Gene

KWMTBOMO07210

Pre Gene Modal

BGIBMGA010379

Annotation

Transmembrane_and_TPR_repeat-containing_protein_CG4341_[Papilio_machaon]

Location

Bomo_Chr12(-):8183569-8193145      View in EpiBrowser

Full name

Protein O-mannosyl-transferase TMTC2      

Alternative Name

Transmembrane and TPR repeat-containing protein CG4341

Location in the cell

Nuclear   Reliability : 2.246

CDS

ATGGCGAGTGAAATATACGTGCAACTTCAACAGTGGCCGCTGGCGGAAAACAGCATTCTTTCAGCCTTGGCCATAGCACCTCAAGACGTACGGACACATGTCACACTTGCACAAATACTTGCGAGAAACACGAGTAGAAGTATGGAAGCCGAGCTGTGGTTCAAAAAGGCGCTGCTGTTAGCACCTCAAGATCCTTCTATAAGAGATCAATTTGGCATGTTTCTGAGATCACATCGTCGCTTCCGCGAATCTGCGGAACAGATGGTCGTGGCTGCGCAGCTGTCGCCTGACAGCGGTGCGAGGGCTGCGGCGGCCGCCAGAGCGCTCCGTGACGCTCGAAGGTGCAGGGCGGCGGAGCGTTGGTACGCTCGGGCGGTACAGTTAAATCCTGAGGACGCCGAGTACCATTCGAACTTGGGTGCTATTTTGCATCTGAACGGGAAATATACGGCAGCCGCAACCTCATACAGACGGGCGTTACAACTACAACCAAATGATGAAATCACTACAACCAATTTAAAGAGAGTCAGAGCACTCATGCACAGTCAAAGAAGGAAATAA

Protein

MASEIYVQLQQWPLAENSILSALAIAPQDVRTHVTLAQILARNTSRSMEAELWFKKALLLAPQDPSIRDQFGMFLRSHRRFRESAEQMVVAAQLSPDSGARAAAAARALRDARRCRAAERWYARAVQLNPEDAEYHSNLGAILHLNGKYTAAATSYRRALQLQPNDEITTTNLKRVRALMHSQRRK

Description

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.

Catalytic Activity

dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + dolichyl phosphate + H(+)
dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + dolichyl phosphate + H(+)

Similarity

Belongs to the TMTC family.

Keywords

Complete proteome   Endoplasmic reticulum   Glycoprotein   Membrane   Reference proteome   Repeat   TPR repeat   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Protein O-mannosyl-transferase TMTC2

Uniprot

H9JLH8   A0A2A4JNW9   A0A2H1VZ31   A0A194R1Q8   A0A194PNS7   A0A212EKC9   + More
E2B0N8   E9J7B8   F4WW45   A0A026WYN7   A0A151I0T4   A0A0C9QIH1   A0A1W4WY55   A0A182PDC7   A0A139WIR8   Q173Y0   A0A182NEX7   A0A182TNN1   A0A1Y1LQF1   A0A182T2T0   A0A182WGZ9   A0A182MGQ3   A0A3L8DQ71   A0A310SSG2   A0A182Q4V4   A0A0C9QIU6   A0A182KUP7   A0A195E681   A0A195CS84   A0A158NLN7   A0A195EYY3   A0A182JKL0   A0A034V6F5   W5J9R9   A0A336M5N9   A0A087ZZ21   B4K196   A0A0L7RHA6   E0VJB9   A0A151X0I8   A0A1J1ISB8   A0A1I8NT25   Q7PW27   B0W1L0   A0A1S4H0X0   A0A2Y9D0U1   A0A3F2Z0B9   A0A1I8JU75   A0A0M5J148   A0A0K8UQ23   A0A0R3NYV8   B4GQP8   A0A3B0JAT6   B4ID37   K7J8E8   Q29NN5   A0A1I8MSG5   B4KF59   A0A084VG61   A0A0Q9WBU3   A0A0Q9X5S2   B4JDV2   B4LTZ2   T1JUJ3   B4P2Z6   A0A0K8UUU0   A0A1W4V3Z8   B4Q6L4   A0A0J9QUD2   A0A0K8VBB5   A8DYS8   B4N0P0   A0A0L0CG41   A0A0A1WHS0   Q9V3X5   A0A2C9H8B6   A0A0K8SAD1   A0A0A9XPY3   A0A0A9XP05   B3MM56   A0A023F1Y8   W8B300   A0A1A9XVZ6   A0A1B0AP41   A0A1A9UXH9   A0A1A9Z7Q0   A0A0R3NUM7   A0A2S2P6E9   A0A2P2IA48   A0A1D2NLW8   A0A0R3NU98   A0A0R3NUM8   Q29KX4   J9LDN4   A0A3B0JHP9   A0A1A9WKL7   J9K7L0   B4N0F9   T1JJZ4   A0A2S2P253  

EC Number

2.4.1.109

Pubmed

19121390    26354079    22118469    20798317    21282665    21719571    + More
24508170    18362917    19820115    17510324    28004739    30249741    20966253    21347285    25348373    20920257    23761445    17994087    20566863    12364791    15632085    20075255    25315136    24438588    18057021    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26108605    25830018    12537569    26823975    25401762    25474469    24495485    27289101   

EMBL

BABH01005744    BABH01005745    BABH01005746    BABH01005747    NWSH01000877    PCG73755.1    + More
ODYU01005175    SOQ45782.1    KQ460883    KPJ11180.1    KQ459603    KPI92780.1    AGBW02014278    OWR41936.1    GL444666    EFN60710.1    GL768455    EFZ11297.1    GL888404    EGI61634.1    KK107063    EZA61117.1    KQ976605    KYM79346.1    GBYB01003304    JAG73071.1    KQ971338    KYB27853.1    CH477415    EAT41392.1    GEZM01049761    JAV75863.1    AXCM01001361    AXCM01001362    QOIP01000005    RLU22383.1    KQ759820    OAD62727.1    AXCN02000839    GBYB01000537    JAG70304.1    KQ979579    KYN20678.1    KQ977349    KYN03362.1    ADTU01019585    ADTU01019586    ADTU01019587    ADTU01019588    ADTU01019589    ADTU01019590    ADTU01019591    ADTU01019592    ADTU01019593    ADTU01019594    KQ981914    KYN33117.1    GAKP01021633    GAKP01021632    JAC37320.1    ADMH02001866    ETN60746.1    UFQS01000563    UFQT01000563    SSX04978.1    SSX25340.1    CH916886    EDV90990.1    KQ414596    KOC70106.1    DS235221    EEB13475.1    KQ982611    KYQ53883.1    CVRI01000058    CRL02602.1    AAAB01008984    EAA14710.5    DS231822    EDS25808.1    APCN01003740    APCN01003741    CP012523    ALC38086.1    GDHF01023535    JAI28779.1    CH379059    KRT03734.1    CH479187    EDW39920.1    OUUW01000004    SPP79105.1    CH480829    EDW45463.1    EAL34183.2    CH933807    EDW13042.2    ATLV01012673    ATLV01012674    ATLV01012675    ATLV01012676    ATLV01012677    ATLV01012678    ATLV01012679    ATLV01012680    ATLV01012681    ATLV01012682    KE524808    KFB36955.1    CH940649    KRF81994.1    KRG03558.1    KRG03559.1    CH916368    EDW03472.1    EDW65045.1    CAEY01000779    CM000157    EDW87203.1    KRJ97054.1    GDHF01021845    JAI30469.1    CM000361    EDX03280.1    CM002910    KMY87404.1    GDHF01026642    GDHF01016172    JAI25672.1    JAI36142.1    AE014134    ABV53597.2    CH963920    EDW77653.1    JRES01000438    KNC31187.1    GBXI01016081    JAC98210.1    AF181645    GBRD01015583    GDHC01011318    JAG50243.1    JAQ07311.1    GBHO01021933    JAG21671.1    GBHO01021935    JAG21669.1    CH902620    EDV30871.2    GBBI01003354    JAC15358.1    GAMC01015132    JAB91423.1    JXJN01001131    JXJN01001132    JXJN01001133    CH379061    KRT04698.1    GGMR01012424    MBY25043.1    IACF01005308    LAB70894.1    LJIJ01000009    ODN06209.1    KRT04696.1    KRT04697.1    EAL33050.3    ABLF02039474    ABLF02039475    ABLF02039478    ABLF02039479    ABLF02039481    ABLF02039482    ABLF02039483    ABLF02039486    ABLF02039490    ABLF02060120    OUUW01000006    SPP81867.1    ABLF02029874    ABLF02029877    ABLF02033061    EDW77572.1    JH430375    GGMR01010952    MBY23571.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000000311    + More
UP000007755    UP000053097    UP000078540    UP000192223    UP000075885    UP000007266    UP000008820    UP000075884    UP000075902    UP000075901    UP000075920    UP000075883    UP000279307    UP000075886    UP000075882    UP000078492    UP000078542    UP000005205    UP000078541    UP000075880    UP000000673    UP000005203    UP000001070    UP000053825    UP000009046    UP000075809    UP000183832    UP000095300    UP000007062    UP000002320    UP000075840    UP000075903    UP000075900    UP000092553    UP000001819    UP000008744    UP000268350    UP000001292    UP000002358    UP000095301    UP000009192    UP000030765    UP000008792    UP000015104    UP000002282    UP000192221    UP000000304    UP000000803    UP000007798    UP000037069    UP000076407    UP000007801    UP000092443    UP000092460    UP000078200    UP000092445    UP000094527    UP000007819    UP000091820   

PRIDE

H9JLH8    Q9V3X5   

Pfam

PF00515   TPR_1        + More
PF13176   TPR_7
PF13181   TPR_8
PF08409   DUF1736
PF07719   TPR_2
PF07721   TPR_4
PF17874   TPR_MalT
PF13231   PMT_2
PF14529   Exo_endo_phos_2

Interpro

IPR001440   TPR_1        + More
IPR019734   TPR_repeat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       
IPR013618   DUF1736       
IPR013105   TPR_2       
IPR011717   TPR-4       
IPR041617   TPR_MalT       
IPR038731   RgtA/B/C-like       
IPR036875   Znf_CCHC_sf       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR005135   Endo/exonuclease/phosphatase       

SUPFAM

SSF48452   SSF48452        + More
SSF56219   SSF56219       
SSF57756   SSF57756       

Gene 3D

1.25.40.10     3.60.10.10    

ProteinModelPortal

H9JLH8   A0A2A4JNW9   A0A2H1VZ31   A0A194R1Q8   A0A194PNS7   A0A212EKC9   + More
E2B0N8   E9J7B8   F4WW45   A0A026WYN7   A0A151I0T4   A0A0C9QIH1   A0A1W4WY55   A0A182PDC7   A0A139WIR8   Q173Y0   A0A182NEX7   A0A182TNN1   A0A1Y1LQF1   A0A182T2T0   A0A182WGZ9   A0A182MGQ3   A0A3L8DQ71   A0A310SSG2   A0A182Q4V4   A0A0C9QIU6   A0A182KUP7   A0A195E681   A0A195CS84   A0A158NLN7   A0A195EYY3   A0A182JKL0   A0A034V6F5   W5J9R9   A0A336M5N9   A0A087ZZ21   B4K196   A0A0L7RHA6   E0VJB9   A0A151X0I8   A0A1J1ISB8   A0A1I8NT25   Q7PW27   B0W1L0   A0A1S4H0X0   A0A2Y9D0U1   A0A3F2Z0B9   A0A1I8JU75   A0A0M5J148   A0A0K8UQ23   A0A0R3NYV8   B4GQP8   A0A3B0JAT6   B4ID37   K7J8E8   Q29NN5   A0A1I8MSG5   B4KF59   A0A084VG61   A0A0Q9WBU3   A0A0Q9X5S2   B4JDV2   B4LTZ2   T1JUJ3   B4P2Z6   A0A0K8UUU0   A0A1W4V3Z8   B4Q6L4   A0A0J9QUD2   A0A0K8VBB5   A8DYS8   B4N0P0   A0A0L0CG41   A0A0A1WHS0   Q9V3X5   A0A2C9H8B6   A0A0K8SAD1   A0A0A9XPY3   A0A0A9XP05   B3MM56   A0A023F1Y8   W8B300   A0A1A9XVZ6   A0A1B0AP41   A0A1A9UXH9   A0A1A9Z7Q0   A0A0R3NUM7   A0A2S2P6E9   A0A2P2IA48   A0A1D2NLW8   A0A0R3NU98   A0A0R3NUM8   Q29KX4   J9LDN4   A0A3B0JHP9   A0A1A9WKL7   J9K7L0   B4N0F9   T1JJZ4   A0A2S2P253  

PDB

6B85     E-value=2.5699e-08,     Score=135

KEGG

101744805    K23424 protein O-mannosyl-transferase [EC:2.4.1.-] | (RefSeq) transmembrane and TPR repeat-containin

GO

GO:0016021   GO:0042802   GO:0016740   GO:0003676   GO:0008270   GO:0000030   GO:0005783   GO:0004169   GO:0005515   GO:0016810   GO:0005576   GO:0006030   GO:0008061   GO:0003824   GO:0016702   GO:0016295   GO:0016296  

Subcellular location

Membrane  
Endoplasmic reticulum  

Length:

186

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00608999999999999

Exp number, first 60 AAs:

0.00494

Total prob of N-in:

0.20539

outside

1  -  186

 

 

Pi

60.378655

Theta

175.180515

Tajima's D

-0.70019

CLR

106.372094

CSRT

0.1968401579921

Interpretation

Uncertain