AldOxase/xan_DH_Mopterin-bd       
IPR016167   FAD-bd_PCMH_sub1       
IPR016169   FAD-bd_PCMH_sub2       
IPR014309   Xanthine_DH_Mopterin-bd_su       
IPR012675   Beta-grasp_dom_sf       
IPR036640   ABC1_TM_sf       
IPR027417   P-loop_NTPase       
IPR011527   ABC1_TM_dom       
IPR017871   ABC_transporter_CS       
IPR003439   ABC_transporter-like       
IPR003593   AAA+_ATPase       
IPR001497   MethylDNA_cys_MeTrfase_AS       
IPR022533   Cox20       
IPR002213   UDP_glucos_trans       
IPR035595   UDP_glycos_trans_CS       
IPR017978   GPCR_3_C       
SUPFAM
SSF54665   SSF54665        + More
SSF54292   SSF54292       
SSF55447   SSF55447       
SSF56176   SSF56176       
SSF56003   SSF56003       
SSF47741   SSF47741       
SSF90123   SSF90123       
SSF52540   SSF52540       
PDB
4YTY     E-value=0,     Score=3550

Ontologies

Topology

Subcellular location
Peroxisome  
Length:
1356
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.26157000000001
Exp number, first 60 AAs:
0.03534
Total prob of N-in:
0.05018
outside
1  -  1356
 
 

Population Genetic Test Statistics

Pi
26.564183
Theta
21.109782
Tajima's D
0.252965
CLR
0.564871
CSRT
0.450927453627319
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
26280517 AITDDIAIMQER 100.00 4e-11
26280517 NGDIVQGSYSIVEPDGTR 100.00 5e-06
26280517 GFGGIGGIIR 100.00 1e-05
25044914 GFGGIGGIIR 100.00 1e-05
26280517 SDKVIHESSPAYTFR 100.00 3e-05
26280517 ATEGHPSIIFAR 100.00 3e-05
26280517 IGAAVPSASDVGPVSAYFVQR 100.00 9e-05
25044914 IGAVETETGIAGEGSHK 100.00 9e-05
26822097 KEDDEIEIFCSSQHPSEIAK 100.00 5e-04
26280517 RYAIPEGAAPETVESR 100.00 5e-04
26822097 EQNSIGPIFHDEEIFAR 100.00 0.004
26280517 WEGYPHDQNTWEPVENMETCK 100.00 0.004
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